JP2007506661A - ピラゾリジンジオン誘導体 - Google Patents
ピラゾリジンジオン誘導体 Download PDFInfo
- Publication number
- JP2007506661A JP2007506661A JP2006515947A JP2006515947A JP2007506661A JP 2007506661 A JP2007506661 A JP 2007506661A JP 2006515947 A JP2006515947 A JP 2006515947A JP 2006515947 A JP2006515947 A JP 2006515947A JP 2007506661 A JP2007506661 A JP 2007506661A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- propoxy
- pyrazolidine
- dione
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/542—Alkylated benzaldehydes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
- C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
- C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
- C07D231/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2003/006616 WO2005002574A1 (fr) | 2003-06-24 | 2003-06-24 | Derives de pyrazolidinedione et leur utilisation en tant qu'inhibiteurs de l'agregation des plaquettes |
PCT/EP2004/006471 WO2005000281A2 (fr) | 2003-06-24 | 2004-06-16 | Derives de pyrazolidinedione |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007506661A true JP2007506661A (ja) | 2007-03-22 |
JP2007506661A5 JP2007506661A5 (fr) | 2007-07-19 |
Family
ID=33547562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006515947A Pending JP2007506661A (ja) | 2003-06-24 | 2004-06-16 | ピラゾリジンジオン誘導体 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1638540A2 (fr) |
JP (1) | JP2007506661A (fr) |
CN (1) | CN1812782A (fr) |
AU (1) | AU2003249865A1 (fr) |
CA (1) | CA2529436A1 (fr) |
WO (2) | WO2005002574A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6016788B2 (ja) * | 2011-05-16 | 2016-10-26 | 国立大学法人九州大学 | DOCK−Aサブファミリー分子によるRac活性化を制御する低分子化合物及びその用途 |
WO2017131149A1 (fr) * | 2016-01-29 | 2017-08-03 | 小野薬品工業株式会社 | Dérivé de tétrahydronaphtalène |
JP2020510043A (ja) * | 2017-03-15 | 2020-04-02 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | P2y12受容体アンタゴニストの皮下投与 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2005026127A1 (ja) * | 2003-09-11 | 2006-11-16 | 株式会社医薬分子設計研究所 | プラスミノゲンアクチベータインヒビター−1阻害剤 |
JPWO2007020935A1 (ja) * | 2005-08-17 | 2009-02-26 | 小野薬品工業株式会社 | P2y12受容体および/またはp2y14受容体ブロッカーを含有してなる疼痛治療剤 |
TWI391378B (zh) | 2006-03-16 | 2013-04-01 | Astellas Pharma Inc | 喹啉酮衍生物或其製藥學上可被容許之鹽 |
JP5560202B2 (ja) | 2007-12-26 | 2014-07-23 | サノフイ | P2y12拮抗薬としてのピラゾール−カルボキサミド誘導体 |
EP2238128B1 (fr) | 2007-12-26 | 2012-08-22 | Sanofi | Pyrazole-carboxamides hétérocycliques utilisés en tant qu'antagonistes du récepteur p2y12 |
EP3342777B1 (fr) * | 2015-08-28 | 2023-01-11 | Sekisui Medical Co., Ltd. | Composé benzyle |
US11584710B2 (en) | 2017-07-31 | 2023-02-21 | Horitzonts Tecnologics Hungary Korlátolt Felelosségu Társaság | Compounds for treating infections |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2012634A1 (fr) * | 1990-03-20 | 1991-09-20 | Hassan Salari | Tyrphostines pour le traitement des allergies et des affections inflammatoires et cardiovasculaires |
WO2002102359A2 (fr) * | 2001-06-18 | 2002-12-27 | Applied Research Systems Ars Holding N.V. | Derives d'alkylidene pyrazolidinedione |
WO2003002569A1 (fr) * | 2001-06-29 | 2003-01-09 | Novo Nordisk A/S | Procede permettant d'inhiber ptp1b et / ou ptp de lymphocyte t et / ou d'autres ptpases a reste asp en position 48 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ516850A (en) * | 1999-07-30 | 2004-09-24 | Abbott Gmbh & Co | 2-pyrazolin-5-ones |
WO2003074550A2 (fr) * | 2002-03-01 | 2003-09-12 | Pintex Pharmaceuticals, Inc. | Composes de modulation de pin1 et procedes d'utilisation correspondant |
-
2003
- 2003-06-24 WO PCT/EP2003/006616 patent/WO2005002574A1/fr active Application Filing
- 2003-06-24 AU AU2003249865A patent/AU2003249865A1/en not_active Abandoned
-
2004
- 2004-06-16 CA CA002529436A patent/CA2529436A1/fr not_active Abandoned
- 2004-06-16 EP EP04739938A patent/EP1638540A2/fr not_active Withdrawn
- 2004-06-16 JP JP2006515947A patent/JP2007506661A/ja active Pending
- 2004-06-16 WO PCT/EP2004/006471 patent/WO2005000281A2/fr active Application Filing
- 2004-06-16 CN CNA2004800177171A patent/CN1812782A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2012634A1 (fr) * | 1990-03-20 | 1991-09-20 | Hassan Salari | Tyrphostines pour le traitement des allergies et des affections inflammatoires et cardiovasculaires |
WO2002102359A2 (fr) * | 2001-06-18 | 2002-12-27 | Applied Research Systems Ars Holding N.V. | Derives d'alkylidene pyrazolidinedione |
WO2003002569A1 (fr) * | 2001-06-29 | 2003-01-09 | Novo Nordisk A/S | Procede permettant d'inhiber ptp1b et / ou ptp de lymphocyte t et / ou d'autres ptpases a reste asp en position 48 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6016788B2 (ja) * | 2011-05-16 | 2016-10-26 | 国立大学法人九州大学 | DOCK−Aサブファミリー分子によるRac活性化を制御する低分子化合物及びその用途 |
WO2017131149A1 (fr) * | 2016-01-29 | 2017-08-03 | 小野薬品工業株式会社 | Dérivé de tétrahydronaphtalène |
JPWO2017131149A1 (ja) * | 2016-01-29 | 2018-11-22 | 小野薬品工業株式会社 | テトラヒドロナフタレン誘導体 |
US10730830B2 (en) | 2016-01-29 | 2020-08-04 | Ono Pharmaceutical Co., Ltd. | Tetrahydronaphthalene derivative |
JP2022000450A (ja) * | 2016-01-29 | 2022-01-04 | 小野薬品工業株式会社 | テトラヒドロナフタレン誘導体 |
JP7279758B2 (ja) | 2016-01-29 | 2023-05-23 | 小野薬品工業株式会社 | テトラヒドロナフタレン誘導体 |
JP2020510043A (ja) * | 2017-03-15 | 2020-04-02 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | P2y12受容体アンタゴニストの皮下投与 |
Also Published As
Publication number | Publication date |
---|---|
CA2529436A1 (fr) | 2005-01-16 |
WO2005000281A2 (fr) | 2005-01-06 |
EP1638540A2 (fr) | 2006-03-29 |
AU2003249865A1 (en) | 2005-01-21 |
CN1812782A (zh) | 2006-08-02 |
WO2005000281A3 (fr) | 2005-04-14 |
WO2005002574A1 (fr) | 2005-01-13 |
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