JP2007505159A5 - - Google Patents

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Publication number

JP2007505159A5

JP2007505159A5 JP2006533223A JP2006533223A JP2007505159A5 JP 2007505159 A5 JP2007505159 A5 JP 2007505159A5 JP 2006533223 A JP2006533223 A JP 2006533223A JP 2006533223 A JP2006533223 A JP 2006533223A JP 2007505159 A5 JP2007505159 A5 JP 2007505159A5

Authority

JP

Japan

Prior art keywords

cells

erythropoietin

injury

administered

pharmaceutical composition

Prior art date

2004-05-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• Espacenet
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• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 58
• 102000003951 Erythropoietin Human genes 0.000 claims 52
• 108090000394 Erythropoietin Proteins 0.000 claims 52
• 229940105423 erythropoietin Drugs 0.000 claims 52
• 230000006378 damage Effects 0.000 claims 40
• 208000014674 injury Diseases 0.000 claims 36
• 210000004027 cell Anatomy 0.000 claims 33
• 238000000034 method Methods 0.000 claims 30
• 208000027418 Wounds and injury Diseases 0.000 claims 27
• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 102000004127 Cytokines Human genes 0.000 claims 22
• 108090000695 Cytokines Proteins 0.000 claims 22
• 230000002669 organ and tissue protective effect Effects 0.000 claims 22
• 230000001225 therapeutic effect Effects 0.000 claims 22
• 210000004962 mammalian cell Anatomy 0.000 claims 14
• 210000000056 organ Anatomy 0.000 claims 10
• 210000001519 tissue Anatomy 0.000 claims 10
• 230000008733 trauma Effects 0.000 claims 9
• 150000001720 carbohydrates Chemical class 0.000 claims 8
• 235000014633 carbohydrates Nutrition 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 7
• 108010027485 asialoerythropoietin Proteins 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 5
• 208000006011 Stroke Diseases 0.000 claims 4
• 210000004556 brain Anatomy 0.000 claims 4
• 230000003325 follicular Effects 0.000 claims 4
• 210000003494 hepatocyte Anatomy 0.000 claims 4
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
• 210000001013 sinoatrial node Anatomy 0.000 claims 4
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• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 230000035899 viability Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
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• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
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• 206010007558 Cardiac failure chronic Diseases 0.000 claims 2
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 2
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 2
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 2
• 206010012289 Dementia Diseases 0.000 claims 2
• 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
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• 208000003098 Ganglion Cysts Diseases 0.000 claims 2
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• 102000005744 Glycoside Hydrolases Human genes 0.000 claims 2
• 108010031186 Glycoside Hydrolases Proteins 0.000 claims 2
• 208000010496 Heart Arrest Diseases 0.000 claims 2
• 208000001953 Hypotension Diseases 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
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• 208000005400 Synovial Cyst Diseases 0.000 claims 2
• 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 2
• 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 2
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• 210000002556 adrenal cortex cell Anatomy 0.000 claims 2
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• 235000001014 amino acid Nutrition 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
• 210000001992 atrioventricular node Anatomy 0.000 claims 2
• 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
• 210000003050 axon Anatomy 0.000 claims 2
• 230000002612 cardiopulmonary effect Effects 0.000 claims 2
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• 210000003737 chromaffin cell Anatomy 0.000 claims 2
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• 239000000835 fiber Substances 0.000 claims 2
• 230000001434 glomerular Effects 0.000 claims 2
• 210000003904 glomerular cell Anatomy 0.000 claims 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
• 210000002175 goblet cell Anatomy 0.000 claims 2
• 238000005534 hematocrit Methods 0.000 claims 2
• 210000002287 horizontal cell Anatomy 0.000 claims 2
• 230000036543 hypotension Effects 0.000 claims 2
• 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 210000004347 intestinal mucosa Anatomy 0.000 claims 2
• 210000003292 kidney cell Anatomy 0.000 claims 2
• 210000001865 kupffer cell Anatomy 0.000 claims 2
• 210000005265 lung cell Anatomy 0.000 claims 2
• 208000002780 macular degeneration Diseases 0.000 claims 2
• 230000006984 memory degeneration Effects 0.000 claims 2
• 208000023060 memory loss Diseases 0.000 claims 2
• PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims 2
• 229960001810 meprednisone Drugs 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 230000002107 myocardial effect Effects 0.000 claims 2
• 208000010125 myocardial infarction Diseases 0.000 claims 2
• 210000004457 myocytus nodalis Anatomy 0.000 claims 2
• 230000004770 neurodegeneration Effects 0.000 claims 2
• 208000015122 neurodegenerative disease Diseases 0.000 claims 2
• 210000003668 pericyte Anatomy 0.000 claims 2
• 210000000608 photoreceptor cell Anatomy 0.000 claims 2
• 230000002947 procoagulating effect Effects 0.000 claims 2
• 230000005855 radiation Effects 0.000 claims 2
• 230000002207 retinal effect Effects 0.000 claims 2
• 208000032253 retinal ischemia Diseases 0.000 claims 2
• 210000001116 retinal neuron Anatomy 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 210000000717 sertoli cell Anatomy 0.000 claims 2
• 125000005629 sialic acid group Chemical group 0.000 claims 2
• 210000000813 small intestine Anatomy 0.000 claims 2
• 208000020431 spinal cord injury Diseases 0.000 claims 2
• 210000004500 stellate cell Anatomy 0.000 claims 2
• 210000000130 stem cell Anatomy 0.000 claims 2
• 210000001550 testis Anatomy 0.000 claims 2
• 229960000187 tissue plasminogen activator Drugs 0.000 claims 2
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 2
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 230000025033 vasoconstriction Effects 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 210000004413 cardiac myocyte Anatomy 0.000 claims 1
• 210000002064 heart cell Anatomy 0.000 claims 1
• 210000000663 muscle cell Anatomy 0.000 claims 1
• 230000002611 ovarian Effects 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 210000004291 uterus Anatomy 0.000 claims 1