JP2007503268A5 - - Google Patents

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Publication number
JP2007503268A5
JP2007503268A5 JP2006524827A JP2006524827A JP2007503268A5 JP 2007503268 A5 JP2007503268 A5 JP 2007503268A5 JP 2006524827 A JP2006524827 A JP 2006524827A JP 2006524827 A JP2006524827 A JP 2006524827A JP 2007503268 A5 JP2007503268 A5 JP 2007503268A5
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JP
Japan
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irm
delivery device
microneedle
compound
agonist
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JP2006524827A
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Japanese (ja)
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JP2007503268A (ja
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Priority claimed from PCT/US2004/027633 external-priority patent/WO2005020912A2/en
Publication of JP2007503268A publication Critical patent/JP2007503268A/ja
Publication of JP2007503268A5 publication Critical patent/JP2007503268A5/ja
Pending legal-status Critical Current

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JP2006524827A 2003-08-25 2004-08-25 免疫応答修飾化合物の送達 Pending JP2007503268A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49762803P 2003-08-25 2003-08-25
PCT/US2004/027633 WO2005020912A2 (en) 2003-08-25 2004-08-25 Delivery of immune response modifier compounds

Publications (2)

Publication Number Publication Date
JP2007503268A JP2007503268A (ja) 2007-02-22
JP2007503268A5 true JP2007503268A5 (enExample) 2007-11-22

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JP2006524827A Pending JP2007503268A (ja) 2003-08-25 2004-08-25 免疫応答修飾化合物の送達

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US (1) US8961477B2 (enExample)
EP (1) EP1658035A4 (enExample)
JP (1) JP2007503268A (enExample)
AU (2) AU2004268616B2 (enExample)
CA (1) CA2536249A1 (enExample)
WO (1) WO2005020912A2 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
JP2007503268A (ja) 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
NZ546274A (en) 2003-10-03 2009-12-24 3M Innovative Properties Co Pyrazolopyridines and analags thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
US8541438B2 (en) 2004-06-18 2013-09-24 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合[1,2]イミダゾ[4,5−c]環状化合物
ES2392648T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
NZ560543A (en) * 2005-01-28 2012-01-12 Galenbio Inc Immunologically active compositions using pathogen associated molecular patterns (PAMP)
WO2007120121A2 (en) 2005-02-09 2007-10-25 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted thiazolo[4,5-c] ring compounds and methods
EP1846419B1 (en) 2005-02-09 2014-04-16 3M Innovative Properties Company Alkoxy-substituted thiazoloquinolines and thiazolonaphthyridines
US8658666B2 (en) 2005-02-11 2014-02-25 3M Innovative Properties Company Substituted imidazoquinolines and imidazonaphthyridines
US8158794B2 (en) 2005-02-23 2012-04-17 3M Innovative Properties Company Hydroxyalkyl substituted imidazoquinoline compounds and methods
JP2008543725A (ja) 2005-02-23 2008-12-04 コーリー ファーマシューティカル グループ,インコーポレイテッド ヒドロキシアルキル置換イミダゾキノリン
JP2008531568A (ja) 2005-02-23 2008-08-14 コーリー ファーマシューティカル グループ,インコーポレイテッド ヒドロキシアルキルで置換されたイミダゾナフチリジン
AU2006216686A1 (en) 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Method of preferentially inducing the biosynthesis of interferon
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
ZA200803029B (en) 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
CA2621831A1 (en) 2005-09-09 2007-03-15 Coley Pharmaceutical Group, Inc. Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
JP5247458B2 (ja) 2005-11-04 2013-07-24 スリーエム・イノベイティブ・プロパティーズ・カンパニー ヒドロキシ及びアルコキシ置換1h−イミダゾキノリン及び方法
AU2006311462A1 (en) * 2005-11-09 2007-05-18 Cheng Si Yuan (China-International) Hepatitis Research Foundation Diagnostic and therapeutic methods and agents
EP1988896A4 (en) 2006-02-22 2011-07-27 3M Innovative Properties Co CONJUGATES TO MODIFY IMMUNE REACTIONS
US8329721B2 (en) 2006-03-15 2012-12-11 3M Innovative Properties Company Hydroxy and alkoxy substituted 1H-imidazonaphthyridines and methods
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
WO2008030511A2 (en) 2006-09-06 2008-03-13 Coley Pharmaceuticial Group, Inc. Substituted 3,4,6,7-tetrahydro-5h, 1,2a,4a,8-tetraazacyclopenta[cd]phenalenes
KR20100025514A (ko) 2007-04-25 2010-03-09 임뮤룩스, 인코포레이티드 Nkt 활성화제,cd40 효능제 및 임의의 항원의 애주번트 조합물 및 상승적인 세포 면역성의 유도에 의한 용도
US20090041810A1 (en) * 2007-07-09 2009-02-12 Andrianov Alexander K Immunostimulating polyphosphazene compounds for intradermal immunization
US20090016935A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Coating formulations including polyphosphazene polyelectrolytes and biologically active agents and asperities coated with such formulations
US20100160368A1 (en) * 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
GEP20156418B (en) 2009-07-13 2016-01-11 Medicis Pharmaceutical Corp Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts
US9693950B2 (en) 2010-05-28 2017-07-04 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
CA2808624C (en) 2010-08-17 2019-05-14 3M Innovative Properties Company Lipidated immune response modifier compound compositions, formulations, and methods
EP3366311B1 (en) 2011-06-03 2020-02-26 3M Innovative Properties Co. Hydrazino-1h-imidazoquinolin-4-amines and conjugates made therefrom
CA2838158C (en) 2011-06-03 2019-07-16 3M Innovative Properties Company Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
MX346625B (es) * 2011-06-24 2017-03-27 Flugen Inc Mutantes de virus de influenza y usos para los mismos.
US20130096532A1 (en) * 2011-10-17 2013-04-18 Rutgers, The State University Of New Jersey Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery
US10821276B2 (en) * 2012-12-14 2020-11-03 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
KR101724655B1 (ko) * 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
US20180008703A1 (en) 2015-01-27 2018-01-11 3M Innovative Properties Company Alum-containing coating formulations for microneedle vaccine patches
MA52701A (fr) 2015-03-16 2021-03-31 Hoffmann La Roche Traitement combiné avec un agoniste tlr7 et un inhibiteur d'assemblage de capside du virus de l'hépatite b
EP3359129B1 (en) 2015-10-09 2022-02-23 Kindeva Drug Delivery L.P. Zinc compositions for coated microneedle arrays
CN108430515B (zh) 2015-10-29 2021-11-12 诺华股份有限公司 包含toll-样受体激动剂的抗体缀合物
AU2017253674B2 (en) 2016-04-18 2021-07-29 Kindeva Drug Delivery L.P. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
CA3086439A1 (en) 2017-12-20 2019-06-27 3M Innovative Properties Company Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
WO2019136133A1 (en) 2018-01-03 2019-07-11 The Trustees Of Columbia University In The City Of New York Microneedle for local delivery of therapeutic agent
EP3804696A1 (en) * 2019-10-07 2021-04-14 Unigroup ApS A multi-component wart destructing means
WO2021087179A1 (en) * 2019-10-29 2021-05-06 The Regents Of The University Of California Periodontal micropatch and uses thereof
AU2020386380A1 (en) * 2019-11-18 2022-06-02 Anna O. LIKHACHEVA System for conforming treatment applicators to non-uniform surfaces
EP4153139A4 (en) * 2020-05-21 2025-07-30 Vaxess Tech Inc COMPOSITIONS AND DEVICES FOR VACCINE DELIVERY AND USES THEREOF

Family Cites Families (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3167073A (en) * 1962-01-16 1965-01-26 Rosenthal Sol Roy Transcutaneous injection device
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3314941A (en) * 1964-06-23 1967-04-18 American Cyanamid Co Novel substituted pyridodiazepins
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
ZA848968B (en) 1983-11-18 1986-06-25 Riker Laboratories Inc 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US4988515A (en) * 1988-01-28 1991-01-29 The Regents Of The Univ. Of Calif. Cardioplegic solution
US5238944A (en) 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5756747A (en) * 1989-02-27 1998-05-26 Riker Laboratories, Inc. 1H-imidazo 4,5-c!quinolin-4-amines
US5037986A (en) * 1989-03-23 1991-08-06 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
NZ232740A (en) 1989-04-20 1992-06-25 Riker Laboratories Inc Solution for parenteral administration comprising a 1h-imidazo(4,5-c) quinolin-4-amine derivative, an acid and a tonicity adjuster
US4988815A (en) 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
HU217080B (hu) 1990-10-05 1999-11-29 Minnesota Mining And Manufacturing Co. Új eljárás imidazo[4,5-c]kinolin-4-amin-származékok előállítására
TW279133B (enExample) 1990-12-13 1996-06-21 Elan Med Tech
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5175296A (en) 1991-03-01 1992-12-29 Minnesota Mining And Manufacturing Company Imidazo[4,5-c]quinolin-4-amines and processes for their preparation
US5268376A (en) 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
CZ288182B6 (en) 1993-07-15 2001-05-16 Minnesota Mining & Mfg Imidazo[4,5-c]pyridine-4-amines and pharmaceutical preparations based thereon
US5352784A (en) 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5804566A (en) 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
FR2720003B1 (fr) * 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
WO1996010630A1 (en) 1994-09-30 1996-04-11 Rutgers, The State University Direct introduction of foreign materials into cells
US5482936A (en) * 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US5853383A (en) 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JPH09208584A (ja) 1996-01-29 1997-08-12 Terumo Corp アミド誘導体、およびそれを含有する医薬製剤、および合成中間体
JPH09255926A (ja) 1996-03-26 1997-09-30 Diatex Co Ltd 粘着テープ
US6068623A (en) * 1997-03-06 2000-05-30 Percusurge, Inc. Hollow medical wires and methods of constructing same
US5741908A (en) * 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
US5693811A (en) 1996-06-21 1997-12-02 Minnesota Mining And Manufacturing Company Process for preparing tetrahdroimidazoquinolinamines
KR19990044383A (ko) * 1996-07-03 1999-06-25 나가시마 카쭈시게, 노미야마 아키히코 신규 퓨린 유도체
US6387938B1 (en) * 1996-07-05 2002-05-14 Mochida Pharmaceutical Co., Ltd. Benzimidazole derivatives
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
ES2290969T3 (es) * 1996-10-25 2008-02-16 Minnesota Mining And Manufacturing Company Compuestos modificadores de la respuesta inmune para el tratamiento de enfermedades mediadas por th2 y relacionadas.
US5910306A (en) * 1996-11-14 1999-06-08 The United States Of America As Represented By The Secretary Of The Army Transdermal delivery system for antigen
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US5939090A (en) 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
WO1998030562A1 (en) 1997-01-09 1998-07-16 Terumo Kabushiki Kaisha Novel amide derivatives and intermediates for the synthesis thereof
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6426334B1 (en) * 1997-04-30 2002-07-30 Hybridon, Inc. Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
WO1998052581A1 (en) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6329381B1 (en) 1997-11-28 2001-12-11 Sumitomo Pharmaceuticals Company, Limited Heterocyclic compounds
ATE406935T1 (de) 1997-12-11 2008-09-15 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
UA67760C2 (uk) * 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
TW572758B (en) * 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6352722B1 (en) * 1997-12-23 2002-03-05 Quadrant Holdings Cambridge Limited Derivatized carbohydrates, compositions comprised thereof and methods of use thereof
JPH11222432A (ja) 1998-02-03 1999-08-17 Terumo Corp インターフェロンを誘起するアミド誘導体を含有する外用剤
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US6110929A (en) * 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd 1h―イミダゾピリジン誘導体
CA2341446C (en) * 1998-08-31 2008-10-07 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
JP2002532165A (ja) 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
US6245776B1 (en) * 1999-01-08 2001-06-12 3M Innovative Properties Company Formulations and methods for treatment of mucosal associated conditions with an immune response modifier
US20020058674A1 (en) * 1999-01-08 2002-05-16 Hedenstrom John C. Systems and methods for treating a mucosal surface
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
ATE256484T1 (de) 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
JP2000247884A (ja) 1999-03-01 2000-09-12 Sumitomo Pharmaceut Co Ltd アラキドン酸誘発皮膚疾患治療剤
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
EP1196558A1 (fr) 1999-06-08 2002-04-17 Aventis Pasteur Oligonucleotide immunostimulant
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6756382B2 (en) * 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6451810B1 (en) 1999-06-10 2002-09-17 3M Innovative Properties Company Amide substituted imidazoquinolines
US6573273B1 (en) * 1999-06-10 2003-06-03 3M Innovative Properties Company Urea substituted imidazoquinolines
US6541485B1 (en) * 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
JP5268214B2 (ja) 1999-08-13 2013-08-21 イデラ ファーマシューティカルズ インコーポレイテッド ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6376669B1 (en) * 1999-11-05 2002-04-23 3M Innovative Properties Company Dye labeled imidazoquinoline compounds
EP1235611B1 (en) 1999-11-15 2005-09-07 Velcro Industries B.V. Skin attachment member
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6894060B2 (en) 2000-03-30 2005-05-17 3M Innovative Properties Company Method for the treatment of dermal lesions caused by envenomation
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
DE10036282A1 (de) 2000-07-26 2002-02-07 Bosch Gmbh Robert Verfahren und Vorrichtung zur Steuerung einer Antriebseinheit
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
BR0113749A (pt) 2000-09-08 2004-06-22 Alza Corp Métodos para inibir a diminuição no fluxo de droga transdérmica por inibição do fechamento das vias
US20020055517A1 (en) * 2000-09-15 2002-05-09 3M Innovative Properties Company Methods for delaying recurrence of herpes virus symptoms
GB0023008D0 (en) * 2000-09-20 2000-11-01 Glaxo Group Ltd Improvements in vaccination
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
BR0114909A (pt) 2000-10-26 2004-02-03 Alza Corp Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
JP2002145777A (ja) 2000-11-06 2002-05-22 Sumitomo Pharmaceut Co Ltd アラキドン酸誘発皮膚疾患治療剤
EP2578252B1 (en) 2000-11-30 2019-01-09 Valeritas, Inc. Device with substantially freely movable micro-probe over the housing
UA74593C2 (en) 2000-12-08 2006-01-16 3M Innovative Properties Co Substituted imidazopyridines
US6664265B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6545016B1 (en) * 2000-12-08 2003-04-08 3M Innovative Properties Company Amide substituted imidazopyridines
US6664264B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6677347B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
US6660747B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6660735B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Urea substituted imidazoquinoline ethers
US6677348B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6667312B2 (en) 2000-12-08 2003-12-23 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6664260B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Heterocyclic ether substituted imidazoquinolines
US6525064B1 (en) * 2000-12-08 2003-02-25 3M Innovative Properties Company Sulfonamido substituted imidazopyridines
AU2002232498B2 (en) 2000-12-08 2006-05-04 3M Innovative Properties Company Screening method for identifying compounds that selectively induce interferon alpha
UA74852C2 (en) 2000-12-08 2006-02-15 3M Innovative Properties Co Urea-substituted imidazoquinoline ethers
US6545017B1 (en) * 2000-12-08 2003-04-08 3M Innovative Properties Company Urea substituted imidazopyridines
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
WO2002085447A2 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
JP2005519849A (ja) 2001-06-15 2005-07-07 スリーエム イノベイティブ プロパティズ カンパニー 歯周病の治療用免疫応答調節剤
EP1416986A4 (en) 2001-06-29 2005-12-14 Becton Dickinson Co INTRADERMIC DISTRIBUTION OF VACCINES AND GENE THERAPEUTIC AGENTS VIA MICROCANNULE
CA2458876A1 (en) * 2001-08-30 2003-03-13 3M Innovative Properties Company Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
EP1469903A2 (en) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Microneedle with membrane
US20030139364A1 (en) * 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds
EP1439870B1 (en) * 2001-10-29 2009-01-14 Becton, Dickinson and Company Device for the delivery of a substance
US20040014779A1 (en) * 2001-11-16 2004-01-22 3M Innovative Properties Company Methods and compositions related to IRM compounds and toll-like recptor pathways
EP1450810A4 (en) 2001-11-16 2005-11-30 Uab Research Foundation XANTHINE INHIBITION
EP1459727B1 (en) 2001-11-22 2010-06-09 Japan Science and Technology Agency Nonhuman model animal unresponsive to immunopotentiating synthetic compound
DE60228611D1 (de) 2001-11-29 2008-10-09 3M Innovative Properties Co Pharmazeutische formulierung umfassend ein die immunantwort modifizierendes mittel
US6677349B1 (en) * 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
GB0201736D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd DNA dosage forms
CA2475595C (en) 2002-02-22 2012-07-10 3M Innovative Properties Company Method of reducing and preventing uvb-induced immunosuppression
US20030185835A1 (en) * 2002-03-19 2003-10-02 Braun Ralph P. Adjuvant for vaccines
US7015262B2 (en) 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
US6743920B2 (en) * 2002-05-29 2004-06-01 3M Innovative Properties Company Process for imidazo[4,5-c]pyridin-4-amines
WO2003103584A2 (en) 2002-06-07 2003-12-18 3M Innovative Properties Company Ether substituted imidazopyridines
AR040302A1 (es) * 2002-06-28 2005-03-23 Alza Corp Dispositivos para la liberacion transdermica de farmacos, que presentan microprotrusiones recubiertas
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
AR040819A1 (es) * 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
ATE488246T1 (de) * 2002-08-15 2010-12-15 3M Innovative Properties Co Immunstimulatorische zusammensetzungen und verfahren zur stimulierung einer immunantwort
JP2006503068A (ja) 2002-09-26 2006-01-26 スリーエム イノベイティブ プロパティズ カンパニー 1h−イミダゾダイマー
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
WO2004053057A2 (en) 2002-12-11 2004-06-24 3M Innovative Properties Company Gene expression systems and recombinant cell lines
WO2004053452A2 (en) * 2002-12-11 2004-06-24 3M Innovative Properties Company Assays relating to toll-like receptor activity
CA2510375A1 (en) * 2002-12-20 2004-07-15 3M Innovative Properties Company Aryl / hetaryl substituted imidazoquinolines
JP2006512391A (ja) * 2002-12-30 2006-04-13 スリーエム イノベイティブ プロパティズ カンパニー 組み合わせ免疫賦活薬
JP2006517974A (ja) * 2003-02-13 2006-08-03 スリーエム イノベイティブ プロパティズ カンパニー Irm化合物およびトル様受容体8に関する方法および組成物
JP2006519020A (ja) 2003-02-27 2006-08-24 スリーエム イノベイティブ プロパティズ カンパニー Tlr介在生物活性の選択的調節
WO2004078138A2 (en) 2003-03-04 2004-09-16 3M Innovative Properties Company Prophylactic treatment of uv-induced epidermal neoplasia
JP2006519877A (ja) 2003-03-07 2006-08-31 スリーエム イノベイティブ プロパティズ カンパニー 1−アミノ1h−イミダゾキノリン
EP1603476A4 (en) 2003-03-13 2010-01-13 3M Innovative Properties Co PROCESS FOR REMOVING TATTOO
WO2004080293A2 (en) 2003-03-13 2004-09-23 3M Innovative Properties Company Methods for diagnosing skin lesions
NZ567227A (en) 2003-03-13 2010-01-29 3M Innovative Properties Co Methods of improving skin quality through topical application of an immune response modifier such as imiquimod
US20040191833A1 (en) 2003-03-25 2004-09-30 3M Innovative Properties Company Selective activation of cellular activities mediated through a common toll-like receptor
US20040192585A1 (en) 2003-03-25 2004-09-30 3M Innovative Properties Company Treatment for basal cell carcinoma
WO2004108072A2 (en) 2003-04-10 2004-12-16 3M Innovative Properties Company Delivery of immune response modifier compounds using metal-containing particulate support materials
EP1617845A4 (en) 2003-04-28 2006-09-20 3M Innovative Properties Co COMPOSITIONS AND METHODS FOR INDUCING OPOID RECEPTORS
ES2290738T3 (es) 2003-06-30 2008-02-16 Alza Corporation Procedimiento para revestir microproyecciones de perforacion de la piel.
WO2005004842A2 (en) 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
CA2530954A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
CN1863572A (zh) * 2003-08-04 2006-11-15 阿尔扎公司 提高药剂经皮流通量的方法和装置
JP2007501252A (ja) * 2003-08-05 2007-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調整剤を含有する製剤
JP2007503268A (ja) 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
ES2342069T4 (es) * 2003-09-05 2011-01-26 Anadys Pharmaceuticals, Inc. Ligandos de tlr7 para el tratamiento de la hepatitis c.
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1678293A2 (en) * 2003-10-23 2006-07-12 Alza Corporation Compositions of stabilized dna for coating microprojections
CA2543086A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US20050106227A1 (en) * 2003-10-28 2005-05-19 Samuel Zalipsky Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections
US20050123565A1 (en) * 2003-10-31 2005-06-09 Janardhanan Subramony System and method for transdermal vaccine delivery
AU2004292953A1 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system

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