JP2007502837A5 - - Google Patents
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- Publication number
- JP2007502837A5 JP2007502837A5 JP2006524063A JP2006524063A JP2007502837A5 JP 2007502837 A5 JP2007502837 A5 JP 2007502837A5 JP 2006524063 A JP2006524063 A JP 2006524063A JP 2006524063 A JP2006524063 A JP 2006524063A JP 2007502837 A5 JP2007502837 A5 JP 2007502837A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sample
- antibody
- small epitope
- biomarker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 59
- 102000004169 proteins and genes Human genes 0.000 claims 31
- 108090000623 proteins and genes Proteins 0.000 claims 31
- 239000000090 biomarker Substances 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000024891 symptom Diseases 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 244000052769 pathogen Species 0.000 claims 5
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 239000003053 toxin Substances 0.000 claims 5
- 231100000765 toxin Toxicity 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49615403P | 2003-08-18 | 2003-08-18 | |
| US51172003P | 2003-10-15 | 2003-10-15 | |
| PCT/US2004/027005 WO2005019831A2 (en) | 2003-08-18 | 2004-08-18 | Methods for reducing complexity of a sample using small epitope antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502837A JP2007502837A (ja) | 2007-02-15 |
| JP2007502837A5 true JP2007502837A5 (cg-RX-API-DMAC7.html) | 2007-12-13 |
Family
ID=34221395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524063A Pending JP2007502837A (ja) | 2003-08-18 | 2004-08-18 | 小型エピトープ抗体を使用するサンプルの複雑さを低減するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20050131219A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1658506A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007502837A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1864068B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004267802B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2536062A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005019831A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004035742A2 (en) * | 2002-10-15 | 2004-04-29 | Abmetrix, Inc. | Sets of digital antibodies directed against short epitopes, and methods using same |
| CN1864068B (zh) * | 2003-08-18 | 2010-10-13 | 特提斯生物科学公司 | 用小表位抗体降低样品复杂度的方法 |
| EP1844322A4 (en) * | 2005-01-31 | 2009-06-10 | Insilicos Llc | METHOD FOR IDENTIFICATION OF BIOMARKERS BY MEANS OF MASS SPECTROMETRY TECHNIQUES |
| US7763423B2 (en) * | 2005-09-30 | 2010-07-27 | Pacific Biosciences Of California, Inc. | Substrates having low density reactive groups for monitoring enzyme activity |
| WO2008076139A1 (en) * | 2006-03-10 | 2008-06-26 | Tethys Bioscience, Inc. | Multiplex protein fractionation |
| US20080050747A1 (en) * | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
| US8975216B2 (en) * | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| DE102006015001A1 (de) * | 2006-03-31 | 2007-10-11 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung |
| WO2007117444A2 (en) * | 2006-03-31 | 2007-10-18 | Yinghe Hu | Protein detection by aptamers |
| CA2686039A1 (en) * | 2007-05-03 | 2008-11-13 | Tethys Bioscience, Inc. | Binding reagents that contain small epitope binding molecules |
| WO2010047797A2 (en) * | 2008-10-21 | 2010-04-29 | Research Foundation Of The City University Of New York | Single quantum-dot-based aptameric sensors |
| US9202678B2 (en) * | 2008-11-14 | 2015-12-01 | Board Of Trustees Of Michigan State University | Ultrafast laser system for biological mass spectrometry |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| KR20130084091A (ko) | 2012-01-16 | 2013-07-24 | 삼성전자주식회사 | 화상형성장치 |
| WO2023200284A1 (ko) * | 2022-04-15 | 2023-10-19 | 재단법인대구경북과학기술원 | 생체 시료 내 지질 연관 단백질의 질량 분석을 위한 지질 연관 단백질의 정제 및 농축 방법 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4774339A (en) * | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| US5217869A (en) * | 1987-10-13 | 1993-06-08 | Terrapin Technologies, Inc. | Method to produce immunodiagnostic reagents |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5168499A (en) * | 1990-05-02 | 1992-12-01 | California Institute Of Technology | Fault detection and bypass in a sequence information signal processor |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| GB9115364D0 (en) * | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US6210671B1 (en) * | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| JPH0793370A (ja) * | 1993-09-27 | 1995-04-07 | Hitachi Device Eng Co Ltd | 遺伝子データベース検索システム |
| US6017693A (en) * | 1994-03-14 | 2000-01-25 | University Of Washington | Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry |
| US5701256A (en) * | 1995-05-31 | 1997-12-23 | Cold Spring Harbor Laboratory | Method and apparatus for biological sequence comparison |
| US6265150B1 (en) * | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
| NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| US6410245B1 (en) * | 1998-04-01 | 2002-06-25 | Affymax, Inc. | Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions |
| US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| US7198896B2 (en) * | 1998-09-04 | 2007-04-03 | Cell Signaling Technology, Inc. | Immunoaffinity isolation of modified peptides from complex mixtures |
| US6441140B1 (en) * | 1998-09-04 | 2002-08-27 | Cell Signaling Technology, Inc. | Production of motif-specific and context-independent antibodies using peptide libraries as antigens |
| JP2002544488A (ja) * | 1999-05-07 | 2002-12-24 | クアンタム ドット コーポレイション | 半導体ナノクリスタルを用いて分析物を検出する方法 |
| US20020015952A1 (en) * | 1999-07-30 | 2002-02-07 | Anderson Norman G. | Microarrays and their manufacture by slicing |
| US7351540B1 (en) * | 2000-03-17 | 2008-04-01 | Merck Patent Gmbh | Protein isolation and analysis |
| ATE344456T1 (de) * | 2000-05-05 | 2006-11-15 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
| EP1350106A2 (en) * | 2000-08-11 | 2003-10-08 | Agilix Corporation | Ultra-sensitive detection systems |
| GB0022978D0 (en) * | 2000-09-19 | 2000-11-01 | Oxford Glycosciences Uk Ltd | Detection of peptides |
| JP2002191364A (ja) * | 2000-12-26 | 2002-07-09 | Mitsubishi Chemicals Corp | タンパク質の検出あるいは定量方法 |
| WO2002061047A2 (en) * | 2001-02-01 | 2002-08-08 | Ciphergen Biosystems, Inc. | Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry |
| US20030219734A1 (en) * | 2001-04-13 | 2003-11-27 | Biosite Incorporated | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US7117096B2 (en) * | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| US20030022240A1 (en) * | 2001-04-17 | 2003-01-30 | Peizhi Luo | Generation and affinity maturation of antibody library in silico |
| US20040010376A1 (en) * | 2001-04-17 | 2004-01-15 | Peizhi Luo | Generation and selection of protein library in silico |
| US6833441B2 (en) * | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| AU2002341862C1 (en) * | 2001-09-27 | 2009-01-29 | Purdue Research Foundation | Controlling isotope effects during fractionation of analytes |
| US7175983B2 (en) * | 2001-11-02 | 2007-02-13 | Abmaxis, Inc. | Adapter-directed display systems |
| US7473535B2 (en) * | 2002-08-20 | 2009-01-06 | The Institute For Systems Biology | Chemical reagents and methods for detection and quantification of proteins in complex mixtures |
| US20030119063A1 (en) * | 2002-09-03 | 2003-06-26 | Pham Thang T. | High accuracy protein identification |
| WO2004035742A2 (en) * | 2002-10-15 | 2004-04-29 | Abmetrix, Inc. | Sets of digital antibodies directed against short epitopes, and methods using same |
| CN1864068B (zh) * | 2003-08-18 | 2010-10-13 | 特提斯生物科学公司 | 用小表位抗体降低样品复杂度的方法 |
-
2004
- 2004-08-18 CN CN2004800295981A patent/CN1864068B/zh not_active Expired - Fee Related
- 2004-08-18 EP EP04786542A patent/EP1658506A2/en not_active Withdrawn
- 2004-08-18 JP JP2006524063A patent/JP2007502837A/ja active Pending
- 2004-08-18 CA CA002536062A patent/CA2536062A1/en not_active Abandoned
- 2004-08-18 US US10/921,380 patent/US20050131219A1/en not_active Abandoned
- 2004-08-18 AU AU2004267802A patent/AU2004267802B2/en not_active Ceased
- 2004-08-18 WO PCT/US2004/027005 patent/WO2005019831A2/en not_active Ceased
-
2006
- 2006-10-23 US US11/585,507 patent/US20070042431A1/en not_active Abandoned
-
2007
- 2007-08-07 US US11/890,884 patent/US20080241934A1/en not_active Abandoned
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