JP2007500723A5 - - Google Patents

Download PDF

Info

Publication number
JP2007500723A5
JP2007500723A5 JP2006522108A JP2006522108A JP2007500723A5 JP 2007500723 A5 JP2007500723 A5 JP 2007500723A5 JP 2006522108 A JP2006522108 A JP 2006522108A JP 2006522108 A JP2006522108 A JP 2006522108A JP 2007500723 A5 JP2007500723 A5 JP 2007500723A5
Authority
JP
Japan
Prior art keywords
formulation
antagonist
joint
preparation
high specificity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006522108A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007500723A (ja
Filing date
Publication date
Priority claimed from US10/630,227 external-priority patent/US8361467B2/en
Application filed filed Critical
Publication of JP2007500723A publication Critical patent/JP2007500723A/ja
Publication of JP2007500723A5 publication Critical patent/JP2007500723A5/ja
Pending legal-status Critical Current

Links

JP2006522108A 2003-07-30 2004-07-30 肢体関節への高特異性サイトカイン抑制因子の嚢横断的投与 Pending JP2007500723A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/630,227 US8361467B2 (en) 2003-07-30 2003-07-30 Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
PCT/US2004/024725 WO2005011689A2 (en) 2003-07-30 2004-07-30 Treatment of inflamed joints

Publications (2)

Publication Number Publication Date
JP2007500723A JP2007500723A (ja) 2007-01-18
JP2007500723A5 true JP2007500723A5 (https=) 2007-06-07

Family

ID=34103795

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006522108A Pending JP2007500723A (ja) 2003-07-30 2004-07-30 肢体関節への高特異性サイトカイン抑制因子の嚢横断的投与

Country Status (6)

Country Link
US (1) US8361467B2 (https=)
EP (1) EP1675589A2 (https=)
JP (1) JP2007500723A (https=)
AU (1) AU2004260683A1 (https=)
CA (1) CA2534327A1 (https=)
WO (1) WO2005011689A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115557B2 (en) * 1998-09-25 2006-10-03 Sciaticon Ab Use of certain drugs for treating nerve root injury
US20060002935A1 (en) * 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
US20080008713A1 (en) * 2002-06-28 2008-01-10 Domantis Limited Single domain antibodies against tnfr1 and methods of use therefor
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
EP1778134A1 (en) * 2004-07-27 2007-05-02 Synthes USA Supplementation or replacement of a nucleus pulposus, of an intervertebral disc
US20060241758A1 (en) * 2005-04-20 2006-10-26 Sdgi Holdings, Inc. Facet spacers
EP3725299A1 (en) * 2005-06-24 2020-10-21 Duke University A direct drug delivery system based on thermally responsive biopolymers
JP2009508970A (ja) 2005-09-21 2009-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 疼痛の局所造影および治療のためのシステム、組成物並びに方法
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
US20080015465A1 (en) * 2006-06-15 2008-01-17 Scuderi Gaetano J Methods for diagnosing and treating pain in the spinal cord
CA2697784A1 (en) * 2006-07-07 2008-01-10 Bioassets Development Corporation Novel regimens for treating diseases and disorders
US20080082170A1 (en) * 2006-09-29 2008-04-03 Peterman Marc M Apparatus and methods for surgical repair
US8057458B2 (en) * 2006-10-30 2011-11-15 Warsaw Orthopedic, Inc. Method for treating facet pain
US7709215B2 (en) * 2007-06-01 2010-05-04 Cytonics Corporation Method for diagnosing and treating acute joint injury
ES2327480B1 (es) * 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
US7938834B2 (en) * 2007-07-13 2011-05-10 Thomas F Roush Hybrid fusion/arthroplasty device
US7910123B2 (en) * 2007-09-05 2011-03-22 Warsaw Orthopedic Methods of treating a trauma or disorder of the knee joint by local administration and sustained-delivery of a biological agent
US20090062922A1 (en) * 2007-09-05 2009-03-05 Mckay William F Method and apparatus for delivering treatment to a joint
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US7993666B2 (en) * 2008-04-18 2011-08-09 Warsaw Orthopedic, Inc. Methods and compositions for treating pain comprising a statin
JP6205133B2 (ja) 2009-07-10 2017-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
US9308190B2 (en) 2011-06-06 2016-04-12 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
WO2013059634A1 (en) * 2011-10-20 2013-04-25 The Regents Of The University Of California Use of cdk9 inhibitors to reduce cartilage degradation
US10238450B2 (en) * 2013-11-13 2019-03-26 Thixos Llc Devices, kits and methods relating to treatment of facet joints
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
JP6930913B2 (ja) 2014-10-14 2021-09-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 炎症を阻害するためのｃｄｋ９及びｂｒｄ４阻害剤の使用法
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
AU2016301282B2 (en) 2015-08-03 2022-03-17 Children's Medical Center Corporation Charged ion channel blockers and methods for use
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
US10549081B2 (en) 2016-06-23 2020-02-04 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112021017809A2 (pt) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Bloqueadores de canais iônicos substituídos por éster e métodos para uso
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2020234961C1 (en) 2019-03-11 2025-08-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
CN113811305A (zh) 2019-03-11 2021-12-17 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091586A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US11332446B2 (en) 2020-03-11 2022-05-17 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US49256A (en) * 1865-08-08 Improvement in fruit-jars
US26244A (en) * 1859-11-29 Machine for registering music
US16195A (en) * 1856-12-09 Improvement in implements for rolling seeds in the earth
US39651A (en) * 1863-08-25 Harness and trace buckle
US3678158A (en) 1971-05-11 1972-07-18 Worthington Bio Chem Corp Treatment of herniated intervertebral discs of mammals
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
DK144800C (da) 1980-04-21 1982-10-25 Forenede Bryggerier As Fremgangsmaade til udvinding af enzymer,fortrinsvis cu,zn-superoxid-dismutase (sod),catalase og carbonsyreanhydrase,fra blod
US4435506A (en) 1982-08-13 1984-03-06 Miles Laboratories, Inc. Isolation of superoxide dismutase
US4870163A (en) 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US4696816A (en) 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
EP0288088B1 (en) 1987-04-24 1994-03-09 Teijin Limited Detection of tumor necrosis factor; monoclonal antibody and kit
KR0148009B1 (ko) 1988-05-27 1998-08-01 그래고리 비. 아보트 인터루킨-1 억제제
JPH03215430A (ja) 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
DE69027121T3 (de) 1989-08-07 2001-08-30 Peptech Ltd., Dee Why Bindeligande für tumornekrosisfaktor
US5095037B1 (en) 1989-12-21 1995-12-19 Nissho Kk Combined anti-inflammatory agent
GB9022648D0 (en) 1990-10-18 1990-11-28 Charing Cross Sunley Research Polypeptide and its use
US5223248A (en) 1991-02-11 1993-06-29 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing antiplaque properties
US5656272A (en) 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
EP1097945B1 (en) 1991-03-18 2007-07-04 New York University Monoclonal and chimeric antibody specific for human tumor necrosis factor
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5656644A (en) 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
DK0625989T3 (da) 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US5258371A (en) 1992-05-29 1993-11-02 Kuraray Co., Ltd. Method to reduce connective tissue destruction
US5368841A (en) 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
TW303299B (https=) 1993-07-22 1997-04-21 Lilly Co Eli
US5602156A (en) 1993-09-17 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Method for inhibiting metalloproteinase expression
CA2183566A1 (en) 1994-02-18 1995-08-24 Yendra Linnau Composition and method for preventing and treating inflammation with immunoglobulin a
US20030207827A1 (en) 1995-12-22 2003-11-06 William J. Boyle Osteoprotegerin
ES2233768T3 (es) 1996-02-02 2005-06-16 Alza Corporation Liberacion prolongada de un agente activo utilizando un sistema implantable.
CA2244664C (en) 1996-02-09 2008-06-03 Amgen Inc. Composition comprising interleukin-1 inhibitor and controlled release polymer
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
AU729086C (en) 1996-03-05 2006-12-14 Depuy Acromed, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US5824084A (en) 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
JP4771563B2 (ja) 1996-12-06 2011-09-14 アムジエン・インコーポレーテツド Ｉｌ−１媒介疾患を処置するためにｉｌ−１インヒビターを使用する組合せ療法
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
RU2222534C2 (ru) 1997-04-24 2004-01-27 Орто-Макнейл Фармасьютикал, Инк. Замещенные имидазолы, способ их получения, фармацевтическая композиция на их основе, способы лечения цитокин-опосредованных заболеваний
GB9713726D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
CA2301174C (en) 1997-08-16 2007-11-27 Orthogen Gentechnologie Gmbh A method for inducing therapeutically-effective proteins
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
BR9813740A (pt) 1997-12-18 2000-10-10 Lilly Co Eli Teriparatìdeo cristalino
EP0950417A3 (en) 1998-02-23 2000-02-23 Pfizer Products Inc. Treatment of skeletal disorders
JP2002506030A (ja) 1998-03-13 2002-02-26 メルク エンド カムパニー インコーポレーテッド 骨再吸収の阻害方法
AU3548999A (en) * 1998-04-03 1999-10-25 Chiron Corporation Use of igfi for treating articular cartilage disorders
SE9803710L (sv) 1998-09-25 2000-03-26 A & Science Invest Ab Användning av vissa substanser för behandling av nervrotsskador
US7115557B2 (en) 1998-09-25 2006-10-03 Sciaticon Ab Use of certain drugs for treating nerve root injury
US20010006948A1 (en) 1998-11-25 2001-07-05 James D. Kang Gene transfer to intervertebral disc cells
DE19903876B4 (de) 1999-02-01 2006-09-28 Orthogen Gentechnologie Gmbh Verfahren zur in-vitro-Bildung und Anreicherung von Interleukin-1 Rezeptor-Antagonisten
US6015557A (en) 1999-02-24 2000-01-18 Tobinick; Edward L. Tumor necrosis factor antagonists for the treatment of neurological disorders
US6419944B2 (en) 1999-02-24 2002-07-16 Edward L. Tobinick Cytokine antagonists for the treatment of localized disorders
US20030007972A1 (en) 1999-02-24 2003-01-09 Edward Tobinick Cytokine antagonists and other biologics for the treatment of bone metastases
US6537549B2 (en) 1999-02-24 2003-03-25 Edward L. Tobinick Cytokine antagonists for the treatment of localized disorders
US6982089B2 (en) 1999-02-24 2006-01-03 Tact Ip, Llc Cytokine antagonists for neurological and neuropsychiatric disorders
US6428576B1 (en) 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6340369B1 (en) 1999-08-13 2002-01-22 Bret A. Ferree Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
US6352557B1 (en) 1999-08-13 2002-03-05 Bret A. Ferree Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells
US6541477B2 (en) 1999-08-27 2003-04-01 Scios, Inc. Inhibitors of p38-a kinase
US20020010471A1 (en) 2000-02-04 2002-01-24 Wironen John F. Methods for injecting materials into bone
US6554830B1 (en) 2000-04-10 2003-04-29 Sdgi Holdings, Inc. Fenestrated surgical anchor and method
US6645485B2 (en) 2000-05-10 2003-11-11 Allan R. Dunn Method of treating inflammation in the joints of a body
US6800298B1 (en) 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US20020032155A1 (en) 2000-06-30 2002-03-14 Ferree Bret A. Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors
US20020026244A1 (en) 2000-08-30 2002-02-28 Trieu Hai H. Intervertebral disc nucleus implants and methods
US6756215B1 (en) * 2000-10-20 2004-06-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Functionalized TGF-β fusion proteins
AU2002232399A1 (en) * 2000-11-03 2002-05-15 Control Delivery Systems Improved device and method for treating conditions of a joint
US6593310B1 (en) 2000-11-21 2003-07-15 Arthropharm Pty. Ltd. Treatment of osteoporosis
DE60120494T2 (de) 2000-12-22 2006-12-21 Ortho-Mcneil Pharmaceutical, Inc. Substituieten triazoldiamin derivaten und ihre verwendung als kinase inhibitoren
US20020082697A1 (en) 2000-12-22 2002-06-27 Damien Christopher J. Implantable osteogenic material
US20030069639A1 (en) 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
CA2817619A1 (en) * 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
SE0102067D0 (sv) 2001-06-11 2001-06-11 A & Science Invest Ab Prevention of neovascularization of intervertebral discs and/or of tissues with local inflammation
CA2451245A1 (en) 2001-06-25 2003-01-03 Depuy International Limited Liposomal encapsulation of glycosaminoglycans for the treatment of arthritic joints
US20030008817A1 (en) * 2001-07-03 2003-01-09 Tom Sander Cross-link reversing agent
US20030220692A1 (en) 2002-02-09 2003-11-27 Shapiro Irving M. Preparations of nucleus pulposus cells and methods for their generation, identification, and use
FR2836681B1 (fr) 2002-03-04 2004-06-18 Centre Nat Rech Scient Compose phosphocalcique modifie, composition injectable le contenant
US20040219142A1 (en) 2002-07-19 2004-11-04 Abbott Laboratories S.A. Treatment of skin and nail disorders using TNFalpha inhibitors
US7674250B2 (en) 2002-08-05 2010-03-09 Boston Scientific Scimed, Inc. Methods of delivering therapeutic agents
AR047712A1 (es) 2002-09-07 2006-02-15 Royal Veterinary College Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas
US20040193274A1 (en) 2003-03-28 2004-09-30 Trieu Hai H. Materials and methods for augmenting and/or repairing intervertebral discs
US20040193270A1 (en) 2003-03-31 2004-09-30 Depuyacromed, Inc. Implantable bone graft
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
BRPI0410331A (pt) 2003-05-13 2006-05-30 Depuy Spine Inc método para tratar doença de disco degenerativa
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US20040229878A1 (en) 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US20050100538A1 (en) 2003-07-31 2005-05-12 Attawia Mohamed Intradiscal injection of anti-oxidants
US7897384B2 (en) 2003-09-08 2011-03-01 Ethicon, Inc. Chondrocyte therapeutic delivery system
US20050208095A1 (en) 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
CA2565849C (en) 2004-05-11 2013-01-29 The General Hospital Corporation Dba Massachusetts General Hospital Methods for making oxidation resistant polymeric material
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US20090162351A1 (en) 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase

Similar Documents

Publication Publication Date Title
JP2007500723A5 (https=)
US8361467B2 (en) Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US8728523B2 (en) Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8067397B2 (en) Transdiscal administration of cycline compounds
US7429378B2 (en) Transdiscal administration of high affinity anti-MMP inhibitors
US20040229878A1 (en) Transdiscal administration of specific inhibitors of P38 kinase
US8986696B2 (en) Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
AU2004294967B2 (en) Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
EP1631266B1 (en) A method of treating degenerative disc disease
US20090162351A1 (en) Transdiscal administration of inhibitors of p38 MAP kinase
JP2007502327A5 (https=)
Wei et al. Mechanisms modulating inflammatory osteolysis: a review with insights into therapeutic targets
Ghazanfari et al. Reviewing advances in rheumatoid arthritis treatment: from disease-modifying antirheumatic drugs to innovative drug delivery systems