JP2007500697A5 - - Google Patents
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- Publication number
- JP2007500697A5 JP2007500697A5 JP2006521912A JP2006521912A JP2007500697A5 JP 2007500697 A5 JP2007500697 A5 JP 2007500697A5 JP 2006521912 A JP2006521912 A JP 2006521912A JP 2006521912 A JP2006521912 A JP 2006521912A JP 2007500697 A5 JP2007500697 A5 JP 2007500697A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- microbial
- gmp
- biofilm
- cyclic dinucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- PKFDLKSEZWEFGL-MHARETSRSA-N c-di-GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=C(C(NC(N)=N5)=O)N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 PKFDLKSEZWEFGL-MHARETSRSA-N 0.000 claims 12
- 125000004122 cyclic group Chemical group 0.000 claims 12
- 230000000813 microbial effect Effects 0.000 claims 11
- 244000000010 microbial pathogen Species 0.000 claims 10
- 208000035143 Bacterial infection Diseases 0.000 claims 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims 6
- 230000032770 biofilm formation Effects 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 241000191967 Staphylococcus aureus Species 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000005757 colony formation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 2
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 208000004396 mastitis Diseases 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49002903P | 2003-07-28 | 2003-07-28 | |
| PCT/US2004/023498 WO2005030186A2 (en) | 2003-07-28 | 2004-07-22 | Method for attenuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500697A JP2007500697A (ja) | 2007-01-18 |
| JP2007500697A5 true JP2007500697A5 (https=) | 2007-09-13 |
Family
ID=34392905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521912A Pending JP2007500697A (ja) | 2003-07-28 | 2004-07-22 | 微生物病原体の毒性を減弱させる方法、および微生物のバイオフィルム形成を阻害する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8367716B2 (https=) |
| EP (1) | EP1651242A2 (https=) |
| JP (1) | JP2007500697A (https=) |
| AU (1) | AU2004275696B2 (https=) |
| CA (1) | CA2533873A1 (https=) |
| IL (1) | IL173065A (https=) |
| WO (1) | WO2005030186A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1729781B1 (en) * | 2004-03-15 | 2012-10-24 | Karaolis, David K. R. | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| WO2006073514A2 (en) * | 2004-08-25 | 2006-07-13 | Tufts University | Compositions, methods and kits for repressing virulence in gram positive bacteria |
| EP1782826A1 (en) * | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
| CN101801521B (zh) | 2007-05-14 | 2015-06-17 | 纽约州立大学研究基金会 | 生物膜中细菌细胞内的生理学分散响应诱导 |
| WO2009100456A2 (en) * | 2008-02-08 | 2009-08-13 | Prothera, Inc. | Inhibition and treatment of gastrointestinal biofilms |
| WO2009133560A1 (en) * | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| US20120178710A1 (en) * | 2009-07-01 | 2012-07-12 | Rutgers, The State University Of New Jersey | Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof |
| CN102199183B (zh) * | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
| CN101843899B (zh) * | 2010-05-24 | 2012-11-07 | 中国人民解放军第三军医大学 | 耐甲氧西林金黄色葡萄球菌（mrsa）重组多亚单位基因工程疫苗及其制备方法 |
| WO2012021554A1 (en) * | 2010-08-09 | 2012-02-16 | Yale University | Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use |
| US8450293B2 (en) | 2010-08-10 | 2013-05-28 | Rutgers, The State University Of New Jersey | Synthesis and characterization of C8 analogs of c-di-GMP |
| CN104507538B (zh) | 2012-06-08 | 2018-04-06 | 艾杜罗生物科技公司 | 癌症免疫疗法的组合物和方法 |
| PL2931738T3 (pl) | 2012-12-13 | 2019-07-31 | Aduro Biotech, Inc. | Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania |
| PT2934598T (pt) | 2012-12-19 | 2018-07-24 | Univ Texas | Focalização farmacêutica de uma trajetória de sinalização de dinucleótido cíclico de mamífero |
| CN104152472A (zh) * | 2012-12-28 | 2014-11-19 | 陶飞 | 一种双鸟苷酸环化酶基因、载体、工程菌及其应用 |
| JP6153116B2 (ja) * | 2013-01-09 | 2017-06-28 | 国立大学法人東北大学 | トリアゾール連結型環状ジヌクレオチド類縁体 |
| WO2014179335A1 (en) | 2013-04-29 | 2014-11-06 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| WO2014179760A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| RS59500B1 (sr) | 2013-05-18 | 2019-12-31 | Aduro Biotech Inc | Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“ |
| EP2996472B1 (en) * | 2013-05-18 | 2019-03-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| EP3027227A4 (en) | 2013-07-31 | 2018-05-23 | Memorial Sloan Kettering Cancer Center | Sting crystals and modulators |
| US9315523B2 (en) | 2013-12-06 | 2016-04-19 | Rutgers, The State University Of New Jersey | Cyclic dinucleosides |
| PE20170198A1 (es) | 2014-06-04 | 2017-04-08 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| HK1248603A1 (zh) | 2015-03-10 | 2018-10-19 | Aduro Biotech, Inc. | 用於活化"干扰素基因的刺激剂"依懒性信号传导的组合物和方法 |
| TWI704154B (zh) | 2015-12-03 | 2020-09-11 | 英商葛蘭素史克智慧財產發展有限公司 | 新穎化合物 |
| SG10201912074PA (en) | 2016-03-18 | 2020-02-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| WO2018100558A2 (en) | 2016-12-01 | 2018-06-07 | Takeda Pharmaceutical Company Limited | Cyclic dinucleotide |
| WO2019043634A2 (en) * | 2017-08-30 | 2019-03-07 | Beijing Xuanyi Pharmasciences Co., Ltd. | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
| JP7195317B2 (ja) | 2017-11-10 | 2022-12-23 | 武田薬品工業株式会社 | Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2020031083A1 (en) * | 2018-08-06 | 2020-02-13 | KHAN, Khalid | Antimicrobial formulations comprising vancomycin or tobramycin |
| JP7621974B2 (ja) | 2019-05-09 | 2025-01-27 | アリゴス セラピューティクス インコーポレイテッド | Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物 |
| CN114085887A (zh) * | 2020-08-25 | 2022-02-25 | 中国科学院大连化学物理研究所 | 一种基于仿生微球的铜绿假单胞菌耐药浓度的检测方法 |
| JP7397996B2 (ja) | 2020-11-09 | 2023-12-13 | 武田薬品工業株式会社 | 抗体薬物コンジュゲート |
| CN114099657B (zh) * | 2021-11-04 | 2022-05-17 | 暨南大学 | 一种溶藻弧菌减毒活疫苗及其制备方法与应用 |
| KR102551061B1 (ko) * | 2022-05-26 | 2023-07-03 | 중앙대학교 산학협력단 | Saha를 유효성분으로 포함하는 살모넬라 속 균주에 의한 바이오필름 생성 저해용 조성물 |
| CN118956719B (zh) * | 2024-07-31 | 2025-05-09 | 武汉市仪泰环境科技有限公司 | 一种毒性检测中加快微生物挂膜的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268274A (en) * | 1989-04-12 | 1993-12-07 | Cetus Corporation | Methods and nucleic acid sequences for the expression of the cellulose synthase operon |
| AU1672492A (en) * | 1991-05-03 | 1992-12-21 | University Technologies International Inc. | Biofilm reduction method |
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| US20020091074A1 (en) * | 2000-09-20 | 2002-07-11 | Wooley Richard E. | Medical compositions, dressings and methods for treating microbial infections of skin lesions |
| US20020169288A1 (en) * | 2001-03-15 | 2002-11-14 | Magnus Hook | Collagen-binding adhesin from staphylococcus epidermidis and method of use |
| JP2002302404A (ja) * | 2001-04-02 | 2002-10-18 | Shiseido Co Ltd | 抗菌防黴助剤 |
| US7189351B2 (en) * | 2001-10-25 | 2007-03-13 | Spherix Incorporated | D-tagatose as an anti-biofilm agent |
-
2004
- 2004-07-22 AU AU2004275696A patent/AU2004275696B2/en not_active Ceased
- 2004-07-22 US US10/565,591 patent/US8367716B2/en not_active Expired - Fee Related
- 2004-07-22 JP JP2006521912A patent/JP2007500697A/ja active Pending
- 2004-07-22 EP EP04809506A patent/EP1651242A2/en not_active Withdrawn
- 2004-07-22 WO PCT/US2004/023498 patent/WO2005030186A2/en not_active Ceased
- 2004-07-22 CA CA002533873A patent/CA2533873A1/en not_active Abandoned
-
2006
- 2006-01-10 IL IL173065A patent/IL173065A/en active IP Right Grant
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