JP2007500697A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007500697A5 JP2007500697A5 JP2006521912A JP2006521912A JP2007500697A5 JP 2007500697 A5 JP2007500697 A5 JP 2007500697A5 JP 2006521912 A JP2006521912 A JP 2006521912A JP 2006521912 A JP2006521912 A JP 2006521912A JP 2007500697 A5 JP2007500697 A5 JP 2007500697A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- microbial
- gmp
- biofilm
- cyclic dinucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- PKFDLKSEZWEFGL-MHARETSRSA-N c-di-GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=C(C(NC(N)=N5)=O)N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 PKFDLKSEZWEFGL-MHARETSRSA-N 0.000 claims 12
- 125000004122 cyclic group Chemical group 0.000 claims 12
- 230000000813 microbial effect Effects 0.000 claims 11
- 244000000010 microbial pathogen Species 0.000 claims 10
- 208000035143 Bacterial infection Diseases 0.000 claims 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims 6
- 230000032770 biofilm formation Effects 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 241000191967 Staphylococcus aureus Species 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000005757 colony formation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 2
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000005075 mammary gland Anatomy 0.000 claims 1
- 208000004396 mastitis Diseases 0.000 claims 1
- 229940118696 vibrio cholerae Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49002903P | 2003-07-28 | 2003-07-28 | |
| PCT/US2004/023498 WO2005030186A2 (en) | 2003-07-28 | 2004-07-22 | Method for attenuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500697A JP2007500697A (ja) | 2007-01-18 |
| JP2007500697A5 true JP2007500697A5 (https=) | 2007-09-13 |
Family
ID=34392905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521912A Pending JP2007500697A (ja) | 2003-07-28 | 2004-07-22 | 微生物病原体の毒性を減弱させる方法、および微生物のバイオフィルム形成を阻害する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8367716B2 (https=) |
| EP (1) | EP1651242A2 (https=) |
| JP (1) | JP2007500697A (https=) |
| AU (1) | AU2004275696B2 (https=) |
| CA (1) | CA2533873A1 (https=) |
| IL (1) | IL173065A (https=) |
| WO (1) | WO2005030186A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005089777A1 (en) | 2004-03-15 | 2005-09-29 | Karaolis David K R | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| WO2006073514A2 (en) * | 2004-08-25 | 2006-07-13 | Tufts University | Compositions, methods and kits for repressing virulence in gram positive bacteria |
| EP1782826A1 (en) * | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| PL2254591T3 (pl) | 2008-02-08 | 2018-01-31 | Prothera Inc | Inhibicja i leczenie biofilmów żołądkowo-jelitowych |
| WO2009133560A1 (en) * | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| US20120178710A1 (en) * | 2009-07-01 | 2012-07-12 | Rutgers, The State University Of New Jersey | Synthesis of cyclic diguanosine monophosphate and thiophosphate analogs thereof |
| CN102199183B (zh) * | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
| CN101843899B (zh) * | 2010-05-24 | 2012-11-07 | 中国人民解放军第三军医大学 | 耐甲氧西林金黄色葡萄球菌（mrsa）重组多亚单位基因工程疫苗及其制备方法 |
| WO2012021554A1 (en) * | 2010-08-09 | 2012-02-16 | Yale University | Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use |
| US8450293B2 (en) | 2010-08-10 | 2013-05-28 | Rutgers, The State University Of New Jersey | Synthesis and characterization of C8 analogs of c-di-GMP |
| EP2858722B8 (en) | 2012-06-08 | 2018-02-21 | Aduro BioTech, Inc. | Compostions and methods for cancer immunotherapy |
| US9695212B2 (en) | 2012-12-13 | 2017-07-04 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| EP2934598B1 (en) | 2012-12-19 | 2018-04-18 | Board Of Regents, The University Of Texas System | Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway |
| CN104152472A (zh) * | 2012-12-28 | 2014-11-19 | 陶飞 | 一种双鸟苷酸环化酶基因、载体、工程菌及其应用 |
| WO2014109256A1 (ja) * | 2013-01-09 | 2014-07-17 | 国立大学法人東北大学 | トリアゾール連結型環状ジヌクレオチド類縁体 |
| US9840533B2 (en) | 2013-04-29 | 2017-12-12 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| WO2014179760A1 (en) * | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| WO2014189806A1 (en) * | 2013-05-18 | 2014-11-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
| US9315523B2 (en) | 2013-12-06 | 2016-04-19 | Rutgers, The State University Of New Jersey | Cyclic dinucleosides |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| PE20210255A1 (es) | 2016-12-01 | 2021-02-10 | Takeda Pharmaceuticals Co | Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon) |
| MX2020002303A (es) * | 2017-08-30 | 2020-09-10 | Beijing Xuanyi Pharmasciences Co Ltd | Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon. |
| KR20200098511A (ko) | 2017-11-10 | 2020-08-20 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 조절제 화합물, 및 제조 및 사용 방법 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3833329A1 (en) * | 2018-08-06 | 2021-06-16 | Khan, Khalid | Antimicrobial formulations comprising vancomycin or tobramycin |
| WO2020227421A1 (en) | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| CN114085887A (zh) * | 2020-08-25 | 2022-02-25 | 中国科学院大连化学物理研究所 | 一种基于仿生微球的铜绿假单胞菌耐药浓度的检测方法 |
| IL302390A (en) | 2020-11-09 | 2023-06-01 | Takeda Pharmaceuticals Co | Drug antibody conjugates |
| CN114099657B (zh) * | 2021-11-04 | 2022-05-17 | 暨南大学 | 一种溶藻弧菌减毒活疫苗及其制备方法与应用 |
| KR102551061B1 (ko) * | 2022-05-26 | 2023-07-03 | 중앙대학교 산학협력단 | Saha를 유효성분으로 포함하는 살모넬라 속 균주에 의한 바이오필름 생성 저해용 조성물 |
| CN118956719B (zh) * | 2024-07-31 | 2025-05-09 | 武汉市仪泰环境科技有限公司 | 一种毒性检测中加快微生物挂膜的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268274A (en) * | 1989-04-12 | 1993-12-07 | Cetus Corporation | Methods and nucleic acid sequences for the expression of the cellulose synthase operon |
| WO1992019286A1 (en) * | 1991-05-03 | 1992-11-12 | University Technologies International, Inc. | Biofilm reduction method |
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| US20020091074A1 (en) * | 2000-09-20 | 2002-07-11 | Wooley Richard E. | Medical compositions, dressings and methods for treating microbial infections of skin lesions |
| US20020169288A1 (en) * | 2001-03-15 | 2002-11-14 | Magnus Hook | Collagen-binding adhesin from staphylococcus epidermidis and method of use |
| JP2002302404A (ja) * | 2001-04-02 | 2002-10-18 | Shiseido Co Ltd | 抗菌防黴助剤 |
| US7189351B2 (en) * | 2001-10-25 | 2007-03-13 | Spherix Incorporated | D-tagatose as an anti-biofilm agent |
-
2004
- 2004-07-22 AU AU2004275696A patent/AU2004275696B2/en not_active Ceased
- 2004-07-22 WO PCT/US2004/023498 patent/WO2005030186A2/en not_active Ceased
- 2004-07-22 US US10/565,591 patent/US8367716B2/en not_active Expired - Fee Related
- 2004-07-22 CA CA002533873A patent/CA2533873A1/en not_active Abandoned
- 2004-07-22 JP JP2006521912A patent/JP2007500697A/ja active Pending
- 2004-07-22 EP EP04809506A patent/EP1651242A2/en not_active Withdrawn
-
2006
- 2006-01-10 IL IL173065A patent/IL173065A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007500697A5 (https=) | ||
| CN101573031B (zh) | 抗微生物组合物 | |
| El-Feky et al. | Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces | |
| Marcinkiewicz et al. | Antibiotic resistance: a" dark side" of biofilm‑associated chronic infections | |
| Konop et al. | Certain aspects of silver and silver nanoparticles in wound care: a minireview | |
| Percival et al. | Antiseptics for treating infected wounds: efficacy on biofilms and effect of pH | |
| EP2515869B1 (en) | Wound care products | |
| CA2786880C (en) | Antimicrobial agents and methods of use | |
| JP2012522037A5 (https=) | ||
| WO2005030186A3 (en) | Method for attenuating virulence of microbial pathogens and for inhibiting microbial biofilm formation | |
| JP2009526751A5 (https=) | ||
| US20260115372A1 (en) | Wound care product | |
| WO2012013577A1 (en) | Composition for coating medical devices containing lae and a polycationic amphoteric polymer | |
| JP2018500387A5 (https=) | ||
| KR102613671B1 (ko) | 항균제의 급속 방출을 위한 의료용 접착제 | |
| ATE528311T1 (de) | Glycomimetische inhibitoren des pa-il-lectins, pa-iil-lectins oder beider lectine aus pseudomonas | |
| JP2010527960A5 (https=) | ||
| KR20100017153A (ko) | 균막 형성을 처리하기 위한 트리아졸 화합물 | |
| Kim et al. | Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats | |
| CA3242451A1 (en) | An injectable pharmaceutical composition for the treatment of respiratory diseases in animals | |
| EP3305305A3 (en) | Silicate containing compositions and methods of treatment | |
| WO2020201833A8 (en) | Gepotidacin for use in the treatment of bacterial urinary tract infections | |
| JP2024009968A5 (https=) | ||
| JP2014503469A5 (https=) | ||
| Rhoads et al. | Evidence of biofilms in wounds and potential ramifications |