JP2007500171A5 - - Google Patents

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Publication number
JP2007500171A5
JP2007500171A5 JP2006521581A JP2006521581A JP2007500171A5 JP 2007500171 A5 JP2007500171 A5 JP 2007500171A5 JP 2006521581 A JP2006521581 A JP 2006521581A JP 2006521581 A JP2006521581 A JP 2006521581A JP 2007500171 A5 JP2007500171 A5 JP 2007500171A5
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JP
Japan
Prior art keywords
alkyl
heteroaryl
aryl
alkenyl
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006521581A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007500171A (ja
JP4908210B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2004/051625 external-priority patent/WO2005011686A1/en
Publication of JP2007500171A publication Critical patent/JP2007500171A/ja
Publication of JP2007500171A5 publication Critical patent/JP2007500171A5/ja
Application granted granted Critical
Publication of JP4908210B2 publication Critical patent/JP4908210B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2006521581A 2003-07-28 2004-07-27 Ｐｉ３キナーゼ阻害剤として使用するための２−イミノ−４−（チオ）オキソ−５−ポリシクロビニルアゾリン類 Expired - Fee Related JP4908210B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03102313.8 2003-07-28
EP03102313 2003-07-28
PCT/EP2004/051625 WO2005011686A1 (en) 2003-07-28 2004-07-27 2-imino-4-(thio) oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors

Publications (3)

Publication Number Publication Date
JP2007500171A JP2007500171A (ja) 2007-01-11
JP2007500171A5 true JP2007500171A5 (https=) 2007-09-13
JP4908210B2 JP4908210B2 (ja) 2012-04-04

Family

ID=34112474

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521581A Expired - Fee Related JP4908210B2 (ja) 2003-07-28 2004-07-27 Ｐｉ３キナーゼ阻害剤として使用するための２−イミノ−４−（チオ）オキソ−５−ポリシクロビニルアゾリン類

Country Status (9)

Country Link
US (1) US8106214B2 (https=)
EP (1) EP1648452B1 (https=)
JP (1) JP4908210B2 (https=)
CA (1) CA2531140C (https=)
DE (1) DE602004022170D1 (https=)
ES (1) ES2328146T3 (https=)
IL (1) IL173195A (https=)
NO (1) NO332434B1 (https=)
WO (1) WO2005011686A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523957A (ja) * 2004-02-25 2007-08-23 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
EP1765817A1 (en) 2004-07-01 2007-03-28 F.Hoffmann-La Roche Ag Thiazolinone unsubstituted quinolines
CA2576765C (en) * 2004-09-03 2013-05-28 Applied Research Systems Ars Holding N.V. Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors
US7253285B2 (en) * 2004-09-17 2007-08-07 Hoffmann-La Roche Inc. Thiazolinone 4-monosubstituted quinolines
US7241893B2 (en) 2004-09-17 2007-07-10 Hoffman-La Roche Inc. Thiazolinone 2-substituted quinolines
RU2405782C2 (ru) * 2004-10-14 2010-12-10 Ф.Хоффманн-Ля Рош Аг Хиназолинилметилентиазолиноны в качестве cdk-1 ингибиторов
US7304074B2 (en) * 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
PE20070083A1 (es) * 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
JP2009507072A (ja) * 2005-09-07 2009-02-19 ラボラトワール セローノ ソシエテ アノニム 子宮内膜症の処置のためのｐｉ３ｋ阻害剤
US20080306057A1 (en) * 2005-10-11 2008-12-11 Laboratories Serono Sa P13K Inhibitors for the Treatment of Endometriosis
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
WO2007113005A2 (en) * 2006-04-03 2007-10-11 European Molecular Biology Laboratory (Embl) 2-substituted 3-aminosulfonyl-thiophene derivatives as aurora kinase inhibitors
TW200815429A (en) * 2006-04-11 2008-04-01 Smithkline Beecham Corp Thiazolidinedione derivatives as PI3 kinase inhibitors
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
US20080255115A1 (en) * 2007-04-11 2008-10-16 Michael Gerard Darcy Thiazolidinedione derivatives as pi3 kinase inhibitors
PE20090288A1 (es) * 2007-05-10 2009-04-03 Smithkline Beecham Corp Derivados de quinoxalina como inhibidores de la pi3 quinasa
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
FR2919608B1 (fr) * 2007-08-01 2012-10-05 Univ Rennes Derives d'imidazolones,procede de preparation et applications biologiques
TW200942544A (en) 2008-03-03 2009-10-16 Takeda Pharmaceutical Combination drug
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
CN103108873A (zh) * 2010-07-16 2013-05-15 皮拉马尔企业有限公司 作为激酶抑制剂的取代的咪唑并喹啉衍生物
CN102584809B (zh) * 2011-01-14 2014-12-24 湘北威尔曼制药股份有限公司 胺基噻唑烷酮化合物及其制备方法与在制备抗肿瘤药物中的应用
CN104520303B (zh) 2012-07-30 2017-04-12 国立大学法人京都大学 关于精神神经疾病或恶性肿瘤的化合物及医药组合物
US10310802B2 (en) * 2014-03-26 2019-06-04 Unanimous A. I., Inc. System and method for moderating real-time closed-loop collaborative decisions on mobile devices
CN106588909B (zh) * 2017-01-06 2019-08-27 广东工业大学 一种喹啉类衍生物的制备及其在抗炎中的应用
CR20200553A (es) 2018-04-18 2021-04-08 Constellation Pharmaceuticals Inc Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos
CN120097995A (zh) 2018-05-21 2025-06-06 星座制药公司 甲基修饰酶的调节剂、其组合物和用途
WO2021016414A1 (en) 2019-07-24 2021-01-28 Constellation Pharmaceuticals, Inc. Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH052200A (ja) 1990-09-28 1993-01-08 Toshiba Corp 有機非線形光学材料
JP3871354B2 (ja) * 1994-07-29 2007-01-24 株式会社フジモト・コーポレーション 新規な２−（ｎ−シアノイミノ）チアゾリジン−４−オン誘導体
CN1681811B (zh) 2002-07-10 2010-05-26 默克雪兰诺有限公司 唑烷酮-乙烯基稠合的-苯衍生物
MXPA05005406A (es) * 2002-11-22 2005-08-03 Smithkline Beecham Corp Compuestos quimicos novedosos.
CA2576765C (en) 2004-09-03 2013-05-28 Applied Research Systems Ars Holding N.V. Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors

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