JP2006528199A5 - - Google Patents

Info

Publication number

JP2006528199A5

JP2006528199A5 JP2006521248A JP2006521248A JP2006528199A5 JP 2006528199 A5 JP2006528199 A5 JP 2006528199A5 JP 2006521248 A JP2006521248 A JP 2006521248A JP 2006521248 A JP2006521248 A JP 2006521248A JP 2006528199 A5 JP2006528199 A5 JP 2006528199A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

ethyl

composition according

formula

purine

Prior art date

2004-07-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 150000001875 compounds Chemical class 0.000 claims 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
• -1 hydroxy, amino Chemical group 0.000 claims 5
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 4
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 4
• 239000005977 Ethylene Chemical group 0.000 claims 4
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 2
• 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 2
• 102000009346 Adenosine receptors Human genes 0.000 claims 2
• 108050000203 Adenosine receptors Proteins 0.000 claims 2
• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 206010030113 Oedema Diseases 0.000 claims 1
• 208000001647 Renal Insufficiency Diseases 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 230000003042 antagnostic effect Effects 0.000 claims 1
• 206010003119 arrhythmia Diseases 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 150000004985 diamines Chemical class 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 125000001475 halogen functional group Chemical group 0.000 claims 1
• 230000004217 heart function Effects 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 208000028867 ischemia Diseases 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 201000006370 kidney failure Diseases 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 201000008383 nephritis Diseases 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 230000008085 renal dysfunction Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000000547 substituted alkyl group Chemical group 0.000 claims 1