CA2533402A1 - A1 adenosine receptor antagonists - Google Patents
A1 adenosine receptor antagonists Download PDFInfo
- Publication number
- CA2533402A1 CA2533402A1 CA002533402A CA2533402A CA2533402A1 CA 2533402 A1 CA2533402 A1 CA 2533402A1 CA 002533402 A CA002533402 A CA 002533402A CA 2533402 A CA2533402 A CA 2533402A CA 2533402 A1 CA2533402 A1 CA 2533402A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- ethyl
- alkyl
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 101150007969 ADORA1 gene Proteins 0.000 title claims abstract description 14
- 229940121359 adenosine receptor antagonist Drugs 0.000 title description 12
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title description 12
- 150000001875 compounds Chemical class 0.000 claims abstract description 127
- -1 hydroxy, amino Chemical group 0.000 claims abstract description 62
- 238000000034 method Methods 0.000 claims abstract description 32
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 26
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 201000010099 disease Diseases 0.000 claims abstract description 16
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 15
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 241000124008 Mammalia Species 0.000 claims abstract description 10
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 9
- 208000006673 asthma Diseases 0.000 claims abstract description 9
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 7
- 210000002216 heart Anatomy 0.000 claims abstract description 6
- 210000003734 kidney Anatomy 0.000 claims abstract description 6
- 206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 5
- 206010019280 Heart failures Diseases 0.000 claims abstract description 5
- 206010020772 Hypertension Diseases 0.000 claims abstract description 5
- 206010030113 Oedema Diseases 0.000 claims abstract description 5
- 208000001647 Renal Insufficiency Diseases 0.000 claims abstract description 5
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 5
- 206010003119 arrhythmia Diseases 0.000 claims abstract description 5
- 210000004556 brain Anatomy 0.000 claims abstract description 5
- 230000006378 damage Effects 0.000 claims abstract description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 5
- 230000004217 heart function Effects 0.000 claims abstract description 5
- 208000014674 injury Diseases 0.000 claims abstract description 5
- 208000028867 ischemia Diseases 0.000 claims abstract description 5
- 201000006370 kidney failure Diseases 0.000 claims abstract description 5
- 201000008383 nephritis Diseases 0.000 claims abstract description 5
- 230000008085 renal dysfunction Effects 0.000 claims abstract description 5
- 208000023504 respiratory system disease Diseases 0.000 claims abstract description 5
- 150000002148 esters Chemical class 0.000 claims abstract description 4
- 239000000651 prodrug Substances 0.000 claims abstract description 3
- 229940002612 prodrug Drugs 0.000 claims abstract description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 4
- 230000003042 antagnostic effect Effects 0.000 claims abstract 2
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims description 45
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 29
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 11
- 239000005977 Ethylene Chemical group 0.000 claims description 11
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- PKGIWKARLRXHQM-UHFFFAOYSA-N 2-n-benzyl-9-ethyl-8-pyrazol-1-ylpurine-2,6-diamine Chemical compound N1=C2N(CC)C(N3N=CC=C3)=NC2=C(N)N=C1NCC1=CC=CC=C1 PKGIWKARLRXHQM-UHFFFAOYSA-N 0.000 claims description 5
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
- OYFCPAOCSNBIPL-UHFFFAOYSA-N 9-ethyl-2-n-[(4-fluorophenyl)methyl]-8-pyrazol-1-ylpurine-2,6-diamine Chemical compound N1=C2N(CC)C(N3N=CC=C3)=NC2=C(N)N=C1NCC1=CC=C(F)C=C1 OYFCPAOCSNBIPL-UHFFFAOYSA-N 0.000 claims description 2
- XGGPNVZPSLDYQH-UHFFFAOYSA-N 9-ethyl-2-n-[2-(4-fluorophenyl)ethyl]-8-pyrazol-1-ylpurine-2,6-diamine Chemical compound N1=C2N(CC)C(N3N=CC=C3)=NC2=C(N)N=C1NCCC1=CC=C(F)C=C1 XGGPNVZPSLDYQH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- NMBXRFVRUCQLPL-UHFFFAOYSA-N 2-n-[2-(4-fluorophenyl)ethyl]-9-methyl-8-pyrazol-1-ylpurine-2,6-diamine Chemical compound N1=C2N(C)C(N3N=CC=C3)=NC2=C(N)N=C1NCCC1=CC=C(F)C=C1 NMBXRFVRUCQLPL-UHFFFAOYSA-N 0.000 claims 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 56
- 239000000203 mixture Substances 0.000 description 46
- 125000003118 aryl group Chemical group 0.000 description 39
- 125000001072 heteroaryl group Chemical group 0.000 description 38
- 238000002360 preparation method Methods 0.000 description 29
- 239000004480 active ingredient Substances 0.000 description 27
- 239000002904 solvent Substances 0.000 description 27
- 125000003545 alkoxy group Chemical group 0.000 description 24
- 150000001412 amines Chemical class 0.000 description 24
- 238000006243 chemical reaction Methods 0.000 description 24
- 229910052736 halogen Inorganic materials 0.000 description 23
- 150000002367 halogens Chemical class 0.000 description 23
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 20
- 125000000623 heterocyclic group Chemical group 0.000 description 20
- 125000004432 carbon atom Chemical group C* 0.000 description 19
- 125000004181 carboxyalkyl group Chemical group 0.000 description 19
- 125000000753 cycloalkyl group Chemical group 0.000 description 19
- 239000003826 tablet Substances 0.000 description 19
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 125000003342 alkenyl group Chemical group 0.000 description 18
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 18
- 125000000392 cycloalkenyl group Chemical group 0.000 description 17
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
- 125000000304 alkynyl group Chemical group 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 14
- 239000004615 ingredient Substances 0.000 description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 13
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 11
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 125000004414 alkyl thio group Chemical group 0.000 description 10
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 125000002252 acyl group Chemical group 0.000 description 9
- 125000004442 acylamino group Chemical group 0.000 description 9
- 125000004423 acyloxy group Chemical group 0.000 description 9
- 239000005557 antagonist Substances 0.000 description 9
- 125000005110 aryl thio group Chemical group 0.000 description 9
- 125000004104 aryloxy group Chemical group 0.000 description 9
- 125000005553 heteroaryloxy group Chemical group 0.000 description 9
- 239000000546 pharmaceutical excipient Substances 0.000 description 9
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 9
- 150000003573 thiols Chemical class 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 8
- 229930194542 Keto Natural products 0.000 description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- 125000000033 alkoxyamino group Chemical group 0.000 description 8
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 8
- 125000006598 aminocarbonylamino group Chemical group 0.000 description 8
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 8
- 125000004429 atom Chemical group 0.000 description 8
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 125000005368 heteroarylthio group Chemical group 0.000 description 8
- 125000004468 heterocyclylthio group Chemical group 0.000 description 8
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 description 8
- 125000000468 ketone group Chemical group 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
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- 238000010992 reflux Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 235000019359 magnesium stearate Nutrition 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 6
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- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 125000003107 substituted aryl group Chemical group 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 4
- 101150078577 Adora2b gene Proteins 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 4
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 4
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 4
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 238000005160 1H NMR spectroscopy Methods 0.000 description 3
- RMFWVOLULURGJI-UHFFFAOYSA-N 2,6-dichloro-7h-purine Chemical compound ClC1=NC(Cl)=C2NC=NC2=N1 RMFWVOLULURGJI-UHFFFAOYSA-N 0.000 description 3
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48946903P | 2003-07-22 | 2003-07-22 | |
| US60/489,469 | 2003-07-22 | ||
| PCT/US2004/023632 WO2005009445A1 (en) | 2003-07-22 | 2004-07-22 | A1 adenosine receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2533402A1 true CA2533402A1 (en) | 2005-02-03 |
Family
ID=34102883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002533402A Abandoned CA2533402A1 (en) | 2003-07-22 | 2004-07-22 | A1 adenosine receptor antagonists |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7022710B2 (enExample) |
| EP (1) | EP1646390B1 (enExample) |
| JP (1) | JP2006528199A (enExample) |
| KR (1) | KR20060037383A (enExample) |
| AT (1) | ATE410168T1 (enExample) |
| CA (1) | CA2533402A1 (enExample) |
| DE (1) | DE602004017005D1 (enExample) |
| WO (1) | WO2005009445A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005047268A2 (en) * | 2003-11-10 | 2005-05-26 | X-Ceptor Therapeutics, Inc. | Substituted pyrimidine compositions and methods of use |
| US20080280926A1 (en) * | 2003-12-16 | 2008-11-13 | Palle Venkata P | Phosphodiesterase Inhibitors |
| US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
| ES2361886T3 (es) * | 2006-06-27 | 2011-06-24 | Cbt Development Limited | Profármacos adenosina acetil 2',3'-metilideno novedosos para uso como profármacos para agonistas del receptor adenosina. |
| WO2009052310A1 (en) * | 2007-10-16 | 2009-04-23 | Cv Therapeutics, Inc | A3 adenosine receptor antagonists |
| BRPI0909157A2 (pt) * | 2008-03-26 | 2015-11-24 | Advinus Therapeutics Private Ltd | compostos heterocíclicos como antagonistas de receptores de adenosina |
| DE102008039083A1 (de) * | 2008-08-21 | 2010-02-25 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Aminopyrazole und ihre Verwendung |
| US20130109645A1 (en) | 2010-03-31 | 2013-05-02 | The united States of America,as represented by Secretary,Dept.,of Health and Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
| WO2024105159A1 (en) * | 2022-11-16 | 2024-05-23 | University Of Zurich | Ligands of the m6a-rna readers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US6545002B1 (en) * | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| DK1208100T3 (da) * | 1999-08-31 | 2003-06-30 | Univ Vanderbilt | Selektive antagonister af A2B adenosinreceptorer |
| KR20020042248A (ko) * | 2000-11-30 | 2002-06-05 | 한가람 | 문장으로부터의 감정 인식 및 표시 방법과 시스템 |
| EP1401837B1 (en) * | 2001-06-29 | 2005-10-19 | Cv Therapeutics, Inc. | Purine derivatives as a2b adenosine receptor antagonists |
| WO2003006465A1 (en) * | 2001-07-13 | 2003-01-23 | Cv Therapeutics, Inc. | Partial and full agonist of a adenosine receptors |
| US7968523B2 (en) | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| AU2002361374A1 (en) * | 2001-12-21 | 2003-07-09 | JSW-Research Forschungslabor GmbH% | Pyrazolyl-substituted triazoloquinoxalines |
-
2004
- 2004-07-22 WO PCT/US2004/023632 patent/WO2005009445A1/en not_active Ceased
- 2004-07-22 KR KR1020067001373A patent/KR20060037383A/ko not_active Ceased
- 2004-07-22 JP JP2006521248A patent/JP2006528199A/ja active Pending
- 2004-07-22 CA CA002533402A patent/CA2533402A1/en not_active Abandoned
- 2004-07-22 AT AT04778924T patent/ATE410168T1/de not_active IP Right Cessation
- 2004-07-22 US US10/897,047 patent/US7022710B2/en not_active Expired - Fee Related
- 2004-07-22 EP EP04778924A patent/EP1646390B1/en not_active Expired - Lifetime
- 2004-07-22 DE DE602004017005T patent/DE602004017005D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE410168T1 (de) | 2008-10-15 |
| HK1093422A1 (en) | 2007-03-02 |
| WO2005009445A1 (en) | 2005-02-03 |
| US20050059683A1 (en) | 2005-03-17 |
| JP2006528199A (ja) | 2006-12-14 |
| DE602004017005D1 (de) | 2008-11-20 |
| EP1646390A1 (en) | 2006-04-19 |
| US7022710B2 (en) | 2006-04-04 |
| EP1646390B1 (en) | 2008-10-08 |
| KR20060037383A (ko) | 2006-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |