JP2006527366A - 拡散試料採取装置用の静止拡散セル - Google Patents
拡散試料採取装置用の静止拡散セル Download PDFInfo
- Publication number
- JP2006527366A JP2006527366A JP2006509305A JP2006509305A JP2006527366A JP 2006527366 A JP2006527366 A JP 2006527366A JP 2006509305 A JP2006509305 A JP 2006509305A JP 2006509305 A JP2006509305 A JP 2006509305A JP 2006527366 A JP2006527366 A JP 2006527366A
- Authority
- JP
- Japan
- Prior art keywords
- diffusion
- chamber
- outlet
- receptor
- diffusion cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009792 diffusion process Methods 0.000 title claims abstract description 228
- 238000005070 sampling Methods 0.000 title claims abstract description 53
- 230000003068 static effect Effects 0.000 title description 4
- 239000012528 membrane Substances 0.000 claims description 29
- 239000006260 foam Substances 0.000 abstract description 6
- 210000004379 membrane Anatomy 0.000 description 28
- 239000000463 material Substances 0.000 description 27
- 238000013461 design Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 14
- 230000007246 mechanism Effects 0.000 description 11
- 239000000523 sample Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000003756 stirring Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
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- 239000000203 mixture Substances 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
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- 239000012530 fluid Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
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- 230000003014 reinforcing effect Effects 0.000 description 3
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- 229920006362 Teflon® Polymers 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
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- 210000000981 epithelium Anatomy 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000002386 leaching Methods 0.000 description 2
- 229910001092 metal group alloy Inorganic materials 0.000 description 2
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- 238000013019 agitation Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- -1 transmucosal patches Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
- G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45890503P | 2003-03-28 | 2003-03-28 | |
| PCT/US2004/009193 WO2004086004A1 (en) | 2003-03-28 | 2004-03-27 | Static diffusion cell for diffusion sampling systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006527366A true JP2006527366A (ja) | 2006-11-30 |
| JP2006527366A5 JP2006527366A5 (enExample) | 2007-01-18 |
Family
ID=33098290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509305A Pending JP2006527366A (ja) | 2003-03-28 | 2004-03-27 | 拡散試料採取装置用の静止拡散セル |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7470535B2 (enExample) |
| EP (1) | EP1608950A1 (enExample) |
| JP (1) | JP2006527366A (enExample) |
| KR (1) | KR20050113256A (enExample) |
| CN (1) | CN1768257A (enExample) |
| AU (1) | AU2004223328A1 (enExample) |
| CA (1) | CA2520439A1 (enExample) |
| MX (1) | MXPA05010435A (enExample) |
| NO (1) | NO20054947L (enExample) |
| NZ (1) | NZ542397A (enExample) |
| WO (1) | WO2004086004A1 (enExample) |
| ZA (1) | ZA200508728B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013512448A (ja) * | 2009-12-01 | 2013-04-11 | ヘルス プロテクション エージェンシー | 分析方法および装置 |
| JP5299817B2 (ja) * | 2007-01-31 | 2013-09-25 | コスメディ製薬株式会社 | 経皮吸収製剤の拡散測定装置 |
| JP2020126081A (ja) * | 2014-08-20 | 2020-08-20 | エフ.ホフマン−ラ ロッシュ アーゲー | シミュレートされた生理環境における物質の挙動を分析するインビトロ方法および装置 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006527366A (ja) * | 2003-03-28 | 2006-11-30 | アルザ・コーポレーション | 拡散試料採取装置用の静止拡散セル |
| US20090064768A1 (en) * | 2007-03-13 | 2009-03-12 | Emad Alkhawam | Devices for Determining the Release Profile of Macromolecules and Methods of Using the Same |
| HUP0900073A2 (en) * | 2009-02-06 | 2010-11-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process and equipment for inquiry medical product on dermal surface |
| FR2951089B1 (fr) * | 2009-10-09 | 2013-07-05 | Univ Franche Comte | Insert de diffusion pour l'analyse de membrane, kit-cellule-unite et procede de diffusion |
| US20110120214A1 (en) * | 2009-11-23 | 2011-05-26 | Logan Instruments Corp. | Transdermal diffusion cell testing vessel and methods using same |
| US8322193B2 (en) * | 2009-11-23 | 2012-12-04 | Logan Instruments Corp. | Transdermal diffusion cell testing arrangements and methods |
| CN105785059B (zh) * | 2010-02-26 | 2018-06-01 | 希森美康株式会社 | 试剂容器 |
| CN102854292A (zh) * | 2012-09-27 | 2013-01-02 | 苏州出入境检验检疫局检验检疫综合技术中心 | 一种透皮扩散池及其制备方法 |
| US9581577B2 (en) * | 2012-10-12 | 2017-02-28 | National University Of Singapore | Miniaturized flow-through cell |
| US9535082B2 (en) | 2013-03-13 | 2017-01-03 | Abbott Laboratories | Methods and apparatus to agitate a liquid |
| USD978375S1 (en) | 2013-03-13 | 2023-02-14 | Abbott Laboratories | Reagent container |
| US10058866B2 (en) | 2013-03-13 | 2018-08-28 | Abbott Laboratories | Methods and apparatus to mitigate bubble formation in a liquid |
| USD962471S1 (en) | 2013-03-13 | 2022-08-30 | Abbott Laboratories | Reagent container |
| FR3005163A1 (fr) * | 2013-04-24 | 2014-10-31 | Biomerieux Sa | Dispositif de filtration et concentration automatique de microorganismes. |
| CN104458504A (zh) * | 2013-09-16 | 2015-03-25 | 中国科学院大连化学物理研究所 | 一种扩散池膜组件及扩散池 |
| CN104007045B (zh) * | 2014-05-12 | 2016-03-23 | 河海大学 | 一种泥水盾构机泥浆成膜数值模拟方法 |
| WO2016168445A1 (en) | 2015-04-17 | 2016-10-20 | Pion Inc. | Apparatus and method for the assessment of concentration profiling and permeability rates |
| US10252315B2 (en) * | 2015-06-22 | 2019-04-09 | Horomo, Llc | Metal punch assembly and method of use thereof |
| US10705004B2 (en) * | 2015-10-01 | 2020-07-07 | Galderma Research & Development | Diffusion cell and uses for evaluating the diffusion of a compound through a membrane |
| US10884010B1 (en) * | 2020-05-22 | 2021-01-05 | PermeGear, Inc. | Diffusion cell with recirculating receptor chamber |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US4740309A (en) * | 1986-08-29 | 1988-04-26 | Iprx, Inc. | Methods and apparatus for determining the rate of movement of a study substance through a membrane |
| US4667504A (en) * | 1986-10-02 | 1987-05-26 | The United States Of America As Represented By The Secretary Of The Air Force | Flow through device for determination of the penetration rate of chemicals across biological membranes in vitro |
| US4863696A (en) * | 1987-08-03 | 1989-09-05 | Crown Glass Company, Inc. | Apparatus for the percutaneous absorption of fluids |
| US5198109A (en) * | 1992-03-23 | 1993-03-30 | Hanson Research Corp. | Diffusion cell |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| US6521191B1 (en) * | 1999-07-07 | 2003-02-18 | Novosis Ag | Permeation cell for in vitro determination of skin permeation of pharmaceutical drugs |
| JP2006527366A (ja) * | 2003-03-28 | 2006-11-30 | アルザ・コーポレーション | 拡散試料採取装置用の静止拡散セル |
-
2004
- 2004-03-27 JP JP2006509305A patent/JP2006527366A/ja active Pending
- 2004-03-27 CA CA002520439A patent/CA2520439A1/en not_active Abandoned
- 2004-03-27 US US10/810,453 patent/US7470535B2/en not_active Expired - Lifetime
- 2004-03-27 EP EP04749440A patent/EP1608950A1/en not_active Withdrawn
- 2004-03-27 KR KR1020057018182A patent/KR20050113256A/ko not_active Withdrawn
- 2004-03-27 CN CNA2004800086098A patent/CN1768257A/zh active Pending
- 2004-03-27 NZ NZ542397A patent/NZ542397A/en unknown
- 2004-03-27 MX MXPA05010435A patent/MXPA05010435A/es not_active Application Discontinuation
- 2004-03-27 AU AU2004223328A patent/AU2004223328A1/en not_active Abandoned
- 2004-03-27 WO PCT/US2004/009193 patent/WO2004086004A1/en not_active Ceased
-
2005
- 2005-10-25 NO NO20054947A patent/NO20054947L/no not_active Application Discontinuation
- 2005-10-27 ZA ZA200508728A patent/ZA200508728B/en unknown
-
2008
- 2008-11-21 US US12/275,612 patent/US8133721B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5299817B2 (ja) * | 2007-01-31 | 2013-09-25 | コスメディ製薬株式会社 | 経皮吸収製剤の拡散測定装置 |
| JP2013512448A (ja) * | 2009-12-01 | 2013-04-11 | ヘルス プロテクション エージェンシー | 分析方法および装置 |
| JP2020126081A (ja) * | 2014-08-20 | 2020-08-20 | エフ.ホフマン−ラ ロッシュ アーゲー | シミュレートされた生理環境における物質の挙動を分析するインビトロ方法および装置 |
| JP6993463B2 (ja) | 2014-08-20 | 2022-01-13 | エフ.ホフマン-ラ ロッシュ アーゲー | シミュレートされた生理環境における物質の挙動を分析するインビトロ方法および装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2520439A1 (en) | 2004-10-07 |
| US20090075323A1 (en) | 2009-03-19 |
| AU2004223328A1 (en) | 2004-10-07 |
| MXPA05010435A (es) | 2005-11-04 |
| NZ542397A (en) | 2008-03-28 |
| CN1768257A (zh) | 2006-05-03 |
| US8133721B2 (en) | 2012-03-13 |
| NO20054947D0 (no) | 2005-10-25 |
| ZA200508728B (en) | 2007-04-25 |
| EP1608950A1 (en) | 2005-12-28 |
| NO20054947L (no) | 2005-12-16 |
| KR20050113256A (ko) | 2005-12-01 |
| WO2004086004A1 (en) | 2004-10-07 |
| US20050019903A1 (en) | 2005-01-27 |
| US7470535B2 (en) | 2008-12-30 |
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Legal Events
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| A521 | Request for written amendment filed |
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