CA2520439A1 - Static diffusion cell for diffusion sampling systems - Google Patents
Static diffusion cell for diffusion sampling systems Download PDFInfo
- Publication number
- CA2520439A1 CA2520439A1 CA002520439A CA2520439A CA2520439A1 CA 2520439 A1 CA2520439 A1 CA 2520439A1 CA 002520439 A CA002520439 A CA 002520439A CA 2520439 A CA2520439 A CA 2520439A CA 2520439 A1 CA2520439 A1 CA 2520439A1
- Authority
- CA
- Canada
- Prior art keywords
- diffusion
- receptor
- compartment
- outlet
- diffusion cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000009792 diffusion process Methods 0.000 title claims abstract description 221
- 238000005070 sampling Methods 0.000 title claims abstract description 50
- 230000003068 static effect Effects 0.000 title abstract description 10
- 239000012528 membrane Substances 0.000 claims abstract description 63
- 210000004379 membrane Anatomy 0.000 description 58
- 239000000463 material Substances 0.000 description 28
- 238000013461 design Methods 0.000 description 20
- 238000012360 testing method Methods 0.000 description 15
- 230000007246 mechanism Effects 0.000 description 11
- 238000003756 stirring Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 5
- 230000004907 flux Effects 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 230000003014 reinforcing effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 230000003466 anti-cipated effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000004955 epithelial membrane Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910001092 metal group alloy Inorganic materials 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008299 semisolid dosage form Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
- G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45890503P | 2003-03-28 | 2003-03-28 | |
| US60/458,905 | 2003-03-28 | ||
| PCT/US2004/009193 WO2004086004A1 (en) | 2003-03-28 | 2004-03-27 | Static diffusion cell for diffusion sampling systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2520439A1 true CA2520439A1 (en) | 2004-10-07 |
Family
ID=33098290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002520439A Abandoned CA2520439A1 (en) | 2003-03-28 | 2004-03-27 | Static diffusion cell for diffusion sampling systems |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7470535B2 (enExample) |
| EP (1) | EP1608950A1 (enExample) |
| JP (1) | JP2006527366A (enExample) |
| KR (1) | KR20050113256A (enExample) |
| CN (1) | CN1768257A (enExample) |
| AU (1) | AU2004223328A1 (enExample) |
| CA (1) | CA2520439A1 (enExample) |
| MX (1) | MXPA05010435A (enExample) |
| NO (1) | NO20054947L (enExample) |
| NZ (1) | NZ542397A (enExample) |
| WO (1) | WO2004086004A1 (enExample) |
| ZA (1) | ZA200508728B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006527366A (ja) * | 2003-03-28 | 2006-11-30 | アルザ・コーポレーション | 拡散試料採取装置用の静止拡散セル |
| WO2008093412A1 (ja) * | 2007-01-31 | 2008-08-07 | Cosmed Pharmaceutical Co., Ltd. | 経皮吸収製剤の拡散測定装置 |
| US20090064768A1 (en) * | 2007-03-13 | 2009-03-12 | Emad Alkhawam | Devices for Determining the Release Profile of Macromolecules and Methods of Using the Same |
| HUP0900073A2 (en) * | 2009-02-06 | 2010-11-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process and equipment for inquiry medical product on dermal surface |
| FR2951089B1 (fr) * | 2009-10-09 | 2013-07-05 | Univ Franche Comte | Insert de diffusion pour l'analyse de membrane, kit-cellule-unite et procede de diffusion |
| US20110120214A1 (en) * | 2009-11-23 | 2011-05-26 | Logan Instruments Corp. | Transdermal diffusion cell testing vessel and methods using same |
| US8322193B2 (en) * | 2009-11-23 | 2012-12-04 | Logan Instruments Corp. | Transdermal diffusion cell testing arrangements and methods |
| GB0921048D0 (en) * | 2009-12-01 | 2010-01-13 | Health Prot Agency | Assay method and apparatus |
| CN105785059B (zh) * | 2010-02-26 | 2018-06-01 | 希森美康株式会社 | 试剂容器 |
| CN102854292A (zh) * | 2012-09-27 | 2013-01-02 | 苏州出入境检验检疫局检验检疫综合技术中心 | 一种透皮扩散池及其制备方法 |
| US9581577B2 (en) * | 2012-10-12 | 2017-02-28 | National University Of Singapore | Miniaturized flow-through cell |
| US9535082B2 (en) | 2013-03-13 | 2017-01-03 | Abbott Laboratories | Methods and apparatus to agitate a liquid |
| USD978375S1 (en) | 2013-03-13 | 2023-02-14 | Abbott Laboratories | Reagent container |
| US10058866B2 (en) | 2013-03-13 | 2018-08-28 | Abbott Laboratories | Methods and apparatus to mitigate bubble formation in a liquid |
| USD962471S1 (en) | 2013-03-13 | 2022-08-30 | Abbott Laboratories | Reagent container |
| FR3005163A1 (fr) * | 2013-04-24 | 2014-10-31 | Biomerieux Sa | Dispositif de filtration et concentration automatique de microorganismes. |
| CN104458504A (zh) * | 2013-09-16 | 2015-03-25 | 中国科学院大连化学物理研究所 | 一种扩散池膜组件及扩散池 |
| CN104007045B (zh) * | 2014-05-12 | 2016-03-23 | 河海大学 | 一种泥水盾构机泥浆成膜数值模拟方法 |
| CA2957332A1 (en) * | 2014-08-20 | 2016-02-25 | F. Hoffmann-La Roche Ag | In vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment |
| WO2016168445A1 (en) | 2015-04-17 | 2016-10-20 | Pion Inc. | Apparatus and method for the assessment of concentration profiling and permeability rates |
| US10252315B2 (en) * | 2015-06-22 | 2019-04-09 | Horomo, Llc | Metal punch assembly and method of use thereof |
| US10705004B2 (en) * | 2015-10-01 | 2020-07-07 | Galderma Research & Development | Diffusion cell and uses for evaluating the diffusion of a compound through a membrane |
| US10884010B1 (en) * | 2020-05-22 | 2021-01-05 | PermeGear, Inc. | Diffusion cell with recirculating receptor chamber |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US4740309A (en) * | 1986-08-29 | 1988-04-26 | Iprx, Inc. | Methods and apparatus for determining the rate of movement of a study substance through a membrane |
| US4667504A (en) * | 1986-10-02 | 1987-05-26 | The United States Of America As Represented By The Secretary Of The Air Force | Flow through device for determination of the penetration rate of chemicals across biological membranes in vitro |
| US4863696A (en) * | 1987-08-03 | 1989-09-05 | Crown Glass Company, Inc. | Apparatus for the percutaneous absorption of fluids |
| US5198109A (en) * | 1992-03-23 | 1993-03-30 | Hanson Research Corp. | Diffusion cell |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| US6521191B1 (en) * | 1999-07-07 | 2003-02-18 | Novosis Ag | Permeation cell for in vitro determination of skin permeation of pharmaceutical drugs |
| JP2006527366A (ja) * | 2003-03-28 | 2006-11-30 | アルザ・コーポレーション | 拡散試料採取装置用の静止拡散セル |
-
2004
- 2004-03-27 JP JP2006509305A patent/JP2006527366A/ja active Pending
- 2004-03-27 CA CA002520439A patent/CA2520439A1/en not_active Abandoned
- 2004-03-27 US US10/810,453 patent/US7470535B2/en not_active Expired - Lifetime
- 2004-03-27 EP EP04749440A patent/EP1608950A1/en not_active Withdrawn
- 2004-03-27 KR KR1020057018182A patent/KR20050113256A/ko not_active Withdrawn
- 2004-03-27 CN CNA2004800086098A patent/CN1768257A/zh active Pending
- 2004-03-27 NZ NZ542397A patent/NZ542397A/en unknown
- 2004-03-27 MX MXPA05010435A patent/MXPA05010435A/es not_active Application Discontinuation
- 2004-03-27 AU AU2004223328A patent/AU2004223328A1/en not_active Abandoned
- 2004-03-27 WO PCT/US2004/009193 patent/WO2004086004A1/en not_active Ceased
-
2005
- 2005-10-25 NO NO20054947A patent/NO20054947L/no not_active Application Discontinuation
- 2005-10-27 ZA ZA200508728A patent/ZA200508728B/en unknown
-
2008
- 2008-11-21 US US12/275,612 patent/US8133721B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090075323A1 (en) | 2009-03-19 |
| AU2004223328A1 (en) | 2004-10-07 |
| MXPA05010435A (es) | 2005-11-04 |
| NZ542397A (en) | 2008-03-28 |
| CN1768257A (zh) | 2006-05-03 |
| US8133721B2 (en) | 2012-03-13 |
| NO20054947D0 (no) | 2005-10-25 |
| ZA200508728B (en) | 2007-04-25 |
| EP1608950A1 (en) | 2005-12-28 |
| NO20054947L (no) | 2005-12-16 |
| KR20050113256A (ko) | 2005-12-01 |
| WO2004086004A1 (en) | 2004-10-07 |
| JP2006527366A (ja) | 2006-11-30 |
| US20050019903A1 (en) | 2005-01-27 |
| US7470535B2 (en) | 2008-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8133721B2 (en) | Static diffusion cell for diffusion sampling systems | |
| US7354774B2 (en) | Self aliquoting sample storage plate | |
| US7431884B2 (en) | Chemical assays | |
| US4594884A (en) | Diffusion measuring device | |
| US7326561B2 (en) | Flow-thru chip cartridge, chip holder, system and method thereof | |
| JP4127679B2 (ja) | 核酸検出カセット及び核酸検出装置 | |
| US4948564A (en) | Multi-well filter strip and composite assemblies | |
| JP2002542024A (ja) | サンプル送達のための装置および方法 | |
| JP2007529203A (ja) | 統合細胞操作及び測定方法及び装置 | |
| US20030091477A1 (en) | Flow-thru chip cartridge, chip holder, system & method thereof | |
| US12066364B2 (en) | Automated staining system | |
| US5183760A (en) | Apparatus for in vitro determination of substances across membranes, biological tissues, or cell cultures | |
| CN108300654B (zh) | 评估可移动生物活体药代动力学的芯片及实时检测系统 | |
| US11668723B2 (en) | Automated dissolution/permeation testing system | |
| JPS6356276A (ja) | 細胞生物学的試験を行うための装置 | |
| US20220065757A1 (en) | Microfluidic Device for Image Multiplexing | |
| US5882495A (en) | Electrophoresis system | |
| US6149871A (en) | System for processing multiple specimens of biological fluid | |
| CZ20021923A3 (cs) | Způsob pro přímou analýzu vzorku z procesu a kapilární elektroforetické zařízení pro jeho provádění | |
| EP0170098A2 (en) | Dialysis cell | |
| US20110120214A1 (en) | Transdermal diffusion cell testing vessel and methods using same | |
| US11768216B2 (en) | Diffusion cell with recirculating receptor chamber | |
| US11430279B2 (en) | Functionalized microfluidic device and method | |
| WO2016034766A1 (en) | A method and a device for measuring permeability of molecules through a sample | |
| HU231596B1 (hu) | Tárgylemez takaró eszköz, valamint inkubációs kamra, amely ilyen tárgylemez takaró eszközt tartalmaz |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |