CA2520439A1 - Static diffusion cell for diffusion sampling systems - Google Patents
Static diffusion cell for diffusion sampling systems Download PDFInfo
- Publication number
- CA2520439A1 CA2520439A1 CA002520439A CA2520439A CA2520439A1 CA 2520439 A1 CA2520439 A1 CA 2520439A1 CA 002520439 A CA002520439 A CA 002520439A CA 2520439 A CA2520439 A CA 2520439A CA 2520439 A1 CA2520439 A1 CA 2520439A1
- Authority
- CA
- Canada
- Prior art keywords
- diffusion
- receptor
- compartment
- outlet
- diffusion cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000009792 diffusion process Methods 0.000 title claims abstract description 221
- 238000005070 sampling Methods 0.000 title claims abstract description 50
- 230000003068 static effect Effects 0.000 title abstract description 10
- 239000012528 membrane Substances 0.000 claims abstract description 63
- 210000004379 membrane Anatomy 0.000 description 58
- 239000000463 material Substances 0.000 description 28
- 238000013461 design Methods 0.000 description 20
- 238000012360 testing method Methods 0.000 description 15
- 230000007246 mechanism Effects 0.000 description 11
- 238000003756 stirring Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000003556 assay Methods 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 5
- 230000004907 flux Effects 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 230000003014 reinforcing effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 230000003466 anti-cipated effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000004955 epithelial membrane Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910001092 metal group alloy Inorganic materials 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008299 semisolid dosage form Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/20—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials
- G01N1/2035—Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials by deviating part of a fluid stream, e.g. by drawing-off or tapping
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4005—Concentrating samples by transferring a selected component through a membrane
- G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
Landscapes
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45890503P | 2003-03-28 | 2003-03-28 | |
| US60/458,905 | 2003-03-28 | ||
| PCT/US2004/009193 WO2004086004A1 (en) | 2003-03-28 | 2004-03-27 | Static diffusion cell for diffusion sampling systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2520439A1 true CA2520439A1 (en) | 2004-10-07 |
Family
ID=33098290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002520439A Abandoned CA2520439A1 (en) | 2003-03-28 | 2004-03-27 | Static diffusion cell for diffusion sampling systems |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7470535B2 (enExample) |
| EP (1) | EP1608950A1 (enExample) |
| JP (1) | JP2006527366A (enExample) |
| KR (1) | KR20050113256A (enExample) |
| CN (1) | CN1768257A (enExample) |
| AU (1) | AU2004223328A1 (enExample) |
| CA (1) | CA2520439A1 (enExample) |
| MX (1) | MXPA05010435A (enExample) |
| NO (1) | NO20054947L (enExample) |
| NZ (1) | NZ542397A (enExample) |
| WO (1) | WO2004086004A1 (enExample) |
| ZA (1) | ZA200508728B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768257A (zh) * | 2003-03-28 | 2006-05-03 | 阿尔扎公司 | 用于扩散取样系统的静态扩散池 |
| JP5299817B2 (ja) * | 2007-01-31 | 2013-09-25 | コスメディ製薬株式会社 | 経皮吸収製剤の拡散測定装置 |
| US20090064768A1 (en) * | 2007-03-13 | 2009-03-12 | Emad Alkhawam | Devices for Determining the Release Profile of Macromolecules and Methods of Using the Same |
| HUP0900073A2 (en) * | 2009-02-06 | 2010-11-29 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process and equipment for inquiry medical product on dermal surface |
| FR2951089B1 (fr) * | 2009-10-09 | 2013-07-05 | Univ Franche Comte | Insert de diffusion pour l'analyse de membrane, kit-cellule-unite et procede de diffusion |
| US8322193B2 (en) * | 2009-11-23 | 2012-12-04 | Logan Instruments Corp. | Transdermal diffusion cell testing arrangements and methods |
| US20110120214A1 (en) * | 2009-11-23 | 2011-05-26 | Logan Instruments Corp. | Transdermal diffusion cell testing vessel and methods using same |
| GB0921048D0 (en) * | 2009-12-01 | 2010-01-13 | Health Prot Agency | Assay method and apparatus |
| KR101543062B1 (ko) * | 2010-02-26 | 2015-08-07 | 시스멕스 가부시키가이샤 | 분석장치 및 시약용기 |
| CN102854292A (zh) * | 2012-09-27 | 2013-01-02 | 苏州出入境检验检疫局检验检疫综合技术中心 | 一种透皮扩散池及其制备方法 |
| SG10201602817VA (en) * | 2012-10-12 | 2016-05-30 | Univ Singapore | A miniaturized flow-through cell |
| US9535082B2 (en) | 2013-03-13 | 2017-01-03 | Abbott Laboratories | Methods and apparatus to agitate a liquid |
| USD962471S1 (en) | 2013-03-13 | 2022-08-30 | Abbott Laboratories | Reagent container |
| US10058866B2 (en) | 2013-03-13 | 2018-08-28 | Abbott Laboratories | Methods and apparatus to mitigate bubble formation in a liquid |
| USD978375S1 (en) | 2013-03-13 | 2023-02-14 | Abbott Laboratories | Reagent container |
| FR3005163A1 (fr) * | 2013-04-24 | 2014-10-31 | Biomerieux Sa | Dispositif de filtration et concentration automatique de microorganismes. |
| CN104458504A (zh) * | 2013-09-16 | 2015-03-25 | 中国科学院大连化学物理研究所 | 一种扩散池膜组件及扩散池 |
| CN104007045B (zh) * | 2014-05-12 | 2016-03-23 | 河海大学 | 一种泥水盾构机泥浆成膜数值模拟方法 |
| JP6705808B2 (ja) * | 2014-08-20 | 2020-06-03 | エフ．ホフマン−ラ ロッシュ アーゲー | シミュレートされた生理環境における物質の挙動を分析するインビトロ方法および装置 |
| US10228358B2 (en) | 2015-04-17 | 2019-03-12 | Pion Inc. | Apparatus and method for the assessment of concentration profiling and permeability rates |
| US10252315B2 (en) * | 2015-06-22 | 2019-04-09 | Horomo, Llc | Metal punch assembly and method of use thereof |
| WO2017055769A1 (fr) * | 2015-10-01 | 2017-04-06 | Galderma Research & Development | Cellule de diffusion et utilisations pour évaluer la diffusion d'un composé à travers une membrane |
| US10884010B1 (en) * | 2020-05-22 | 2021-01-05 | PermeGear, Inc. | Diffusion cell with recirculating receptor chamber |
| CN118794843B (zh) * | 2024-09-13 | 2024-11-15 | 广东工业大学 | 一种适用于气体暴露的体外透皮扩散试验装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US4740309A (en) * | 1986-08-29 | 1988-04-26 | Iprx, Inc. | Methods and apparatus for determining the rate of movement of a study substance through a membrane |
| US4667504A (en) * | 1986-10-02 | 1987-05-26 | The United States Of America As Represented By The Secretary Of The Air Force | Flow through device for determination of the penetration rate of chemicals across biological membranes in vitro |
| US4863696A (en) * | 1987-08-03 | 1989-09-05 | Crown Glass Company, Inc. | Apparatus for the percutaneous absorption of fluids |
| US5198109A (en) * | 1992-03-23 | 1993-03-30 | Hanson Research Corp. | Diffusion cell |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| US6521191B1 (en) * | 1999-07-07 | 2003-02-18 | Novosis Ag | Permeation cell for in vitro determination of skin permeation of pharmaceutical drugs |
| CN1768257A (zh) * | 2003-03-28 | 2006-05-03 | 阿尔扎公司 | 用于扩散取样系统的静态扩散池 |
-
2004
- 2004-03-27 CN CNA2004800086098A patent/CN1768257A/zh active Pending
- 2004-03-27 KR KR1020057018182A patent/KR20050113256A/ko not_active Withdrawn
- 2004-03-27 AU AU2004223328A patent/AU2004223328A1/en not_active Abandoned
- 2004-03-27 MX MXPA05010435A patent/MXPA05010435A/es not_active Application Discontinuation
- 2004-03-27 JP JP2006509305A patent/JP2006527366A/ja active Pending
- 2004-03-27 EP EP04749440A patent/EP1608950A1/en not_active Withdrawn
- 2004-03-27 NZ NZ542397A patent/NZ542397A/en unknown
- 2004-03-27 US US10/810,453 patent/US7470535B2/en not_active Expired - Lifetime
- 2004-03-27 WO PCT/US2004/009193 patent/WO2004086004A1/en not_active Ceased
- 2004-03-27 CA CA002520439A patent/CA2520439A1/en not_active Abandoned
-
2005
- 2005-10-25 NO NO20054947A patent/NO20054947L/no not_active Application Discontinuation
- 2005-10-27 ZA ZA200508728A patent/ZA200508728B/en unknown
-
2008
- 2008-11-21 US US12/275,612 patent/US8133721B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004223328A1 (en) | 2004-10-07 |
| US7470535B2 (en) | 2008-12-30 |
| NO20054947L (no) | 2005-12-16 |
| MXPA05010435A (es) | 2005-11-04 |
| NO20054947D0 (no) | 2005-10-25 |
| WO2004086004A1 (en) | 2004-10-07 |
| US20090075323A1 (en) | 2009-03-19 |
| EP1608950A1 (en) | 2005-12-28 |
| NZ542397A (en) | 2008-03-28 |
| ZA200508728B (en) | 2007-04-25 |
| US20050019903A1 (en) | 2005-01-27 |
| CN1768257A (zh) | 2006-05-03 |
| US8133721B2 (en) | 2012-03-13 |
| KR20050113256A (ko) | 2005-12-01 |
| JP2006527366A (ja) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |