JP2006526638A5 - - Google Patents
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- JP2006526638A5 JP2006526638A5 JP2006514964A JP2006514964A JP2006526638A5 JP 2006526638 A5 JP2006526638 A5 JP 2006526638A5 JP 2006514964 A JP2006514964 A JP 2006514964A JP 2006514964 A JP2006514964 A JP 2006514964A JP 2006526638 A5 JP2006526638 A5 JP 2006526638A5
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- JP
- Japan
- Prior art keywords
- configuration
- line represents
- phenyl
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000068 chlorophenyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229940054534 ophthalmic solution Drugs 0.000 claims 2
- 239000002997 ophthalmic solution Substances 0.000 claims 2
- -1 trifluoromethylphenyl Chemical group 0.000 claims 2
- PRHMJGGMXUDIEY-QNSVNVJESA-N 2-[4-[(2r)-2-[4-(3-chlorophenyl)-3-hydroxybutyl]-5-oxopyrrolidin-1-yl]butoxy]acetic acid Chemical compound C=1C=CC(Cl)=CC=1CC(O)CC[C@@H]1CCC(=O)N1CCCCOCC(O)=O PRHMJGGMXUDIEY-QNSVNVJESA-N 0.000 claims 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 0 *COCCCC*1OCC[C@@]1CCNNCO*=C Chemical compound *COCCCC*1OCC[C@@]1CCNNCO*=C 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/453,207 US6734206B1 (en) | 2003-06-02 | 2003-06-02 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| PCT/US2004/016516 WO2004108670A1 (en) | 2003-06-02 | 2004-05-25 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006526638A JP2006526638A (ja) | 2006-11-24 |
| JP2006526638A5 true JP2006526638A5 (https=) | 2007-07-12 |
Family
ID=32230466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514964A Pending JP2006526638A (ja) | 2003-06-02 | 2004-05-25 | 眼圧降下剤としての３−オキサ−８−アザプロスタグランジン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6734206B1 (https=) |
| EP (1) | EP1638936B1 (https=) |
| JP (1) | JP2006526638A (https=) |
| AT (1) | ATE496886T1 (https=) |
| AU (1) | AU2004245492B2 (https=) |
| BR (1) | BRPI0410926A (https=) |
| CA (1) | CA2528010C (https=) |
| DE (1) | DE602004031225D1 (https=) |
| ES (1) | ES2358513T3 (https=) |
| WO (1) | WO2004108670A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6734201B1 (en) * | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents |
| WO2007056087A1 (en) | 2005-11-03 | 2007-05-18 | Allergan, Inc. | Prostaglandins and analogues as agents for lowering intraocular pressure |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| US8783923B2 (en) * | 2010-03-18 | 2014-07-22 | Chung Yuan Christian University | Auto lamp structure |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994274A (en) | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| WO2000038667A2 (en) | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| AP2001002357A0 (en) * | 1999-12-22 | 2001-12-31 | Pfizer Prod Inc | EP4 receptor selective agonists in the treatment of osteoporosis. |
| DE60120007T2 (de) | 2000-01-31 | 2006-11-16 | Pfizer Products Inc., Groton | Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz |
| US20010056060A1 (en) | 2000-02-07 | 2001-12-27 | Cameron Kimberly O. | Treatment of osteoporsis with EP2/EP4 receptor selective agonists |
| JP4063468B2 (ja) | 2000-02-22 | 2008-03-19 | 株式会社カネボウ化粧品 | 寒天被覆処理顔料およびメイクアップ化粧料 |
| WO2002024647A1 (en) | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| PT1339678E (pt) * | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| AU2002259210B2 (en) * | 2001-06-14 | 2007-11-08 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| RU2296122C2 (ru) * | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
| ES2254726T3 (es) * | 2001-07-16 | 2006-06-16 | F. Hoffmann-La Roche Ag | Analogos de prostaglandina como agonistas receptores de ep4. |
| NZ530885A (en) | 2001-07-23 | 2007-09-28 | Ono Pharmaceutical Co | Remedies for diseases with bone mass loss having EP4 agonist as the active ingredient |
| CA2478653A1 (en) * | 2002-03-18 | 2003-09-25 | Pfizer Products Inc. | Methods of treatment with selective ep4 receptor agonists |
| BR0308493A (pt) * | 2002-03-18 | 2005-01-11 | Pfizer Prod Inc | Uso de agonistas de receptor seletivo de ep4 para o tratamento da insuficiência hepática, perda de permeabilidade do canal arterial, glaucoma ou hipertensão ocular |
-
2003
- 2003-06-02 US US10/453,207 patent/US6734206B1/en not_active Expired - Fee Related
-
2004
- 2004-05-25 WO PCT/US2004/016516 patent/WO2004108670A1/en not_active Ceased
- 2004-05-25 JP JP2006514964A patent/JP2006526638A/ja active Pending
- 2004-05-25 EP EP04753359A patent/EP1638936B1/en not_active Expired - Lifetime
- 2004-05-25 CA CA2528010A patent/CA2528010C/en not_active Expired - Fee Related
- 2004-05-25 ES ES04753359T patent/ES2358513T3/es not_active Expired - Lifetime
- 2004-05-25 AU AU2004245492A patent/AU2004245492B2/en not_active Ceased
- 2004-05-25 AT AT04753359T patent/ATE496886T1/de not_active IP Right Cessation
- 2004-05-25 DE DE602004031225T patent/DE602004031225D1/de not_active Expired - Lifetime
- 2004-05-25 BR BRPI0410926-0A patent/BRPI0410926A/pt not_active IP Right Cessation
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