JP2006524208A5 - - Google Patents
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- Publication number
- JP2006524208A5 JP2006524208A5 JP2006505245A JP2006505245A JP2006524208A5 JP 2006524208 A5 JP2006524208 A5 JP 2006524208A5 JP 2006505245 A JP2006505245 A JP 2006505245A JP 2006505245 A JP2006505245 A JP 2006505245A JP 2006524208 A5 JP2006524208 A5 JP 2006524208A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound according
- substituted
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229940126601 medicinal product Drugs 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- BVRCPMXFRMVPNG-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxo-n-pyridin-4-ylacetamide Chemical compound C=1NC2=CC=CC=C2C=1C(=O)C(=O)NC1=CC=NC=C1 BVRCPMXFRMVPNG-UHFFFAOYSA-N 0.000 claims 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 claims 1
- -1 3-nitrobenzyl Chemical group 0.000 claims 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 claims 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000012059 conventional drug carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 210000003979 eosinophil Anatomy 0.000 claims 1
- AMANDCZTVNQSNB-UHFFFAOYSA-N glyoxamide Chemical compound NC(=O)C=O AMANDCZTVNQSNB-UHFFFAOYSA-N 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10318611A DE10318611A1 (de) | 2003-04-24 | 2003-04-24 | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
| PCT/EP2004/004338 WO2004094405A1 (de) | 2003-04-24 | 2004-04-23 | 4-, 6- oder 7-hydroxyindole mit n-oxidgruppen und deren verwendung als therapeutika |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524208A JP2006524208A (ja) | 2006-10-26 |
| JP2006524208A5 true JP2006524208A5 (https=) | 2007-03-22 |
Family
ID=33154393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006505245A Withdrawn JP2006524208A (ja) | 2003-04-24 | 2004-04-23 | Ｎ−オキシド基を有する４−、６−または７−ヒドロキシインドールおよび治療薬としての該化合物の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7067536B2 (https=) |
| EP (1) | EP1615912A1 (https=) |
| JP (1) | JP2006524208A (https=) |
| KR (1) | KR20060021831A (https=) |
| CN (1) | CN1777600A (https=) |
| AR (1) | AR044081A1 (https=) |
| AU (1) | AU2004232482A1 (https=) |
| BR (1) | BRPI0409793A (https=) |
| CA (1) | CA2523048A1 (https=) |
| DE (1) | DE10318611A1 (https=) |
| MX (1) | MXPA05011437A (https=) |
| NO (1) | NO20055517L (https=) |
| RU (1) | RU2005136431A (https=) |
| TW (1) | TW200503693A (https=) |
| WO (1) | WO2004094405A1 (https=) |
| ZA (1) | ZA200507258B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200738677A (en) * | 2005-06-27 | 2007-10-16 | Elbion Ag | Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them |
| WO2007056457A2 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| US8884020B2 (en) * | 2006-08-07 | 2014-11-11 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
| DK2124944T3 (da) * | 2007-03-14 | 2012-04-23 | Ranbaxy Lab Ltd | Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19636150A1 (de) | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| DE19814838C2 (de) | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| TR200003130T2 (tr) | 1998-04-28 | 2001-01-22 | Arzneimittelwerk Dresden Gmbh | Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| CA2459886A1 (en) | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 1-glyoxlylamide indolizines for treating cancer |
| US20040116462A1 (en) | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
| DE10253426B4 (de) * | 2002-11-15 | 2005-09-22 | Elbion Ag | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
| DE10318609A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
-
2003
- 2003-04-24 DE DE10318611A patent/DE10318611A1/de not_active Withdrawn
-
2004
- 2004-04-16 US US10/825,862 patent/US7067536B2/en not_active Expired - Fee Related
- 2004-04-21 TW TW093111114A patent/TW200503693A/zh unknown
- 2004-04-23 MX MXPA05011437A patent/MXPA05011437A/es unknown
- 2004-04-23 KR KR1020057020097A patent/KR20060021831A/ko not_active Withdrawn
- 2004-04-23 AU AU2004232482A patent/AU2004232482A1/en not_active Abandoned
- 2004-04-23 BR BRPI0409793-9A patent/BRPI0409793A/pt not_active Application Discontinuation
- 2004-04-23 JP JP2006505245A patent/JP2006524208A/ja not_active Withdrawn
- 2004-04-23 WO PCT/EP2004/004338 patent/WO2004094405A1/de not_active Ceased
- 2004-04-23 AR ARP040101396A patent/AR044081A1/es not_active Application Discontinuation
- 2004-04-23 CN CNA2004800110345A patent/CN1777600A/zh active Pending
- 2004-04-23 RU RU2005136431/04A patent/RU2005136431A/ru not_active Application Discontinuation
- 2004-04-23 CA CA002523048A patent/CA2523048A1/en not_active Abandoned
- 2004-04-23 EP EP04729109A patent/EP1615912A1/de not_active Withdrawn
-
2005
- 2005-09-09 ZA ZA200507258A patent/ZA200507258B/en unknown
- 2005-11-22 NO NO20055517A patent/NO20055517L/no not_active Application Discontinuation
-
2006
- 2006-01-30 US US11/342,428 patent/US20060128758A1/en not_active Abandoned
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