DE10318611A1 - 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika - Google Patents

4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika Download PDF

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Publication number
DE10318611A1
DE10318611A1 DE10318611A DE10318611A DE10318611A1 DE 10318611 A1 DE10318611 A1 DE 10318611A1 DE 10318611 A DE10318611 A DE 10318611A DE 10318611 A DE10318611 A DE 10318611A DE 10318611 A1 DE10318611 A1 DE 10318611A1
Authority
DE
Germany
Prior art keywords
alkyl
aryl
oxopyridin
compounds
glyoxylsäureamid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10318611A
Other languages
German (de)
English (en)
Inventor
Norbert Dr. Höfgen
Hildegard Dr. Kuss
Karin Steinike
Ute Egerland
Chris Dr. Rundfeldt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elbion GmbH
Original Assignee
Elbion GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elbion GmbH filed Critical Elbion GmbH
Priority to DE10318611A priority Critical patent/DE10318611A1/de
Priority to US10/825,862 priority patent/US7067536B2/en
Priority to TW093111114A priority patent/TW200503693A/zh
Priority to EP04729109A priority patent/EP1615912A1/de
Priority to CA002523048A priority patent/CA2523048A1/en
Priority to MXPA05011437A priority patent/MXPA05011437A/es
Priority to CNA2004800110345A priority patent/CN1777600A/zh
Priority to KR1020057020097A priority patent/KR20060021831A/ko
Priority to PCT/EP2004/004338 priority patent/WO2004094405A1/de
Priority to ARP040101396A priority patent/AR044081A1/es
Priority to RU2005136431/04A priority patent/RU2005136431A/ru
Priority to AU2004232482A priority patent/AU2004232482A1/en
Priority to JP2006505245A priority patent/JP2006524208A/ja
Priority to BRPI0409793-9A priority patent/BRPI0409793A/pt
Publication of DE10318611A1 publication Critical patent/DE10318611A1/de
Priority to ZA200507258A priority patent/ZA200507258B/en
Priority to NO20055517A priority patent/NO20055517L/no
Priority to US11/342,428 priority patent/US20060128758A1/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/08—Antiallergic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
DE10318611A 2003-04-24 2003-04-24 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika Withdrawn DE10318611A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE10318611A DE10318611A1 (de) 2003-04-24 2003-04-24 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
US10/825,862 US7067536B2 (en) 2003-04-24 2004-04-16 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
TW093111114A TW200503693A (en) 2003-04-24 2004-04-21 4-, 6- or 7-hydroxyindoles with n-oxide groups and the use thereof as therapeutic agents
ARP040101396A AR044081A1 (es) 2003-04-24 2004-04-23 4-,6- o 7- hidroxiindol glioxilamidas y su uso como agentes terapeuticos
RU2005136431/04A RU2005136431A (ru) 2003-04-24 2004-04-23 4-, 6-или 7-гидроксииндолы с n-оксидными группами и их применение в качестве терапевтических средств
MXPA05011437A MXPA05011437A (es) 2003-04-24 2004-04-23 4-, 6- o 7-hidroxiindoles comprendiendo grupos de n-oxidos y su uso como terapeuticos.
CNA2004800110345A CN1777600A (zh) 2003-04-24 2004-04-23 具有n－氧化物基团的4－、6－或7－羟基吲哚及其作为治疗剂的用途
KR1020057020097A KR20060021831A (ko) 2003-04-24 2004-04-23 Ｎ-옥사이드 그룹을 포함하는 4-, 6- 또는7-하이드록시인돌 및 치료학적 제제로서의 이의 용도
PCT/EP2004/004338 WO2004094405A1 (de) 2003-04-24 2004-04-23 4-, 6- oder 7-hydroxyindole mit n-oxidgruppen und deren verwendung als therapeutika
EP04729109A EP1615912A1 (de) 2003-04-24 2004-04-23 4-, 6- oder 7-hydroxyindole mit n-oxidgruppen und deren verwendung als therapeutika
CA002523048A CA2523048A1 (en) 2003-04-24 2004-04-23 4-, 6- o 7-hydroxyindoles having n-oxide groups and the use thereof as therapeutic agents
AU2004232482A AU2004232482A1 (en) 2003-04-24 2004-04-23 4-, 6- o 7-hydroxyindoles having N-oxide groups and the use thereof as therapeutic agents
JP2006505245A JP2006524208A (ja) 2003-04-24 2004-04-23 Ｎ−オキシド基を有する４−、６−または７−ヒドロキシインドールおよび治療薬としての該化合物の使用
BRPI0409793-9A BRPI0409793A (pt) 2003-04-24 2004-04-23 4-,6- ou 7-hidroxiindóis com grupos n-óxido e sua aplicação como produtos terapêuticos
ZA200507258A ZA200507258B (en) 2003-04-24 2005-09-09 4, 6-, or 7-hydroxyindoles having n-oxide groups and the use thereof as therapeutic agents
NO20055517A NO20055517L (no) 2003-04-24 2005-11-22 4-,6-O 7-hydroksyindoler med N-oksidgrupper og anvendelse av disse som terapeutiske midler
US11/342,428 US20060128758A1 (en) 2003-04-24 2006-01-30 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10318611A DE10318611A1 (de) 2003-04-24 2003-04-24 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika

Publications (1)

Publication Number Publication Date
DE10318611A1 true DE10318611A1 (de) 2004-11-11

Family

ID=33154393

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10318611A Withdrawn DE10318611A1 (de) 2003-04-24 2003-04-24 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika

Country Status (16)

Country Link
US (2) US7067536B2 (https=)
EP (1) EP1615912A1 (https=)
JP (1) JP2006524208A (https=)
KR (1) KR20060021831A (https=)
CN (1) CN1777600A (https=)
AR (1) AR044081A1 (https=)
AU (1) AU2004232482A1 (https=)
BR (1) BRPI0409793A (https=)
CA (1) CA2523048A1 (https=)
DE (1) DE10318611A1 (https=)
MX (1) MXPA05011437A (https=)
NO (1) NO20055517L (https=)
RU (1) RU2005136431A (https=)
TW (1) TW200503693A (https=)
WO (1) WO2004094405A1 (https=)
ZA (1) ZA200507258B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200738677A (en) * 2005-06-27 2007-10-16 Elbion Ag Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
US8884020B2 (en) * 2006-08-07 2014-11-11 Ironwood Pharmaceuticals, Inc. Indole compounds
DK2124944T3 (da) * 2007-03-14 2012-04-23 Ranbaxy Lab Ltd Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636150A1 (de) 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
DE19814838C2 (de) 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
CA2459886A1 (en) 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 1-glyoxlylamide indolizines for treating cancer
US20040116462A1 (en) 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika

Also Published As

Publication number Publication date
CA2523048A1 (en) 2004-11-04
CN1777600A (zh) 2006-05-24
US7067536B2 (en) 2006-06-27
NO20055517D0 (no) 2005-11-22
MXPA05011437A (es) 2005-12-12
JP2006524208A (ja) 2006-10-26
TW200503693A (en) 2005-02-01
US20040242643A1 (en) 2004-12-02
US20060128758A1 (en) 2006-06-15
AU2004232482A1 (en) 2004-11-04
NO20055517L (no) 2006-01-18
WO2004094405A1 (de) 2004-11-04
RU2005136431A (ru) 2006-03-20
KR20060021831A (ko) 2006-03-08
BRPI0409793A (pt) 2006-05-30
ZA200507258B (en) 2006-06-28
EP1615912A1 (de) 2006-01-18
AR044081A1 (es) 2005-08-24

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