JP2006523711A - 免疫調節因子としてのｂ７−ｈ３の使用 - Google Patents
免疫調節因子としてのｂ７−ｈ３の使用 Download PDFInfo
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Classifications
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46334203P | 2003-04-17 | 2003-04-17 | |
| PCT/US2004/011767 WO2004093894A2 (en) | 2003-04-17 | 2004-04-16 | Use of b7-h3 as an immunoregulatory agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007095108A Division JP2007191489A (ja) | 2003-04-17 | 2007-03-30 | 免疫調節因子としてのｂ７−ｈ３の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006523711A true JP2006523711A (ja) | 2006-10-19 |
| JP2006523711A5 JP2006523711A5 (https=) | 2007-05-24 |
Family
ID=33310770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006510118A Withdrawn JP2006523711A (ja) | 2003-04-17 | 2004-04-16 | 免疫調節因子としてのｂ７−ｈ３の使用 |
| JP2007095108A Withdrawn JP2007191489A (ja) | 2003-04-17 | 2007-03-30 | 免疫調節因子としてのｂ７−ｈ３の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007095108A Withdrawn JP2007191489A (ja) | 2003-04-17 | 2007-03-30 | 免疫調節因子としてのｂ７−ｈ３の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050002935A1 (https=) |
| EP (1) | EP1620119A2 (https=) |
| JP (2) | JP2006523711A (https=) |
| KR (1) | KR20060017496A (https=) |
| CN (1) | CN1809370A (https=) |
| AU (1) | AU2004231748A1 (https=) |
| BR (1) | BRPI0409476A (https=) |
| CA (1) | CA2521847A1 (https=) |
| CO (1) | CO5700783A2 (https=) |
| MX (1) | MXPA05011050A (https=) |
| NO (1) | NO20054790L (https=) |
| RU (1) | RU2005135739A (https=) |
| WO (1) | WO2004093894A2 (https=) |
| ZA (1) | ZA200508367B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022515932A (ja) * | 2018-12-24 | 2022-02-22 | ▲海▼▲東▼ 黄 | 突然変異型ヒト２Ｉｇ－Ｂ７－Ｈ３タンパク質コーディング遺伝子、組換えベクター及びそれを含む宿主細胞、並びに薬物組成物及びその応用 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
| US6965018B2 (en) | 2000-06-06 | 2005-11-15 | Bristol-Myers Squibb Company | Antibodies directed to B7-related polypeptide, BSL-2 |
| CN1761680A (zh) | 2002-12-26 | 2006-04-19 | 武田药品工业株式会社 | 肿瘤迁移抑制素衍生物及其用途 |
| CA2571420A1 (en) | 2004-06-25 | 2006-01-05 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| AU2007325872B2 (en) * | 2006-11-08 | 2012-12-13 | Macrogenics West, Inc. | TES7 and antibodies that bind thereto |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| EP2542256B1 (en) | 2010-03-04 | 2019-05-22 | MacroGenics, Inc. | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| WO2012147713A1 (ja) * | 2011-04-25 | 2012-11-01 | 第一三共株式会社 | 抗ｂ７－ｈ３抗体 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| KR20160135190A (ko) | 2014-02-14 | 2016-11-25 | 앤드류 에스. 카이 | 혈관형성 암의 치료를 위한 개선된 방법 |
| BR112018006817A2 (pt) | 2015-10-08 | 2018-10-23 | Macrogenics Inc | método de tratamento do câncer |
| GEP20227398B (en) | 2016-04-15 | 2022-07-25 | Macrogenics Inc | Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof |
| MX2019011117A (es) * | 2017-03-31 | 2019-11-05 | Jiangsu Hengrui Medicine Co | Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos. |
| CN109097366A (zh) * | 2017-06-21 | 2018-12-28 | 黄海东 | 突变的人2Ig-B7-H3蛋白编码基因、重组载体、其药物组合物及其应用 |
| US12312406B2 (en) | 2018-11-09 | 2025-05-27 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Anti-B7-H3 antibody, preparation method therefor, conjugate and application thereof |
| CN118878681A (zh) * | 2019-07-18 | 2024-11-01 | 泰州复旦张江药业有限公司 | 一种抗b7-h3抗体及其制备方法、其偶联物和应用 |
| CN111454357B (zh) * | 2019-08-14 | 2022-03-15 | 康诺亚生物医药科技（成都）有限公司 | 一种含有抗体的肿瘤治疗剂的开发和应用 |
| CN111088227A (zh) * | 2019-12-31 | 2020-05-01 | 广州航华生物医药科技有限公司 | 一种细胞分离培养液和t细胞分离培养的方法 |
| EP4257154A4 (en) | 2021-02-09 | 2026-04-22 | Medilink Therapeutics Suzhou Co Ltd | CONJUGATED WITH A BIOACTIVE SUBSTANCE, ITS PREPARATION PROCESS AND ITS USE |
| CN113144181B (zh) * | 2021-04-20 | 2022-07-19 | 徐州医科大学 | 一种靶向b7h3的dna疫苗、制备方法及应用 |
| CN118647408A (zh) | 2022-02-16 | 2024-09-13 | 苏州宜联生物医药有限公司 | 抗体-艾日布林或其衍生物的偶联物、其中间体、制备方法、药物组合物和用途 |
| CN119212733A (zh) | 2022-05-18 | 2024-12-27 | 苏州宜联生物医药有限公司 | 包含蛋白降解剂类生物活性化合物的抗体药物偶联物及其制备方法和用途 |
| WO2024148521A1 (zh) * | 2023-01-10 | 2024-07-18 | 周田弘 | 重组人2Ig-B7-H3蛋白编码基因、重组载体、宿主细胞、药物组合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6965018B2 (en) * | 2000-06-06 | 2005-11-15 | Bristol-Myers Squibb Company | Antibodies directed to B7-related polypeptide, BSL-2 |
| US6891030B2 (en) * | 2000-07-27 | 2005-05-10 | Mayo Foundation For Medical Education And Research | T-cell immunoregulatory molecule |
| EP1423402A4 (en) * | 2001-08-02 | 2006-07-05 | Lilly Co Eli | NOVEL ANALOGUES OF POLYPEPTIDES AND HYBRID PROTEINS AND METHODS OF USE |
-
2004
- 2004-04-15 US US10/824,481 patent/US20050002935A1/en not_active Abandoned
- 2004-04-16 JP JP2006510118A patent/JP2006523711A/ja not_active Withdrawn
- 2004-04-16 CA CA002521847A patent/CA2521847A1/en not_active Abandoned
- 2004-04-16 WO PCT/US2004/011767 patent/WO2004093894A2/en not_active Ceased
- 2004-04-16 MX MXPA05011050A patent/MXPA05011050A/es not_active Application Discontinuation
- 2004-04-16 RU RU2005135739/13A patent/RU2005135739A/ru not_active Application Discontinuation
- 2004-04-16 CN CNA2004800170492A patent/CN1809370A/zh not_active Withdrawn
- 2004-04-16 EP EP04750222A patent/EP1620119A2/en not_active Withdrawn
- 2004-04-16 AU AU2004231748A patent/AU2004231748A1/en not_active Abandoned
- 2004-04-16 KR KR1020057019786A patent/KR20060017496A/ko not_active Withdrawn
- 2004-04-16 BR BRPI0409476-0A patent/BRPI0409476A/pt not_active IP Right Cessation
-
2005
- 2005-10-14 ZA ZA200508367A patent/ZA200508367B/en unknown
- 2005-10-18 NO NO20054790A patent/NO20054790L/no not_active Application Discontinuation
- 2005-11-17 CO CO05116756A patent/CO5700783A2/es not_active Application Discontinuation
-
2007
- 2007-03-30 JP JP2007095108A patent/JP2007191489A/ja not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022515932A (ja) * | 2018-12-24 | 2022-02-22 | ▲海▼▲東▼ 黄 | 突然変異型ヒト２Ｉｇ－Ｂ７－Ｈ３タンパク質コーディング遺伝子、組換えベクター及びそれを含む宿主細胞、並びに薬物組成物及びその応用 |
| JP7315703B2 (ja) | 2018-12-24 | 2023-07-26 | ▲海▼▲東▼ 黄 | 組み換えヒト２Ｉｇ－Ｂ７－Ｈ３タンパク質コーディング遺伝子、組換えベクター及びそれを含む宿主細胞、並びに薬物組成物及びその応用 |
| US12415846B2 (en) | 2018-12-24 | 2025-09-16 | Shanghai Renyousheng Gene Technology Co., Ltd. | Recombinant human 2IG-B7-H3 protein coding gene, recombinant vector, host cell comprising the same, pharmaceutical composition and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CO5700783A2 (es) | 2006-11-30 |
| WO2004093894A3 (en) | 2005-03-24 |
| CN1809370A (zh) | 2006-07-26 |
| WO2004093894A2 (en) | 2004-11-04 |
| NO20054790D0 (no) | 2005-10-18 |
| US20050002935A1 (en) | 2005-01-06 |
| NO20054790L (no) | 2005-11-16 |
| EP1620119A2 (en) | 2006-02-01 |
| WO2004093894A8 (en) | 2005-05-19 |
| CA2521847A1 (en) | 2004-11-04 |
| JP2007191489A (ja) | 2007-08-02 |
| RU2005135739A (ru) | 2006-03-20 |
| BRPI0409476A (pt) | 2006-05-02 |
| MXPA05011050A (es) | 2006-03-17 |
| AU2004231748A1 (en) | 2004-11-04 |
| ZA200508367B (en) | 2007-04-25 |
| KR20060017496A (ko) | 2006-02-23 |
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