JP2006522062A5 - - Google Patents

Info

Publication number

JP2006522062A5

JP2006522062A5 JP2006504970A JP2006504970A JP2006522062A5 JP 2006522062 A5 JP2006522062 A5 JP 2006522062A5 JP 2006504970 A JP2006504970 A JP 2006504970A JP 2006504970 A JP2006504970 A JP 2006504970A JP 2006522062 A5 JP2006522062 A5 JP 2006522062A5

Authority

JP

Japan

Prior art keywords

methyl

dihydro

benzodiazepine

dioxolo

aminophenyl

Prior art date

2004-04-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 description 6
• JACAAXNEHGBPOQ-LLVKDONJSA-N Talampanel Chemical compound C([C@H](N(N=1)C(C)=O)C)C2=CC=3OCOC=3C=C2C=1C1=CC=C(N)C=C1 JACAAXNEHGBPOQ-LLVKDONJSA-N 0.000 description 4
• QZULPCPLWGCGSL-UHFFFAOYSA-N irampanel Chemical compound CN(C)CCOC1=CC=CC=C1C1=NC(C=2C=CC=CC=2)=NO1 QZULPCPLWGCGSL-UHFFFAOYSA-N 0.000 description 4
• 125000000217 alkyl group Chemical group 0.000 description 3
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 2
• MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 description 2
• -1 4-carboxyphenyl Chemical group 0.000 description 2
• AEFZZVQZPBFFPN-UHFFFAOYSA-N 7-[4-[(4-carboxyphenyl)carbamoyloxymethyl]imidazol-1-yl]-3-oxo-6-(trifluoromethyl)-4h-quinoxaline-2-carboxylic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC(=O)OCC1=CN(C=2C(=CC=3NC(=O)C(C(O)=O)=NC=3C=2)C(F)(F)F)C=N1 AEFZZVQZPBFFPN-UHFFFAOYSA-N 0.000 description 2
• CBHCOCUJJQDHSR-UHFFFAOYSA-N 7-acetyl-5-(4-aminophenyl)-8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-8-carbonitrile Chemical compound C12=CC=3OCOC=3C=C2CC(C#N)(C)N(C(=O)C)N=C1C1=CC=C(N)C=C1 CBHCOCUJJQDHSR-UHFFFAOYSA-N 0.000 description 2
• PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
• 239000005557 antagonist Substances 0.000 description 2
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
• 229950010390 irampanel Drugs 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• IEWVBTBLBYYUTR-UHFFFAOYSA-M sodium;2-[[5-[4-(dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-7,9-dihydro-6h-pyrrolo[3,2-h]isoquinolin-3-yl]amino]oxy-4-hydroxybutanoate Chemical compound [Na+].C1=CC(S(=O)(=O)N(C)C)=CC=C1C1=CC2=C(NOC(CCO)C([O-])=O)C(=O)N=C2C2=C1CCN(C)C2 IEWVBTBLBYYUTR-UHFFFAOYSA-M 0.000 description 2
• 229950004608 talampanel Drugs 0.000 description 2
• 229940035305 topamax Drugs 0.000 description 2
• 229960004394 topiramate Drugs 0.000 description 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 2
• FPXVCCSOTAQPIV-UHFFFAOYSA-N 4-(8-chloro-2-methyl-11h-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline Chemical compound C12=CC(Cl)=CC=C2CC2=NC(C)=CN2N=C1C1=CC=C(N)C=C1 FPXVCCSOTAQPIV-UHFFFAOYSA-N 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 125000001118 alkylidene group Chemical group 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 125000004093 cyano group Chemical group *C#N 0.000 description 1
• 125000002993 cycloalkylene group Chemical group 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
• SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical compound C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 description 1