JP2006519875A5 - - Google Patents
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- JP2006519875A5 JP2006519875A5 JP2006509174A JP2006509174A JP2006519875A5 JP 2006519875 A5 JP2006519875 A5 JP 2006519875A5 JP 2006509174 A JP2006509174 A JP 2006509174A JP 2006509174 A JP2006509174 A JP 2006509174A JP 2006519875 A5 JP2006519875 A5 JP 2006519875A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- carbon atoms
- composition according
- disease
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 50
- -1 3-ethoxy-4-methoxy-phenyl Chemical group 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 16
- 150000002367 halogens Chemical class 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 125000004442 acylamino group Chemical group 0.000 claims description 3
- 125000003282 alkyl amino group Chemical group 0.000 claims description 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 3
- VBWIZSYFQSOUFQ-UHFFFAOYSA-N cyclohexanecarbonitrile Chemical compound N#CC1CCCCC1 VBWIZSYFQSOUFQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 239000003112 inhibitor Substances 0.000 claims 14
- 102000004127 Cytokines Human genes 0.000 claims 13
- 108090000695 Cytokines Proteins 0.000 claims 13
- 208000015114 central nervous system disease Diseases 0.000 claims 13
- 208000018737 Parkinson disease Diseases 0.000 claims 10
- 239000004480 active ingredient Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 229940099362 Catechol O methyltransferase inhibitor Drugs 0.000 claims 6
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims 6
- 206010034010 Parkinsonism Diseases 0.000 claims 6
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 claims 6
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims 6
- 208000012902 Nervous system disease Diseases 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 208000014094 Dystonic disease Diseases 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 208000010118 dystonia Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 102100040999 Catechol O-methyltransferase Human genes 0.000 claims 3
- 108020002739 Catechol O-methyltransferase Proteins 0.000 claims 3
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 3
- 108010062431 Monoamine oxidase Proteins 0.000 claims 3
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 3
- 229960003805 amantadine Drugs 0.000 claims 3
- 230000003474 anti-emetic effect Effects 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims 3
- 239000002111 antiemetic agent Substances 0.000 claims 3
- 229940125683 antiemetic agent Drugs 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 3
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 2
- 206010008748 Chorea Diseases 0.000 claims 2
- 208000003098 Ganglion Cysts Diseases 0.000 claims 2
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 208000016285 Movement disease Diseases 0.000 claims 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 208000027089 Parkinsonian disease Diseases 0.000 claims 2
- 208000020764 Sensation disease Diseases 0.000 claims 2
- 208000005400 Synovial Cyst Diseases 0.000 claims 2
- 206010044565 Tremor Diseases 0.000 claims 2
- 206010068100 Vascular parkinsonism Diseases 0.000 claims 2
- 208000018839 Wilson disease Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 208000012601 choreatic disease Diseases 0.000 claims 2
- 230000001149 cognitive effect Effects 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical group OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims 2
- 230000007850 degeneration Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 201000006517 essential tremor Diseases 0.000 claims 2
- 230000005021 gait Effects 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000007787 long-term memory Effects 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 230000036651 mood Effects 0.000 claims 2
- 230000002151 myoclonic effect Effects 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 230000001953 sensory effect Effects 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 230000037418 vocal dysfunction Effects 0.000 claims 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45237403P | 2003-03-06 | 2003-03-06 | |
| PCT/US2004/006782 WO2004080393A2 (en) | 2003-03-06 | 2004-03-05 | Selective cytokine inhibitory drugs for treating disorders of the central nervous system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519875A JP2006519875A (ja) | 2006-08-31 |
| JP2006519875A5 true JP2006519875A5 (https=) | 2006-10-12 |
Family
ID=32990646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509174A Pending JP2006519875A (ja) | 2003-03-06 | 2004-03-05 | 中枢神経系障害を治療するための選択的サイトカイン阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1605935A4 (https=) |
| JP (1) | JP2006519875A (https=) |
| KR (1) | KR100831545B1 (https=) |
| CN (1) | CN1780616B (https=) |
| AU (1) | AU2004220607B2 (https=) |
| BR (1) | BRPI0408113A (https=) |
| CA (1) | CA2517845A1 (https=) |
| IL (1) | IL170710A0 (https=) |
| MX (1) | MXPA05009435A (https=) |
| NZ (1) | NZ542408A (https=) |
| WO (1) | WO2004080393A2 (https=) |
| ZA (1) | ZA200507322B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
| EA202092673A3 (ru) | 2010-02-09 | 2021-05-31 | Дзе Джонс Хопкинс Юниверсити | Способы и композиции для улучшения когнитивной функции |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| JP2017141222A (ja) * | 2016-02-09 | 2017-08-17 | 国立大学法人帯広畜産大学 | パーキンソン病に併発した認知障害の治療剤及びそのスクリーニング方法 |
| LT3697399T (lt) * | 2017-10-18 | 2026-01-12 | Intrabio Ltd | Terapiniai agentai, skirti panaudoti gydant neramių kojų sindromą |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| WO2022098106A1 (ko) * | 2020-11-04 | 2022-05-12 | 주식회사 오에이티씨 | 클로르프로마진을 포함하는 신경 염증성 질환의 예방 또는 치료용 조성물 |
| CN119280228B (zh) * | 2024-11-06 | 2025-09-19 | 桂林医学院附属医院 | 帕金森病神经保护作用药物及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| US5698579A (en) * | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
| AR003951A1 (es) * | 1995-05-26 | 1998-09-30 | Pfizer | Formulacion farmaceutica sinergica para el tratamiento de la enfermedad de parkinson y composiciones para prepararla. |
| US5728845A (en) * | 1995-08-29 | 1998-03-17 | Celgene Corporation | Immunotherapeutic nitriles |
| JP3568749B2 (ja) * | 1996-12-17 | 2004-09-22 | 株式会社デンソー | 半導体のドライエッチング方法 |
| CA2295295A1 (en) * | 1997-07-31 | 1999-02-11 | Celgene Corporation | Substituted alkanohydroxamic acids and method of reducing tnf.alpha. levels |
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US6177077B1 (en) * | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
| US6471961B1 (en) * | 1999-02-24 | 2002-10-29 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| US6667316B1 (en) * | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US6623736B2 (en) * | 2000-05-02 | 2003-09-23 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| WO2003080048A1 (en) * | 2002-03-20 | 2003-10-02 | Celgene Corporation | (-)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| KR20050000400A (ko) * | 2002-04-12 | 2005-01-03 | 셀진 코포레이션 | 줄기 및 전구 세포 분화의 조절, 측정 및 이들의 용도 |
| US20040175382A1 (en) * | 2003-03-06 | 2004-09-09 | Schafer Peter H. | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
-
2004
- 2004-03-05 MX MXPA05009435A patent/MXPA05009435A/es not_active Application Discontinuation
- 2004-03-05 BR BRPI0408113-7A patent/BRPI0408113A/pt not_active IP Right Cessation
- 2004-03-05 KR KR1020057016598A patent/KR100831545B1/ko not_active Expired - Fee Related
- 2004-03-05 WO PCT/US2004/006782 patent/WO2004080393A2/en not_active Ceased
- 2004-03-05 EP EP04717992A patent/EP1605935A4/en not_active Withdrawn
- 2004-03-05 CN CN2004800118192A patent/CN1780616B/zh not_active Expired - Fee Related
- 2004-03-05 CA CA002517845A patent/CA2517845A1/en not_active Abandoned
- 2004-03-05 AU AU2004220607A patent/AU2004220607B2/en not_active Ceased
- 2004-03-05 JP JP2006509174A patent/JP2006519875A/ja active Pending
- 2004-03-05 ZA ZA200507322A patent/ZA200507322B/en unknown
- 2004-03-05 NZ NZ542408A patent/NZ542408A/en unknown
-
2005
- 2005-09-06 IL IL170710A patent/IL170710A0/en unknown
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