JP2008523102A5 - - Google Patents
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- Publication number
- JP2008523102A5 JP2008523102A5 JP2007545718A JP2007545718A JP2008523102A5 JP 2008523102 A5 JP2008523102 A5 JP 2008523102A5 JP 2007545718 A JP2007545718 A JP 2007545718A JP 2007545718 A JP2007545718 A JP 2007545718A JP 2008523102 A5 JP2008523102 A5 JP 2008523102A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- pharmaceutical composition
- alkyl
- hydrogen atom
- pde4 modulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CCN(C(*)*C)C(C)=O Chemical compound CCN(C(*)*C)C(C)=O 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63498204P | 2004-12-13 | 2004-12-13 | |
| PCT/US2005/045071 WO2006065814A1 (en) | 2004-12-13 | 2005-12-12 | Compositions comprising pde4 modulators and their use for the treatment or prevention of airway inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008523102A JP2008523102A (ja) | 2008-07-03 |
| JP2008523102A5 true JP2008523102A5 (https=) | 2009-02-12 |
Family
ID=36121316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545718A Abandoned JP2008523102A (ja) | 2004-12-13 | 2005-12-12 | Ｐｄｅ４モジュレーターを含有する組成物及び気道炎症の治療又は予防のためのそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060148882A1 (https=) |
| EP (1) | EP1838294A1 (https=) |
| JP (1) | JP2008523102A (https=) |
| KR (1) | KR20070092276A (https=) |
| CN (1) | CN101111235A (https=) |
| AR (1) | AR052047A1 (https=) |
| AU (1) | AU2005316593A1 (https=) |
| BR (1) | BRPI0519030A2 (https=) |
| CA (1) | CA2590903A1 (https=) |
| IL (1) | IL183858A0 (https=) |
| MX (1) | MX2007006992A (https=) |
| WO (1) | WO2006065814A1 (https=) |
| ZA (1) | ZA200705540B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
| MXPA06012279A (es) * | 2004-04-23 | 2007-01-31 | Celgene Corp | Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar. |
| BRPI0617673C1 (pt) * | 2005-10-19 | 2012-05-22 | Ranbaxy Lab Ltd | composições de inibidores de fosfodiesterase do tipo iv |
| EP2395995A1 (en) * | 2009-02-10 | 2011-12-21 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
| CN108059635B (zh) | 2009-05-14 | 2021-10-01 | 天津合美医药科技有限公司 | 噻吩衍生物 |
| MX341050B (es) * | 2010-04-07 | 2016-08-05 | Celgene Corp * | Metodos para tratar infeccion viral respiratoria. |
| JP6143675B2 (ja) | 2010-12-16 | 2017-06-07 | セルジーン コーポレイション | 難溶性薬物の制御放出経口剤形及びその使用 |
| JP2014505054A (ja) * | 2011-01-10 | 2014-02-27 | セルジーン コーポレイション | シクロプロパンカルボン酸｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシ−フェニル）−２−メタンスルホニル−エチル］−３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−４−イル｝−アミドの経口剤形 |
| EP2663549B1 (en) * | 2011-01-10 | 2018-03-14 | Celgene Corporation | Phenethylsulfone isoindoline derivatives as inhibitors of pde 4 and/or cytokines |
| ES2711100T3 (es) | 2011-03-07 | 2019-04-30 | Celgene Corp | Métodos para tratar enfermedades usando compuestos isoindolina |
| JP6022548B2 (ja) | 2011-04-28 | 2016-11-09 | セルジーン コーポレイション | Ｐｄｅ４阻害剤を自己免疫疾患及び炎症性疾患の治療及び管理に使用する方法及び組成物 |
| WO2014151180A1 (en) | 2013-03-14 | 2014-09-25 | Celgene Corporation | Treatment of psoriatic arthritis using apremilast |
| WO2015112568A1 (en) * | 2014-01-24 | 2015-07-30 | Celgene Corporation | Methods for the treatment of obesity using apremilast |
| US10092541B2 (en) | 2014-08-15 | 2018-10-09 | Celgene Corporation | Methods for the treatment of diseases ameliorated by PDE4 inhibition using dosage titration of apremilast |
| US10011611B2 (en) | 2015-08-14 | 2018-07-03 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
| AU2017317123B9 (en) * | 2016-08-22 | 2021-11-25 | Medshine Discovery Inc. | PDE4 inhibitor |
| DK3590924T3 (da) * | 2017-02-28 | 2022-01-03 | Kangpu Biopharmaceuticals Inc | Hidtil ukendt isoindolinderivat og farmaceutisk sammensætning og anvendelse deraf |
| JP2020510071A (ja) * | 2017-03-16 | 2020-04-02 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特発性肺線維症の治療 |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| US6667316B1 (en) * | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
| US6699899B1 (en) * | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
| US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| TW200501945A (en) * | 2002-11-06 | 2005-01-16 | Celgene Corp | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
| EP1581205A1 (en) * | 2002-11-18 | 2005-10-05 | Celgene Corporation | Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| BR0317885A (pt) * | 2002-12-30 | 2005-12-06 | Celgene Corp | Composto, isÈmeros s e r enantiomericamente puros do mesmo, composição farmacêutica e métodos de inibir pde4 e mmp, de modular a produção de tnf-alfa, de tratar ou prevenir mds, de tratar doença mieloproliferativa, angiogênese indesejada, câncer, uma doença, inflamação dos pulmões, depressão, distúrbio pulmonar obstrutivo crÈnico, doença inflamatória do intestino, dermatite atópica, psorìase, doença de crohn, artrite reumatóide, asma, eslcerose múltipla e doença cardìaca em um mamìfero e de tratar, prevenir ou controlar a sìndrome de dor regional complexa |
| MXPA06012279A (es) * | 2004-04-23 | 2007-01-31 | Celgene Corp | Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar. |
| BRPI0418801A (pt) * | 2004-05-05 | 2007-10-16 | Celgene Corp | métodos de tratamento, controle ou prevenção de um cáncer especìfico, e de uma doença associada com angiogênese indesejada, de redução ou prevenção de um efeito adverso, composição farmacêutica, e, kit |
| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
-
2005
- 2005-12-12 KR KR1020077015958A patent/KR20070092276A/ko not_active Withdrawn
- 2005-12-12 ZA ZA200705540A patent/ZA200705540B/xx unknown
- 2005-12-12 CA CA002590903A patent/CA2590903A1/en not_active Abandoned
- 2005-12-12 CN CNA2005800476591A patent/CN101111235A/zh active Pending
- 2005-12-12 MX MX2007006992A patent/MX2007006992A/es unknown
- 2005-12-12 WO PCT/US2005/045071 patent/WO2006065814A1/en not_active Ceased
- 2005-12-12 JP JP2007545718A patent/JP2008523102A/ja not_active Abandoned
- 2005-12-12 AU AU2005316593A patent/AU2005316593A1/en not_active Abandoned
- 2005-12-12 EP EP05853888A patent/EP1838294A1/en not_active Withdrawn
- 2005-12-12 BR BRPI0519030-4A patent/BRPI0519030A2/pt not_active IP Right Cessation
- 2005-12-13 AR ARP050105222A patent/AR052047A1/es not_active Application Discontinuation
- 2005-12-13 US US11/299,702 patent/US20060148882A1/en not_active Abandoned
-
2007
- 2007-06-12 IL IL183858A patent/IL183858A0/en unknown
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