JP2006519782A5 - - Google Patents
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- Publication number
- JP2006519782A5 JP2006519782A5 JP2006502481A JP2006502481A JP2006519782A5 JP 2006519782 A5 JP2006519782 A5 JP 2006519782A5 JP 2006502481 A JP2006502481 A JP 2006502481A JP 2006502481 A JP2006502481 A JP 2006502481A JP 2006519782 A5 JP2006519782 A5 JP 2006519782A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolidone
- pharmaceutical composition
- rbmp
- nmp
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-ethylpyrrolidin-2-one Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 claims 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- PZYDAVFRVJXFHS-UHFFFAOYSA-N N-Cyclohexyl-2-pyrrolidone Chemical compound O=C1CCCN1C1CCCCC1 PZYDAVFRVJXFHS-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N n-methylpyrrolidone Chemical group CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
Images
Claims (3)
- 請求項２に記載の医薬組成物において、前記ピロリドンは１ - メチル - ２ - ピロリドン（ＮＭＰ）、 １ - エチル - ２ - ピロリドン（ＮＥＰ）、 ２ - ピロリドン（ＰＢ）および１ - シクロヘキシル - ２ - ピロリドン（ＣＰ）より選択されることを特徴とする医薬組成物。
- 生分解性ポリマ中に、少なくとも一つの遺伝子組換え骨形成蛋白質（ｒＢＭＰ）および、少なくとも一つのピロリドンを含み、前記少なくとも一つのｒＢＭＰは 0.001 〜 4 mgの量が存在し、前記少なくとも一つのピロリドンは、1 〜 20 mmol/lの量が存在し、該量は骨形成を相乗的に高めるものであることを特徴とする医薬組成物。
- 請求項１４に記載の医薬組成物において、前記ピロリドンはＮＭＰであり、前記生分解性ポリマがポリ - Ｄ，Ｌ - ラクチド - co - グリコリド（ＰＬＧＡ）であることを特徴とする医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/354,856 US7074412B2 (en) | 2003-01-30 | 2003-01-30 | Pharmaceutical composition |
| PCT/IB2004/000577 WO2004067027A2 (en) | 2003-01-30 | 2004-01-29 | Osteogenic composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519782A JP2006519782A (ja) | 2006-08-31 |
| JP2006519782A5 true JP2006519782A5 (ja) | 2007-03-01 |
Family
ID=32770436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502481A Pending JP2006519782A (ja) | 2003-01-30 | 2004-01-29 | 医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7074412B2 (ja) |
| EP (1) | EP1589989A2 (ja) |
| JP (1) | JP2006519782A (ja) |
| KR (1) | KR20050105446A (ja) |
| CN (1) | CN100490893C (ja) |
| AU (1) | AU2004208569B2 (ja) |
| BR (1) | BRPI0407178A (ja) |
| CA (1) | CA2513712A1 (ja) |
| WO (1) | WO2004067027A2 (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7189409B2 (en) * | 2004-03-09 | 2007-03-13 | Inion Ltd. | Bone grafting material, method and implant |
| US20060258578A1 (en) * | 2005-05-10 | 2006-11-16 | The University Of Zurich | Pharmaceutical composition |
| KR100865759B1 (ko) * | 2007-05-07 | 2008-10-29 | 울산대학교 산학협력단 | 사람의 골형성단백질-2를 암호화하는 유전자를 이용한 재조합된 사람의 골형성단백질-2의 제조방법 |
| KR100932945B1 (ko) * | 2009-01-16 | 2009-12-21 | 원광대학교산학협력단 | 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 |
| KR100932948B1 (ko) * | 2009-01-16 | 2009-12-21 | 원광대학교산학협력단 | Ｂｍｐ-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 |
| KR100932947B1 (ko) * | 2009-01-16 | 2009-12-21 | 원광대학교산학협력단 | 안지오제닌을 함유하는 뼈 재생용 조성물 |
| EP2442747A4 (en) | 2009-06-17 | 2016-11-09 | Univ Columbia | DENTAL BRACES |
| US20150335400A1 (en) * | 2009-06-17 | 2015-11-26 | The Trustees Of Columbia University In The City Of New York | Tooth scaffolds |
| WO2012101173A1 (en) * | 2011-01-26 | 2012-08-02 | Universität Zürich | N-methyl-2-pyrrolidone for prevention and treatment of bone loss |
| WO2017019833A1 (en) * | 2015-07-29 | 2017-02-02 | Medivation Technologies, Inc. | Compositions containing repair cells and cationic dyes |
| WO2017019832A1 (en) * | 2015-07-29 | 2017-02-02 | Medivation Technologies, Inc. | Methods and compositions using repair cells and cationic dyes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| EP0560014A1 (en) | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
| US6992066B2 (en) | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| WO2000048550A2 (en) * | 1999-02-16 | 2000-08-24 | Sulzer Biologics, Inc. | Device and method for regeneration and repair of cartilage lesions |
| US20030105530A1 (en) | 2001-12-04 | 2003-06-05 | Inion Ltd. | Biodegradable implant and method for manufacturing one |
| US6926903B2 (en) * | 2001-12-04 | 2005-08-09 | Inion Ltd. | Resorbable polymer composition, implant and method of making implant |
-
2003
- 2003-01-30 US US10/354,856 patent/US7074412B2/en not_active Expired - Fee Related
-
2004
- 2004-01-29 BR BR0407178-6A patent/BRPI0407178A/pt not_active Application Discontinuation
- 2004-01-29 CN CNB200480005562XA patent/CN100490893C/zh not_active Expired - Fee Related
- 2004-01-29 AU AU2004208569A patent/AU2004208569B2/en not_active Ceased
- 2004-01-29 EP EP04706251A patent/EP1589989A2/en not_active Withdrawn
- 2004-01-29 KR KR1020057014086A patent/KR20050105446A/ko not_active Application Discontinuation
- 2004-01-29 CA CA002513712A patent/CA2513712A1/en not_active Abandoned
- 2004-01-29 WO PCT/IB2004/000577 patent/WO2004067027A2/en active Search and Examination
- 2004-01-29 JP JP2006502481A patent/JP2006519782A/ja active Pending
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