KR100932948B1 - Bmp-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 - Google Patents
Bmp-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 Download PDFInfo
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Abstract
Description
그룹 | 골 이식재 | 2주 | 4주 | 8주 |
대조군 | MBCP/피브린 블록 | - | - | - |
실험군 | MBCP/피브린 블록+rhBMP-2 | - | - | - |
그룹 | 골 이식재 | 2 주(*) | 4 주 | 8 주(*) |
대조군 | MBCP/피브린 블록(*) | 161.17 (± 5.31) | 190.90 (± 2.00) | 234.07 (± 7.18) |
실험군 | MBCP/피브린 블록+rhBMP-2 | 186.17 (± 5.24) | 197.70 (± 5.27) | 260.03 (± 0.76) |
Claims (15)
- 피브린 글루에 사람의 사체에서 유래된 골 분말, 사람을 제외한 동물에서 유래된 골 분말 및 합성된 골 분말 중에서 선택된 적어도 1종의 골 분말이 혼합되고 동결건조되어, 뼈 성장촉진을 위한 인자를 수용하기 위한 복수의 세공이 형성되며 100~3,000 kPa의 강도를 가진 굳은 상태로, 뼈 재생이 필요한 결손부에 적합한 형상을 가지고, 상기 뼈 성장촉진을 위한 인자로 BMP-2(Bone-Morphogenic Protein-2)를 포함하는 뼈 재생용 스캐폴드.
- 제 1항에 있어서, (a) BMP-2를 코딩하는 DNA 서열을 이 DNA 서열에 작동가능하게 연결되어 그의 발현을 조절하는 하나 이상의 발현 조절 서열을 포함하는 벡터에 삽입시키고, (b) 이로부터 형성된 재조합 발현 벡터로 숙주를 형질전환시키며, (c) 생성된 형질전환체를 상기 DNA 서열이 발현될 수 있는 배지 및 조건하에서 배양하고, (d) 배양물로부터 BMP-2를 분리하는 단계를 거쳐 생산되는 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 스캐폴드는 동결건조되기 전 형상을 가지도록 처리된 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 스캐폴드는 형틀 내에서 동결건조된 것을 특징으로 하는 스캐폴드.
- 제4항에 있어서, 상기 형틀은 (a) 3차원 CT를 이용한 3차원 두개골 모형 제작 과정, (b) 상기 3차원 모형에서 치과용 레진을 이용하여 결손부위에 적합한 스캐폴드 제작용 형틀을 만드는 과정으로 제조되는 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 골 분말은 뼈 세포가 제거된 뼈의 분쇄물인 것을 특징으로 하는 스캐폴드.
- 삭제
- 제1항에 있어서, 상기 피브린 글루는 피브리노겐과 트롬빈을 포함하는 것을 특징으로 하는 스캐폴드.
- 제8항에 있어서, 상기 피브리노겐은 10 내지 1000mg/ml의 농도로 포함되는 것을 특징으로 하는 스캐폴드.
- 제8항에 있어서, 상기 트롬빈은 0.1 내지 1000IU/ml의 농도로 포함되는 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 피브린 글루는 아프로티닌(aprotinin) 또는 염화칼슘을 추가로 포함하는 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 피브린 글루는 수용성 바인더를 추가로 포함하는 것을 특징으로 하는 스캐폴드.
- 제12항에 있어서, 상기 수용성 바인더는 세포배양배지, 증류수 또는 혈액인 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 골 분말과 피브린 글루는 1~10 대 1의 비율로 이루어지는 것을 특징으로 하는 스캐폴드.
- 제1항에 있어서, 상기 뼈 성장촉진을 위한 인자는 호르몬, 사이토카인 또는 줄기세포인 것을 특징으로 하는 스캐폴드.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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KR1020090003893A KR100932948B1 (ko) | 2009-01-16 | 2009-01-16 | Bmp-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 |
US13/126,715 US20120003272A1 (en) | 2009-01-16 | 2009-02-02 | Concrete scaffold containing bmp-2 and made of bone powder and fibrin glue |
EP09838422.5A EP2388021A4 (en) | 2009-01-16 | 2009-02-02 | SOLID SUPPORT CONTAINING BMP-2 AND MANUFACTURED FROM BONE POWDER AND FIBRIN ADHESIVE |
PCT/KR2009/000505 WO2010082701A1 (ko) | 2009-01-16 | 2009-02-02 | Bmp-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 |
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KR1020090003893A KR100932948B1 (ko) | 2009-01-16 | 2009-01-16 | Bmp-2를 함유하는 골 분말과 피브린 글루로 이루어진 고형의 스캐폴드 |
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US (1) | US20120003272A1 (ko) |
EP (1) | EP2388021A4 (ko) |
KR (1) | KR100932948B1 (ko) |
WO (1) | WO2010082701A1 (ko) |
Citations (2)
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KR20050105446A (ko) * | 2003-01-30 | 2005-11-04 | 더 유니버시티 오브 취리히 | 골형성 조성물 |
WO2006031196A1 (en) * | 2004-09-14 | 2006-03-23 | Agency For Science, Technology And Research | Porous biomaterial-filler composite and a method for making the same |
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US6559119B1 (en) * | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
US6048964A (en) * | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
US5914121A (en) * | 1997-02-12 | 1999-06-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts |
US6696073B2 (en) * | 1999-02-23 | 2004-02-24 | Osteotech, Inc. | Shaped load-bearing osteoimplant and methods of making same |
KR100702250B1 (ko) * | 2005-06-13 | 2007-04-03 | 세원셀론텍(주) | 피브린 혼합형 골절 유합용 반고형성 뼈세포 조성물 및이의 제조방법 |
WO2007126411A2 (en) * | 2005-07-28 | 2007-11-08 | Carnegie Mellon University | Biocompatible polymers and methods of use |
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- 2009-01-16 KR KR1020090003893A patent/KR100932948B1/ko active IP Right Grant
- 2009-02-02 EP EP09838422.5A patent/EP2388021A4/en not_active Withdrawn
- 2009-02-02 US US13/126,715 patent/US20120003272A1/en not_active Abandoned
- 2009-02-02 WO PCT/KR2009/000505 patent/WO2010082701A1/ko active Application Filing
Patent Citations (2)
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KR20050105446A (ko) * | 2003-01-30 | 2005-11-04 | 더 유니버시티 오브 취리히 | 골형성 조성물 |
WO2006031196A1 (en) * | 2004-09-14 | 2006-03-23 | Agency For Science, Technology And Research | Porous biomaterial-filler composite and a method for making the same |
Non-Patent Citations (1)
Title |
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‘Micro-architecture of calcium phosphate granules and fibrin glue composite for bone tissue engineering’, Biomaterals, vol.27 pp.2716-2722 (2006.05.) |
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US20120003272A1 (en) | 2012-01-05 |
EP2388021A4 (en) | 2014-01-15 |
EP2388021A1 (en) | 2011-11-23 |
WO2010082701A1 (ko) | 2010-07-22 |
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