JP2006519589A5 - - Google Patents

Info

Publication number

JP2006519589A5

JP2006519589A5 JP2004565695A JP2004565695A JP2006519589A5 JP 2006519589 A5 JP2006519589 A5 JP 2006519589A5 JP 2004565695 A JP2004565695 A JP 2004565695A JP 2004565695 A JP2004565695 A JP 2004565695A JP 2006519589 A5 JP2006519589 A5 JP 2006519589A5

Authority

JP

Japan

Prior art keywords

seq

protein

antibody

cancer

sequence

Prior art date

2003-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000623 proteins and genes Proteins 0.000 claims description 569
• 102000004169 proteins and genes Human genes 0.000 claims description 374
• 206010028980 Neoplasm Diseases 0.000 claims description 233
• 210000004027 cell Anatomy 0.000 claims description 220
• 238000000034 method Methods 0.000 claims description 197
• 230000014509 gene expression Effects 0.000 claims description 176
• 201000011510 cancer Diseases 0.000 claims description 170
• 150000007523 nucleic acids Chemical group 0.000 claims description 163
• 239000000523 sample Substances 0.000 claims description 150
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 143
• 102000039446 nucleic acids Human genes 0.000 claims description 134
• 108020004707 nucleic acids Proteins 0.000 claims description 134
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 123
• 229920001184 polypeptide Polymers 0.000 claims description 109
• 230000027455 binding Effects 0.000 claims description 96
• 238000009739 binding Methods 0.000 claims description 96
• 102000040430 polynucleotide Human genes 0.000 claims description 90
• 108091033319 polynucleotide Proteins 0.000 claims description 90
• 239000002157 polynucleotide Substances 0.000 claims description 90
• 230000000694 effects Effects 0.000 claims description 81
• 239000003795 chemical substances by application Substances 0.000 claims description 69
• 239000012634 fragment Substances 0.000 claims description 57
• 239000003814 drug Substances 0.000 claims description 53
• 239000012867 bioactive agent Substances 0.000 claims description 50
• 238000012216 screening Methods 0.000 claims description 50
• 125000003729 nucleotide group Chemical group 0.000 claims description 47
• 239000002773 nucleotide Substances 0.000 claims description 44
• 239000000427 antigen Substances 0.000 claims description 42
• 108091007433 antigens Proteins 0.000 claims description 41
• 102000036639 antigens Human genes 0.000 claims description 41
• 238000001514 detection method Methods 0.000 claims description 39
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 35
• 229940079593 drug Drugs 0.000 claims description 35
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 23
• 230000000295 complement effect Effects 0.000 claims description 21
• 238000012360 testing method Methods 0.000 claims description 21
• 210000004408 hybridoma Anatomy 0.000 claims description 15
• 238000000338 in vitro Methods 0.000 claims description 15
• 239000003112 inhibitor Substances 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 13
• 238000002493 microarray Methods 0.000 claims description 12
• 229940124597 therapeutic agent Drugs 0.000 claims description 12
• 238000004519 manufacturing process Methods 0.000 claims description 10
• 210000002966 serum Anatomy 0.000 claims description 9
• 239000002246 antineoplastic agent Substances 0.000 claims description 8
• 230000002401 inhibitory effect Effects 0.000 claims description 7
• 238000012544 monitoring process Methods 0.000 claims description 7
• 230000008569 process Effects 0.000 claims description 5
• 230000003827 upregulation Effects 0.000 claims description 5
• 239000013068 control sample Substances 0.000 claims description 4
• 230000010261 cell growth Effects 0.000 claims description 3
• 230000003472 neutralizing effect Effects 0.000 claims description 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 230000001093 anti-cancer Effects 0.000 claims 3
• 239000013610 patient sample Substances 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 description 358
• 210000001519 tissue Anatomy 0.000 description 93
• 241000282414 Homo sapiens Species 0.000 description 83
• 108020004414 DNA Proteins 0.000 description 55
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 47
• 238000009396 hybridization Methods 0.000 description 47
• 239000000203 mixture Substances 0.000 description 47
• 239000000047 product Substances 0.000 description 45
• 238000003556 assay Methods 0.000 description 44
• 239000002299 complementary DNA Substances 0.000 description 41
• 235000001014 amino acid Nutrition 0.000 description 40
• 201000010099 disease Diseases 0.000 description 39
• 239000007787 solid Substances 0.000 description 37
• 230000001225 therapeutic effect Effects 0.000 description 34
• 206010025323 Lymphomas Diseases 0.000 description 30
• 238000003752 polymerase chain reaction Methods 0.000 description 30
• 150000001413 amino acids Chemical class 0.000 description 29
• 239000013615 primer Substances 0.000 description 29
• 230000000875 corresponding effect Effects 0.000 description 28
• 238000011282 treatment Methods 0.000 description 27
• 150000001875 compounds Chemical class 0.000 description 26
• -1 antibodies Proteins 0.000 description 25
• 238000006467 substitution reaction Methods 0.000 description 25
• 108091034117 Oligonucleotide Proteins 0.000 description 24
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 23
• 238000004458 analytical method Methods 0.000 description 23
• 230000000692 anti-sense effect Effects 0.000 description 23
• 239000002585 base Substances 0.000 description 23
• 108020004999 messenger RNA Proteins 0.000 description 23
• 239000013604 expression vector Substances 0.000 description 22
• 239000000126 substance Substances 0.000 description 22
• 241000699666 Mus <mouse, genus> Species 0.000 description 21
• 238000006243 chemical reaction Methods 0.000 description 21
• 239000000243 solution Substances 0.000 description 21
• 238000000018 DNA microarray Methods 0.000 description 20
• 108060003951 Immunoglobulin Proteins 0.000 description 20
• 238000003745 diagnosis Methods 0.000 description 20
• 102000018358 immunoglobulin Human genes 0.000 description 20
• 230000001965 increasing effect Effects 0.000 description 20
• 238000003780 insertion Methods 0.000 description 20
• 230000037431 insertion Effects 0.000 description 20
• 230000003211 malignant effect Effects 0.000 description 20
• 230000035772 mutation Effects 0.000 description 19
• 230000001105 regulatory effect Effects 0.000 description 19
• 150000003839 salts Chemical class 0.000 description 19
• 239000013598 vector Substances 0.000 description 19
• 241001465754 Metazoa Species 0.000 description 18
• 208000032839 leukemia Diseases 0.000 description 18
• 241000700605 Viruses Species 0.000 description 16
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 16
• 102000052575 Proto-Oncogene Human genes 0.000 description 15
• 108700020978 Proto-Oncogene Proteins 0.000 description 15
• 230000003834 intracellular effect Effects 0.000 description 15
• 238000002560 therapeutic procedure Methods 0.000 description 15
• 241000699670 Mus sp. Species 0.000 description 14
• 108020004711 Nucleic Acid Probes Proteins 0.000 description 14
• 238000007792 addition Methods 0.000 description 14
• 239000002671 adjuvant Substances 0.000 description 14
• 230000003321 amplification Effects 0.000 description 14
• 239000003153 chemical reaction reagent Substances 0.000 description 14
• 230000010354 integration Effects 0.000 description 14
• 239000003446 ligand Substances 0.000 description 14
• 238000003199 nucleic acid amplification method Methods 0.000 description 14
• 239000002853 nucleic acid probe Substances 0.000 description 14
• 102000005962 receptors Human genes 0.000 description 14
• 230000004071 biological effect Effects 0.000 description 13
• 108020003175 receptors Proteins 0.000 description 13
• 208000024891 symptom Diseases 0.000 description 13
• 102000035160 transmembrane proteins Human genes 0.000 description 13
• 108091005703 transmembrane proteins Proteins 0.000 description 13
• 241001430294 unidentified retrovirus Species 0.000 description 13
• 108091026890 Coding region Proteins 0.000 description 12
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 12
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 12
• 241000124008 Mammalia Species 0.000 description 12
• 230000001580 bacterial effect Effects 0.000 description 12
• 239000011324 bead Substances 0.000 description 12
• 230000004927 fusion Effects 0.000 description 12
• 238000001415 gene therapy Methods 0.000 description 12
• 230000004048 modification Effects 0.000 description 12
• 238000012986 modification Methods 0.000 description 12
• 206010006187 Breast cancer Diseases 0.000 description 11
• 201000009030 Carcinoma Diseases 0.000 description 11
• 102000004190 Enzymes Human genes 0.000 description 11
• 108090000790 Enzymes Proteins 0.000 description 11
• 239000002253 acid Substances 0.000 description 11
• 230000008859 change Effects 0.000 description 11
• 238000005516 engineering process Methods 0.000 description 11
• 230000003053 immunization Effects 0.000 description 11
• 238000002360 preparation method Methods 0.000 description 11
• 208000026310 Breast neoplasm Diseases 0.000 description 10
• 108010041986 DNA Vaccines Proteins 0.000 description 10
• 238000003491 array Methods 0.000 description 10
• 230000015572 biosynthetic process Effects 0.000 description 10
• 230000007423 decrease Effects 0.000 description 10
• 238000012217 deletion Methods 0.000 description 10
• 230000037430 deletion Effects 0.000 description 10
• 230000006870 function Effects 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 239000002777 nucleoside Substances 0.000 description 10
• 230000001566 pro-viral effect Effects 0.000 description 10
• 238000003786 synthesis reaction Methods 0.000 description 10
• 230000035897 transcription Effects 0.000 description 10
• 238000013518 transcription Methods 0.000 description 10
• 229940021995 DNA vaccine Drugs 0.000 description 9
• 108700020796 Oncogene Proteins 0.000 description 9
• 206010060862 Prostate cancer Diseases 0.000 description 9
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 9
• 241000283984 Rodentia Species 0.000 description 9
• 208000009956 adenocarcinoma Diseases 0.000 description 9
• 229940127089 cytotoxic agent Drugs 0.000 description 9
• 239000003623 enhancer Substances 0.000 description 9
• 239000000499 gel Substances 0.000 description 9
• 238000002649 immunization Methods 0.000 description 9
• 238000009169 immunotherapy Methods 0.000 description 9
• 239000012528 membrane Substances 0.000 description 9
• 238000012163 sequencing technique Methods 0.000 description 9
• 238000005406 washing Methods 0.000 description 9
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
• 102000053602 DNA Human genes 0.000 description 8
• 241000282412 Homo Species 0.000 description 8
• 108091005461 Nucleic proteins Chemical group 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• 238000010171 animal model Methods 0.000 description 8
• 239000012472 biological sample Substances 0.000 description 8
• 210000004369 blood Anatomy 0.000 description 8
• 239000008280 blood Substances 0.000 description 8
• 230000012010 growth Effects 0.000 description 8
• 238000003384 imaging method Methods 0.000 description 8
• 230000028993 immune response Effects 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 210000004379 membrane Anatomy 0.000 description 8
• 238000010369 molecular cloning Methods 0.000 description 8
• 150000003833 nucleoside derivatives Chemical class 0.000 description 8
• 238000011002 quantification Methods 0.000 description 8
• 238000010561 standard procedure Methods 0.000 description 8
• 239000000758 substrate Substances 0.000 description 8
• 235000000346 sugar Nutrition 0.000 description 8
• 208000005623 Carcinogenesis Diseases 0.000 description 7
• 108010090804 Streptavidin Proteins 0.000 description 7
• 230000004913 activation Effects 0.000 description 7
• 230000036952 cancer formation Effects 0.000 description 7
• 231100000504 carcinogenesis Toxicity 0.000 description 7
• 230000001413 cellular effect Effects 0.000 description 7
• 230000008878 coupling Effects 0.000 description 7
• 238000010168 coupling process Methods 0.000 description 7
• 238000005859 coupling reaction Methods 0.000 description 7
• 208000035475 disorder Diseases 0.000 description 7
• 239000007850 fluorescent dye Substances 0.000 description 7
• 230000013595 glycosylation Effects 0.000 description 7
• 238000006206 glycosylation reaction Methods 0.000 description 7
• 229940124452 immunizing agent Drugs 0.000 description 7
• 238000011534 incubation Methods 0.000 description 7
• 239000000463 material Substances 0.000 description 7
• 230000001404 mediated effect Effects 0.000 description 7
• 229910052751 metal Inorganic materials 0.000 description 7
• 239000002184 metal Substances 0.000 description 7
• 210000000056 organ Anatomy 0.000 description 7
• 238000004393 prognosis Methods 0.000 description 7
• 238000000746 purification Methods 0.000 description 7
• 150000003384 small molecules Chemical class 0.000 description 7
• 241000894007 species Species 0.000 description 7
• 238000012546 transfer Methods 0.000 description 7
• 230000009261 transgenic effect Effects 0.000 description 7
• 230000003612 virological effect Effects 0.000 description 7
• 241000894006 Bacteria Species 0.000 description 6
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 6
• 241000714177 Murine leukemia virus Species 0.000 description 6
• 241000283973 Oryctolagus cuniculus Species 0.000 description 6
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 6
• 238000002869 basic local alignment search tool Methods 0.000 description 6
• 239000000872 buffer Substances 0.000 description 6
• 150000001720 carbohydrates Chemical class 0.000 description 6
• 238000012512 characterization method Methods 0.000 description 6
• 230000000052 comparative effect Effects 0.000 description 6
• 230000021615 conjugation Effects 0.000 description 6
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 6
• 239000002254 cytotoxic agent Substances 0.000 description 6
• 231100000599 cytotoxic agent Toxicity 0.000 description 6
• 238000001962 electrophoresis Methods 0.000 description 6
• 125000000524 functional group Chemical group 0.000 description 6
• 239000003102 growth factor Substances 0.000 description 6
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 6
• 230000002209 hydrophobic effect Effects 0.000 description 6
• 230000002163 immunogen Effects 0.000 description 6
• 230000006698 induction Effects 0.000 description 6
• 210000004698 lymphocyte Anatomy 0.000 description 6
• 239000003550 marker Substances 0.000 description 6
• 239000011159 matrix material Substances 0.000 description 6
• 239000002245 particle Substances 0.000 description 6
• 230000001177 retroviral effect Effects 0.000 description 6
• 238000007423 screening assay Methods 0.000 description 6
• 238000001890 transfection Methods 0.000 description 6
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 5
• 108020005544 Antisense RNA Proteins 0.000 description 5
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
• 108020004705 Codon Proteins 0.000 description 5
• 241000238631 Hexapoda Species 0.000 description 5
• 239000000020 Nitrocellulose Substances 0.000 description 5
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 5
• 102000043276 Oncogene Human genes 0.000 description 5
• 108010076504 Protein Sorting Signals Proteins 0.000 description 5
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
• 238000002105 Southern blotting Methods 0.000 description 5
• 125000000539 amino acid group Chemical group 0.000 description 5
• 125000003277 amino group Chemical group 0.000 description 5
• 239000005557 antagonist Substances 0.000 description 5
• 238000013459 approach Methods 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 238000001574 biopsy Methods 0.000 description 5
• 229940098773 bovine serum albumin Drugs 0.000 description 5
• 230000004663 cell proliferation Effects 0.000 description 5
• 239000003184 complementary RNA Substances 0.000 description 5
• 235000018417 cysteine Nutrition 0.000 description 5
• 230000003247 decreasing effect Effects 0.000 description 5
• 230000003828 downregulation Effects 0.000 description 5
• 239000003937 drug carrier Substances 0.000 description 5
• 230000002255 enzymatic effect Effects 0.000 description 5
• 230000002068 genetic effect Effects 0.000 description 5
• 210000005260 human cell Anatomy 0.000 description 5
• 238000003018 immunoassay Methods 0.000 description 5
• 238000003119 immunoblot Methods 0.000 description 5
• 238000007901 in situ hybridization Methods 0.000 description 5
• 238000002372 labelling Methods 0.000 description 5
• 125000005647 linker group Chemical group 0.000 description 5
• 238000005259 measurement Methods 0.000 description 5
• 201000001441 melanoma Diseases 0.000 description 5
• 150000002739 metals Chemical class 0.000 description 5
• 229920001220 nitrocellulos Polymers 0.000 description 5
• 239000012071 phase Substances 0.000 description 5
• 239000002953 phosphate buffered saline Substances 0.000 description 5
• 210000002381 plasma Anatomy 0.000 description 5
• 230000003248 secreting effect Effects 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 230000009870 specific binding Effects 0.000 description 5
• 239000003053 toxin Substances 0.000 description 5
• 231100000765 toxin Toxicity 0.000 description 5
• 108700012359 toxins Proteins 0.000 description 5
• 210000004881 tumor cell Anatomy 0.000 description 5
• 239000003981 vehicle Substances 0.000 description 5
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 4
• 108010001857 Cell Surface Receptors Proteins 0.000 description 4
• 102000004127 Cytokines Human genes 0.000 description 4
• 108090000695 Cytokines Proteins 0.000 description 4
• 239000003155 DNA primer Substances 0.000 description 4
• 238000002965 ELISA Methods 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 108090000144 Human Proteins Proteins 0.000 description 4
• 102000003839 Human Proteins Human genes 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
• 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 4
• 108010038807 Oligopeptides Proteins 0.000 description 4
• 102000015636 Oligopeptides Human genes 0.000 description 4
• 108700026244 Open Reading Frames Proteins 0.000 description 4
• 238000012408 PCR amplification Methods 0.000 description 4
• 108091093037 Peptide nucleic acid Proteins 0.000 description 4
• 206010035226 Plasma cell myeloma Diseases 0.000 description 4
• 241000288906 Primates Species 0.000 description 4
• 241000700159 Rattus Species 0.000 description 4
• 229920006362 Teflon® Polymers 0.000 description 4
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
• 150000007513 acids Chemical class 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 239000000556 agonist Substances 0.000 description 4
• 150000001412 amines Chemical class 0.000 description 4
• 239000011230 binding agent Substances 0.000 description 4
• 229960002685 biotin Drugs 0.000 description 4
• 235000020958 biotin Nutrition 0.000 description 4
• 239000011616 biotin Substances 0.000 description 4
• 230000000903 blocking effect Effects 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 238000010367 cloning Methods 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• 238000011156 evaluation Methods 0.000 description 4
• 238000002474 experimental method Methods 0.000 description 4
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
• 108020001507 fusion proteins Proteins 0.000 description 4
• 102000037865 fusion proteins Human genes 0.000 description 4
• 238000001476 gene delivery Methods 0.000 description 4
• 239000011521 glass Substances 0.000 description 4
• 229940072221 immunoglobulins Drugs 0.000 description 4
• 238000011065 in-situ storage Methods 0.000 description 4
• 208000015181 infectious disease Diseases 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 239000002502 liposome Substances 0.000 description 4
• 230000004807 localization Effects 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 4
• 102000035118 modified proteins Human genes 0.000 description 4
• 108091005573 modified proteins Proteins 0.000 description 4
• 230000009871 nonspecific binding Effects 0.000 description 4
• 238000010606 normalization Methods 0.000 description 4
• 210000004940 nucleus Anatomy 0.000 description 4
• 230000036961 partial effect Effects 0.000 description 4
• 230000000704 physical effect Effects 0.000 description 4
• 230000001766 physiological effect Effects 0.000 description 4
• 210000002307 prostate Anatomy 0.000 description 4
• 230000005855 radiation Effects 0.000 description 4
• 230000002285 radioactive effect Effects 0.000 description 4
• 230000009467 reduction Effects 0.000 description 4
• 238000011160 research Methods 0.000 description 4
• 238000003757 reverse transcription PCR Methods 0.000 description 4
• 239000007790 solid phase Substances 0.000 description 4
• RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
• 230000002103 transcriptional effect Effects 0.000 description 4
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 201000003076 Angiosarcoma Diseases 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 241000283707 Capra Species 0.000 description 3
• 102000014914 Carrier Proteins Human genes 0.000 description 3
• 102000000844 Cell Surface Receptors Human genes 0.000 description 3
• 241000699800 Cricetinae Species 0.000 description 3
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 239000004471 Glycine Substances 0.000 description 3
• 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 3
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 241001529936 Murinae Species 0.000 description 3
• 101710163270 Nuclease Proteins 0.000 description 3
• 239000004677 Nylon Substances 0.000 description 3
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• 241000276498 Pollachius virens Species 0.000 description 3
• 239000002202 Polyethylene glycol Substances 0.000 description 3
• 229920001213 Polysorbate 20 Polymers 0.000 description 3
• 239000004793 Polystyrene Substances 0.000 description 3
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
• 102000001253 Protein Kinase Human genes 0.000 description 3
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 3
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 3
• 102000014400 SH2 domains Human genes 0.000 description 3
• 108050003452 SH2 domains Proteins 0.000 description 3
• 206010039491 Sarcoma Diseases 0.000 description 3
• 108091027544 Subgenomic mRNA Proteins 0.000 description 3
• 239000004809 Teflon Substances 0.000 description 3
• 108700019146 Transgenes Proteins 0.000 description 3
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
• 102000044209 Tumor Suppressor Genes Human genes 0.000 description 3
• 108700025716 Tumor Suppressor Genes Proteins 0.000 description 3
• 108700005077 Viral Genes Proteins 0.000 description 3
• 230000000890 antigenic effect Effects 0.000 description 3
• 239000000074 antisense oligonucleotide Substances 0.000 description 3
• 238000012230 antisense oligonucleotides Methods 0.000 description 3
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
• 230000001588 bifunctional effect Effects 0.000 description 3
• 230000000975 bioactive effect Effects 0.000 description 3
• 230000033228 biological regulation Effects 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• 239000001506 calcium phosphate Substances 0.000 description 3
• 229910000389 calcium phosphate Inorganic materials 0.000 description 3
• 235000011010 calcium phosphates Nutrition 0.000 description 3
• 230000032823 cell division Effects 0.000 description 3
• 239000013592 cell lysate Substances 0.000 description 3
• 239000000919 ceramic Substances 0.000 description 3
• 125000003636 chemical group Chemical group 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 239000003086 colorant Substances 0.000 description 3
• 239000007822 coupling agent Substances 0.000 description 3
• 230000001351 cycling effect Effects 0.000 description 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
• 229940104302 cytosine Drugs 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 238000002405 diagnostic procedure Methods 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 239000000975 dye Substances 0.000 description 3
• 230000008482 dysregulation Effects 0.000 description 3
• 238000004520 electroporation Methods 0.000 description 3
• 239000000284 extract Substances 0.000 description 3
• 239000012530 fluid Substances 0.000 description 3
• 210000004602 germ cell Anatomy 0.000 description 3
• 150000004676 glycans Chemical class 0.000 description 3
• 239000001963 growth medium Substances 0.000 description 3
• 125000000623 heterocyclic group Chemical group 0.000 description 3
• 238000013537 high throughput screening Methods 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 3
• 229940127121 immunoconjugate Drugs 0.000 description 3
• 230000016784 immunoglobulin production Effects 0.000 description 3
• 230000002779 inactivation Effects 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 238000009830 intercalation Methods 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 210000003563 lymphoid tissue Anatomy 0.000 description 3
• 210000004962 mammalian cell Anatomy 0.000 description 3
• 238000002703 mutagenesis Methods 0.000 description 3
• 231100000350 mutagenesis Toxicity 0.000 description 3
• 229930014626 natural product Natural products 0.000 description 3
• 125000003835 nucleoside group Chemical group 0.000 description 3
• 229920001778 nylon Polymers 0.000 description 3
• 239000002751 oligonucleotide probe Substances 0.000 description 3
• 230000002018 overexpression Effects 0.000 description 3
• 230000000144 pharmacologic effect Effects 0.000 description 3
• 239000010452 phosphate Substances 0.000 description 3
• 230000026731 phosphorylation Effects 0.000 description 3
• 238000006366 phosphorylation reaction Methods 0.000 description 3
• 229920003023 plastic Polymers 0.000 description 3
• 239000004033 plastic Substances 0.000 description 3
• 230000008488 polyadenylation Effects 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
• 229920001282 polysaccharide Polymers 0.000 description 3
• 239000005017 polysaccharide Substances 0.000 description 3
• 229920002223 polystyrene Polymers 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 230000000750 progressive effect Effects 0.000 description 3
• 230000002062 proliferating effect Effects 0.000 description 3
• 230000000069 prophylactic effect Effects 0.000 description 3
• 238000000159 protein binding assay Methods 0.000 description 3
• 108060006633 protein kinase Proteins 0.000 description 3
• 230000004850 protein–protein interaction Effects 0.000 description 3
• 238000003127 radioimmunoassay Methods 0.000 description 3
• 239000011347 resin Substances 0.000 description 3
• 229920005989 resin Polymers 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 230000002441 reversible effect Effects 0.000 description 3
• 238000012552 review Methods 0.000 description 3
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 235000004400 serine Nutrition 0.000 description 3
• 210000003491 skin Anatomy 0.000 description 3
• 125000001424 substituent group Chemical group 0.000 description 3
• 150000008163 sugars Chemical class 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• 210000001550 testis Anatomy 0.000 description 3
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 3
• 230000005030 transcription termination Effects 0.000 description 3
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
• 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• 241000701447 unidentified baculovirus Species 0.000 description 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• JTLDBJGKDYQKGB-UHFFFAOYSA-N 3,4-bis(4-methoxyphenyl)-2-methylbenzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(C)=C1C1=CC=C(OC)C=C1 JTLDBJGKDYQKGB-UHFFFAOYSA-N 0.000 description 2
• NJYVEMPWNAYQQN-UHFFFAOYSA-N 5-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C21OC(=O)C1=CC(C(=O)O)=CC=C21 NJYVEMPWNAYQQN-UHFFFAOYSA-N 0.000 description 2
• BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 description 2
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
• 108010066676 Abrin Proteins 0.000 description 2
• 229930024421 Adenine Natural products 0.000 description 2
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
• 102000009027 Albumins Human genes 0.000 description 2
• 108010088751 Albumins Proteins 0.000 description 2
• 108091093088 Amplicon Proteins 0.000 description 2
• 108020000948 Antisense Oligonucleotides Proteins 0.000 description 2
• 241000228212 Aspergillus Species 0.000 description 2
• 206010003571 Astrocytoma Diseases 0.000 description 2
• 241000972773 Aulopiformes Species 0.000 description 2
• 108090001008 Avidin Proteins 0.000 description 2
• 244000063299 Bacillus subtilis Species 0.000 description 2
• 235000014469 Bacillus subtilis Nutrition 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• 241000700198 Cavia Species 0.000 description 2
• 108020004635 Complementary DNA Proteins 0.000 description 2
• 239000004971 Cross linker Substances 0.000 description 2
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 2
• 230000006820 DNA synthesis Effects 0.000 description 2
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 241000283086 Equidae Species 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• 241000588724 Escherichia coli Species 0.000 description 2
• 241000282326 Felis catus Species 0.000 description 2
• 201000008808 Fibrosarcoma Diseases 0.000 description 2
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 108010031186 Glycoside Hydrolases Proteins 0.000 description 2
• 102000005744 Glycoside Hydrolases Human genes 0.000 description 2
• 208000001258 Hemangiosarcoma Diseases 0.000 description 2
• 229920000209 Hexadimethrine bromide Polymers 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
• 229930010555 Inosine Natural products 0.000 description 2
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
• 102100034343 Integrase Human genes 0.000 description 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 208000007766 Kaposi sarcoma Diseases 0.000 description 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 2
• 208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• 241000713333 Mouse mammary tumor virus Species 0.000 description 2
• 208000034578 Multiple myelomas Diseases 0.000 description 2
• 241000699660 Mus musculus Species 0.000 description 2
• 108091061960 Naked DNA Proteins 0.000 description 2
• 206010029260 Neuroblastoma Diseases 0.000 description 2
• 206010061332 Paraganglion neoplasm Diseases 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 108010004729 Phycoerythrin Proteins 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• 229920000954 Polyglycolide Polymers 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• 239000013614 RNA sample Substances 0.000 description 2
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
• 108020004511 Recombinant DNA Proteins 0.000 description 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
• 108091028664 Ribonucleotide Proteins 0.000 description 2
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
• 108010071390 Serum Albumin Proteins 0.000 description 2
• 102000007562 Serum Albumin Human genes 0.000 description 2
• 241000700584 Simplexvirus Species 0.000 description 2
• 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 2
• 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 2
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 239000006180 TBST buffer Substances 0.000 description 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 2
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 206010000269 abscess Diseases 0.000 description 2
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
• 229960000643 adenine Drugs 0.000 description 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
• 238000001042 affinity chromatography Methods 0.000 description 2
• 238000001261 affinity purification Methods 0.000 description 2
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 2
• 230000004075 alteration Effects 0.000 description 2
• 239000004599 antimicrobial Substances 0.000 description 2
• 210000001367 artery Anatomy 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• 102000005936 beta-Galactosidase Human genes 0.000 description 2
• 108010005774 beta-Galactosidase Proteins 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• 239000013060 biological fluid Substances 0.000 description 2
• 230000008827 biological function Effects 0.000 description 2
• 210000001124 body fluid Anatomy 0.000 description 2
• 239000010839 body fluid Substances 0.000 description 2
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
• 238000010805 cDNA synthesis kit Methods 0.000 description 2
• 238000004364 calculation method Methods 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 235000014633 carbohydrates Nutrition 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 230000021164 cell adhesion Effects 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 235000010980 cellulose Nutrition 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• 238000002512 chemotherapy Methods 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 230000002860 competitive effect Effects 0.000 description 2
• 230000001268 conjugating effect Effects 0.000 description 2
• 108091036078 conserved sequence Proteins 0.000 description 2
• 238000002247 constant time method Methods 0.000 description 2
• 238000011109 contamination Methods 0.000 description 2
• 238000004132 cross linking Methods 0.000 description 2
• 239000003431 cross linking reagent Substances 0.000 description 2
• 230000009260 cross reactivity Effects 0.000 description 2
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 2
• 150000001945 cysteines Chemical class 0.000 description 2
• 108010057085 cytokine receptors Proteins 0.000 description 2
• 102000003675 cytokine receptors Human genes 0.000 description 2
• 230000002950 deficient Effects 0.000 description 2
• 238000002716 delivery method Methods 0.000 description 2
• 210000003298 dental enamel Anatomy 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 230000009274 differential gene expression Effects 0.000 description 2
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 2
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
• 238000007876 drug discovery Methods 0.000 description 2
• 238000007878 drug screening assay Methods 0.000 description 2
• 230000000668 effect on calcium Effects 0.000 description 2
• 238000001378 electrochemiluminescence detection Methods 0.000 description 2
• 239000003995 emulsifying agent Substances 0.000 description 2
• 238000005538 encapsulation Methods 0.000 description 2
• 230000002124 endocrine Effects 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 230000001605 fetal effect Effects 0.000 description 2
• 239000000835 fiber Substances 0.000 description 2
• 230000002538 fungal effect Effects 0.000 description 2
• 238000007429 general method Methods 0.000 description 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 2
• 229930182470 glycoside Natural products 0.000 description 2
• 150000002338 glycosides Chemical class 0.000 description 2
• 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 2
• 238000003306 harvesting Methods 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 210000002443 helper t lymphocyte Anatomy 0.000 description 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
• 238000002744 homologous recombination Methods 0.000 description 2
• 230000006801 homologous recombination Effects 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• 206010020718 hyperplasia Diseases 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 230000003100 immobilizing effect Effects 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000000984 immunochemical effect Effects 0.000 description 2
• 238000001114 immunoprecipitation Methods 0.000 description 2
• 239000000411 inducer Substances 0.000 description 2
• 229960003786 inosine Drugs 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• 230000005865 ionizing radiation Effects 0.000 description 2
• DRAVOWXCEBXPTN-UHFFFAOYSA-N isoguanine Chemical compound NC1=NC(=O)NC2=C1NC=N2 DRAVOWXCEBXPTN-UHFFFAOYSA-N 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 210000000244 kidney pelvis Anatomy 0.000 description 2
• 238000000370 laser capture micro-dissection Methods 0.000 description 2
• 230000003902 lesion Effects 0.000 description 2
• 239000007791 liquid phase Substances 0.000 description 2
• 210000001165 lymph node Anatomy 0.000 description 2
• 208000003747 lymphoid leukemia Diseases 0.000 description 2
• 210000002540 macrophage Anatomy 0.000 description 2
• 239000011777 magnesium Substances 0.000 description 2
• 159000000003 magnesium salts Chemical class 0.000 description 2
• 239000006249 magnetic particle Substances 0.000 description 2
• 230000036210 malignancy Effects 0.000 description 2
• 201000009020 malignant peripheral nerve sheath tumor Diseases 0.000 description 2
• 230000000873 masking effect Effects 0.000 description 2
• 239000002609 medium Substances 0.000 description 2
• 206010061289 metastatic neoplasm Diseases 0.000 description 2
• 230000011987 methylation Effects 0.000 description 2
• 238000007069 methylation reaction Methods 0.000 description 2
• 238000000520 microinjection Methods 0.000 description 2
• 235000013336 milk Nutrition 0.000 description 2
• 210000004080 milk Anatomy 0.000 description 2
• 239000008267 milk Substances 0.000 description 2
• 238000000329 molecular dynamics simulation Methods 0.000 description 2
• 208000025113 myeloid leukemia Diseases 0.000 description 2
• 201000000050 myeloid neoplasm Diseases 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 210000005170 neoplastic cell Anatomy 0.000 description 2
• 230000009826 neoplastic cell growth Effects 0.000 description 2
• 230000001613 neoplastic effect Effects 0.000 description 2
• 208000029974 neurofibrosarcoma Diseases 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 238000011275 oncology therapy Methods 0.000 description 2
• 239000013307 optical fiber Substances 0.000 description 2
• 238000005457 optimization Methods 0.000 description 2
• 201000008968 osteosarcoma Diseases 0.000 description 2
• 230000002611 ovarian Effects 0.000 description 2
• 208000007312 paraganglioma Diseases 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• 239000008188 pellet Substances 0.000 description 2
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
• 238000010647 peptide synthesis reaction Methods 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
• 150000004713 phosphodiesters Chemical class 0.000 description 2
• 150000003904 phospholipids Chemical class 0.000 description 2
• 238000001259 photo etching Methods 0.000 description 2
• 230000035790 physiological processes and functions Effects 0.000 description 2
• INAAIJLSXJJHOZ-UHFFFAOYSA-N pibenzimol Chemical compound C1CN(C)CCN1C1=CC=C(N=C(N2)C=3C=C4NC(=NC4=CC=3)C=3C=CC(O)=CC=3)C2=C1 INAAIJLSXJJHOZ-UHFFFAOYSA-N 0.000 description 2
• 239000013612 plasmid Substances 0.000 description 2
• 239000004633 polyglycolic acid Substances 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 230000010469 pro-virus integration Effects 0.000 description 2
• 230000004952 protein activity Effects 0.000 description 2
• 210000001938 protoplast Anatomy 0.000 description 2
• ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
• 238000001959 radiotherapy Methods 0.000 description 2
• 102000027426 receptor tyrosine kinases Human genes 0.000 description 2
• 108091008598 receptor tyrosine kinases Proteins 0.000 description 2
• 238000010188 recombinant method Methods 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 208000015608 reproductive system cancer Diseases 0.000 description 2
• 230000000241 respiratory effect Effects 0.000 description 2
• 230000004043 responsiveness Effects 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 2
• 239000002336 ribonucleotide Substances 0.000 description 2
• 125000002652 ribonucleotide group Chemical group 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 235000019515 salmon Nutrition 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 238000010845 search algorithm Methods 0.000 description 2
• 230000035945 sensitivity Effects 0.000 description 2
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
• 230000019491 signal transduction Effects 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 239000001509 sodium citrate Substances 0.000 description 2
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
• 229910001415 sodium ion Inorganic materials 0.000 description 2
• 239000006104 solid solution Substances 0.000 description 2
• 210000004989 spleen cell Anatomy 0.000 description 2
• 206010041823 squamous cell carcinoma Diseases 0.000 description 2
• 230000006641 stabilisation Effects 0.000 description 2
• 238000011105 stabilization Methods 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• 230000008093 supporting effect Effects 0.000 description 2
• 239000000829 suppository Substances 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 229940113082 thymine Drugs 0.000 description 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
• 231100000167 toxic agent Toxicity 0.000 description 2
• 239000003440 toxic substance Substances 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 230000009466 transformation Effects 0.000 description 2
• 238000011830 transgenic mouse model Methods 0.000 description 2
• 238000013519 translation Methods 0.000 description 2
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
• 230000004614 tumor growth Effects 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 229940035893 uracil Drugs 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 108700026220 vif Genes Proteins 0.000 description 2
• 238000009736 wetting Methods 0.000 description 2
• 239000000080 wetting agent Substances 0.000 description 2
• 229940075420 xanthine Drugs 0.000 description 2
• 210000005253 yeast cell Anatomy 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 description 1
• PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
• 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 1
• RVCKCEDKBVEEHL-UHFFFAOYSA-N 2,3,4,5,6-pentachlorobenzyl alcohol Chemical compound OCC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl RVCKCEDKBVEEHL-UHFFFAOYSA-N 0.000 description 1
• 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
• OEXZVWQQTFVIDS-UHFFFAOYSA-N 2-(chloromethyl)-3,4-bis(4-methoxyphenyl)benzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(CCl)=C1C1=CC=C(OC)C=C1 OEXZVWQQTFVIDS-UHFFFAOYSA-N 0.000 description 1
• DWWYUMNNFKUIJS-UHFFFAOYSA-N 2-(hydroxymethyl)-3,4-bis(4-methoxyphenyl)benzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(CO)=C1C1=CC=C(OC)C=C1 DWWYUMNNFKUIJS-UHFFFAOYSA-N 0.000 description 1
• XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 description 1
• ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
• NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 description 1
• AZIDPTARTNUQSR-UHFFFAOYSA-N 3-(2,5-dioxopyrrol-1-yl)benzoic acid;1-hydroxypyrrolidine-2,5-dione Chemical compound ON1C(=O)CCC1=O.OC(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 AZIDPTARTNUQSR-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• BIGBDMFRWJRLGJ-UHFFFAOYSA-N 3-benzyl-1,5-didiazoniopenta-1,4-diene-2,4-diolate Chemical compound [N-]=[N+]=CC(=O)C(C(=O)C=[N+]=[N-])CC1=CC=CC=C1 BIGBDMFRWJRLGJ-UHFFFAOYSA-N 0.000 description 1
• VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
• 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 1
• TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
• HUDPLKWXRLNSPC-UHFFFAOYSA-N 4-aminophthalhydrazide Chemical compound O=C1NNC(=O)C=2C1=CC(N)=CC=2 HUDPLKWXRLNSPC-UHFFFAOYSA-N 0.000 description 1
• NLPWSMKACWGINL-UHFFFAOYSA-N 4-azido-2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(N=[N+]=[N-])C=C1O NLPWSMKACWGINL-UHFFFAOYSA-N 0.000 description 1
• WQZIDRAQTRIQDX-UHFFFAOYSA-N 6-carboxy-x-rhodamine Chemical compound OC(=O)C1=CC=C(C([O-])=O)C=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 WQZIDRAQTRIQDX-UHFFFAOYSA-N 0.000 description 1
• 241000714186 AKR (endogenous) murine leukemia virus Species 0.000 description 1
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 206010069754 Acquired gene mutation Diseases 0.000 description 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
• 208000016557 Acute basophilic leukemia Diseases 0.000 description 1
• 208000004804 Adenomatous Polyps Diseases 0.000 description 1
• 108010000239 Aequorin Proteins 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• 108091023043 Alu Element Proteins 0.000 description 1
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
• 206010002198 Anaphylactic reaction Diseases 0.000 description 1
• 241000203069 Archaea Species 0.000 description 1
• 241000945470 Arcturus Species 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 240000003291 Armoracia rusticana Species 0.000 description 1
• 102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 241000304886 Bacilli Species 0.000 description 1
• 108020004513 Bacterial RNA Proteins 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
• 208000007690 Brenner tumor Diseases 0.000 description 1
• 206010073258 Brenner tumour Diseases 0.000 description 1
• 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 201000000274 Carcinosarcoma Diseases 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 206010008583 Chloroma Diseases 0.000 description 1
• 208000005243 Chondrosarcoma Diseases 0.000 description 1
• 201000009047 Chordoma Diseases 0.000 description 1
• 208000006332 Choriocarcinoma Diseases 0.000 description 1
• 206010008805 Chromosomal abnormalities Diseases 0.000 description 1
• 206010061764 Chromosomal deletion Diseases 0.000 description 1
• 208000031404 Chromosome Aberrations Diseases 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 241000759568 Corixa Species 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 101710095468 Cyclase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N D-Maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 239000003298 DNA probe Substances 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 108010092160 Dactinomycin Proteins 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
• 102000016607 Diphtheria Toxin Human genes 0.000 description 1
• 108010053187 Diphtheria Toxin Proteins 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 241000255601 Drosophila melanogaster Species 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 206010058314 Dysplasia Diseases 0.000 description 1
• 102000001301 EGF receptor Human genes 0.000 description 1
• 108060006698 EGF receptor Proteins 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 108010000912 Egg Proteins Proteins 0.000 description 1
• 102000002322 Egg Proteins Human genes 0.000 description 1
• 206010014611 Encephalitis venezuelan equine Diseases 0.000 description 1
• 208000001976 Endocrine Gland Neoplasms Diseases 0.000 description 1
• 101710202200 Endolysin A Proteins 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 108010042407 Endonucleases Proteins 0.000 description 1
• 102000004533 Endonucleases Human genes 0.000 description 1
• 102100030013 Endoribonuclease Human genes 0.000 description 1
• 101710199605 Endoribonuclease Proteins 0.000 description 1
• 206010014967 Ependymoma Diseases 0.000 description 1
• 206010066919 Epidemic polyarthritis Diseases 0.000 description 1
• 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 1
• 208000036566 Erythroleukaemia Diseases 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 108060002716 Exonuclease Proteins 0.000 description 1
• 101710082714 Exotoxin A Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 241000192125 Firmicutes Species 0.000 description 1
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 208000007569 Giant Cell Tumors Diseases 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• 241000235503 Glomus Species 0.000 description 1
• 108091052347 Glucose transporter family Proteins 0.000 description 1
• 102000042092 Glucose transporter family Human genes 0.000 description 1
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• 229920002683 Glycosaminoglycan Polymers 0.000 description 1
• 206010018498 Goitre Diseases 0.000 description 1
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
• 206010018691 Granuloma Diseases 0.000 description 1
• 208000005234 Granulosa Cell Tumor Diseases 0.000 description 1
• 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
• 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 239000012981 Hank's balanced salt solution Substances 0.000 description 1
• 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• LYCVKHSJGDMDLM-LURJTMIESA-N His-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CN=CN1 LYCVKHSJGDMDLM-LURJTMIESA-N 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
• 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
• 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
• 101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
• 102000016844 Immunoglobulin-like domains Human genes 0.000 description 1
• 108050006430 Immunoglobulin-like domains Proteins 0.000 description 1
• 208000026350 Inborn Genetic disease Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 102000003746 Insulin Receptor Human genes 0.000 description 1
• 108010001127 Insulin Receptor Proteins 0.000 description 1
• 108010002352 Interleukin-1 Proteins 0.000 description 1
• 102000000589 Interleukin-1 Human genes 0.000 description 1
• 102000000588 Interleukin-2 Human genes 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
• 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
• 108010002386 Interleukin-3 Proteins 0.000 description 1
• 244000285963 Kluyveromyces fragilis Species 0.000 description 1
• 235000014663 Kluyveromyces fragilis Nutrition 0.000 description 1
• RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
• 108010001831 LDL receptors Proteins 0.000 description 1
• 102000000853 LDL receptors Human genes 0.000 description 1
• 241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 208000018142 Leiomyosarcoma Diseases 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 206010024305 Leukaemia monocytic Diseases 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• 102000004083 Lymphotoxin-alpha Human genes 0.000 description 1
• 108090000542 Lymphotoxin-alpha Proteins 0.000 description 1
• 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 description 1
• 208000007369 Malignant Mixed Tumor Diseases 0.000 description 1
• 206010072448 Malignant blue naevus Diseases 0.000 description 1
• 206010064912 Malignant transformation Diseases 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
• 206010027145 Melanocytic naevus Diseases 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 206010027193 Meningioma malignant Diseases 0.000 description 1
• 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 206010054949 Metaplasia Diseases 0.000 description 1
• 206010027476 Metastases Diseases 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 208000003445 Mouth Neoplasms Diseases 0.000 description 1
• 208000013811 Mueller mixed tumour Diseases 0.000 description 1
• 108010085220 Multiprotein Complexes Proteins 0.000 description 1
• 102000007474 Multiprotein Complexes Human genes 0.000 description 1
• 108010021466 Mutant Proteins Proteins 0.000 description 1
• 102000008300 Mutant Proteins Human genes 0.000 description 1
• 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
• 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 102000048850 Neoplasm Genes Human genes 0.000 description 1
• 108700019961 Neoplasm Genes Proteins 0.000 description 1
• 108010025020 Nerve Growth Factor Proteins 0.000 description 1
• 102000007072 Nerve Growth Factors Human genes 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 238000000636 Northern blotting Methods 0.000 description 1
• 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
• 108091007494 Nucleic acid- binding domains Proteins 0.000 description 1
• 230000004989 O-glycosylation Effects 0.000 description 1
• 208000008589 Obesity Diseases 0.000 description 1
• 208000007871 Odontogenic Tumors Diseases 0.000 description 1
• 241000320412 Ogataea angusta Species 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
• 208000010191 Osteitis Deformans Diseases 0.000 description 1
• 101150036326 PMT2 gene Proteins 0.000 description 1
• 208000027868 Paget disease Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 108010067902 Peptide Library Proteins 0.000 description 1
• 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
• 206010034811 Pharyngeal cancer Diseases 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
• 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
• 241000235648 Pichia Species 0.000 description 1
• 208000009077 Pigmented Nevus Diseases 0.000 description 1
• 208000007641 Pinealoma Diseases 0.000 description 1
• 208000002151 Pleural effusion Diseases 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 102100033237 Pro-epidermal growth factor Human genes 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 108020004518 RNA Probes Proteins 0.000 description 1
• 239000003391 RNA probe Substances 0.000 description 1
• 238000013381 RNA quantification Methods 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 108010039491 Ricin Proteins 0.000 description 1
• 241000710942 Ross River virus Species 0.000 description 1
• 102000000395 SH3 domains Human genes 0.000 description 1
• 108050008861 SH3 domains Proteins 0.000 description 1
• 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
• 101100043108 Schizosaccharomyces pombe (strain 972 / ATCC 24843) spb1 gene Proteins 0.000 description 1
• 241000555745 Sciuridae Species 0.000 description 1
• 208000034189 Sclerosis Diseases 0.000 description 1
• 241000710961 Semliki Forest virus Species 0.000 description 1
• 101710113029 Serine/threonine-protein kinase Proteins 0.000 description 1
• 208000003252 Signet Ring Cell Carcinoma Diseases 0.000 description 1
• BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
• 241000710960 Sindbis virus Species 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
• 108010017622 Somatomedin Receptors Proteins 0.000 description 1
• 102000004584 Somatomedin Receptors Human genes 0.000 description 1
• 101000582398 Staphylococcus aureus Replication initiation protein Proteins 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 235000014962 Streptococcus cremoris Nutrition 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 101000930762 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) Signal recognition particle receptor FtsY Proteins 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 230000005867 T cell response Effects 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 206010042971 T-cell lymphoma Diseases 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 210000001744 T-lymphocyte Anatomy 0.000 description 1
• 101710137500 T7 RNA polymerase Proteins 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 206010043276 Teratoma Diseases 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
• 239000004473 Threonine Substances 0.000 description 1
• 201000009365 Thymic carcinoma Diseases 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 108700009124 Transcription Initiation Site Proteins 0.000 description 1
• 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
• 108010033576 Transferrin Receptors Proteins 0.000 description 1
• 102000007238 Transferrin Receptors Human genes 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• 229940122618 Trypsin inhibitor Drugs 0.000 description 1
• 101710162629 Trypsin inhibitor Proteins 0.000 description 1
• 102000004243 Tubulin Human genes 0.000 description 1
• 108090000704 Tubulin Proteins 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 1
• 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 1
• 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 description 1
• 208000002687 Venezuelan Equine Encephalomyelitis Diseases 0.000 description 1
• 201000009145 Venezuelan equine encephalitis Diseases 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 208000008383 Wilms tumor Diseases 0.000 description 1
• 206010052428 Wound Diseases 0.000 description 1
• 208000027418 Wounds and injury Diseases 0.000 description 1
• 241000235015 Yarrowia lipolytica Species 0.000 description 1
• 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• 230000035508 accumulation Effects 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 208000006336 acinar cell carcinoma Diseases 0.000 description 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
• 230000036982 action potential Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 208000021841 acute erythroid leukemia Diseases 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 208000002517 adenoid cystic carcinoma Diseases 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 201000008395 adenosquamous carcinoma Diseases 0.000 description 1
• 108060000200 adenylate cyclase Proteins 0.000 description 1
• 102000030621 adenylate cyclase Human genes 0.000 description 1
• 238000009098 adjuvant therapy Methods 0.000 description 1
• 208000020990 adrenal cortex carcinoma Diseases 0.000 description 1
• 230000001919 adrenal effect Effects 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000032683 aging Effects 0.000 description 1
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
• PPQRONHOSHZGFQ-LMVFSUKVSA-N aldehydo-D-ribose 5-phosphate Chemical group OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PPQRONHOSHZGFQ-LMVFSUKVSA-N 0.000 description 1
• 125000000217 alkyl group Chemical group 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• 108010004469 allophycocyanin Proteins 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 230000009435 amidation Effects 0.000 description 1
• 238000007112 amidation reaction Methods 0.000 description 1
• 229960003896 aminopterin Drugs 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• 210000002255 anal canal Anatomy 0.000 description 1
• 230000036783 anaphylactic response Effects 0.000 description 1
• 208000003455 anaphylaxis Diseases 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 239000010775 animal oil Substances 0.000 description 1
• 230000003302 anti-idiotype Effects 0.000 description 1
• 230000002788 anti-peptide Effects 0.000 description 1
• 230000009830 antibody antigen interaction Effects 0.000 description 1
• 210000000628 antibody-producing cell Anatomy 0.000 description 1
• 201000007436 apocrine adenocarcinoma Diseases 0.000 description 1
• 230000006907 apoptotic process Effects 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
• 201000005476 astroblastoma Diseases 0.000 description 1
• 230000003305 autocrine Effects 0.000 description 1
• 230000035578 autophosphorylation Effects 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 201000007551 basophilic adenocarcinoma Diseases 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
• 210000000013 bile duct Anatomy 0.000 description 1
• 108091008324 binding proteins Proteins 0.000 description 1
• 230000008512 biological response Effects 0.000 description 1
• 230000001851 biosynthetic effect Effects 0.000 description 1
• 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 238000009534 blood test Methods 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 201000000220 brain stem cancer Diseases 0.000 description 1
• 210000000621 bronchi Anatomy 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 159000000007 calcium salts Chemical class 0.000 description 1
• 239000003560 cancer drug Substances 0.000 description 1
• 208000035269 cancer or benign tumor Diseases 0.000 description 1
• 229940095731 candida albicans Drugs 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 231100000357 carcinogen Toxicity 0.000 description 1
• 239000003183 carcinogenic agent Substances 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000033366 cell cycle process Effects 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000003915 cell function Effects 0.000 description 1
• 230000022534 cell killing Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000009134 cell regulation Effects 0.000 description 1
• 230000010307 cell transformation Effects 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 230000033077 cellular process Effects 0.000 description 1
• 230000036755 cellular response Effects 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 230000003196 chaotropic effect Effects 0.000 description 1
• 230000005591 charge neutralization Effects 0.000 description 1
• 238000010382 chemical cross-linking Methods 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• 229960005091 chloramphenicol Drugs 0.000 description 1
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
• 208000006990 cholangiocarcinoma Diseases 0.000 description 1
• 201000005217 chondroblastoma Diseases 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 230000001886 ciliary effect Effects 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
• 229960004316 cisplatin Drugs 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 229960002173 citrulline Drugs 0.000 description 1
• 235000013477 citrulline Nutrition 0.000 description 1
• 230000007012 clinical effect Effects 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 238000010835 comparative analysis Methods 0.000 description 1
• 238000012875 competitive assay Methods 0.000 description 1
• 230000009137 competitive binding Effects 0.000 description 1
• 238000002591 computed tomography Methods 0.000 description 1
• 239000003636 conditioned culture medium Substances 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 238000011254 conventional chemotherapy Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 150000001879 copper Chemical class 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 230000002596 correlated effect Effects 0.000 description 1
• 230000001054 cortical effect Effects 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
• 230000001472 cytotoxic effect Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 229960000640 dactinomycin Drugs 0.000 description 1
• 230000009615 deamination Effects 0.000 description 1
• 238000006481 deamination reaction Methods 0.000 description 1
• 230000022811 deglycosylation Effects 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 108010005905 delta-hGHR Proteins 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 230000008021 deposition Effects 0.000 description 1
• 230000002074 deregulated effect Effects 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 239000002274 desiccant Substances 0.000 description 1
• 230000000368 destabilizing effect Effects 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 210000000188 diaphragm Anatomy 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 210000002249 digestive system Anatomy 0.000 description 1
• LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
• 229960005156 digoxin Drugs 0.000 description 1
• LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 238000003113 dilution method Methods 0.000 description 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 1
• 206010013023 diphtheria Diseases 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 238000006073 displacement reaction Methods 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 125000004119 disulfanediyl group Chemical group *SS* 0.000 description 1
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 239000003596 drug target Substances 0.000 description 1
• 230000009977 dual effect Effects 0.000 description 1
• 210000000613 ear canal Anatomy 0.000 description 1
• 210000000959 ear middle Anatomy 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 210000002969 egg yolk Anatomy 0.000 description 1
• 235000013345 egg yolk Nutrition 0.000 description 1
• 230000005672 electromagnetic field Effects 0.000 description 1
• 238000002337 electrophoretic mobility shift assay Methods 0.000 description 1
• 230000009881 electrostatic interaction Effects 0.000 description 1
• 230000012202 endocytosis Effects 0.000 description 1
• 108010028531 enomycin Proteins 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 210000003237 epithelioid cell Anatomy 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• 230000032050 esterification Effects 0.000 description 1
• 238000005886 esterification reaction Methods 0.000 description 1
• 102000013165 exonuclease Human genes 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 208000024519 eye neoplasm Diseases 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 210000004996 female reproductive system Anatomy 0.000 description 1
• 238000000684 flow cytometry Methods 0.000 description 1
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
• 238000001215 fluorescent labelling Methods 0.000 description 1
• 230000003325 follicular Effects 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 239000012458 free base Substances 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 235000011087 fumaric acid Nutrition 0.000 description 1
• 238000002825 functional assay Methods 0.000 description 1
• 210000000232 gallbladder Anatomy 0.000 description 1
• 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
• 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 description 1
• 201000000052 gastrinoma Diseases 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 238000001879 gelation Methods 0.000 description 1
• 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 1
• 238000003209 gene knockout Methods 0.000 description 1
• 238000010363 gene targeting Methods 0.000 description 1
• 208000016361 genetic disease Diseases 0.000 description 1
• 210000004392 genitalia Anatomy 0.000 description 1
• 210000004195 gingiva Anatomy 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
• 201000003872 goiter Diseases 0.000 description 1
• 208000030316 grade III meningioma Diseases 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 210000004565 granule cell Anatomy 0.000 description 1
• 239000005090 green fluorescent protein Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 230000009033 hematopoietic malignancy Effects 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 208000006359 hepatoblastoma Diseases 0.000 description 1
• 229940022353 herceptin Drugs 0.000 description 1
• 125000004404 heteroalkyl group Chemical group 0.000 description 1
• 125000001072 heteroaryl group Chemical group 0.000 description 1
• 208000029824 high grade glioma Diseases 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 102000054751 human RUNX1T1 Human genes 0.000 description 1
• LIAWOTKNAVAKCX-UHFFFAOYSA-N hydrazine;dihydrochloride Chemical compound Cl.Cl.NN LIAWOTKNAVAKCX-UHFFFAOYSA-N 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 125000001165 hydrophobic group Chemical group 0.000 description 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
• 230000033444 hydroxylation Effects 0.000 description 1
• 238000005805 hydroxylation reaction Methods 0.000 description 1
• 229960002591 hydroxyproline Drugs 0.000 description 1
• 210000003026 hypopharynx Anatomy 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 238000010166 immunofluorescence Methods 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 230000002637 immunotoxin Effects 0.000 description 1
• 239000002596 immunotoxin Substances 0.000 description 1
• 229940051026 immunotoxin Drugs 0.000 description 1
• 231100000608 immunotoxin Toxicity 0.000 description 1
• 230000008676 import Effects 0.000 description 1
• 238000012606 in vitro cell culture Methods 0.000 description 1
• 238000012750 in vivo screening Methods 0.000 description 1
• 230000000415 inactivating effect Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 231100000405 induce cancer Toxicity 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 150000007529 inorganic bases Chemical class 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 238000002743 insertional mutagenesis Methods 0.000 description 1
• 230000008611 intercellular interaction Effects 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 210000003228 intrahepatic bile duct Anatomy 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 159000000014 iron salts Chemical class 0.000 description 1
• 239000012948 isocyanate Substances 0.000 description 1
• 238000001155 isoelectric focusing Methods 0.000 description 1
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• 229950003188 isovaleryl diethylamide Drugs 0.000 description 1
• 229960000318 kanamycin Drugs 0.000 description 1
• 229930027917 kanamycin Natural products 0.000 description 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
• 229930182823 kanamycin A Natural products 0.000 description 1
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
• 208000022013 kidney Wilms tumor Diseases 0.000 description 1
• 230000006651 lactation Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229910052747 lanthanoid Inorganic materials 0.000 description 1
• 150000002602 lanthanoids Chemical class 0.000 description 1
• 210000002429 large intestine Anatomy 0.000 description 1
• 210000000867 larynx Anatomy 0.000 description 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 210000004901 leucine-rich repeat Anatomy 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 210000000088 lip Anatomy 0.000 description 1
• 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
• 125000003473 lipid group Chemical group 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 229910003002 lithium salt Inorganic materials 0.000 description 1
• 159000000002 lithium salts Chemical class 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 239000012160 loading buffer Substances 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 239000006210 lotion Substances 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 210000002751 lymph Anatomy 0.000 description 1
• 208000025036 lymphosarcoma Diseases 0.000 description 1
• 239000006166 lysate Substances 0.000 description 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 230000002101 lytic effect Effects 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 239000000696 magnetic material Substances 0.000 description 1
• 238000002595 magnetic resonance imaging Methods 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 210000004995 male reproductive system Anatomy 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 230000036212 malign transformation Effects 0.000 description 1
• 201000007055 malignant Leydig cell tumor Diseases 0.000 description 1
• 208000029559 malignant endocrine neoplasm Diseases 0.000 description 1
• 201000011614 malignant glioma Diseases 0.000 description 1
• 208000006178 malignant mesothelioma Diseases 0.000 description 1
• 208000021810 malignant mixed neoplasm Diseases 0.000 description 1
• 201000000289 malignant teratoma Diseases 0.000 description 1
• 208000016847 malignant urinary system neoplasm Diseases 0.000 description 1
• 208000027202 mammary Paget disease Diseases 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 150000002696 manganese Chemical class 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 208000000516 mast-cell leukemia Diseases 0.000 description 1
• 210000001370 mediastinum Anatomy 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 201000008806 mesenchymal cell neoplasm Diseases 0.000 description 1
• 230000015689 metaplastic ossification Effects 0.000 description 1
• 230000009401 metastasis Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 208000037819 metastatic cancer Diseases 0.000 description 1
• 208000011575 metastatic malignant neoplasm Diseases 0.000 description 1
• 229940098779 methanesulfonic acid Drugs 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• RXMBKOPBFXCPDD-UHFFFAOYSA-N methoxyphosphonamidous acid Chemical compound COP(N)O RXMBKOPBFXCPDD-UHFFFAOYSA-N 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
• 239000011325 microbead Substances 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 239000004005 microsphere Substances 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 230000002438 mitochondrial effect Effects 0.000 description 1
• 239000003226 mitogen Substances 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 230000004879 molecular function Effects 0.000 description 1
• 239000003068 molecular probe Substances 0.000 description 1
• 201000006894 monocytic leukemia Diseases 0.000 description 1
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 1
• 210000000214 mouth Anatomy 0.000 description 1
• 210000002643 mouth floor Anatomy 0.000 description 1
• 201000010879 mucinous adenocarcinoma Diseases 0.000 description 1
• 238000002887 multiple sequence alignment Methods 0.000 description 1
• 230000000869 mutational effect Effects 0.000 description 1
• 201000005962 mycosis fungoides Diseases 0.000 description 1
• 201000005987 myeloid sarcoma Diseases 0.000 description 1
• 208000001611 myxosarcoma Diseases 0.000 description 1
• 229940022007 naked DNA vaccine Drugs 0.000 description 1
• 210000003928 nasal cavity Anatomy 0.000 description 1
• 210000001989 nasopharynx Anatomy 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 201000008026 nephroblastoma Diseases 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 201000011682 nervous system cancer Diseases 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 208000027831 neuroepithelial neoplasm Diseases 0.000 description 1
• 230000001272 neurogenic effect Effects 0.000 description 1
• 239000003900 neurotrophic factor Substances 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 239000002547 new drug Substances 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 1
• 230000036963 noncompetitive effect Effects 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 210000001331 nose Anatomy 0.000 description 1
• 230000001473 noxious effect Effects 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 235000020824 obesity Nutrition 0.000 description 1
• 201000008106 ocular cancer Diseases 0.000 description 1
• 210000002560 odontocyte Anatomy 0.000 description 1
• 208000027825 odontogenic neoplasm Diseases 0.000 description 1
• 208000004128 odontoma Diseases 0.000 description 1
• 235000014593 oils and fats Nutrition 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 229940124276 oligodeoxyribonucleotide Drugs 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 210000002747 omentum Anatomy 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 201000000890 orbital cancer Diseases 0.000 description 1
• 210000003463 organelle Anatomy 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 210000003300 oropharynx Anatomy 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 125000004043 oxo group Chemical group O=* 0.000 description 1
• 125000005702 oxyalkylene group Chemical group 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 210000002741 palatine tonsil Anatomy 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
• 201000001494 papillary transitional carcinoma Diseases 0.000 description 1
• 208000031101 papillary transitional cell carcinoma Diseases 0.000 description 1
• 230000003076 paracrine Effects 0.000 description 1
• 230000007918 pathogenicity Effects 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 210000003899 penis Anatomy 0.000 description 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
• 210000001322 periplasm Anatomy 0.000 description 1
• 210000003200 peritoneal cavity Anatomy 0.000 description 1
• 238000002823 phage display Methods 0.000 description 1
• 239000002831 pharmacologic agent Substances 0.000 description 1
• 210000003800 pharynx Anatomy 0.000 description 1
• 108010076042 phenomycin Proteins 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 125000000405 phenylalanyl group Chemical group 0.000 description 1
• 208000028591 pheochromocytoma Diseases 0.000 description 1
• 150000008298 phosphoramidates Chemical class 0.000 description 1
• 238000003566 phosphorylation assay Methods 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 208000024724 pineal body neoplasm Diseases 0.000 description 1
• 208000021857 pituitary gland basophilic carcinoma Diseases 0.000 description 1
• 208000031223 plasma cell leukemia Diseases 0.000 description 1
• 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 239000004417 polycarbonate Substances 0.000 description 1
• 229920000515 polycarbonate Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 229920000193 polymethacrylate Polymers 0.000 description 1
• 208000014081 polyp of colon Diseases 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 229920001299 polypropylene fumarate Polymers 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 159000000001 potassium salts Chemical class 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 230000001855 preneoplastic effect Effects 0.000 description 1
• 150000003141 primary amines Chemical class 0.000 description 1
• 238000007639 printing Methods 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
• 235000019260 propionic acid Nutrition 0.000 description 1
• 210000005267 prostate cell Anatomy 0.000 description 1
• 210000000064 prostate epithelial cell Anatomy 0.000 description 1
• 238000002731 protein assay Methods 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 239000002534 radiation-sensitizing agent Substances 0.000 description 1
• 238000002708 random mutagenesis Methods 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 102000027427 receptor guanylyl cyclases Human genes 0.000 description 1
• 108091008596 receptor guanylyl cyclases Proteins 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000025915 regulation of apoptotic process Effects 0.000 description 1
• 230000003252 repetitive effect Effects 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 201000007048 respiratory system cancer Diseases 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 238000012340 reverse transcriptase PCR Methods 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 210000003079 salivary gland Anatomy 0.000 description 1
• 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 description 1
• 238000005464 sample preparation method Methods 0.000 description 1
• 201000008407 sebaceous adenocarcinoma Diseases 0.000 description 1
• 239000013545 self-assembled monolayer Substances 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 150000003355 serines Chemical class 0.000 description 1
• 210000000717 sertoli cell Anatomy 0.000 description 1
• 201000008123 signet ring cell adenocarcinoma Diseases 0.000 description 1
• 229910000077 silane Inorganic materials 0.000 description 1
• 229920002379 silicone rubber Polymers 0.000 description 1
• 239000004945 silicone rubber Substances 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 208000000649 small cell carcinoma Diseases 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 208000021795 small intestine disease Diseases 0.000 description 1
• 229940126586 small molecule drug Drugs 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 210000004872 soft tissue Anatomy 0.000 description 1
• 239000011343 solid material Substances 0.000 description 1
• 238000002764 solid phase assay Methods 0.000 description 1
• 238000005063 solubilization Methods 0.000 description 1
• 230000007928 solubilization Effects 0.000 description 1
• 239000002195 soluble material Substances 0.000 description 1
• 210000001082 somatic cell Anatomy 0.000 description 1
• 230000037439 somatic mutation Effects 0.000 description 1
• 230000002269 spontaneous effect Effects 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 238000007447 staining method Methods 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 230000004960 subcellular localization Effects 0.000 description 1
• 125000000547 substituted alkyl group Chemical group 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 206010042863 synovial sarcoma Diseases 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• 238000010189 synthetic method Methods 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 210000001138 tear Anatomy 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
• 239000010409 thin film Substances 0.000 description 1
• 125000004149 thio group Chemical group *S* 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
• 229940104230 thymidine Drugs 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 210000002105 tongue Anatomy 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 231100000041 toxicology testing Toxicity 0.000 description 1
• 208000029335 trabecular adenocarcinoma Diseases 0.000 description 1
• 210000003437 trachea Anatomy 0.000 description 1
• FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
• 230000005026 transcription initiation Effects 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 206010044412 transitional cell carcinoma Diseases 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 230000005945 translocation Effects 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
• 239000002753 trypsin inhibitor Substances 0.000 description 1
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
• 230000004565 tumor cell growth Effects 0.000 description 1
• 230000005740 tumor formation Effects 0.000 description 1
• 238000013060 ultrafiltration and diafiltration Methods 0.000 description 1
• 230000036967 uncompetitive effect Effects 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 230000002485 urinary effect Effects 0.000 description 1
• 201000004435 urinary system cancer Diseases 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 210000001215 vagina Anatomy 0.000 description 1
• 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 229960003048 vinblastine Drugs 0.000 description 1
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 210000003905 vulva Anatomy 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 238000001262 western blot Methods 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1