JP2006519225A - 依存症治療用医薬組成物 - Google Patents

依存症治療用医薬組成物 Download PDF

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JP2006519225A
JP2006519225A JP2006502684A JP2006502684A JP2006519225A JP 2006519225 A JP2006519225 A JP 2006519225A JP 2006502684 A JP2006502684 A JP 2006502684A JP 2006502684 A JP2006502684 A JP 2006502684A JP 2006519225 A JP2006519225 A JP 2006519225A
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drug
acetylcholine
type
pharmaceutical composition
cocaine
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Japanese (ja)
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JP2006519225A5 (https=
Inventor
重忠 中西
貴俊 疋田
アイラ・パスタン
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社団法人芝蘭会
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2006502684A 2003-02-27 2004-02-26 依存症治療用医薬組成物 Pending JP2006519225A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44986803P 2003-02-27 2003-02-27
PCT/JP2004/002301 WO2004075916A1 (en) 2003-02-27 2004-02-26 Pharmaceutical composition for treatment of drug dependence

Publications (2)

Publication Number Publication Date
JP2006519225A true JP2006519225A (ja) 2006-08-24
JP2006519225A5 JP2006519225A5 (https=) 2007-04-12

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ID=32927586

Family Applications (1)

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JP2006502684A Pending JP2006519225A (ja) 2003-02-27 2004-02-26 依存症治療用医薬組成物

Country Status (8)

Country Link
US (1) US20060058336A1 (https=)
EP (1) EP1603595B1 (https=)
JP (1) JP2006519225A (https=)
AT (1) ATE487492T1 (https=)
AU (1) AU2004216360B2 (https=)
CA (1) CA2516618A1 (https=)
DE (1) DE602004029993D1 (https=)
WO (1) WO2004075916A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050192271A1 (en) * 2003-07-15 2005-09-01 Hythiam, Inc. Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse
WO2003032914A2 (en) * 2001-10-17 2003-04-24 Eisai Co., Ltd. Methods for treating substance abuse with cholinesterase inhibitors
WO2006013546A2 (en) * 2004-07-28 2006-02-09 Ranbaxy Laboratories Limited Process for the preparation of pure galantamine
MX2010001390A (es) * 2007-08-06 2010-08-02 Synosia Therapeutics Inc Métodos para el tratamiento de dependencia.
KR101037235B1 (ko) 2009-04-24 2011-05-25 충남대학교산학협력단 노르갈란타민 화합물을 유효성분으로 함유하는 탈모 방지 및 발모 개선용 조성물
US20120129838A1 (en) * 2009-04-24 2012-05-24 The Industry & Academic Cooperation In Chungnam National University Composition for Preventing and Treating Alopecia Disorder Containing Morgalanthamine Compounds as an Active Ingredient
KR101037237B1 (ko) 2009-04-24 2011-05-25 충남대학교산학협력단 노르갈란타민 화합물을 유효성분으로 함유하는 탈모 질환의 예방 및 치료용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505633A (ja) * 1993-01-23 1996-06-18 エル テー エス ローマン テラピー・システーメ ゲー.エム.ベー.ハー ウント コンパニー カー.ゲー ニコチン依存症治療のための薬学的処方
JPH09506371A (ja) * 1994-04-29 1997-06-24 ファイザー インク. 神経伝達物質放出増強薬としての新規な非環式および環式アミド類
JPH11505519A (ja) * 1995-03-17 1999-05-21 エルティエス ローマン テラピー−ズュステーメ ゲーエムベーハー ガランタミンの分離方法
JPH11171861A (ja) * 1997-12-12 1999-06-29 Eisai Co Ltd ドネペジルの製造法
WO2002085370A1 (de) * 2001-04-24 2002-10-31 Hf Arzneimittelforschung Gmbh Verwendung von galanthamin zur behandlung von krankheitserscheinungen des zentralen nervensystems aufgrund von intoxikationen mit psychotropen substanzen

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
EP0584185B1 (en) * 1991-05-14 1999-08-11 Ernir Snorrason Treatment of fatigue syndrome with cholinesterase inhibitors
US6010715A (en) * 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
US5278176A (en) * 1992-08-21 1994-01-11 Abbott Laboratories Nicotine derivatives that enhance cognitive function
US5580876A (en) * 1992-09-21 1996-12-03 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
CA2222133C (en) * 1995-06-07 2002-12-24 Cygnus, Inc. Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen
US5824684A (en) * 1997-02-21 1998-10-20 Synapse Pharmaceuticals International, Inc. Method for treating drug and alcohol addiction
JP2001513497A (ja) * 1997-08-08 2001-09-04 メドサン、リセルカ エス.アール.エル. 胃分泌過多および腎損傷の予防作用を有する抗炎症剤の製造のための化合物2−メトキシフェニル−1−メチル−5p−メチルベンゾイル−ピロール−2−アセトアミドアセテートの使用
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
US5948433A (en) * 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
DE19738855C2 (de) * 1997-09-05 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit haftklebender Reservoirschicht und unidirektional elastischer Rückschicht
IL125809A (en) * 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
US20030153598A1 (en) * 2000-07-25 2003-08-14 Raymond Pratt Methods for treating Parkinson's disease with cholinesterase inhibitors
EP1311272B1 (en) * 2000-03-03 2006-11-22 Eisai Co., Ltd. Novel methods using cholinesterase inhibitors
US20060183776A9 (en) * 2000-03-03 2006-08-17 Eisai Co., Ltd. Liquid dosage formulations of donepezil
AU2002229101A1 (en) * 2000-12-20 2002-07-01 Michigan Biotechnology Institute Soy milk juice beverage
WO2003024450A1 (en) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating prion diseases
WO2003032914A2 (en) * 2001-10-17 2003-04-24 Eisai Co., Ltd. Methods for treating substance abuse with cholinesterase inhibitors
JP2004189706A (ja) * 2002-12-13 2004-07-08 Eisai Co Ltd 高度アルツハイマー型痴呆治療剤
US20050018839A1 (en) * 2003-07-23 2005-01-27 Weiser William Bruce Electronic device cradle organizer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505633A (ja) * 1993-01-23 1996-06-18 エル テー エス ローマン テラピー・システーメ ゲー.エム.ベー.ハー ウント コンパニー カー.ゲー ニコチン依存症治療のための薬学的処方
JPH09506371A (ja) * 1994-04-29 1997-06-24 ファイザー インク. 神経伝達物質放出増強薬としての新規な非環式および環式アミド類
JPH11505519A (ja) * 1995-03-17 1999-05-21 エルティエス ローマン テラピー−ズュステーメ ゲーエムベーハー ガランタミンの分離方法
JPH11171861A (ja) * 1997-12-12 1999-06-29 Eisai Co Ltd ドネペジルの製造法
WO2002085370A1 (de) * 2001-04-24 2002-10-31 Hf Arzneimittelforschung Gmbh Verwendung von galanthamin zur behandlung von krankheitserscheinungen des zentralen nervensystems aufgrund von intoxikationen mit psychotropen substanzen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6010012958, WONG, C.−L. et al, "Further studies on the role of cholinergic mechanisms in the development of increased naloxone poten", EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, vol.56, no.1−2, p.115−121 *
JPN6010012959, KRUSZEWSKA, A. et al, "The role of acetylcholine in the developement of physical morphine dependance in rats", Acta Poliniae Pharmaceutica, 1984, vol.41, no.3, p.381−384 *
JPN7010000726, BOROWSKI, T. B. et al, "The effects of tacrine on cocaine self−administration in rats: a potential pharmacotherapy for cocai", SOCIETY FOR NEUROSCIENCE, 2000, vol.26, no.1−2, #293.18 *
JPN7010000727, MAJEWSKA, M. D. et al, "DHEAS: a maverick agent in cocaine dependence", SOCIETY FOR NEUROSCIENCE ABSTRACTS, 2000, vol.26, no.1−2, #681.3 *

Also Published As

Publication number Publication date
EP1603595B1 (en) 2010-11-10
CA2516618A1 (en) 2004-09-10
AU2004216360A2 (en) 2004-09-10
DE602004029993D1 (de) 2010-12-23
ATE487492T1 (de) 2010-11-15
WO2004075916A1 (en) 2004-09-10
AU2004216360B2 (en) 2009-09-17
EP1603595A4 (en) 2008-04-16
AU2004216360A1 (en) 2004-09-10
EP1603595A1 (en) 2005-12-14
US20060058336A1 (en) 2006-03-16

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