JP2006517109A5 - - Google Patents

Download PDF

Info

Publication number
JP2006517109A5
JP2006517109A5 JP2006503535A JP2006503535A JP2006517109A5 JP 2006517109 A5 JP2006517109 A5 JP 2006517109A5 JP 2006503535 A JP2006503535 A JP 2006503535A JP 2006503535 A JP2006503535 A JP 2006503535A JP 2006517109 A5 JP2006517109 A5 JP 2006517109A5
Authority
JP
Japan
Prior art keywords
antibody
seq
antibodies
human
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006503535A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006517109A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/004176 external-priority patent/WO2004068931A2/en
Publication of JP2006517109A publication Critical patent/JP2006517109A/ja
Publication of JP2006517109A5 publication Critical patent/JP2006517109A5/ja
Pending legal-status Critical Current

Links

JP2006503535A 2003-02-07 2004-02-06 アンフィレグリン抗体ならびに癌および乾癬を処置するためのその使用 Pending JP2006517109A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44564003P 2003-02-07 2003-02-07
US53390103P 2003-12-30 2003-12-30
PCT/US2004/004176 WO2004068931A2 (en) 2003-02-07 2004-02-06 Amphiregulin antibodies and their use to treat cancer and psoriasis

Publications (2)

Publication Number Publication Date
JP2006517109A JP2006517109A (ja) 2006-07-20
JP2006517109A5 true JP2006517109A5 (enExample) 2007-03-29

Family

ID=32853408

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006503535A Pending JP2006517109A (ja) 2003-02-07 2004-02-06 アンフィレグリン抗体ならびに癌および乾癬を処置するためのその使用

Country Status (5)

Country Link
US (2) US7223393B2 (enExample)
EP (1) EP1608684A2 (enExample)
JP (1) JP2006517109A (enExample)
CA (1) CA2515081A1 (enExample)
WO (1) WO2004068931A2 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
EP1493445A1 (en) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of stress-induced ligand-dependent EGFR activation
DE102004010050A1 (de) * 2004-03-02 2005-09-22 Bayer Healthcare Ag Spezifische monoklonale und polyklonale Antikörper für Repinotan und dessen ringoffene Form
EP1773392A4 (en) * 2004-05-27 2009-03-18 Genentech Inc METHOD FOR THE PREVENTION AND TREATMENT OF MAST-CELL-DISORDED DISEASES
JP2008510726A (ja) * 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
JP2007135581A (ja) * 2005-10-20 2007-06-07 Japan Science & Technology Agency 自己免疫性血小板減少性紫斑病(itp)患者の血液細胞特異的遺伝子群
CN101506236B (zh) 2005-11-30 2012-12-12 雅培制药有限公司 抗淀粉样β蛋白的单克隆抗体及其用途
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
US20090220527A1 (en) * 2005-12-21 2009-09-03 Medlmmune, Llc Affinity optimized epha2 agonistic antibodies and methods of use thereof
CN105177091A (zh) 2006-03-31 2015-12-23 中外制药株式会社 用于纯化双特异性抗体的抗体修饰方法
CA2647846C (en) 2006-03-31 2016-06-21 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CA2683109A1 (en) * 2006-10-11 2008-04-17 Fusion Antibodies Limited Combination therapy
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
DK2457928T3 (en) * 2007-03-13 2017-08-28 Univ Zuerich Monoclonal human tumor-specific antibody
JP2010235447A (ja) * 2007-07-30 2010-10-21 Igaku Seibutsugaku Kenkyusho:Kk 炎症性サイトカインの抑制剤
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
KR102339457B1 (ko) 2007-09-26 2021-12-14 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
CA2708532C (en) 2007-12-05 2018-06-05 Chugai Seiyaku Kabushiki Kaisha Anti-il31ra antibody and use thereof
GB0807018D0 (en) 2008-04-17 2008-05-21 Fusion Antibodies Ltd Antibodies and treatment
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
WO2010107109A1 (ja) 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
RU2011151069A (ru) 2009-05-15 2013-06-20 Чугаи Сейяку Кабусики Кайся Анти-axl антитело
WO2010137012A1 (en) 2009-05-25 2010-12-02 Ramot At Tel-Aviv University Ltd. Peptide therapy for amphiregulin mediated diseases
US10150808B2 (en) 2009-09-24 2018-12-11 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
CN103298833B (zh) * 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
KR101857310B1 (ko) 2010-09-29 2018-05-11 가부시키가이샤 에누비 켄코우겡큐쇼 인간 프로스타글란딘 e2 수용체 ep4 에 대한 항체
RU2620071C2 (ru) 2010-11-17 2017-05-22 Чугаи Сеияку Кабушики Каиша Мультиспецифическая связывающая антиген молекула, которая обладает альтернативной функцией к функции фактора свертывания крови viii
EP2679681B2 (en) 2011-02-25 2023-11-15 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific FC antibody
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201326209A (zh) 2011-09-30 2013-07-01 Chugai Pharmaceutical Co Ltd 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
US20140302050A1 (en) * 2011-11-09 2014-10-09 Albert Einstein College Of Medicine Of Yeshiva University Targeting an amphiregulin-derived cell surface neo-epitope
ES2702315T3 (es) 2012-08-24 2019-02-28 Univ California Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis
CN105764922B (zh) 2013-09-27 2020-07-17 中外制药株式会社 多肽异源多聚体的制备方法
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
TWI617580B (zh) 2014-12-19 2018-03-11 中外製藥股份有限公司 抗c5抗體及使用方法
MY181199A (en) 2014-12-19 2020-12-21 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
CN107108729A (zh) 2015-02-05 2017-08-29 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il‑8‑结合抗体,及其应用
RU2730590C2 (ru) 2015-02-27 2020-08-24 Чугаи Сейяку Кабусики Кайся Композиция для лечения заболеваний, связанных с ил-6
IL237852A0 (en) 2015-03-19 2016-03-24 Yeda Res & Dev Antibodies against amphigoline, medical preparations containing them and their use
WO2016159213A1 (ja) 2015-04-01 2016-10-06 中外製薬株式会社 ポリペプチド異種多量体の製造方法
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
CA3004288C (en) 2015-12-28 2025-05-27 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION
BR112018068363A2 (pt) 2016-03-14 2019-01-15 Chugai Seiyaku Kabushiki Kaisha fármaco terapêutico indutor de dano celular para uso em terapia de câncer
TWI820000B (zh) 2016-04-28 2023-11-01 日商中外製藥股份有限公司 含抗體製劑
MX2018016330A (es) 2016-06-27 2020-02-17 Univ California Combinaciones para tratamiento del cáncer.
JP6527643B2 (ja) 2016-08-05 2019-06-05 中外製薬株式会社 Il−8関連疾患の治療用又は予防用組成物
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法
AR113816A1 (es) 2017-11-01 2020-06-17 Chugai Pharmaceutical Co Ltd Variantes e isoformas de anticuerpos con actividad biológica reducida
EP3806888B1 (en) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
KR20220150384A (ko) * 2020-03-27 2022-11-10 내셔널 인스티튜트 오브 바이올로지칼 사이언시스, 베이징 Areg에 대한 항체 및 그 용도
WO2021202798A1 (en) * 2020-04-02 2021-10-07 The United States Of America As Represented By The Secretary Of The Navy Antigen binding proteins to class 5 etec adhesins
US11933781B2 (en) 2020-12-09 2024-03-19 The Regents Of The University Of Colorado Fibrosis model and methods of use thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN118598996B (zh) * 2024-08-08 2024-11-01 康立泰生物医药(青岛)有限公司 一种抗人白介素8抗体及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668629A (en) * 1980-07-18 1987-05-26 The Board Of Trustees Of Leland Stanford Jr. University Human hybridomas, precursors and products
US5115096A (en) 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
FI890312L (fi) 1988-01-25 1989-07-26 Oncogen Amfiregulin: ett nytt bifunktionellt tillvaext modulerande glykoprotein.
AU5816990A (en) 1989-05-12 1990-12-18 State of Oregon, acting by and through The State Board of Education on behalf of The Oregon Health Sciences University, The Keratinocyte autocrine factor
US5262298A (en) 1989-05-12 1993-11-16 The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University Method to assess the ability of a substance to inhibit or stimulate keratinocyte autocrine factor production
US5855885A (en) * 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
FI971532L (fi) 1994-10-14 1997-06-11 Bristol Myers Squibb Co HER4, ihmisen reseptorityrosiinikinaasi, joka kuuluu ryhmään ihokasvutekijäreseptorit
EP0871663A2 (en) * 1995-12-22 1998-10-21 Innogenetics N.V. New form of amphiregulin, methods for producing and using the same and compositions comprising the same
JP2002519000A (ja) 1998-01-28 2002-07-02 カイロン コーポレイション ヒト遺伝子および遺伝子発現産物ii
ATE512225T1 (de) * 1998-04-03 2011-06-15 Chugai Pharmaceutical Co Ltd Humanisierter antikörper gegen den menschlichen gewebefaktor (tf) und verfahren für die konstruktion eines solchen humanisierten antikörpers.
EP1074617A3 (en) 1999-07-29 2004-04-21 Research Association for Biotechnology Primers for synthesising full-length cDNA and their use
ATE367145T1 (de) * 1999-12-21 2007-08-15 Kao Corp Topische kosmetische und pharmazeutische mittel enthaltend spezifische alkoxilierte diester der fumarsäure
AU5081401A (en) * 2000-03-16 2001-10-03 Genentech Inc Anti-tissue factor antibodies with enhanced anticoagulant potency
US20030165831A1 (en) 2000-03-21 2003-09-04 John Lee Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
AU2001266790A1 (en) 2000-06-09 2001-12-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
WO2002010449A2 (en) 2000-07-28 2002-02-07 Compugen Inc. Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
US20020156263A1 (en) 2000-10-05 2002-10-24 Huei-Mei Chen Genes expressed in breast cancer
AU2002239717A1 (en) 2000-10-20 2002-06-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
EP1334113A4 (en) 2000-10-20 2007-08-08 Expression Diagnostics Inc EVALUATION OF LEUCOCYTAIRE EXPRESSION LEVEL
WO2002077234A2 (en) 2000-10-31 2002-10-03 Diadexus, Inc. Compositions and methods relating to colon specific genes and proteins
US20030087855A1 (en) 2001-09-13 2003-05-08 Isis Pharmaceuticals Inc. Antisense modulation of protein kinase R expression
WO2003008583A2 (en) 2001-03-02 2003-01-30 Sagres Discovery Novel compositions and methods for cancer
WO2002074979A2 (en) 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
AU2002307466A1 (en) 2001-04-20 2002-11-05 Millennium Pharmaceutical, Inc. Method for detecting breast cancer cells
WO2002092000A2 (en) 2001-05-11 2002-11-21 Genome Therapeutics Corporation Hbm variants that modulate bone mass and lipid levels
WO2003014159A1 (en) 2001-08-03 2003-02-20 Commonwealth Scientific And Industrial Research Organisation Methods of screening based on the egf receptor crystal structure

Similar Documents

Publication Publication Date Title
US7223393B2 (en) Amphiregulin antibodies and their use to treat cancer and psoriasis
JP2006517109A5 (enExample)
US9855291B2 (en) Anti-kidney associated antigen 1 (KAAG1) antibodies
JP2021120382A (ja) 部位特異的抗体コンジュゲーション方法および組成物
EP2275537B1 (en) Anti-human dlk-1 antibody having anti-tumor activity in vivo
US20080260740A1 (en) Anti-LFL2 Antibodies for the Diagnosis, Prognosis and Treatment of Cancer
KR20170008202A (ko) 흑색종에 사용하기 위한 항-dll3 항체 및 약물 접합체
JP2019516705A (ja) 神経内分泌移行のリスクのある腫瘍を治療するための抗dll3薬物コンジュゲート
JP2016538318A (ja) 新規sez6モジュレーターおよび使用方法
WO2003047623A1 (en) Treatment of prostate cancer by inhibitors of ncam2
AU2016316758B2 (en) Antibodies and assays for detection of CD37
JP2021503915A (ja) ヒト組織因子を標的とするヒト化抗体
WO2011054112A1 (en) Antibodies that specifically block the biological activity of kidney associated antigen 1
US12043671B2 (en) Antibodies targeting an amphiregulin-derived cell surface neo-epitope
CN114514246B (zh) 对nectin-4具有特异性的抗体及其用途
JPWO2012124334A1 (ja) 抗体、乳がんの治療に用いられる医薬組成物、腫瘍検査方法、及び、腫瘍検査用試薬
HK1234432A (en) Antibodies that specifically block the biological activity of a tumor antigen
HK1234432A1 (en) Antibodies that specifically block the biological activity of a tumor antigen
HK1234432B (en) Antibodies that specifically block the biological activity of a tumor antigen