JP2006516655A5 - - Google Patents

Info

Publication number

JP2006516655A5

JP2006516655A5 JP2006503409A JP2006503409A JP2006516655A5 JP 2006516655 A5 JP2006516655 A5 JP 2006516655A5 JP 2006503409 A JP2006503409 A JP 2006503409A JP 2006503409 A JP2006503409 A JP 2006503409A JP 2006516655 A5 JP2006516655 A5 JP 2006516655A5

Authority

JP

Japan

Prior art keywords

antibody

seq

cell

protein

toxin

Prior art date

2004-02-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 238000000034 method Methods 0.000 claims 40
• 210000004027 cell Anatomy 0.000 claims 27
• 102000004169 proteins and genes Human genes 0.000 claims 10
• 108090000623 proteins and genes Proteins 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 8
• 229940127089 cytotoxic agent Drugs 0.000 claims 8
• 239000003053 toxin Substances 0.000 claims 8
• 231100000765 toxin Toxicity 0.000 claims 8
• 239000002254 cytotoxic agent Substances 0.000 claims 6
• 231100000599 cytotoxic agent Toxicity 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 239000002773 nucleotide Substances 0.000 claims 4
• 125000003729 nucleotide group Chemical group 0.000 claims 4
• 230000012010 growth Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 241000894006 Bacteria Species 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
• 102000015833 Cystatin Human genes 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• 108090000790 Enzymes Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
• 229930195731 calicheamicin Natural products 0.000 claims 2
• 230000030833 cell death Effects 0.000 claims 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
• 108050004038 cystatin Proteins 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 239000003966 growth inhibitor Substances 0.000 claims 2
• 201000005202 lung cancer Diseases 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 230000001293 nucleolytic effect Effects 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 238000001814 protein method Methods 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1