JP2006516252A5 - - Google Patents
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- JP2006516252A5 JP2006516252A5 JP2004565732A JP2004565732A JP2006516252A5 JP 2006516252 A5 JP2006516252 A5 JP 2006516252A5 JP 2004565732 A JP2004565732 A JP 2004565732A JP 2004565732 A JP2004565732 A JP 2004565732A JP 2006516252 A5 JP2006516252 A5 JP 2006516252A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- composition
- copolymer
- composition according
- caprolactone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 24
- 229920001577 copolymer Polymers 0.000 claims 13
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 6
- 239000004098 Tetracycline Substances 0.000 claims 5
- 235000014655 lactic acid Nutrition 0.000 claims 5
- 239000004310 lactic acid Substances 0.000 claims 5
- 229960002180 tetracycline Drugs 0.000 claims 5
- 229930101283 tetracycline Natural products 0.000 claims 5
- 235000019364 tetracycline Nutrition 0.000 claims 5
- 150000003522 tetracyclines Chemical class 0.000 claims 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 2
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 239000004053 dental implant Substances 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 230000000921 morphogenic effect Effects 0.000 claims 2
- 230000000399 orthopedic effect Effects 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100022545 Bone morphogenetic protein 8B Human genes 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000000503 Collagen Type II Human genes 0.000 claims 1
- 108010041390 Collagen Type II Proteins 0.000 claims 1
- 102000001187 Collagen Type III Human genes 0.000 claims 1
- 108010069502 Collagen Type III Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 101000899368 Homo sapiens Bone morphogenetic protein 8B Proteins 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 1
- 125000005910 alkyl carbonate group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002379 silicone rubber Polymers 0.000 claims 1
- 239000004945 silicone rubber Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43680602P | 2002-12-27 | 2002-12-27 | |
| PCT/US2003/041330 WO2004060425A2 (en) | 2002-12-27 | 2003-12-24 | Compositions and methods of using collagen and mmpi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516252A JP2006516252A (ja) | 2006-06-29 |
| JP2006516252A5 true JP2006516252A5 (https=) | 2007-02-15 |
Family
ID=32713092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004565732A Withdrawn JP2006516252A (ja) | 2002-12-27 | 2003-12-24 | コラーゲンおよびｍｍｐｉを用いる組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040192658A1 (https=) |
| EP (1) | EP1585555A2 (https=) |
| JP (1) | JP2006516252A (https=) |
| KR (1) | KR20050086949A (https=) |
| CN (1) | CN1732023A (https=) |
| AU (1) | AU2003300379A1 (https=) |
| BR (1) | BR0317715A (https=) |
| CA (1) | CA2509060A1 (https=) |
| WO (1) | WO2004060425A2 (https=) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| JP2006515765A (ja) | 2002-11-15 | 2006-06-08 | エスディージーアイ・ホールディングス・インコーポレーテッド | 滑膜性関節を治療するためのコラーゲンベース材料および方法 |
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| US20050186240A1 (en) * | 2004-02-23 | 2005-08-25 | Ringeisen Timothy A. | Gel suitable for implantation and delivery system |
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| US8419722B2 (en) * | 2004-10-29 | 2013-04-16 | Spinal Restoration, Inc. | Apparatus and method for injection of fibrin sealant in spinal applications |
| US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
| US20060073208A1 (en) | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| DE102005034420A1 (de) * | 2004-12-23 | 2006-07-06 | Ossacur Ag | Gelartiges Material zur Füllung von Knochen- und/oder Knorpeldefekten |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| EP1714642A1 (en) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
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| DE102006026589A1 (de) * | 2006-06-01 | 2007-12-06 | Ossacur Ag | Verwendung eines Kollagens mit osteoinduktiven Wirkstoffen zur Behandlung von Sehnen- und/oder Bänderdefekten |
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| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US20080177330A1 (en) * | 2006-10-24 | 2008-07-24 | Ralph James D | Self-locking screws for medical implants |
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| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
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| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
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| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
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| US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
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| US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
| MX2016007492A (es) | 2013-12-09 | 2017-03-06 | Univ Leland Stanford Junior | Métodos y composiciones para el tratamiento de afecciones asociadas con el envejecimiento. |
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| KR20240025721A (ko) | 2015-06-15 | 2024-02-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 노화와 연관된 질환을 치료하기 위한 방법 및 조성물 |
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-
2003
- 2003-12-24 WO PCT/US2003/041330 patent/WO2004060425A2/en not_active Ceased
- 2003-12-24 JP JP2004565732A patent/JP2006516252A/ja not_active Withdrawn
- 2003-12-24 CN CNA200380107727XA patent/CN1732023A/zh active Pending
- 2003-12-24 AU AU2003300379A patent/AU2003300379A1/en not_active Abandoned
- 2003-12-24 CA CA002509060A patent/CA2509060A1/en not_active Abandoned
- 2003-12-24 BR BR0317715-7A patent/BR0317715A/pt not_active IP Right Cessation
- 2003-12-24 EP EP03814968A patent/EP1585555A2/en not_active Withdrawn
- 2003-12-24 US US10/746,911 patent/US20040192658A1/en not_active Abandoned
- 2003-12-24 KR KR1020057012146A patent/KR20050086949A/ko not_active Withdrawn
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