JP2006516047A - マグネットクランプを備えた経皮アッセイ - Google Patents
マグネットクランプを備えた経皮アッセイ Download PDFInfo
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- JP2006516047A JP2006516047A JP2004548548A JP2004548548A JP2006516047A JP 2006516047 A JP2006516047 A JP 2006516047A JP 2004548548 A JP2004548548 A JP 2004548548A JP 2004548548 A JP2004548548 A JP 2004548548A JP 2006516047 A JP2006516047 A JP 2006516047A
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Classifications
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/0806—Details, e.g. sample holders, mounting samples for testing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/00—Additional constructional details
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- B01L2300/0618—Holders integrated in container to position an object for removable separation walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
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- Toxicology (AREA)
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- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/282,505 US6852526B2 (en) | 2000-07-14 | 2002-10-28 | Transdermal assay with magnetic clamp |
PCT/US2003/034262 WO2004040006A1 (en) | 2002-10-28 | 2003-10-28 | Transdermal assay with magnetic clamp |
Publications (1)
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JP2006516047A true JP2006516047A (ja) | 2006-06-15 |
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JP2004548548A Pending JP2006516047A (ja) | 2002-10-28 | 2003-10-28 | マグネットクランプを備えた経皮アッセイ |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1556501A4 (de) |
JP (1) | JP2006516047A (de) |
AU (1) | AU2003286736A1 (de) |
WO (1) | WO2004040006A1 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011500198A (ja) * | 2007-10-17 | 2011-01-06 | トランスファーマ メディカル リミテッド | 溶出速度の検証 |
JP2011133417A (ja) * | 2009-12-25 | 2011-07-07 | Lvmc Inc | 活性酸素種濃度測定用センサーを用いた皮膚化粧料用抗酸化物質の簡便なスクリーニング方法 |
JP2015219114A (ja) * | 2014-05-19 | 2015-12-07 | 株式会社イントロテック | 透過性試験装置 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005057031B4 (de) * | 2005-11-25 | 2011-04-21 | Innovent E.V. Technologieentwicklung | Vorrichtung für Permeations-oder Stoffdurchgangsuntersuchungen |
FR3100334B1 (fr) * | 2019-09-03 | 2021-07-30 | Fabre Pierre Dermo Cosmetique | Dispositif pour la détermination automatisée du passage percutané et de la métabolisation d’une substance |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
US4317726A (en) * | 1981-02-12 | 1982-03-02 | The United States Of America As Represented By The Secretary Of The Army | Microbial filter assembly |
US4468321A (en) * | 1982-03-12 | 1984-08-28 | Gelman Sciences Inc. | Filter device with magnetic filter clamp |
US4537776A (en) | 1983-06-21 | 1985-08-27 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone |
US4605670A (en) | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
US5006342A (en) | 1986-12-22 | 1991-04-09 | Cygnus Corporation | Resilient transdermal drug delivery device |
US4820720A (en) | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
US4973468A (en) | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
US5306467A (en) * | 1993-02-17 | 1994-04-26 | Hamilton-Thorn Research | Apparatus for measurement of cell concentration in a biological sample employing a magnetic slide loading apparatus |
CA2174140C (en) | 1993-10-28 | 2004-04-06 | Kenneth L. Beattie | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
US5490415A (en) * | 1994-04-15 | 1996-02-13 | Pharmetrix Corporation | Diffusion test apparatus and method |
US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
US5962250A (en) * | 1997-10-28 | 1999-10-05 | Glaxo Group Limited | Split multi-well plate and methods |
DE19943443A1 (de) * | 1999-09-11 | 2001-04-12 | Inst Mikrotechnik Mainz Gmbh | Vorrichtung und Verfahren zur Planarisierung von Titerplatten in Screening- und Synthesesystemen |
WO2002006518A1 (en) * | 2000-07-14 | 2002-01-24 | Transform Pharmaceuticals, Inc. | System and method for optimizing tissue barrier transfer of compounds |
WO2002016941A2 (en) * | 2000-08-23 | 2002-02-28 | The Regents Of The University Of California | A combinatorial method for rapid screening of drug delivery formulations |
DE10106996C2 (de) * | 2001-02-15 | 2003-04-24 | Merck Patent Gmbh | Einrichtung zur Verbindung von Mikrokomponenten |
-
2003
- 2003-10-28 JP JP2004548548A patent/JP2006516047A/ja active Pending
- 2003-10-28 WO PCT/US2003/034262 patent/WO2004040006A1/en active Application Filing
- 2003-10-28 EP EP03777948A patent/EP1556501A4/de not_active Withdrawn
- 2003-10-28 AU AU2003286736A patent/AU2003286736A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011500198A (ja) * | 2007-10-17 | 2011-01-06 | トランスファーマ メディカル リミテッド | 溶出速度の検証 |
JP2011133417A (ja) * | 2009-12-25 | 2011-07-07 | Lvmc Inc | 活性酸素種濃度測定用センサーを用いた皮膚化粧料用抗酸化物質の簡便なスクリーニング方法 |
JP2015219114A (ja) * | 2014-05-19 | 2015-12-07 | 株式会社イントロテック | 透過性試験装置 |
Also Published As
Publication number | Publication date |
---|---|
EP1556501A4 (de) | 2009-04-08 |
AU2003286736A1 (en) | 2004-05-25 |
EP1556501A1 (de) | 2005-07-27 |
WO2004040006A1 (en) | 2004-05-13 |
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