JP2006515829A - 炎症性疾病の処置のための、ａ２ａアデノシン受容体アゴニストの使用 - Google Patents

炎症性疾病の処置のための、ａ２ａアデノシン受容体アゴニストの使用 Download PDF

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JP2006515829A
JP2006515829A JP2003583427A JP2003583427A JP2006515829A JP 2006515829 A JP2006515829 A JP 2006515829A JP 2003583427 A JP2003583427 A JP 2003583427A JP 2003583427 A JP2003583427 A JP 2003583427A JP 2006515829 A JP2006515829 A JP 2006515829A
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carboxylic acid
piperidine
aryl
alkyl
alkylene
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JP2006515829A5 (https=
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ジョエル・エム・リンデン
ゲイル・ダブリュー・サリバン
ティモシー・エル・マクドナルド
ダブリュー・マイケル・シェルド
トム・ジー・オブリグ
ジェイソン・エム・リーガー
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ユニバーシティ オブ バージニア パテント ファウンデーション
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Application filed by ユニバーシティ オブ バージニア パテント ファウンデーション filed Critical ユニバーシティ オブ バージニア パテント ファウンデーション
Publication of JP2006515829A publication Critical patent/JP2006515829A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2003583427A 2002-04-10 2003-04-10 炎症性疾病の処置のための、ａ２ａアデノシン受容体アゴニストの使用 Pending JP2006515829A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37143402P 2002-04-10 2002-04-10
US38718402P 2002-06-07 2002-06-07
PCT/US2003/011146 WO2003086408A1 (en) 2002-04-10 2003-04-10 Use of a2a adenosine receptor agonists for the treatment of inflammatory diseases

Publications (2)

Publication Number Publication Date
JP2006515829A true JP2006515829A (ja) 2006-06-08
JP2006515829A5 JP2006515829A5 (https=) 2006-07-20

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ID=29254444

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JP2003583427A Pending JP2006515829A (ja) 2002-04-10 2003-04-10 炎症性疾病の処置のための、ａ２ａアデノシン受容体アゴニストの使用

Country Status (7)

Country Link
US (1) US20090170803A1 (https=)
EP (1) EP1496911B1 (https=)
JP (1) JP2006515829A (https=)
AT (1) ATE381336T1 (https=)
AU (1) AU2003234716A1 (https=)
DE (1) DE60318192T2 (https=)
WO (1) WO2003086408A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507907A (ja) * 2007-12-20 2011-03-10 ピージーエックスヘルス、リミテッド、ライアビリティー、カンパニー Ａ２ａｒアゴニストとしての置換４−｛３−［６−アミノ−９−（３，４−ジヒドロキシ−テトラヒドロ−フラン−２−イル）−９ｈ−プリン−２−イル］−プロプ−２−イニル｝−ピペリジン−１−カルボン酸エステル
JP2011526894A (ja) * 2008-07-03 2011-10-20 ユニバーシティ オブ バージニア パテント ファウンデーション アパデノソンの単位投薬量

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TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
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GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
US7442687B2 (en) 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
US7576069B2 (en) 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
AU2005267706B2 (en) 2004-08-02 2011-12-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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RU2421464C2 (ru) 2005-10-21 2011-06-20 Новартис Аг Человеческие антитела к il-13 и их терапевтическое применение
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WO2007107598A1 (en) 2006-03-21 2007-09-27 Heinrich-Heine-Universität Düsseldorf Phosphorylated a2a receptor agonists
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JP5781510B2 (ja) 2009-08-12 2015-09-24 ノバルティス アーゲー ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011507907A (ja) * 2007-12-20 2011-03-10 ピージーエックスヘルス、リミテッド、ライアビリティー、カンパニー Ａ２ａｒアゴニストとしての置換４−｛３−［６−アミノ−９−（３，４−ジヒドロキシ−テトラヒドロ−フラン−２−イル）−９ｈ−プリン−２−イル］−プロプ−２−イニル｝−ピペリジン−１−カルボン酸エステル
JP2011526894A (ja) * 2008-07-03 2011-10-20 ユニバーシティ オブ バージニア パテント ファウンデーション アパデノソンの単位投薬量
US9415058B2 (en) 2008-07-03 2016-08-16 University Of Virginia Patent Foundation Unit dosage of Apadenoson
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Also Published As

Publication number Publication date
WO2003086408A8 (en) 2005-01-13
EP1496911A1 (en) 2005-01-19
DE60318192T2 (de) 2008-04-30
US20090170803A1 (en) 2009-07-02
WO2003086408A1 (en) 2003-10-23
AU2003234716A1 (en) 2003-10-27
ATE381336T1 (de) 2008-01-15
DE60318192D1 (de) 2008-01-31
EP1496911B1 (en) 2007-12-19

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