JP2006515747A - 免疫関連疾患の治療のための組成物と方法 - Google Patents

免疫関連疾患の治療のための組成物と方法 Download PDF

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JP2006515747A
JP2006515747A JP2004550183A JP2004550183A JP2006515747A JP 2006515747 A JP2006515747 A JP 2006515747A JP 2004550183 A JP2004550183 A JP 2004550183A JP 2004550183 A JP2004550183 A JP 2004550183A JP 2006515747 A JP2006515747 A JP 2006515747A
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polypeptide
pro
antibody
acid sequence
pro polypeptide
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ヒラリー クラーク，
ジル ショーンフェルド，
ルッカレン， メンノ バン
ピー．， ミッキー ウィリアムズ，
ウィリアム， アイ． ウッド，
トーマス， ディー． ウー，
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Genentech Inc
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JP2004550183A 2002-11-01 2003-10-30 免疫関連疾患の治療のための組成物と方法 Pending JP2006515747A (ja)

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US42339402P 2002-11-01 2002-11-01
PCT/US2003/034312 WO2004041170A2 (en) 2002-11-01 2003-10-30 Compositions and methods for the treatment of immune related diseases

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JP2009263287A Pending JP2010162017A (ja) 2002-11-01 2009-11-18 免疫関連疾患の治療のための組成物と方法

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EP (1) EP1578367A4 (cg-RX-API-DMAC7.html)
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AU (2) AU2003284357A1 (cg-RX-API-DMAC7.html)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007145326A1 (ja) * 2006-06-15 2007-12-21 Riken 炎症性疾患の判定方法
JP2017520271A (ja) * 2014-04-18 2017-07-27 ▲煙▼台聚▲傑▼生物工程有限公司 １５種類の男性生殖関連タンパク質またはその組み合わせの使用
JP2023511358A (ja) * 2020-01-21 2023-03-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 線維化、肥大または心不全の処置または予防における使用のための骨髄由来増殖因子
JP2023085301A (ja) * 2017-05-24 2023-06-20 テリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 高アンモニア血症を治療するためのグルタミン合成酵素の使用

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014787A1 (en) * 1998-07-15 2007-01-18 Human Genome Sciences, Inc. 71 human secreted proteins
US7479555B2 (en) 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US7442777B2 (en) 2000-11-29 2008-10-28 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
US7431923B2 (en) 2005-01-03 2008-10-07 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
US7534429B2 (en) 2000-11-29 2009-05-19 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD63
AU2002332929A1 (en) 2001-09-07 2003-03-24 Bristol-Myers Squibb Company Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39
US7678889B2 (en) * 2002-08-06 2010-03-16 Diadexus, Inc. Compositions and methods relating to ovarian specific genes and proteins
US20050037946A1 (en) * 2003-01-13 2005-02-17 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419
US7094572B2 (en) 2003-03-14 2006-08-22 Bristol-Myers Squibb Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
WO2005019258A2 (en) * 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
EP2270160A1 (en) * 2004-06-14 2011-01-05 Galapagos N.V. Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases
CA2570483A1 (en) 2004-06-21 2006-01-05 Exelixis, Inc. Pgds as modifiers of the pten pathway and methods of use
JPWO2006006477A1 (ja) * 2004-07-09 2008-04-24 国立大学法人三重大学 骨疾患又は関節疾患に関与するポリペプチド及びそのｄｎａ
WO2006007697A1 (en) * 2004-07-16 2006-01-26 Val-Chum, S.E.C. Methods or use of lamin b1 nuclear antigen, fragments and compositions thereof, for inhibiting or reducing a thrombotic event
EP1835933A4 (en) * 2005-01-04 2015-01-07 Yeda Res & Dev HSP60, HSP60-PEPTIDES AND T-CELL VACCINES FOR IMMUNOMODULATION
CA2598436A1 (en) 2005-02-22 2006-08-31 Ceres, Inc. Modulating plant alkaloids
EP1851543A2 (en) 2005-02-24 2007-11-07 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
GB0510627D0 (en) 2005-05-25 2005-06-29 Avidex Ltd Polypeptides
WO2006133461A1 (en) 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
EP1926747A1 (en) * 2005-08-12 2008-06-04 Schering Corporation Mcp1 fusions
GB0519376D0 (en) * 2005-09-23 2005-11-02 Astrazeneca Ab Diagnostic method
US8110184B2 (en) * 2005-09-30 2012-02-07 University Of Kentucky Research Foundation Ex vivo and in vivo methods and related compositions for generating hematopoietic stem cell populations
WO2007053648A2 (en) 2005-10-31 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2007089659A2 (en) * 2006-01-26 2007-08-09 Caprion Pharmaceutical, Inc. Tat-039 and methods of assessing and treating cancer
EP2311477B1 (en) * 2006-03-20 2014-07-09 Japan Science and Technology Agency Use of ip3 receptor-binding protein for controlling phosphatidylinositol metabolism
JP5146944B2 (ja) * 2006-03-20 2013-02-20 独立行政法人理化学研究所 Ｉｐ３受容体結合タンパク質による細胞内標的分子の制御
CA2644663A1 (en) 2006-03-23 2007-09-27 Kirin Pharma Kabushiki Kaisha Agonist antibody to human thrombopoietin receptor
US20070237713A1 (en) 2006-04-04 2007-10-11 Fan Rong A PCan065 Antibody Compositions and Methods of Use
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
FR2908654B1 (fr) 2006-11-20 2014-04-04 Oreal Utilisation cosmetique de proteines de type chitinase
CA2670587A1 (en) * 2006-11-29 2008-06-05 Medical Research Council Assay
WO2008079406A2 (en) * 2006-12-19 2008-07-03 Genentech, Inc. Gene expression markers for inflammatory bowel disease
US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
JP5618544B2 (ja) * 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
WO2008092214A1 (en) * 2007-02-02 2008-08-07 Minomic International Limited Biomarkers for diabetes
US20090208491A1 (en) * 2007-02-14 2009-08-20 Austin Gurney Compositions and Methods for Diagnosing and Treating Cancer
JP5378202B2 (ja) * 2007-03-15 2013-12-25 株式会社リバース・プロテオミクス研究所 脳・神経に特異的あるいは神経分化に特異的なバイオマーカー
WO2008156685A2 (en) * 2007-06-14 2008-12-24 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Tendon stem cells
NZ583429A (en) * 2007-08-24 2012-08-31 Mylexa Pty Ltd Peptides and proteins capable of inhibiting and/or preventing mast cell activation
JP2009055838A (ja) * 2007-08-31 2009-03-19 Nipro Corp 融合タンパク質、該融合タンパク質に関連する遺伝子、ベクター、形質転換体及び抗炎症性医薬組成物
JOP20190083A1 (ar) 2008-06-04 2017-06-16 Amgen Inc بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
MX2011000233A (es) 2008-07-08 2011-05-19 Oncomed Pharm Inc Agentes de union del receptor notch1 y metodos para su uso.
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
MX341149B (es) 2008-10-10 2016-08-09 Amgen Inc Mutantes fgf21 y uso de los mismos.
JP2012507299A (ja) 2008-10-31 2012-03-29 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｌｉｇｈｔ標的分子およびその使用
RU2520748C2 (ru) 2008-12-04 2014-06-27 Санофи Способы и применения, включающие гемсвязывающий белок 1
CN102300874B (zh) 2008-12-08 2015-08-05 卡姆普根有限公司 Tmem154多肽和多核苷酸及其作为产生药物和生物制品的药物靶标的用途
WO2010129600A2 (en) 2009-05-05 2010-11-11 Amgen Inc. Fgf21 mutants and uses thereof
HUE065036T2 (hu) 2009-05-05 2024-04-28 Amgen Inc FGF21 mutánsok és alkalmazásaik
WO2010129890A2 (en) * 2009-05-08 2010-11-11 Virginia Tech Intellectual Properties, Inc. Compounds and methods for inhibiting platelet aggregation
WO2010141999A1 (en) * 2009-06-12 2010-12-16 The University Of Queensland Agents and methods for diagnosing and treating ankylosing spondylitis
MX2011013903A (es) 2009-06-17 2012-05-08 Amgen Inc Polipeptidos quimericos y usos de los mismos.
DK3202898T3 (en) 2009-11-02 2019-01-14 Univ Washington THERAPEUTIC NUCLEASE COMPOSITIONS AND PROCEDURES
US8372952B2 (en) * 2009-12-02 2013-02-12 Amgen Inc. Binding proteins that bind to human FGFR1C, human β-klotho and both human FGFR1C and human β-klotho
UA109888C2 (uk) * 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
CN102958534B (zh) 2010-01-13 2014-11-05 昂考梅德药品有限公司 Notch1结合剂及其使用方法
US8674309B2 (en) 2010-01-28 2014-03-18 Canon Kabushiki Kaisha Scintillator crystal body, method for manufacturing the same, and radiation detector
CA2695337A1 (en) * 2010-03-04 2011-09-04 Ian De Belle Compositions and methods for inhibition of hiv
US8524217B2 (en) 2010-05-11 2013-09-03 Merck Sharp & Dohme Corp. MCP1-Ig fusion variants
EP2975134A3 (en) * 2010-07-22 2016-02-24 Shire Human Genetic Therapies, Inc. Crystal structure of human alpha-n-acetylglucosaminidase
CU24111B1 (es) 2010-11-08 2015-08-27 Novartis Ag Polipéptidos que se enlazan a cxcr2
IT1406405B1 (it) * 2010-12-27 2014-02-21 Univ Roma Molecole peptidiche per il trattamento di patologie mitocondriali
US20140056811A1 (en) * 2010-12-27 2014-02-27 Compugen Ltd. New cell-penetrating peptides and uses thereof
AU2012249360B2 (en) 2011-04-29 2015-12-24 University Of Washington Therapeutic nuclease compositions and methods
EP2707716A1 (en) * 2011-05-13 2014-03-19 Institut National de la Sante et de la Recherche Medicale (INSERM) Method for the diagnosis of early rheumatoid arthritis
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
MX2015005810A (es) 2012-11-07 2015-09-23 Pfizer Anticuerpos anti-notch y conjugados de anticuerpo-farmaco.
WO2014100689A1 (en) 2012-12-21 2014-06-26 Aveo Pharmaceuticals, Inc. Anti-gdf15 antibodies
WO2014141064A1 (en) 2013-03-13 2014-09-18 Novartis Ag Notch2 binding molecules for treating respiratory diseases
WO2015066550A1 (en) 2013-10-31 2015-05-07 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
KR102422580B1 (ko) * 2013-12-29 2022-07-20 큐어랩 온콜로지, 인크. 염증―관련 질환의 예방 및 치료용 ｐ６２／ＳＱＳＴＭ１관련 조성물 및 방법
CA2955086A1 (en) 2014-08-08 2016-02-11 Alector Llc Anti-trem2 antibodies and methods of use thereof
GB201508025D0 (en) 2015-05-11 2015-06-24 Ucl Business Plc Fabry disease gene therapy
PT3445397T (pt) * 2016-04-22 2023-01-13 Vaccinex Inc Exibição de proteína integral de membrana sobre viriões envelopados extracelulares de poxvírus
US20190241878A1 (en) 2016-07-01 2019-08-08 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
KR102033215B1 (ko) * 2016-07-05 2019-10-16 성균관대학교산학협력단 건선 유발 동물 모델 및 이의 용도
GB201700567D0 (en) * 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
TWI811229B (zh) 2017-08-03 2023-08-11 美商阿列克特有限責任公司 抗trem2抗體及其使用方法
CN111315767B (zh) 2017-08-22 2025-03-18 萨纳生物有限责任公司 可溶性干扰素受体及其用途
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
WO2020069373A1 (en) 2018-09-28 2020-04-02 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
US20210388345A1 (en) * 2018-10-22 2021-12-16 Roche Sequencing Solutions, Inc. Profiling of rheumatoid arthritis autoantibody repertoire and peptide classifiers therefor
JP2022522875A (ja) * 2019-03-07 2022-04-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 関節リウマチを予防又は処置するための新規ワクチン戦略
US20250270278A1 (en) * 2020-12-07 2025-08-28 The Research Foundation For The State University Of New York Methods of making water-soluble protein formed in a bacterial expression system, compositions, and methods of use thereof
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy
WO2024231931A1 (en) * 2023-05-08 2024-11-14 Canopy Immuno-Therapeutics Ltd. Ig-like fusion proteins for treating immune thrombocytopenia
WO2025075975A1 (en) * 2023-10-02 2025-04-10 Matice BioSciences, Inc. Peptides from regenerative species and methods for use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012525A1 (en) * 1998-08-27 2000-03-09 Quark Biotech, Inc. Sequences characteristic of hypoxia-regulated gene transcription
JP2001526892A (ja) * 1997-12-23 2001-12-25 イミュネックス・コーポレーション Ｓｉｇｉｒｒｄｎａおよびポリペプチド

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU606946B2 (en) * 1987-04-02 1991-02-21 Beth Israel Hospital Association, The Diagnosing obesity caused by a genetic abnormality and method of therapeutically treating genetically caused obesity
US5223425A (en) * 1987-04-02 1993-06-29 The Beth Israel Hospital Association DNA encoding human adipsin with complement D activity
CA2044940A1 (en) * 1991-06-10 1992-12-11 Inder M. Verma Transdominant negative proto-oncogene
US6956107B2 (en) * 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
CA2362427A1 (en) * 1999-03-08 2000-09-14 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20040002134A1 (en) * 1999-06-03 2004-01-01 Curagen Corporation Novel nucleic acid sequences encoding human KIAA0768 protein-like and human protein PRO228-like polypeptides
EP1276702A2 (en) * 2000-03-31 2003-01-22 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US6867189B2 (en) * 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526892A (ja) * 1997-12-23 2001-12-25 イミュネックス・コーポレーション Ｓｉｇｉｒｒｄｎａおよびポリペプチド
WO2000012525A1 (en) * 1998-08-27 2000-03-09 Quark Biotech, Inc. Sequences characteristic of hypoxia-regulated gene transcription

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007145326A1 (ja) * 2006-06-15 2007-12-21 Riken 炎症性疾患の判定方法
JP2007330166A (ja) * 2006-06-15 2007-12-27 Institute Of Physical & Chemical Research 炎症性疾患の判定方法
US8158351B2 (en) 2006-06-15 2012-04-17 Riken Method for determining inflammatory disease
JP2017520271A (ja) * 2014-04-18 2017-07-27 ▲煙▼台聚▲傑▼生物工程有限公司 １５種類の男性生殖関連タンパク質またはその組み合わせの使用
JP2023085301A (ja) * 2017-05-24 2023-06-20 テリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 高アンモニア血症を治療するためのグルタミン合成酵素の使用
JP7688926B2 (ja) 2017-05-24 2025-06-05 テリス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 高アンモニア血症を治療するためのグルタミン合成酵素の使用
US12359184B2 (en) 2017-05-24 2025-07-15 Thoeris Gmbh Use of glutamine synthetase for treating hyperammonemia
JP2023511358A (ja) * 2020-01-21 2023-03-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 線維化、肥大または心不全の処置または予防における使用のための骨髄由来増殖因子
JP7777532B2 (ja) 2020-01-21 2025-11-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 線維化、肥大または心不全の処置または予防における使用のための骨髄由来増殖因子

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