JP2006514309A - リチウム塩を用いた表面増感ラマン分光法の化学増感 - Google Patents
リチウム塩を用いた表面増感ラマン分光法の化学増感 Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
Claims (26)
- レーザ励起分光により標的検体を分析する段階と、
前記レーザ励起分光は、塩化リチウムによって活性化された金属構造物によって増感される
方法。 - 前記レーザ励起分光が、ラマン分光法である請求項1に記載の方法。
- 前記レーザ励起分光が、表面増感ラマン分光法、表面増感共鳴ラマン分光法、ハイパーラマン分光法、及びコヒーレントアンチストークスラマン分光法からなるグループから少なくとも1つ以上選択される請求項1に記載の方法。
- 前記金属構造物が、銀、金、白金、銅、及びアルミニウム等からなるグループから選択された金属を含む請求項1に記載の方法。
- 前記標的検体が、アミノ酸、ペプチド、ポリペプチド、タンパク質、糖タンパク、リポタンパク質、ヌクレオシド、ヌクレオチド、オリゴヌクレオチド、核酸、デオキシリボース核酸、リボース核酸、ペプチド核酸、糖、炭水化物、オリゴ糖、多糖類、脂肪酸、脂質、ホルモン、代謝体、サイトカイン、ケモカイン、受容体、神経伝達物質、抗原、アレルゲン、抗体、基質、代謝体、共同因子、阻害物質、薬物、調合剤、栄養素、プリオン、毒素、毒薬、火薬、殺虫剤、化学兵器、バイオハザード剤、バクテリア、ウイルス、放射性元素、ビタミン、複素環芳香族化合物、発がん性物質、突然変異原、麻酔薬、アンフェタミン、バルビツール酸塩、幻覚剤、廃棄物、汚染物質、量子ドット、あるいは染料からなるグループから選択される請求項1に記載の方法。
- 前記標的検体が、ヌクレオシド、ヌクレオチド、オリゴヌクレオチド、核酸、アミノ酸、ペプチド、ポリペプチド、及びたんぱく質等からなるグループから選択される請求項1に記載の方法。
- 前記標的検体が、前記塩化リチウムで活性化された金属構造物を有する溶液中に配置される請求項1に記載の方法。
- 前記標的検体が、金属構造物が被覆された基質上に配置される請求項1に記載の方法。
- 前記金属構造物が金属ナノ粒子を含む請求項1に記載の方法。
- レーザ励起分光法のための金属構造物を含む溶液を調製する段階と、
活性化された金属構造物を供給するためのエンハンサーにより前記金属構造物を活性化する段階と、
前記エンハンサーは、前記金属構造物を活性化し、ラマン散乱信号強度を、エンハンサーとして塩化ナトリウムが使用された場合に得られる強度よりもより大きく増感させる
方法。 - 前記エンハンサーが、無機塩である請求項10に記載の方法。
- 前記エンハンサーが、塩化リチウムである請求項10に記載の方法。
- 前記活性化された金属構造物に標的分子を加える段階を更に備え、
前記標的分子がレーザ励起分光法によって分析される
請求項10に記載の方法。 - 前記金属構造物に標的検体を加える段階と、
前記エンハンサーを加えることにより前記金属構造物を活性化させる段階と、
レーザ励起分光法を用いて前記標的検体を分析する段階とを更に備える
請求項10に記載の方法。 - 前記金属構造物が、銀、金、白金、銅、及びアルミニウム等からなるグループから選択される請求項10に記載の方法。
- 前記金属構造物が、金属ナノ粒子を含む請求項10に記載の方法。
- 少なくとも1つ以上のエンハンサーによって標的検体を分析する段階と、
ラマン散乱信号強度を、エンハンサーとして塩化ナトリウムが使用された場合に得られる強度よりもより大きく増感させることができる前記少なくとも1つ以上のエンハンサーの少なくとも1つ以上を同定する段階を更に備える
請求項10に記載の方法。 - 物体の構成であって、
金属構造物層と、
エンハンサーとして塩化ナトリウムが使用された場合に得られる強度よりもより大きく増感させたラマン散乱信号強度を生成する、前記金属構造物層を活性化させるエンハンサー
からなる物体の構成。 - 前記エンハンサーが、無機塩である請求項18に記載の物体の構成。
- 前記エンハンサーが、塩化リチウムである請求項18に記載の物体の構成。
- 前記金属構造物層が、銀、金、白金、銅、及びアルミニウム等からなるグループから選択される金属を含む請求項18に記載の物体の構成。
- 前記金属構造物層が、ナノ粒子を含む請求項18に記載の物体の構成。
- 製造品であって、
基質と、
前記基質上に配置された金属構造物の堆積物とを備え、
前記金属構造物の堆積物は、塩化リチウムによって活性化される
製造品。 - 前記基質上に配置され、レーザ励起分光法を用いて分析される標的検体を更に備える、請求項23に記載の製造品。
- 前記金属構造物の堆積物は、銀、金、白金、銅、及びアルミニウム等からなるグループから選択される金属を含む請求項23に記載の製造品。
- 前記金属構造物の堆積物は、ナノ粒子を含む請求項23に記載の製造品。
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JP2009531547A (ja) * | 2006-03-23 | 2009-09-03 | ザ ユニバーシティー オブ リンカーン | 安定な銀コロイドの調製 |
JP2013535738A (ja) * | 2010-07-26 | 2013-09-12 | インテル コーポレイション | メモリのセグメントをプロテクトするための方法及び装置 |
WO2014188621A1 (ja) * | 2013-05-20 | 2014-11-27 | ウシオ電機株式会社 | 検査方法、センサ |
WO2014188622A1 (ja) * | 2013-05-20 | 2014-11-27 | ウシオ電機株式会社 | 検査方法 |
WO2014188620A1 (ja) * | 2013-05-20 | 2014-11-27 | ウシオ電機株式会社 | センサ、検査方法 |
KR101494131B1 (ko) | 2014-02-27 | 2015-02-16 | 숭실대학교산학협력단 | 은나노 구조체와 라만 분광법을 이용한 진균독소 시트리닌 검출방법 |
JP2020020642A (ja) * | 2018-07-31 | 2020-02-06 | 浜松ホトニクス株式会社 | 被検体分析方法 |
WO2021153253A1 (ja) * | 2020-01-27 | 2021-08-05 | 浜松ホトニクス株式会社 | 細胞分析方法 |
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