JP2006513141A5 - - Google Patents
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- Publication number
- JP2006513141A5 JP2006513141A5 JP2004530000A JP2004530000A JP2006513141A5 JP 2006513141 A5 JP2006513141 A5 JP 2006513141A5 JP 2004530000 A JP2004530000 A JP 2004530000A JP 2004530000 A JP2004530000 A JP 2004530000A JP 2006513141 A5 JP2006513141 A5 JP 2006513141A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- acid
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- 150000008575 L-amino acids Chemical class 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 3
- 229960005261 aspartic acid Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- -1 3,4,5-trihydroxyphenylcarbonyl Chemical group 0.000 claims 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229960002989 glutamic acid Drugs 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229960004799 tryptophan Drugs 0.000 claims 2
- 229960004295 valine Drugs 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- 229930182847 D-glutamic acid Natural products 0.000 claims 1
- 125000004077 D-glutamic acid group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(N([H])[H])=O 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 206010051269 Graft thrombosis Diseases 0.000 claims 1
- 101000622137 Homo sapiens P-selectin Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- 235000013878 L-cysteine Nutrition 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229940124277 aminobutyric acid Drugs 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 201000005008 bacterial sepsis Diseases 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 230000005796 circulatory shock Effects 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960005190 phenylalanine Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078308 | 2002-08-09 | ||
| PCT/EP2003/007260 WO2004018502A1 (en) | 2002-08-09 | 2003-07-04 | Compounds binding to p-selectin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098138A Division JP2010209088A (ja) | 2002-08-09 | 2010-04-21 | Ｐ−セレクチンに対する結合性化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006513141A JP2006513141A (ja) | 2006-04-20 |
| JP2006513141A5 true JP2006513141A5 (https=) | 2006-08-17 |
| JP4563806B2 JP4563806B2 (ja) | 2010-10-13 |
Family
ID=31896910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004530000A Expired - Fee Related JP4563806B2 (ja) | 2002-08-09 | 2003-07-04 | Ｐ−セレクチンに対する結合性化合物 |
| JP2010098138A Withdrawn JP2010209088A (ja) | 2002-08-09 | 2010-04-21 | Ｐ−セレクチンに対する結合性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010098138A Withdrawn JP2010209088A (ja) | 2002-08-09 | 2010-04-21 | Ｐ−セレクチンに対する結合性化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20060217294A1 (https=) |
| EP (1) | EP1527086B1 (https=) |
| JP (2) | JP4563806B2 (https=) |
| AT (1) | ATE383370T1 (https=) |
| AU (1) | AU2003250899A1 (https=) |
| BR (1) | BR0313019A (https=) |
| CA (1) | CA2493471C (https=) |
| DE (1) | DE60318585T2 (https=) |
| ES (1) | ES2299749T3 (https=) |
| MX (1) | MXPA05001599A (https=) |
| WO (1) | WO2004018502A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2299749T3 (es) * | 2002-08-09 | 2008-06-01 | Astellas Pharma Europe B.V. | Compuestos que se unen a p-selectina. |
| DE60329511D1 (de) | 2002-10-11 | 2009-11-12 | Astellas Pharma Europ B V | Verbindungen auf glukosebasis mit affinitüt für p-selektin |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| JP5603074B2 (ja) * | 2006-09-08 | 2014-10-08 | ピラマル イメージング ソシエテ アノニム | １８ｆ標識物質のための化合物と方法 |
| CN105189465B (zh) | 2013-03-21 | 2019-02-26 | 赛诺菲-安万特德国有限公司 | 合成含有乙内酰脲的肽产物 |
| WO2014147129A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| AU2021208650A1 (en) * | 2020-01-16 | 2022-08-11 | Case Western Reserve University | Neutrophil elastase binding peptides and compositions thereof |
| CN115039782A (zh) * | 2022-07-20 | 2022-09-13 | 中国农业科学院植物保护研究所 | 一种化合物在大豆孢囊线虫几丁质酶抑制剂中的应用 |
| WO2025168211A1 (en) | 2023-02-10 | 2025-08-14 | Novo Nordisk A/S | P-selectin peptide ligands |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005314A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of leukocyte adhesion |
| WO1996000581A1 (en) * | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| WO2000027420A1 (en) * | 1998-11-06 | 2000-05-18 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for treatment of cancer |
| EP1288222A1 (en) * | 2001-09-03 | 2003-03-05 | Yamanouchi Europe B.V. | Peptidic compounds selectively binding to P-selectin |
| ES2299749T3 (es) * | 2002-08-09 | 2008-06-01 | Astellas Pharma Europe B.V. | Compuestos que se unen a p-selectina. |
-
2003
- 2003-07-04 ES ES03792179T patent/ES2299749T3/es not_active Expired - Lifetime
- 2003-07-04 CA CA2493471A patent/CA2493471C/en not_active Expired - Fee Related
- 2003-07-04 AU AU2003250899A patent/AU2003250899A1/en not_active Abandoned
- 2003-07-04 US US10/524,172 patent/US20060217294A1/en not_active Abandoned
- 2003-07-04 BR BR0313019-3A patent/BR0313019A/pt not_active Application Discontinuation
- 2003-07-04 MX MXPA05001599A patent/MXPA05001599A/es unknown
- 2003-07-04 JP JP2004530000A patent/JP4563806B2/ja not_active Expired - Fee Related
- 2003-07-04 DE DE60318585T patent/DE60318585T2/de not_active Expired - Lifetime
- 2003-07-04 WO PCT/EP2003/007260 patent/WO2004018502A1/en not_active Ceased
- 2003-07-04 AT AT03792179T patent/ATE383370T1/de not_active IP Right Cessation
- 2003-07-04 EP EP03792179A patent/EP1527086B1/en not_active Expired - Lifetime
-
2008
- 2008-06-25 US US12/146,302 patent/US20090062186A1/en not_active Abandoned
-
2010
- 2010-03-16 US US12/725,199 patent/US20100323969A1/en not_active Abandoned
- 2010-04-21 JP JP2010098138A patent/JP2010209088A/ja not_active Withdrawn
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