JP2006513135A5 - - Google Patents
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- Publication number
- JP2006513135A5 JP2006513135A5 JP2004513330A JP2004513330A JP2006513135A5 JP 2006513135 A5 JP2006513135 A5 JP 2006513135A5 JP 2004513330 A JP2004513330 A JP 2004513330A JP 2004513330 A JP2004513330 A JP 2004513330A JP 2006513135 A5 JP2006513135 A5 JP 2006513135A5
- Authority
- JP
- Japan
- Prior art keywords
- aurora
- screening
- protein
- hybridoma
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004408 hybridoma Anatomy 0.000 claims description 35
- 238000012216 screening Methods 0.000 claims description 32
- 210000004027 cell Anatomy 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 12
- 238000001114 immunoprecipitation Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 241000699670 Mus sp. Species 0.000 claims description 9
- 101100325641 Mus musculus Aurka gene Proteins 0.000 claims description 8
- 108090000144 Human Proteins Proteins 0.000 claims description 6
- 210000003793 centrosome Anatomy 0.000 claims description 6
- 238000010166 immunofluorescence Methods 0.000 claims description 6
- 102000001253 Protein Kinase Human genes 0.000 claims description 4
- 108060006633 protein kinase Proteins 0.000 claims description 4
- 241000699800 Cricetinae Species 0.000 claims description 3
- 241000588724 Escherichia coli Species 0.000 claims description 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000010367 cloning Methods 0.000 claims description 3
- 239000002299 complementary DNA Substances 0.000 claims description 3
- 239000013604 expression vector Substances 0.000 claims description 3
- 210000005260 human cell Anatomy 0.000 claims description 3
- 238000002649 immunization Methods 0.000 claims description 3
- 230000003053 immunization Effects 0.000 claims description 3
- 210000004989 spleen cell Anatomy 0.000 claims description 3
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 4
- 108090000461 Aurora Kinase A Proteins 0.000 claims 3
- 102000004000 Aurora Kinase A Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 108050006400 Cyclin Proteins 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 238000010837 poor prognosis Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000012474 protein marker Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0207212A FR2840905B1 (fr) | 2002-06-12 | 2002-06-12 | Anticorps monoclonal anti-aurora-a, son procede d'obtention, et ses utilisations dans le diagnostic et le traitement des cancers |
| PCT/FR2003/001772 WO2003106500A1 (fr) | 2002-06-12 | 2003-06-12 | Anticorps monoclonal anti-aurora-a, son procede d'obtention, et ses utilisations dans le diagnostic et le traitement des cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006513135A JP2006513135A (ja) | 2006-04-20 |
| JP2006513135A5 true JP2006513135A5 (enExample) | 2006-06-29 |
| JP4555681B2 JP4555681B2 (ja) | 2010-10-06 |
Family
ID=29595167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513330A Expired - Lifetime JP4555681B2 (ja) | 2002-06-12 | 2003-06-12 | 抗オーロラ−ａモノクローナル抗体、該抗体を得る方法、並びに癌の診断および処置のための該抗体の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7514231B2 (enExample) |
| EP (1) | EP1511771B1 (enExample) |
| JP (1) | JP4555681B2 (enExample) |
| AT (1) | ATE420115T1 (enExample) |
| AU (1) | AU2003255671A1 (enExample) |
| CA (1) | CA2489214C (enExample) |
| DE (1) | DE60325725D1 (enExample) |
| FR (1) | FR2840905B1 (enExample) |
| WO (1) | WO2003106500A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2239692C (en) * | 1995-12-18 | 2008-12-16 | Sugen, Inc. | Diagnosis and treatment of aur-1 and/or aur-2 related disorders |
-
2002
- 2002-06-12 FR FR0207212A patent/FR2840905B1/fr not_active Expired - Lifetime
-
2003
- 2003-06-12 AU AU2003255671A patent/AU2003255671A1/en not_active Abandoned
- 2003-06-12 CA CA2489214A patent/CA2489214C/fr not_active Expired - Lifetime
- 2003-06-12 AT AT03760023T patent/ATE420115T1/de not_active IP Right Cessation
- 2003-06-12 US US10/517,645 patent/US7514231B2/en not_active Expired - Lifetime
- 2003-06-12 JP JP2004513330A patent/JP4555681B2/ja not_active Expired - Lifetime
- 2003-06-12 EP EP03760023A patent/EP1511771B1/fr not_active Expired - Lifetime
- 2003-06-12 WO PCT/FR2003/001772 patent/WO2003106500A1/fr not_active Ceased
- 2003-06-12 DE DE60325725T patent/DE60325725D1/de not_active Expired - Lifetime
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