JP2006512362A - 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用 - Google Patents

血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用 Download PDF

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Publication number
JP2006512362A
JP2006512362A JP2004561981A JP2004561981A JP2006512362A JP 2006512362 A JP2006512362 A JP 2006512362A JP 2004561981 A JP2004561981 A JP 2004561981A JP 2004561981 A JP2004561981 A JP 2004561981A JP 2006512362 A JP2006512362 A JP 2006512362A
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Japan
Prior art keywords
phenylthio
ethoxy
methyl
compound
acid
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JP2004561981A
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Japanese (ja)
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JP2006512362A5 (enExample
Inventor
ファビオ・ジャンネッシ
エマヌエラ・タッソーニ
マリア・オルネッラ・ティンティ
ポンペオ・ペッソット
ナタリーナ・デルオモ
アンナ・フロリアーナ・シャッローニ
ティツィアナ・ブルネッティ
フェルディナンド・マリア・ミラッツォ
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of JP2006512362A publication Critical patent/JP2006512362A/ja
Publication of JP2006512362A5 publication Critical patent/JP2006512362A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
JP2004561981A 2002-12-19 2003-12-16 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用 Pending JP2006512362A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000629A ITRM20020629A1 (it) 2002-12-19 2002-12-19 Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.
PCT/IT2003/000820 WO2004056355A1 (en) 2002-12-19 2003-12-16 USE OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXYCARBOXYLIC ACIDS WITH SERUM-GLUCOSE-LOWERING AND SERUM-LIPID-LOWERING ACTIVITY

Publications (2)

Publication Number Publication Date
JP2006512362A true JP2006512362A (ja) 2006-04-13
JP2006512362A5 JP2006512362A5 (enExample) 2007-02-08

Family

ID=32676886

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004561981A Pending JP2006512362A (ja) 2002-12-19 2003-12-16 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用

Country Status (20)

Country Link
US (1) US7375124B2 (enExample)
EP (1) EP1572180B1 (enExample)
JP (1) JP2006512362A (enExample)
KR (1) KR20050085222A (enExample)
CN (1) CN100393309C (enExample)
AR (1) AR042547A1 (enExample)
AT (1) ATE423558T1 (enExample)
AU (1) AU2003288546B8 (enExample)
BR (1) BR0317359A (enExample)
CA (1) CA2506627A1 (enExample)
DE (1) DE60326382D1 (enExample)
DK (1) DK1572180T3 (enExample)
ES (1) ES2321708T3 (enExample)
IT (1) ITRM20020629A1 (enExample)
MX (1) MXPA05005848A (enExample)
PL (1) PL378414A1 (enExample)
PT (1) PT1572180E (enExample)
SI (1) SI1572180T1 (enExample)
TW (1) TWI308564B (enExample)
WO (1) WO2004056355A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846915B2 (en) * 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
MX2009008099A (es) 2007-02-01 2009-12-14 Resverlogix Corp Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
JP5602728B2 (ja) 2008-06-26 2014-10-08 レスバーロジックス コーポレイション キナゾリノン誘導体の製造方法
KR101395952B1 (ko) * 2008-09-05 2014-05-21 어큐셀라 인코포레이티드 안과 질환 및 장애 치료를 위한 황-연결 화합물
EP2382194B1 (en) 2009-01-08 2014-03-12 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ595747A (en) 2009-03-18 2015-06-26 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
EP2421533B1 (en) 2009-04-22 2018-10-17 Resverlogix Corp. Novel anti-inflammatory agents
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN114901641B (zh) * 2020-02-28 2025-06-17 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652646A (en) * 1966-03-31 1972-03-28 Ici Ltd Carboxylic acid derivatives
JPS51125228A (en) * 1974-09-30 1976-11-01 Lafon Labor Preparation of diaryl compounds
JP2005514456A (ja) * 2002-01-15 2005-05-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) * 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB1422679A (en) 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652646A (en) * 1966-03-31 1972-03-28 Ici Ltd Carboxylic acid derivatives
JPS51125228A (en) * 1974-09-30 1976-11-01 Lafon Labor Preparation of diaryl compounds
JP2005514456A (ja) * 2002-01-15 2005-05-19 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ ＰＰＡＲα活性化に応答する疾患の治療に有用なα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の誘導体

Also Published As

Publication number Publication date
SI1572180T1 (sl) 2009-06-30
DK1572180T3 (da) 2009-06-02
CN1728992A (zh) 2006-02-01
TW200420531A (en) 2004-10-16
KR20050085222A (ko) 2005-08-29
PL378414A1 (pl) 2006-04-03
MXPA05005848A (es) 2005-08-26
AR042547A1 (es) 2005-06-22
EP1572180B1 (en) 2009-02-25
US7375124B2 (en) 2008-05-20
AU2003288546A1 (en) 2004-07-14
AU2003288546B2 (en) 2009-04-30
CA2506627A1 (en) 2004-07-08
TWI308564B (en) 2009-04-11
BR0317359A (pt) 2005-11-08
US20060154979A1 (en) 2006-07-13
EP1572180A1 (en) 2005-09-14
DE60326382D1 (de) 2009-04-09
ITRM20020629A1 (it) 2004-06-20
AU2003288546B8 (en) 2009-06-11
HK1087007A1 (en) 2006-10-06
WO2004056355A1 (en) 2004-07-08
ES2321708T3 (es) 2009-06-10
CN100393309C (zh) 2008-06-11
PT1572180E (pt) 2009-05-04
ATE423558T1 (de) 2009-03-15

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