ITRM20020629A1 - Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante. - Google Patents

Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.

Info

Publication number
ITRM20020629A1
ITRM20020629A1 IT000629A ITRM20020629A ITRM20020629A1 IT RM20020629 A1 ITRM20020629 A1 IT RM20020629A1 IT 000629 A IT000629 A IT 000629A IT RM20020629 A ITRM20020629 A IT RM20020629A IT RM20020629 A1 ITRM20020629 A1 IT RM20020629A1
Authority
IT
Italy
Prior art keywords
phenylthiocarboxyl
hypolipidemizing
hypoglycemy
achylphoxycarboxylic
alpha
Prior art date
Application number
IT000629A
Other languages
English (en)
Italian (it)
Inventor
Tiziana Brunetti
Uomo Natalina Dell
Fabio Giannessi
Ferdinando Maria Milazzo
Pompeo Pessotto
Claudio Pisano
Anna Floriana Sciarroni
Emanuela Tassoni
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority to IT000629A priority Critical patent/ITRM20020629A1/it
Priority to PCT/IT2003/000820 priority patent/WO2004056355A1/en
Priority to AU2003288546A priority patent/AU2003288546B8/en
Priority to CA002506627A priority patent/CA2506627A1/en
Priority to ES03780669T priority patent/ES2321708T3/es
Priority to US10/539,833 priority patent/US7375124B2/en
Priority to PT03780669T priority patent/PT1572180E/pt
Priority to JP2004561981A priority patent/JP2006512362A/ja
Priority to CNB200380106699XA priority patent/CN100393309C/zh
Priority to HK06107039.2A priority patent/HK1087007B/xx
Priority to DE60326382T priority patent/DE60326382D1/de
Priority to KR1020057009770A priority patent/KR20050085222A/ko
Priority to DK03780669T priority patent/DK1572180T3/da
Priority to BR0317359-3A priority patent/BR0317359A/pt
Priority to SI200331556T priority patent/SI1572180T1/sl
Priority to EP03780669A priority patent/EP1572180B1/en
Priority to PL378414A priority patent/PL378414A1/pl
Priority to MXPA05005848A priority patent/MXPA05005848A/es
Priority to AT03780669T priority patent/ATE423558T1/de
Priority to TW092136024A priority patent/TWI308564B/zh
Priority to ARP030104731A priority patent/AR042547A1/es
Publication of ITRM20020629A1 publication Critical patent/ITRM20020629A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
IT000629A 2002-12-19 2002-12-19 Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante. ITRM20020629A1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT000629A ITRM20020629A1 (it) 2002-12-19 2002-12-19 Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.
PCT/IT2003/000820 WO2004056355A1 (en) 2002-12-19 2003-12-16 USE OF α-PHENYLTHIOCARBOXYLIC AND α-PHENYLOXYCARBOXYLIC ACIDS WITH SERUM-GLUCOSE-LOWERING AND SERUM-LIPID-LOWERING ACTIVITY
AU2003288546A AU2003288546B8 (en) 2002-12-19 2003-12-16 Use of alpha-phenylthiocarboxylic and alpha-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
CA002506627A CA2506627A1 (en) 2002-12-19 2003-12-16 Use of .alpha.-phenylthiocarboxylic and .alpha.-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
ES03780669T ES2321708T3 (es) 2002-12-19 2003-12-16 Uso de acidos alf-feniltiocarboxilicos con antividad de reduccion de glucosa serica y reduccion de lipidos sericos.
US10/539,833 US7375124B2 (en) 2002-12-19 2003-12-16 Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
PT03780669T PT1572180E (pt) 2002-12-19 2003-12-16 Utilização de ácidos alfa-feniltiocarboxílicos com actividade de redução da glicose sérica e actividade de redução de lípidos no soro
JP2004561981A JP2006512362A (ja) 2002-12-19 2003-12-16 血清グルコース低下および血清脂質低下活性を有するα−フェニルチオカルボン酸およびα−フェニルオキシカルボン酸の使用
CNB200380106699XA CN100393309C (zh) 2002-12-19 2003-12-16 具有降低血清葡萄糖和降低血清脂质活性的α-苯硫基羧酸和α-苯氧基羧酸的用途
HK06107039.2A HK1087007B (en) 2002-12-19 2003-12-16 Use of a-phenylthiocarboxylic and a-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
DE60326382T DE60326382D1 (de) 2002-12-19 2003-12-16 Verwendung von alpha-phenylthiokarbonsäuren mit serumglucose- und serumlipid-senkender wirkung
KR1020057009770A KR20050085222A (ko) 2002-12-19 2003-12-16 혈청-글루코스-강하 및 혈청-지질-강하 활성을 갖는α-페닐티오카복실산 및 α-페닐옥시카복실산의 용도
DK03780669T DK1572180T3 (da) 2002-12-19 2003-12-16 Anvendelse af alfa-phenylthiocarboxylsyrer med serumglucose-sænkende og serumlipid-sænkende virkning
BR0317359-3A BR0317359A (pt) 2002-12-19 2003-12-16 Uso de ácidos alfa-feniltiocarboxìlico e alfa-feniloxicarboxìlico com atividade de diminuição de glicose no soro e diminuição de lipìdios no soro
SI200331556T SI1572180T1 (sl) 2002-12-19 2003-12-16 Uporaba alfa-feniltiokarboksilnih kislin z aktivnostjo zniĺ˝evanja serumske glukoze in serumskih lipidov
EP03780669A EP1572180B1 (en) 2002-12-19 2003-12-16 Use of alpha-phenylthiocarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
PL378414A PL378414A1 (pl) 2002-12-19 2003-12-16 Zastosowanie kwasu Ó-fenylotiokarboksylowego i Ó-fenyloksykarboksylowego o aktywności obniżającej poziom glukozy w surowicy i obniżającej poziom lipidów w surowicy
MXPA05005848A MXPA05005848A (es) 2002-12-19 2003-12-16 Uso de acidos alfa-feniltiocarboxilicos y alfa-feniloxicarboxilicos con actividad reductora de la glucosa en suero y reductora de lipidos en el suero.
AT03780669T ATE423558T1 (de) 2002-12-19 2003-12-16 Verwendung von alpha-phenylthiokarbonsäuren mit serumglucose- und serumlipid-senkender wirkung
TW092136024A TWI308564B (en) 2002-12-19 2003-12-18 Use of alpha-phenylthiocarboxylic and alpha-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
ARP030104731A AR042547A1 (es) 2002-12-19 2003-12-19 Uso de acidos alfa - feniltiocaboxilico y alfa - feniloxicarboxilico con actividad disminuidora de la glucosa en el suero y de los lipidos en el suero

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000629A ITRM20020629A1 (it) 2002-12-19 2002-12-19 Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.

Publications (1)

Publication Number Publication Date
ITRM20020629A1 true ITRM20020629A1 (it) 2004-06-20

Family

ID=32676886

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000629A ITRM20020629A1 (it) 2002-12-19 2002-12-19 Uso di acidi alfa-feniltiocarbossilici e alfa-fenilossicarbossilici ad attivita' ipoglicemizzante e/o ipolipidemizzante.

Country Status (20)

Country Link
US (1) US7375124B2 (enExample)
EP (1) EP1572180B1 (enExample)
JP (1) JP2006512362A (enExample)
KR (1) KR20050085222A (enExample)
CN (1) CN100393309C (enExample)
AR (1) AR042547A1 (enExample)
AT (1) ATE423558T1 (enExample)
AU (1) AU2003288546B8 (enExample)
BR (1) BR0317359A (enExample)
CA (1) CA2506627A1 (enExample)
DE (1) DE60326382D1 (enExample)
DK (1) DK1572180T3 (enExample)
ES (1) ES2321708T3 (enExample)
IT (1) ITRM20020629A1 (enExample)
MX (1) MXPA05005848A (enExample)
PL (1) PL378414A1 (enExample)
PT (1) PT1572180E (enExample)
SI (1) SI1572180T1 (enExample)
TW (1) TWI308564B (enExample)
WO (1) WO2004056355A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846915B2 (en) * 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
MX2009008099A (es) 2007-02-01 2009-12-14 Resverlogix Corp Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
JP5602728B2 (ja) 2008-06-26 2014-10-08 レスバーロジックス コーポレイション キナゾリノン誘導体の製造方法
KR101395952B1 (ko) * 2008-09-05 2014-05-21 어큐셀라 인코포레이티드 안과 질환 및 장애 치료를 위한 황-연결 화합물
EP2382194B1 (en) 2009-01-08 2014-03-12 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ595747A (en) 2009-03-18 2015-06-26 Resverlogix Corp Novel quinazolinones and related compounds for use as anti-inflammatory agents
EP2421533B1 (en) 2009-04-22 2018-10-17 Resverlogix Corp. Novel anti-inflammatory agents
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN114901641B (zh) * 2020-02-28 2025-06-17 四川科伦博泰生物医药股份有限公司 芳香族化合物及其药物组合物和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) * 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
GB1422679A (en) 1972-11-16 1976-01-28 Funai Pharmaceutical Ind Ltd Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same
FR2285859A1 (fr) * 1974-09-30 1976-04-23 Lafon Labor Phenylsulfinyl-amidines et derives
ITRM20020014A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del

Also Published As

Publication number Publication date
SI1572180T1 (sl) 2009-06-30
DK1572180T3 (da) 2009-06-02
CN1728992A (zh) 2006-02-01
TW200420531A (en) 2004-10-16
KR20050085222A (ko) 2005-08-29
PL378414A1 (pl) 2006-04-03
MXPA05005848A (es) 2005-08-26
AR042547A1 (es) 2005-06-22
EP1572180B1 (en) 2009-02-25
US7375124B2 (en) 2008-05-20
AU2003288546A1 (en) 2004-07-14
AU2003288546B2 (en) 2009-04-30
CA2506627A1 (en) 2004-07-08
TWI308564B (en) 2009-04-11
BR0317359A (pt) 2005-11-08
US20060154979A1 (en) 2006-07-13
EP1572180A1 (en) 2005-09-14
DE60326382D1 (de) 2009-04-09
JP2006512362A (ja) 2006-04-13
AU2003288546B8 (en) 2009-06-11
HK1087007A1 (en) 2006-10-06
WO2004056355A1 (en) 2004-07-08
ES2321708T3 (es) 2009-06-10
CN100393309C (zh) 2008-06-11
PT1572180E (pt) 2009-05-04
ATE423558T1 (de) 2009-03-15

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