JP2006512090A5 - - Google Patents

Info

Publication number

JP2006512090A5

JP2006512090A5 JP2005507928A JP2005507928A JP2006512090A5 JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5 JP 2005507928 A JP2005507928 A JP 2005507928A JP 2005507928 A JP2005507928 A JP 2005507928A JP 2006512090 A5 JP2006512090 A5 JP 2006512090A5

Authority

JP

Japan

Prior art keywords

seq

amino acids

acid sequence

polypeptide

amino acid

Prior art date

2003-10-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001413 amino acids Chemical class 0.000 claims 136
• 108090000765 processed proteins & peptides Proteins 0.000 claims 55
• 125000003275 alpha amino acid group Chemical group 0.000 claims 50
• 229920001184 polypeptide Polymers 0.000 claims 49
• 102000004196 processed proteins & peptides Human genes 0.000 claims 49
• 108030001720 Bontoxilysin Proteins 0.000 claims 36
• 102000040430 polynucleotide Human genes 0.000 claims 33
• 108091033319 polynucleotide Proteins 0.000 claims 33
• 239000002157 polynucleotide Substances 0.000 claims 33
• 239000003795 chemical substances by application Substances 0.000 claims 21
• 239000000203 mixture Substances 0.000 claims 17
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
• 238000000034 method Methods 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 11
• 150000007523 nucleic acids Chemical class 0.000 claims 11
• 101000714466 Mus musculus Synaptotagmin-1 Proteins 0.000 claims 10
• 101000891892 Mus musculus Synaptotagmin-2 Proteins 0.000 claims 10
• 108010055170 Synaptotagmin I Proteins 0.000 claims 8
• 102100036417 Synaptotagmin-1 Human genes 0.000 claims 8
• -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 7
• 150000002270 gangliosides Chemical class 0.000 claims 7
• 108010055445 Synaptotagmin II Proteins 0.000 claims 6
• 102100036151 Synaptotagmin-2 Human genes 0.000 claims 6
• 230000000295 complement effect Effects 0.000 claims 6
• 102000003137 synaptotagmin Human genes 0.000 claims 6
• 108060008004 synaptotagmin Proteins 0.000 claims 6
• 241001465754 Metazoa Species 0.000 claims 4
• 239000003446 ligand Substances 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 241000193155 Clostridium botulinum Species 0.000 claims 2
• 229940053031 botulinum toxin Drugs 0.000 claims 2
• 238000009396 hybridization Methods 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000003834 intracellular effect Effects 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 108010074523 rimabotulinumtoxinB Proteins 0.000 claims 2
• 230000000903 blocking effect Effects 0.000 claims 1
• 125000002421 ganglioside group Chemical group 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000001988 toxicity Effects 0.000 claims 1
• 231100000419 toxicity Toxicity 0.000 claims 1