JP2006512090A - ボツリヌス神経毒b受容体およびその使用 - Google Patents

ボツリヌス神経毒b受容体およびその使用 Download PDF

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JP2006512090A
JP2006512090A JP2005507928A JP2005507928A JP2006512090A JP 2006512090 A JP2006512090 A JP 2006512090A JP 2005507928 A JP2005507928 A JP 2005507928A JP 2005507928 A JP2005507928 A JP 2005507928A JP 2006512090 A JP2006512090 A JP 2006512090A
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seq
amino acids
bont
acid sequence
binding
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JP2006512090A5 (enExample
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エドウィン レイモンド チャップマン
ミン ドン
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ウイスコンシン アラムニ リサーチ ファンデーション
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2005507928A 2002-10-31 2003-10-28 ボツリヌス神経毒b受容体およびその使用 Pending JP2006512090A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42295102P 2002-10-31 2002-10-31
US49812803P 2003-08-27 2003-08-27
PCT/US2003/034348 WO2005016233A2 (en) 2002-10-31 2003-10-28 Botulinum neurotoxin b receptors and use thereof

Related Child Applications (1)

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JP2009229744A Division JP2010006833A (ja) 2002-10-31 2009-10-01 ボツリヌス神経毒b受容体およびその使用

Publications (2)

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JP2006512090A true JP2006512090A (ja) 2006-04-13
JP2006512090A5 JP2006512090A5 (enExample) 2006-06-01

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JP2005507928A Pending JP2006512090A (ja) 2002-10-31 2003-10-28 ボツリヌス神経毒b受容体およびその使用
JP2009229744A Pending JP2010006833A (ja) 2002-10-31 2009-10-01 ボツリヌス神経毒b受容体およびその使用

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US (2) US20040191887A1 (enExample)
EP (1) EP1578382B1 (enExample)
JP (2) JP2006512090A (enExample)
AT (1) ATE442161T1 (enExample)
AU (1) AU2003304419A1 (enExample)
CA (1) CA2504532C (enExample)
DE (1) DE60329225D1 (enExample)
ES (1) ES2333319T3 (enExample)
IL (1) IL167943A (enExample)
WO (1) WO2005016233A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023210585A1 (ja) * 2022-04-25 2023-11-02 株式会社Jiksak Bioengineering 標的化剤

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1578382B1 (en) * 2002-10-31 2009-09-09 Wisconsin Alumni Research Foundation Botulinum neurotoxin b receptors and use thereof
US7341843B2 (en) * 2003-04-11 2008-03-11 Allergan, Inc. Botulinum toxin A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy
WO2006113648A2 (en) * 2005-04-18 2006-10-26 University Of Massachusetts Hn-33 compositions and methods
DE102005019302A1 (de) 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
US7985554B2 (en) 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
DE102005051789B4 (de) 2005-10-28 2014-08-07 Toxogen Gmbh Der Botulinus Neurotoxin A Proteinrezeptor und seine Anwendungen
CN101932936B (zh) 2007-09-14 2016-04-27 拜奥麦迪逊公司 利用切割序列和间隔子的共振能量转移测定
US10908146B2 (en) 2011-06-01 2021-02-02 Biomadison, Inc. Compositions and methods for improving sensitivity in cell based assays
US9303285B2 (en) 2012-01-04 2016-04-05 Biomadison, Inc. Methods and compounds for increasing sensitivity of botulinum assays
US12422428B2 (en) 2011-06-01 2025-09-23 Biomadison, Inc. Compositions and methods for cell-based assays
LT2715355T (lt) 2011-06-01 2017-06-12 Biomadison, Inc. Ne fret (fluorescencijos rezonansinės energijos perdavimas) būdu atliekamas botulino tyrimas
US11325954B2 (en) 2011-06-01 2022-05-10 Biomadison, Inc. Compositions and methods for stability testing of botulinum toxin
WO2015021433A1 (en) 2013-08-09 2015-02-12 Biomadison, Inc. Botulinum toxin assay with improved sensitivity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994995B1 (en) * 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
EP1578382B1 (en) * 2002-10-31 2009-09-09 Wisconsin Alumni Research Foundation Botulinum neurotoxin b receptors and use thereof
EP1751284A4 (en) * 2003-12-19 2010-01-13 Wisconsin Alumni Res Found METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXINE
EP1920248B1 (en) * 2005-04-05 2010-09-29 Allergan, Inc. Clostridial toxin activity assays
AU2006299933A1 (en) * 2005-08-02 2007-04-19 Planet Biotechnology, Inc. Improved chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax
US7985554B2 (en) * 2005-10-14 2011-07-26 Wisconsin Alumni Research Foundation Botulinum neurotoxin A receptor and the use thereof
WO2013011055A1 (en) * 2011-07-19 2013-01-24 ETH Zürich Means and methods for determining clostridial neurotoxins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6008055677, FEBS Lett.,Vol.378(1996)p.253−257 *
JPN6008055678, Neurosci.Lett.,Vol.208(1996)p.105−108 *
JPN6008055748, J.Cell Biol.,Vol.162,No.7(Sept.2003)p.1293−1303 *
JPN6008055749, Microb.Pathog.,Vol.25(1998)p.91−99 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023210585A1 (ja) * 2022-04-25 2023-11-02 株式会社Jiksak Bioengineering 標的化剤

Also Published As

Publication number Publication date
EP1578382A4 (en) 2007-08-29
EP1578382B1 (en) 2009-09-09
US8617573B2 (en) 2013-12-31
WO2005016233A3 (en) 2005-08-18
EP1578382A2 (en) 2005-09-28
US20120082672A1 (en) 2012-04-05
ES2333319T3 (es) 2010-02-19
CA2504532A1 (en) 2005-02-24
ATE442161T1 (de) 2009-09-15
AU2003304419A1 (en) 2005-03-07
CA2504532C (en) 2014-09-16
AU2003304419A8 (en) 2005-03-07
WO2005016233A2 (en) 2005-02-24
US20040191887A1 (en) 2004-09-30
DE60329225D1 (de) 2009-10-22
IL167943A (en) 2010-12-30
JP2010006833A (ja) 2010-01-14

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