JP2006511491A5 - - Google Patents
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- JP2006511491A5 JP2006511491A5 JP2004547084A JP2004547084A JP2006511491A5 JP 2006511491 A5 JP2006511491 A5 JP 2006511491A5 JP 2004547084 A JP2004547084 A JP 2004547084A JP 2004547084 A JP2004547084 A JP 2004547084A JP 2006511491 A5 JP2006511491 A5 JP 2006511491A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphodiesterase inhibitor
- pharmaceutical formulation
- type
- formulation according
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 28
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 27
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 7
- -1 lyxazinone Chemical compound 0.000 claims 6
- 201000001880 Sexual dysfunction Diseases 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 231100000872 sexual dysfunction Toxicity 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- JQUKCPUPFALELS-UHFFFAOYSA-N 2-(2-methoxy-4-methylsulfinylphenyl)-3H-imidazo[4,5-c]pyridine Chemical compound COC1=CC(S(C)=O)=CC=C1C1=NC2=CC=NC=C2N1 JQUKCPUPFALELS-UHFFFAOYSA-N 0.000 claims 2
- VXMYWVMXSWJFCV-UHFFFAOYSA-N 3-(4-imidazol-1-ylphenyl)-4,5-dihydro-1h-pyridazin-6-one Chemical compound N1C(=O)CCC(C=2C=CC(=CC=2)N2C=NC=C2)=N1 VXMYWVMXSWJFCV-UHFFFAOYSA-N 0.000 claims 2
- XZPGINPFWXLYNW-UHFFFAOYSA-N 7-(4-methyl-6-oxo-4,5-dihydro-1h-pyridazin-3-yl)-4h-1,4-benzoxazin-3-one Chemical compound CC1CC(=O)NN=C1C1=CC=C(NC(=O)CO2)C2=C1 XZPGINPFWXLYNW-UHFFFAOYSA-N 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229950005840 bemoradan Drugs 0.000 claims 2
- 229950000254 imazodan Drugs 0.000 claims 2
- 229950011537 isomazole Drugs 0.000 claims 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 claims 2
- 229960002164 pimobendan Drugs 0.000 claims 2
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 claims 2
- DOTPSQVYOBAWPQ-UHFFFAOYSA-N pyrazolo[4,3-d]pyrimidin-3-one Chemical group N1=CN=C2C(=O)N=NC2=C1 DOTPSQVYOBAWPQ-UHFFFAOYSA-N 0.000 claims 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 2
- 230000035946 sexual desire Effects 0.000 claims 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical group O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 210000003905 vulva Anatomy 0.000 claims 2
- HJPRDDKCXVCFOH-UHFFFAOYSA-N 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione Chemical compound O=C1N(CCCC)C(=O)N(CCCC)C2=C1N(CC(C)=O)C=N2 HJPRDDKCXVCFOH-UHFFFAOYSA-N 0.000 claims 1
- YLHRMVRLIOIWTO-UHFFFAOYSA-N 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4-dione Chemical compound [O-][N+](=O)C1=CC=CC(N2C(N(CC=3C=CN=CC=3)C(=O)C3=CC=CN=C32)=O)=C1 YLHRMVRLIOIWTO-UHFFFAOYSA-N 0.000 claims 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical compound C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 claims 1
- SSDAKJLEKSSAMH-UHFFFAOYSA-N 2,4-dihydro-1h-pyridazin-3-one Chemical compound O=C1CC=CNN1 SSDAKJLEKSSAMH-UHFFFAOYSA-N 0.000 claims 1
- LZCQFJKUAIWHRW-UHFFFAOYSA-N 3,3-dimethyl-5-(6-oxo-4,5-dihydro-1h-pyridazin-3-yl)-1h-indol-2-one Chemical compound C1=C2C(C)(C)C(=O)NC2=CC=C1C1=NNC(=O)CC1 LZCQFJKUAIWHRW-UHFFFAOYSA-N 0.000 claims 1
- CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 claims 1
- GNWCRBFQZDJFTI-UHFFFAOYSA-N 3-ethyl-1-(3-nitrophenyl)quinazoline-2,4-dione Chemical compound C12=CC=CC=C2C(=O)N(CC)C(=O)N1C1=CC=CC([N+]([O-])=O)=C1 GNWCRBFQZDJFTI-UHFFFAOYSA-N 0.000 claims 1
- FLYJEBSUJDZJDE-UHFFFAOYSA-N 3-phenyl-1h-pyridin-2-one Chemical class O=C1NC=CC=C1C1=CC=CC=C1 FLYJEBSUJDZJDE-UHFFFAOYSA-N 0.000 claims 1
- KJMFQJFNQYWQAV-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinazoline Chemical compound C1=NC=NC2=C(NC=N3)C3=CC=C21 KJMFQJFNQYWQAV-UHFFFAOYSA-N 0.000 claims 1
- JKDNCOYSCWFDAM-UHFFFAOYSA-N 4-(3-butoxy-4-methoxyphenyl)imidazolidin-2-one Chemical compound C1=C(OC)C(OCCCC)=CC(C2NC(=O)NC2)=C1 JKDNCOYSCWFDAM-UHFFFAOYSA-N 0.000 claims 1
- ZUOSZNKVOBXTON-UHFFFAOYSA-N 4-[(3-chloro-4-methoxyphenyl)methylamino]-2-(6,8-dihydro-5h-1,7-naphthyridin-7-yl)-n-(2-morpholin-4-ylethyl)pyrimidine-5-carboxamide Chemical compound C1=C(Cl)C(OC)=CC=C1CNC1=NC(N2CC3=NC=CC=C3CC2)=NC=C1C(=O)NCCN1CCOCC1 ZUOSZNKVOBXTON-UHFFFAOYSA-N 0.000 claims 1
- LDORHCBMWSQLIU-UHFFFAOYSA-N 6-phenyl-1h-pyrimidin-2-one Chemical compound N1C(=O)N=CC=C1C1=CC=CC=C1 LDORHCBMWSQLIU-UHFFFAOYSA-N 0.000 claims 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 claims 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims 1
- UIAYVIIHMORPSJ-UHFFFAOYSA-N N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide Chemical compound C=1C=C2NC(=O)C=CC2=CC=1OCCCC(=O)N(C)C1CCCCC1 UIAYVIIHMORPSJ-UHFFFAOYSA-N 0.000 claims 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical group CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960002105 amrinone Drugs 0.000 claims 1
- RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 claims 1
- OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 claims 1
- 229960001694 anagrelide Drugs 0.000 claims 1
- WEAJZXNPAWBCOA-INIZCTEOSA-N avanafil Chemical group C1=C(Cl)C(OC)=CC=C1CNC1=NC(N2[C@@H](CCC2)CO)=NC=C1C(=O)NCC1=NC=CC=N1 WEAJZXNPAWBCOA-INIZCTEOSA-N 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- MCMSJVMUSBZUCN-YYDJUVGSSA-N chembl285913 Chemical compound C1=2C=C(OC)C(OC)=CC=2CCN(C(N2C)=O)C1=C\C2=N/C1=C(C)C=C(C)C=C1C MCMSJVMUSBZUCN-YYDJUVGSSA-N 0.000 claims 1
- 229950002934 cilostamide Drugs 0.000 claims 1
- 229960004588 cilostazol Drugs 0.000 claims 1
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims 1
- 229950004687 denbufylline Drugs 0.000 claims 1
- 229960002768 dipyridamole Drugs 0.000 claims 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical group C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960000972 enoximone Drugs 0.000 claims 1
- ZJKNESGOIKRXQY-UHFFFAOYSA-N enoximone Chemical compound C1=CC(SC)=CC=C1C(=O)C1=C(C)NC(=O)N1 ZJKNESGOIKRXQY-UHFFFAOYSA-N 0.000 claims 1
- OPQRBXUBWHDHPQ-UHFFFAOYSA-N etazolate Chemical compound CCOC(=O)C1=CN=C2N(CC)N=CC2=C1NN=C(C)C OPQRBXUBWHDHPQ-UHFFFAOYSA-N 0.000 claims 1
- 229950009329 etazolate Drugs 0.000 claims 1
- 230000002964 excitative effect Effects 0.000 claims 1
- HOFSPGAYXKNFAM-UHFFFAOYSA-N imidazo[4,5-f]quinoxalin-2-one Chemical compound C1=CN=C2C3=NC(=O)N=C3C=CC2=N1 HOFSPGAYXKNFAM-UHFFFAOYSA-N 0.000 claims 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims 1
- 229950009856 indolidan Drugs 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 229960003574 milrinone Drugs 0.000 claims 1
- PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 claims 1
- VZXIAVMLJCJLPP-UHFFFAOYSA-N n-[4-(3-oxo-2h-pyrazin-6-yl)phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1C1=NCC(=O)N=C1 VZXIAVMLJCJLPP-UHFFFAOYSA-N 0.000 claims 1
- 229950011565 nitraquazone Drugs 0.000 claims 1
- 229960001789 papaverine Drugs 0.000 claims 1
- 229960001476 pentoxifylline Drugs 0.000 claims 1
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical compound N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 claims 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
- 229930185107 quinolinone Natural products 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical group COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 claims 1
- 229950005741 rolipram Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 229960003310 sildenafil Drugs 0.000 claims 1
- 229960000835 tadalafil Drugs 0.000 claims 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 229950004127 trequinsin Drugs 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 229960002381 vardenafil Drugs 0.000 claims 1
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical group CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 claims 1
- 229950005371 zaprinast Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/279,039 US20040014761A1 (en) | 1997-10-28 | 2002-10-22 | Treatment of female sexual dysfunction with phosphodiesterase inhibitors |
| PCT/US2003/033642 WO2004037262A2 (en) | 2002-10-22 | 2003-10-22 | Immediate release topical pharmaceutical formulation for enhancement of female sexual desire and responsiveness |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006511491A JP2006511491A (ja) | 2006-04-06 |
| JP2006511491A5 true JP2006511491A5 (https=) | 2006-11-30 |
Family
ID=32174580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004547084A Pending JP2006511491A (ja) | 2002-10-22 | 2003-10-22 | 女性の性的欲求および性的反応性を高めるための即放性局所薬学的処方物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040014761A1 (https=) |
| EP (1) | EP1562602A2 (https=) |
| JP (1) | JP2006511491A (https=) |
| AU (1) | AU2003284877A1 (https=) |
| CA (1) | CA2503391A1 (https=) |
| WO (1) | WO2004037262A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| HRP20050633A2 (en) * | 2003-01-23 | 2006-06-30 | Shire Holdings Ag | Formulation and methods for the treatment of thrombocythemia |
| EP1750766B1 (en) | 2004-05-11 | 2013-07-03 | Emotional Brain B.V. | Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
| US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
| US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
| GB0417401D0 (en) * | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| EP1802277B1 (de) * | 2004-10-18 | 2010-01-13 | Polymun Scientific Immunbiologische Forschung GmbH | Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung |
| US8835413B2 (en) * | 2004-10-20 | 2014-09-16 | Endorecherche, Inc. | Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cGMP phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women |
| JP4954085B2 (ja) | 2004-12-06 | 2012-06-13 | メディシノバ， インコーポレイテッド | 神経障害性疼痛及びその関連する症状を治療するためのイブジラスト |
| EP1790343A1 (en) * | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| KR101140110B1 (ko) * | 2006-07-07 | 2012-06-04 | 테바 파마슈티컬 인더스트리즈 리미티드 | 타달라필 및 하나 이상의 담체를 포함하는 고체 조성물 |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| EP1925307A1 (en) * | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
| US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| US20080181876A1 (en) * | 2007-01-30 | 2008-07-31 | Johnson Kirk W | Methods for treating acute and subchronic pain |
| WO2008137012A1 (en) * | 2007-05-03 | 2008-11-13 | Avigen, Inc. | Use of a glial attenuator to prevent amplified pain responses caused by glial priming |
| DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| US8268806B2 (en) | 2007-08-10 | 2012-09-18 | Endorecherche, Inc. | Pharmaceutical compositions |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| EP3045171A1 (en) | 2009-06-24 | 2016-07-20 | Strategic Science & Technologies, LLC | Topical composition |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| CN105920603B (zh) * | 2010-12-29 | 2022-02-11 | 战略科学与技术有限责任公司 | 勃起功能障碍和其它适应症的治疗 |
| JP6051210B2 (ja) * | 2011-06-10 | 2016-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 有機化合物 |
| ES2395801B1 (es) | 2011-06-23 | 2014-06-06 | María Carmen PARDINA PALLEJÀ | "pentoxifilina por vía transvaginal para el tratamiento de la infertilidad" |
| US10322087B2 (en) * | 2015-03-16 | 2019-06-18 | Mireca Medicines Gmbh | Targeted liposomal delivery of cGMP analogues |
| US20170239175A1 (en) * | 2016-02-19 | 2017-08-24 | FSD Pharma Co, LLC | Topical anorgasmia therapy |
| JPWO2023048174A1 (https=) * | 2021-09-22 | 2023-03-30 |
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|---|---|---|---|---|
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| US6251436B1 (en) * | 1995-09-29 | 2001-06-26 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| US5885834A (en) * | 1996-09-30 | 1999-03-23 | Epstein; Paul M. | Antisense oligodeoxynucleotide against phosphodiesterase |
| AU756136B2 (en) * | 1997-06-23 | 2003-01-02 | Queen's University At Kingston | Microdose therapy |
| US6593369B2 (en) * | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
| CA2306837C (en) * | 1997-10-28 | 2007-05-08 | Vivus, Inc. | Treatment of female sexual dysfunction |
| CA2395558C (en) * | 1997-11-12 | 2007-07-17 | Bayer Aktiengesellschaft | Intermediates for 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| US6187790B1 (en) * | 1999-03-04 | 2001-02-13 | Neal R. Cutler | Use of cilostazol for treatment of sexual dysfunction |
| US6277884B1 (en) * | 1998-06-01 | 2001-08-21 | Nitromed, Inc. | Treatment of sexual dysfunction with N-hydroxyguanidine compounds |
| US6436997B1 (en) * | 1998-06-01 | 2002-08-20 | Nitromed, Inc. | Endogenous nitric oxide synthesis under conditions of low oxygen tension |
| DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| AU765128B2 (en) * | 1999-03-22 | 2003-09-11 | Bristol-Myers Squibb Company | Fused pyridopyridazine inhibitors of cGMP phosphodiesterase |
| IT1312310B1 (it) * | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| CA2377369A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| US6436944B1 (en) * | 1999-09-30 | 2002-08-20 | Pfizer Inc. | Combination effective for the treatment of impotence |
| IL139457A0 (en) * | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
| WO2001044228A2 (fr) * | 1999-12-14 | 2001-06-21 | Sanofi-Synthelabo | Derives de quinazolinedione et phtalimide, leurs preparations et leurs applications en therapeutique |
| CA2395418A1 (en) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Isoxazolo pyrimidinones and the use thereof |
| JP2003534377A (ja) * | 2000-05-30 | 2003-11-18 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作働薬 |
| TWI262920B (en) * | 2000-10-27 | 2006-10-01 | Elbion Ag | New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them |
| JP2005503995A (ja) * | 2001-01-26 | 2005-02-10 | アール．ティー． アラモ ベンチャーズ アイ エルエルシー | キノリノン鏡像異性体による性的機能不全および心血管疾患の治療法 |
| US6642244B2 (en) * | 2001-03-16 | 2003-11-04 | Bristol-Myers Squibb Co. | Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase |
| IL157009A0 (en) * | 2001-03-28 | 2004-02-08 | Pfizer | N-phenpropylcyclopentyl-substituted glutaramide derivatives as nep inhibitors for fsad |
-
2002
- 2002-10-22 US US10/279,039 patent/US20040014761A1/en not_active Abandoned
-
2003
- 2003-10-22 AU AU2003284877A patent/AU2003284877A1/en not_active Abandoned
- 2003-10-22 JP JP2004547084A patent/JP2006511491A/ja active Pending
- 2003-10-22 CA CA002503391A patent/CA2503391A1/en not_active Abandoned
- 2003-10-22 EP EP03779198A patent/EP1562602A2/en not_active Withdrawn
- 2003-10-22 WO PCT/US2003/033642 patent/WO2004037262A2/en not_active Ceased
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