JP2006511473A - 蛍光染料及びｍｒｉ造影剤を含む二元機能造影剤 - Google Patents

蛍光染料及びｍｒｉ造影剤を含む二元機能造影剤 Download PDF

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Publication number
JP2006511473A
JP2006511473A JP2004537651A JP2004537651A JP2006511473A JP 2006511473 A JP2006511473 A JP 2006511473A JP 2004537651 A JP2004537651 A JP 2004537651A JP 2004537651 A JP2004537651 A JP 2004537651A JP 2006511473 A JP2006511473 A JP 2006511473A
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Prior art keywords
dual function
detection reagent
function detection
component
optical imaging
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Japanese (ja)
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JP2006511473A5 (enExample
Inventor
ハンクー，レーナ
アマラテュンガ，モーハン・マーク
ウィクト，デニス・クレイマー
ダーウェール，パリトッシュ
イシャーク，ナディーム
シャッド，フェイザル・アーメッド
ジョンソン，ブルース・フレッチャー
ウィリアムズ，エイミー・ケイシー
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General Electric Co
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General Electric Co
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Publication of JP2006511473A publication Critical patent/JP2006511473A/ja
Publication of JP2006511473A5 publication Critical patent/JP2006511473A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004537651A 2002-09-23 2003-08-11 蛍光染料及びｍｒｉ造影剤を含む二元機能造影剤 Pending JP2006511473A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/252,311 US7303741B2 (en) 2002-09-23 2002-09-23 Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
PCT/US2003/025184 WO2004026344A1 (en) 2002-09-23 2003-08-11 Bifunctional contrast agent comprising a fluorescent dye and an mri contrast agent

Publications (2)

Publication Number Publication Date
JP2006511473A true JP2006511473A (ja) 2006-04-06
JP2006511473A5 JP2006511473A5 (enExample) 2006-09-28

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JP2004537651A Pending JP2006511473A (ja) 2002-09-23 2003-08-11 蛍光染料及びｍｒｉ造影剤を含む二元機能造影剤

Country Status (6)

Country Link
US (2) US7303741B2 (enExample)
EP (1) EP1545629A1 (enExample)
JP (1) JP2006511473A (enExample)
CN (1) CN1684710A (enExample)
AU (1) AU2003259769A1 (enExample)
WO (1) WO2004026344A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535126A (ja) * 2006-04-27 2009-10-01 バーンズ−ジューイッシュ ホスピタル 標的組織の検出とイメージング
WO2011109216A3 (en) * 2010-03-01 2012-01-12 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications
JP2012183308A (ja) * 2011-03-03 2012-09-27 Imris Inc Ｍｒ磁石のボアで使用するためのｍｒ適合性の蛍光表示デバイス
WO2012128162A1 (ja) 2011-03-18 2012-09-27 コニカミノルタエムジー株式会社 画像診断用シリカナノ粒子、その製造方法、及び生体物質標識剤
JP2012525883A (ja) * 2009-05-05 2012-10-25 ルミト・アーベー 散乱媒体の拡散ルミネセンスイメージングまたは断層撮影の改善のためのシステム、方法、およびルミネセンスマーカー

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207438A1 (en) 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2005017539A2 (en) * 2003-08-14 2005-02-24 The General Hospital Corporation Imaging pathology
WO2005063304A2 (en) * 2003-12-24 2005-07-14 Board Of Regents, The University Of Texas_System Poly (l-glutamic acid) paramagnetic material complex and use as a biodegradable mri contrast agent
EP1846042A2 (en) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
BRPI0519754A2 (pt) 2005-01-13 2009-03-10 Cinv Ag materiais compàsitos contendo nanopartÍculas de carbono
FI20055653L (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
DE102006021317B3 (de) * 2006-05-06 2007-10-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Fluoreszenzlichtmikroskop zum räumlich hochauflösenden Abbilden einer Struktur einer Probe
WO2008076467A2 (en) * 2006-07-03 2008-06-26 Beth Israel Deaconess Medical Center, Inc. Intraoperative imaging methods
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
EP2268320A4 (en) 2008-03-24 2014-10-01 Univ Texas IMAGING THERAPY OF MYOKARD DISEASE: COMPOSITION, MANUFACTURE AND APPLICATIONS
WO2009121055A1 (en) * 2008-03-28 2009-10-01 Georgia Tech Research Corporation Reduced dye probes for the detection of radical oxygen species
AU2009246822B2 (en) * 2008-03-31 2012-05-03 University Of Louisville Research Foundation, Inc. Site specific fluorescence marking and contrast marker for same
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
US20120083690A1 (en) * 2010-10-04 2012-04-05 Semenov Serguei Y System and method for electromagnetic imaging and therapeutics using specialized nanoparticles
KR101352342B1 (ko) * 2010-11-24 2014-02-17 서울대학교산학협력단 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
CN102167813B (zh) * 2011-01-19 2012-08-08 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102166365B (zh) * 2011-04-25 2012-10-24 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN102397562B (zh) * 2011-11-23 2012-11-28 南昌大学 一种由普鲁士蓝负载Gd3+的造影剂的制备方法
WO2013181119A1 (en) * 2012-06-01 2013-12-05 University Of Massachusetts Medical School Molecular probes for multimodality imaging and tracking of stem cells
US9903821B2 (en) 2013-05-01 2018-02-27 Indian Institute Of Technology Madras Coated mesoflowers for molecular detection and smart barcode materials
KR101567157B1 (ko) * 2013-12-13 2015-11-09 경북대학교 산학협력단 Mri/fi 조영제 및 이의 제조방법
JP7017410B2 (ja) * 2015-01-22 2022-02-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ｉｎ ｖｉｖｏ画像化のためのプロテアーゼ活性化コントラスト剤
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
CN107384385B (zh) * 2017-07-31 2020-10-30 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途
US12226494B2 (en) 2018-12-18 2025-02-18 Bracco Imaging S.P.A. Pharmaceutical compositions comprising Gd-complexes and polyarylene additives
CN110665015A (zh) * 2019-10-23 2020-01-10 中山大学 一种肿瘤微环境响应型荧光/磁共振双模态成像探针

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
JP2001503748A (ja) * 1996-10-30 2001-03-21 フォトゲン インク． 分子薬の光活性における選択性改善と検出のための方法
WO2001082974A2 (en) * 2000-04-21 2001-11-08 Bracco Imaging S.P.A. Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
JP2002514610A (ja) * 1998-05-14 2002-05-21 ザ ジュネラル ホスピタル コーポレーション 分子内発光抑制式近赤外蛍光プローブ
JP2002220348A (ja) * 1985-05-08 2002-08-09 General Hospital Corp 肝臓胆管のｎｍｒコントラスト剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002220348A (ja) * 1985-05-08 2002-08-09 General Hospital Corp 肝臓胆管のｎｍｒコントラスト剤
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6123921A (en) * 1996-07-31 2000-09-26 California Institute Of Technology Bifunctional detection agents having an optical dye linked to an MRI contrast agent
JP2001503748A (ja) * 1996-10-30 2001-03-21 フォトゲン インク． 分子薬の光活性における選択性改善と検出のための方法
JP2002514610A (ja) * 1998-05-14 2002-05-21 ザ ジュネラル ホスピタル コーポレーション 分子内発光抑制式近赤外蛍光プローブ
WO2001082974A2 (en) * 2000-04-21 2001-11-08 Bracco Imaging S.P.A. Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN7009004255, ＪＯＳＥＰＨＳＯＮ，Ｌ． ｅｔ ａｌ, "Ｎｅａｒ−ｉｎｆｒａｒｅｄ ｆｌｕｏｒｅｓｃｅｎｔ ｎａｎｏｐａｒｔｉｃｌｅｓ ａｓ ｃｏｍｂｉｎｅｄ ＭＲ／ｏｐｔｉｃａｌ ｉｍａｇｉｎｇ ｐｒｏｂｅｓ", Ｂｉｏｃｏｎｊｕｇ Ｃｈｅｍ, 2002, Ｖｏｌ．１３， Ｎｏ．３, ｐ．５５４−６０ *
JPN7009004256, ＨＵＢＥＲ，Ｍ．Ｍ． ｅｔ ａｌ, "Ｆｌｕｏｒｅｓｃｅｎｔｌｙ ｄｅｔｅｃｔａｂｌｅ ｍａｇｎｅｔｉｃ ｒｅｓｏｎａｎｃｅ ｉｍａｇｉｎｇ ａｇｅｎｔｓ", Ｂｉｏｃｏｎｊｕｇ Ｃｈｅｍ, 1998, Ｖｏｌ．９， Ｎｏ．２, ｐ．２４２−９ *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009535126A (ja) * 2006-04-27 2009-10-01 バーンズ−ジューイッシュ ホスピタル 標的組織の検出とイメージング
JP2012525883A (ja) * 2009-05-05 2012-10-25 ルミト・アーベー 散乱媒体の拡散ルミネセンスイメージングまたは断層撮影の改善のためのシステム、方法、およびルミネセンスマーカー
US9012869B2 (en) 2009-05-05 2015-04-21 Lumito Ab System, method, and luminescent marker for improved diffuse luminescent imaging or tomography in scattering media
JP2016135316A (ja) * 2009-05-05 2016-07-28 ルミト・アーベー 散乱媒体の拡散ルミネセンスイメージングまたは断層撮影の改善のためのシステム、方法、およびルミネセンスマーカー
JP2018128470A (ja) * 2009-05-05 2018-08-16 ルミト・アーベー 散乱媒体の拡散ルミネセンスイメージングまたは断層撮影の改善のためのシステム、方法、およびルミネセンスマーカー
WO2011109216A3 (en) * 2010-03-01 2012-01-12 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications
JP2012183308A (ja) * 2011-03-03 2012-09-27 Imris Inc Ｍｒ磁石のボアで使用するためのｍｒ適合性の蛍光表示デバイス
WO2012128162A1 (ja) 2011-03-18 2012-09-27 コニカミノルタエムジー株式会社 画像診断用シリカナノ粒子、その製造方法、及び生体物質標識剤
JPWO2012128162A1 (ja) * 2011-03-18 2014-07-24 コニカミノルタ株式会社 画像診断用シリカナノ粒子、その製造方法、及び生体物質標識剤

Also Published As

Publication number Publication date
US20040057903A1 (en) 2004-03-25
US7303741B2 (en) 2007-12-04
AU2003259769A1 (en) 2004-04-08
WO2004026344A1 (en) 2004-04-01
EP1545629A1 (en) 2005-06-29
CN1684710A (zh) 2005-10-19
US20080118439A1 (en) 2008-05-22

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