CN1684710A - 包括荧光染料和mri造影剂的双功能造影剂 - Google Patents

包括荧光染料和mri造影剂的双功能造影剂 Download PDF

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Publication number
CN1684710A
CN1684710A CN03822648.0A CN03822648A CN1684710A CN 1684710 A CN1684710 A CN 1684710A CN 03822648 A CN03822648 A CN 03822648A CN 1684710 A CN1684710 A CN 1684710A
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CN
China
Prior art keywords
detection agent
bifunctional
bifunctional detection
magnetic resonance
composition
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Pending
Application number
CN03822648.0A
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English (en)
Chinese (zh)
Inventor
利娜·汉卡
莫汉·M·阿马拉滕加
德尼塞·K·威克特
帕里托什·达瓦尔
内迪姆·艾沙克
费萨尔·A·斯尤德
布鲁斯·F·约翰逊
埃米·C·威廉斯
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General Electric Co
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General Electric Co
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Application filed by General Electric Co filed Critical General Electric Co
Publication of CN1684710A publication Critical patent/CN1684710A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN03822648.0A 2002-09-23 2003-08-11 包括荧光染料和mri造影剂的双功能造影剂 Pending CN1684710A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/252,311 US7303741B2 (en) 2002-09-23 2002-09-23 Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US10/252,311 2002-09-23

Publications (1)

Publication Number Publication Date
CN1684710A true CN1684710A (zh) 2005-10-19

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ID=31992929

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CN03822648.0A Pending CN1684710A (zh) 2002-09-23 2003-08-11 包括荧光染料和mri造影剂的双功能造影剂

Country Status (6)

Country Link
US (2) US7303741B2 (enExample)
EP (1) EP1545629A1 (enExample)
JP (1) JP2006511473A (enExample)
CN (1) CN1684710A (enExample)
AU (1) AU2003259769A1 (enExample)
WO (1) WO2004026344A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
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CN101484794B (zh) * 2006-05-06 2011-02-23 马克思-普朗克科学促进协会 用于试样结构的空间高分辨率成像的方法和荧光显微镜
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
CN102167813A (zh) * 2011-01-19 2011-08-31 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN107384385A (zh) * 2017-07-31 2017-11-24 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207438A1 (en) 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2005017539A2 (en) * 2003-08-14 2005-02-24 The General Hospital Corporation Imaging pathology
WO2005063304A2 (en) * 2003-12-24 2005-07-14 Board Of Regents, The University Of Texas_System Poly (l-glutamic acid) paramagnetic material complex and use as a biodegradable mri contrast agent
EP1846042A2 (en) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
BRPI0519754A2 (pt) 2005-01-13 2009-03-10 Cinv Ag materiais compàsitos contendo nanopartÍculas de carbono
FI20055653L (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
EP2019667A4 (en) * 2006-04-27 2012-08-22 Barnes Jewish Hospital DETECTION AND IMAGING OF TARGET TISSUE
WO2008076467A2 (en) * 2006-07-03 2008-06-26 Beth Israel Deaconess Medical Center, Inc. Intraoperative imaging methods
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
EP2268320A4 (en) 2008-03-24 2014-10-01 Univ Texas IMAGING THERAPY OF MYOKARD DISEASE: COMPOSITION, MANUFACTURE AND APPLICATIONS
WO2009121055A1 (en) * 2008-03-28 2009-10-01 Georgia Tech Research Corporation Reduced dye probes for the detection of radical oxygen species
AU2009246822B2 (en) * 2008-03-31 2012-05-03 University Of Louisville Research Foundation, Inc. Site specific fluorescence marking and contrast marker for same
US8440167B2 (en) * 2008-10-27 2013-05-14 University Of Virginia Patent Foundation Multimodal imaging of atherosclerotic plaque targeted to LOX-1
CA2760783C (en) * 2009-05-05 2018-06-19 Lumito Ab A system, method, and luminescent marker for improved diffuse luminescent imaging or tomography in scattering media
WO2011109216A2 (en) * 2010-03-01 2011-09-09 University Of Florida Research Foundation, Inc. Nir materials and nanomaterials for theranostic applications
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
US20120083690A1 (en) * 2010-10-04 2012-04-05 Semenov Serguei Y System and method for electromagnetic imaging and therapeutics using specialized nanoparticles
KR101352342B1 (ko) * 2010-11-24 2014-02-17 서울대학교산학협력단 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
EP2494936A3 (en) * 2011-03-03 2012-09-19 Imris Inc. MR compatible optical viewing device for use in the bore of an MR magnet
US20140039166A1 (en) * 2011-03-18 2014-02-06 Konica Minolta, Inc. Silica nanoparticle for diagnostic imaging, method for producing the same, and biosubstance labeling agent
CN102397562B (zh) * 2011-11-23 2012-11-28 南昌大学 一种由普鲁士蓝负载Gd3+的造影剂的制备方法
WO2013181119A1 (en) * 2012-06-01 2013-12-05 University Of Massachusetts Medical School Molecular probes for multimodality imaging and tracking of stem cells
US9903821B2 (en) 2013-05-01 2018-02-27 Indian Institute Of Technology Madras Coated mesoflowers for molecular detection and smart barcode materials
KR101567157B1 (ko) * 2013-12-13 2015-11-09 경북대학교 산학협력단 Mri/fi 조영제 및 이의 제조방법
JP7017410B2 (ja) * 2015-01-22 2022-02-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ｉｎ ｖｉｖｏ画像化のためのプロテアーゼ活性化コントラスト剤
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
US12226494B2 (en) 2018-12-18 2025-02-18 Bracco Imaging S.P.A. Pharmaceutical compositions comprising Gd-complexes and polyarylene additives
CN110665015A (zh) * 2019-10-23 2020-01-10 中山大学 一种肿瘤微环境响应型荧光/磁共振双模态成像探针

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5900228A (en) * 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5832931A (en) * 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484794B (zh) * 2006-05-06 2011-02-23 马克思-普朗克科学促进协会 用于试样结构的空间高分辨率成像的方法和荧光显微镜
CN101554481B (zh) * 2009-05-19 2011-04-13 泸州医学院附属医院 用于spect和mri的双功能显像剂及其制备方法
CN102167813A (zh) * 2011-01-19 2011-08-31 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102167813B (zh) * 2011-01-19 2012-08-08 兰州大学 一种荧光示踪纳米磁共振成像造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN102166365B (zh) * 2011-04-25 2012-10-24 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN107384385A (zh) * 2017-07-31 2017-11-24 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途
CN107384385B (zh) * 2017-07-31 2020-10-30 中山大学 MR/FL双模态成像探针及其制备方法以及掺杂Ho碳量子点的用途

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Publication number Publication date
JP2006511473A (ja) 2006-04-06
US20040057903A1 (en) 2004-03-25
US7303741B2 (en) 2007-12-04
AU2003259769A1 (en) 2004-04-08
WO2004026344A1 (en) 2004-04-01
EP1545629A1 (en) 2005-06-29
US20080118439A1 (en) 2008-05-22

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