JP2006510618A5 - - Google Patents
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- Publication number
- JP2006510618A5 JP2006510618A5 JP2004553852A JP2004553852A JP2006510618A5 JP 2006510618 A5 JP2006510618 A5 JP 2006510618A5 JP 2004553852 A JP2004553852 A JP 2004553852A JP 2004553852 A JP2004553852 A JP 2004553852A JP 2006510618 A5 JP2006510618 A5 JP 2006510618A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- phenyl
- pain
- oxo
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 52
- 208000002193 Pain Diseases 0.000 claims 33
- 230000036407 pain Effects 0.000 claims 29
- 239000000651 prodrug Substances 0.000 claims 28
- 229940002612 prodrug Drugs 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 15
- 239000012453 solvate Substances 0.000 claims 15
- 206010002091 Anaesthesia Diseases 0.000 claims 12
- 230000037005 anaesthesia Effects 0.000 claims 12
- 230000037396 body weight Effects 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- BEQZHFIKTBVCAU-LBPRGKRZSA-N (2s)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(N)CCCCC1=O BEQZHFIKTBVCAU-LBPRGKRZSA-N 0.000 claims 8
- BEQZHFIKTBVCAU-UHFFFAOYSA-N 2-amino-2-(2-chlorophenyl)-1-cyclohexanone Chemical compound C=1C=CC=C(Cl)C=1C1(N)CCCCC1=O BEQZHFIKTBVCAU-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 230000003444 anaesthetic effect Effects 0.000 claims 8
- 230000000202 analgesic effect Effects 0.000 claims 8
- 229960003299 ketamine Drugs 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 7
- LNJROULPSUMIKM-UHFFFAOYSA-N benzyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound ClC1=CC=CC=C1C1(NC(=O)OCC=2C=CC=CC=2)C(=O)CCCC1 LNJROULPSUMIKM-UHFFFAOYSA-N 0.000 claims 5
- HCZIRBMTVSUBQG-UHFFFAOYSA-N butyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OCCCC)CCCCC1=O HCZIRBMTVSUBQG-UHFFFAOYSA-N 0.000 claims 5
- JSMLYOVUWZPMRT-UHFFFAOYSA-N ethyl 2-[[1-(2-chlorophenyl)-2-oxocyclohexyl]amino]acetate Chemical compound C=1C=CC=C(Cl)C=1C1(NCC(=O)OCC)CCCCC1=O JSMLYOVUWZPMRT-UHFFFAOYSA-N 0.000 claims 5
- NFEDRUZLYVEQFI-UHFFFAOYSA-N ethyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OCC)CCCCC1=O NFEDRUZLYVEQFI-UHFFFAOYSA-N 0.000 claims 5
- VRURQRAMHBAFOK-UHFFFAOYSA-N phenyl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound ClC1=CC=CC=C1C1(NC(=O)OC=2C=CC=CC=2)C(=O)CCCC1 VRURQRAMHBAFOK-UHFFFAOYSA-N 0.000 claims 5
- BJHGQFPMVBHYLW-UHFFFAOYSA-N propan-2-yl n-[1-(2-chlorophenyl)-2-oxocyclohexyl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C1(NC(=O)OC(C)C)CCCCC1=O BJHGQFPMVBHYLW-UHFFFAOYSA-N 0.000 claims 5
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 claims 4
- 208000000003 Breakthrough pain Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 4
- 230000035606 childbirth Effects 0.000 claims 4
- 208000004296 neuralgia Diseases 0.000 claims 4
- 208000021722 neuropathic pain Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- -1 azaaryl Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000002270 dispersing agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000007975 buffered saline Substances 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000008223 sterile water Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42679302P | 2002-11-18 | 2002-11-18 | |
| PCT/US2003/036789 WO2004045601A1 (en) | 2002-11-18 | 2003-11-18 | Analgesic uses of norketamine and ketamine/norketamine prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006510618A JP2006510618A (ja) | 2006-03-30 |
| JP2006510618A5 true JP2006510618A5 (cg-RX-API-DMAC10.html) | 2007-01-25 |
Family
ID=32326427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004553852A Withdrawn JP2006510618A (ja) | 2002-11-18 | 2003-11-18 | ノルケタミンおよびケタミン／ノルケタミンプロドラッグの鎮痛的使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040248964A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2027854A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2006510618A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE432697T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2003291037A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2506615A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE60327883D1 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ540282A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2004045601A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523031D0 (en) * | 2005-11-11 | 2005-12-21 | Yaupon Therapeutics | Enhancement of morphine analgesia by s(-)-norketamine |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8252328B2 (en) | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US20070260491A1 (en) * | 2006-05-08 | 2007-11-08 | Pamela Palmer | System for delivery and monitoring of administration of controlled substances |
| WO2009131794A1 (en) * | 2008-03-27 | 2009-10-29 | University Of Kentucky Research Foundation | Opioid-ketamine and norketamine codrug combinations for pain management |
| AU2009296457A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| US8945592B2 (en) | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| EP2454226B1 (en) * | 2009-07-16 | 2017-03-22 | Solvay Fluor GmbH | Process for the preparation of fluoroalkyl (fluoro)alkyl carbonates |
| JP6296985B2 (ja) * | 2011-10-14 | 2018-03-20 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | うつ病及び神経障害性疼痛の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミン、（ｓ）−デヒドロノルケタミン及び他の（ｒ，ｓ）−ケタミンの立体異性デヒドロ及びヒドロキシル化代謝生成物の使用 |
| US20120323214A1 (en) * | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| US20140079740A1 (en) * | 2012-08-02 | 2014-03-20 | ClinPharm Support GmbH | Oral transmucosal adminstration forms of s-ketamine |
| AU2013328280B2 (en) * | 2012-10-08 | 2017-12-21 | Auckland Uniservices Limited | Ketamine derivatives |
| US20140274981A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| KR20220044380A (ko) | 2013-04-12 | 2022-04-07 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 외상후 스트레스 장애의 치료 방법 |
| DK3043785T3 (da) | 2013-09-13 | 2021-11-15 | Univ Chiba Nat Univ Corp | Anvendelse af r-ketamin og salt deraf som lægemidler |
| WO2015101693A1 (es) * | 2013-12-31 | 2015-07-09 | Servicio Andaluz De Salud | Composiciones y preparaciones combinadas para el tratamiento de las algias orofaríngeas |
| CA2936809A1 (en) | 2014-01-14 | 2015-07-23 | Children's Hospital Medical Center | Compositions comprising ketamine for treating an autism spectrum disorder |
| EP3193853A1 (en) | 2014-09-15 | 2017-07-26 | Janssen Pharmaceutica NV | VAL66MET (SNP rs6265) GENOTYPE SPECIFIC DOSING REGIMENS AND METHODS FOR THE TREATMENT OF DEPRESSION |
| KR102604397B1 (ko) | 2014-11-04 | 2023-11-21 | 아카디아 파마슈티칼스 인코포레이티드 | 신경 감쇠 케타민 및 노르케타민 화합물, 이의 유도체, 및 방법 |
| BR112017013311B1 (pt) | 2014-12-23 | 2022-05-31 | Acelrx Pharmaceuticals, Inc | Aparelho para a dispensação de formas de dosagem via oral e transmucosal |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| US11426366B2 (en) | 2015-05-15 | 2022-08-30 | Arizona Board Of Regents On Behalf Of The Universsity Of Arizona | Compositions and methods for treating motor disorders |
| AU2016280161B2 (en) * | 2015-06-19 | 2019-02-21 | Harrow Ip, Llc | Pharmaceutical compositions for anesthesiological applications |
| CN107847469A (zh) | 2015-06-27 | 2018-03-27 | 美国神农制药责任有限公司 | 氯胺酮透皮递送系统 |
| US11827606B2 (en) | 2015-11-18 | 2023-11-28 | Spirify Pharma Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| WO2017087388A1 (en) * | 2015-11-18 | 2017-05-26 | Mitchell Woods Pharmaceuticals, Inc. | Phenyl cyclohexanone derivatives and methods of making and using them |
| KR20180084049A (ko) | 2015-11-19 | 2018-07-24 | 바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. | 제약 화합물의 아민 전구약물 |
| US11006661B2 (en) * | 2016-08-15 | 2021-05-18 | Mamood Valadi | Cigarette-like device for administration of substances |
| EP3507277B8 (en) * | 2016-08-31 | 2021-03-03 | Dart NeuroScience, LLC | Hydroxynorketamine derivatives for the treatment of disorders |
| US9963435B2 (en) | 2016-08-31 | 2018-05-08 | Dart Neuroscience, Llc | Compounds for therapeutic use |
| WO2018079693A1 (ja) * | 2016-10-27 | 2018-05-03 | 国立大学法人 千葉大学 | （ｓ）－ノルケタミンおよびその塩の医薬品としての応用 |
| JP7069295B2 (ja) | 2017-08-17 | 2022-05-17 | エックスダブリューファルマ リミテッド | 活性酸素種スカベンジャー誘導体の調製および使用 |
| CN111356699B (zh) | 2017-09-04 | 2022-08-23 | 凯瑞康宁生物工程（武汉）有限公司 | 活性氧清除剂的制备及用途 |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| WO2019065900A1 (ja) * | 2017-09-27 | 2019-04-04 | 国立大学法人千葉大学 | 神経変性疾患あるいは認知機能障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 |
| SG11202005896WA (en) | 2017-12-22 | 2020-07-29 | Janssen Pharmaceuticals Inc | Esketamine for the treatment of depression |
| DK3505157T3 (da) * | 2017-12-29 | 2022-02-28 | Celon Pharma Sa | Tørpulver-ketaminsammensætning til pulmonal indgivelse ved behandlingsresistent depression |
| CN114805139B (zh) * | 2018-01-10 | 2023-10-20 | 凯瑞康宁生物工程（武汉）有限公司 | 氯胺酮的前药、其组合物和用途 |
| WO2019160057A1 (ja) | 2018-02-15 | 2019-08-22 | 国立大学法人千葉大学 | 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物 |
| CN118121577A (zh) | 2018-05-04 | 2024-06-04 | 感知神经科学公司 | 治疗物质滥用的方法 |
| EP3934632A4 (en) | 2019-03-05 | 2022-11-23 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| CN110538169B (zh) * | 2019-05-24 | 2020-08-25 | 北京大学深圳研究生院 | 一种长效化合物在制备药物中的应用 |
| EP4168385A4 (en) | 2020-06-17 | 2024-07-17 | Spirify Pharma Inc. | HYDROXYNORKETAMINE ANALOGS, COMPOSITIONS COMPRISING THEM AND METHODS OF USE THEREOF |
| US11753378B2 (en) * | 2021-04-19 | 2023-09-12 | Zevra Therapeutics, Inc. | Ketamine compounds and processes for making and using them |
| TWI844074B (zh) | 2021-08-13 | 2024-06-01 | 凱瑞康寧生技股份有限公司 | 氯胺酮衍生物之醫藥組成物及口服劑型 |
| EP4289815A1 (en) | 2022-06-10 | 2023-12-13 | Pcas | Crystalline forms of norketamine |
| EP4577305A4 (en) * | 2022-08-25 | 2026-07-29 | Univ Columbia | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND ANOTHER NEURODEGENERATIVE DISEASE |
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| US713A (en) | 1838-04-25 | Improvement in many-chambered-cylinder fire-arms | ||
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| AU706195B2 (en) | 1995-04-14 | 1999-06-10 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
| WO1997007750A1 (en) * | 1995-08-30 | 1997-03-06 | Weg Stuart L | Administration of ketamine to manage pain and to reduce drug dependency |
| AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
| US6248789B1 (en) | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| EP1132082A1 (en) * | 1996-11-05 | 2001-09-12 | Head Explorer ApS | Use of substances capable of blocking the production of glutamate for treating tension-type headache |
| CA2294480C (en) | 1997-06-23 | 2008-05-20 | Queen's University At Kingston | Microdose therapy of female sexual dysfunction by no, co, and their donors |
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| US20050148673A1 (en) * | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
-
2003
- 2003-11-18 JP JP2004553852A patent/JP2006510618A/ja not_active Withdrawn
- 2003-11-18 EP EP08168894A patent/EP2027854A1/en not_active Withdrawn
- 2003-11-18 AU AU2003291037A patent/AU2003291037A1/en not_active Abandoned
- 2003-11-18 US US10/714,643 patent/US20040248964A1/en not_active Abandoned
- 2003-11-18 CA CA002506615A patent/CA2506615A1/en not_active Abandoned
- 2003-11-18 DE DE60327883T patent/DE60327883D1/de not_active Expired - Fee Related
- 2003-11-18 EP EP03783623A patent/EP1567145B1/en not_active Expired - Lifetime
- 2003-11-18 WO PCT/US2003/036789 patent/WO2004045601A1/en not_active Ceased
- 2003-11-18 NZ NZ540282A patent/NZ540282A/en unknown
- 2003-11-18 AT AT03783623T patent/ATE432697T1/de not_active IP Right Cessation
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