|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4943529A
(en)
|
1982-05-19 |
1990-07-24 |
Gist-Brocades Nv |
Kluyveromyces as a host strain
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
AU2353384A
(en)
|
1983-01-19 |
1984-07-26 |
Genentech Inc. |
Amplification in eukaryotic host cells
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4675187A
(en)
|
1983-05-16 |
1987-06-23 |
Bristol-Myers Company |
BBM-1675, a new antibiotic complex
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
AU3145184A
(en)
|
1983-08-16 |
1985-02-21 |
Zymogenetics Inc. |
High expression of foreign genes in schizosaccharomyces pombe
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4736866B1
(en)
|
1984-06-22 |
1988-04-12 |
|
Transgenic non-human mammals
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
EP0272253A4
(en)
|
1986-03-07 |
1990-02-05 |
Massachusetts Inst Technology |
METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946783A
(en)
|
1987-01-30 |
1990-08-07 |
President And Fellows Of Harvard College |
Periplasmic protease mutants of Escherichia coli
|
|
US5010182A
(en)
|
1987-07-28 |
1991-04-23 |
Chiron Corporation |
DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
|
|
IL87737A
(en)
|
1987-09-11 |
1993-08-18 |
Genentech Inc |
Method for culturing polypeptide factor dependent vertebrate recombinant cells
|
|
GB8724885D0
(en)
|
1987-10-23 |
1987-11-25 |
Binns M M |
Fowlpox virus promotors
|
|
JPH04501201A
(ja)
|
1987-12-21 |
1992-03-05 |
ジ・アップジョン・カンパニー |
発芽植物種子類のアグロバクテリウム媒介形質転換
|
|
AU4005289A
(en)
|
1988-08-25 |
1990-03-01 |
Smithkline Beecham Corporation |
Recombinant saccharomyces
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
DE394538T1
(de)
|
1989-04-28 |
1991-04-11 |
Rhein Biotech Ges. Fuer Biotechnologische Prozesse Und Produkte Mbh, 4000 Duesseldorf |
Hefezellen der schwanniomyces-gattung.
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ATE144793T1
(de)
|
1989-06-29 |
1996-11-15 |
Medarex Inc |
Bispezifische reagenzien für die aids-therapie
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
US5206161A
(en)
|
1991-02-01 |
1993-04-27 |
Genentech, Inc. |
Human plasma carboxypeptidase B
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
AU3178993A
(en)
|
1991-11-25 |
1993-06-28 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ES2091684T3
(es)
|
1992-11-13 |
1996-11-01 |
Idec Pharma Corp |
Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
|
|
EP0616812B1
(en)
|
1993-03-24 |
1999-11-03 |
Berlex Biosciences |
Combination with anti-hormonal compounds and binding molecules for the treatment of cancer
|
|
US5989811A
(en)
*
|
1994-09-29 |
1999-11-23 |
Urocor, Inc. |
Sextant core biopsy predictive mechanism for non-organ confined disease status
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5750345A
(en)
*
|
1995-10-31 |
1998-05-12 |
Evanston Hospital Corporation |
Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
|
|
US6458939B1
(en)
|
1996-03-15 |
2002-10-01 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
|
|
KR100532178B1
(ko)
|
1996-11-27 |
2005-12-01 |
제넨테크, 인크. |
인간화 항-CD11a 항체
|
|
AU4228699A
(en)
|
1998-06-03 |
1999-12-20 |
Northwestern University |
Cellular proteins which mediate herpesvirus entry
|
|
US6518033B1
(en)
|
1998-08-05 |
2003-02-11 |
The Research Foundation Of State University Of New York |
Method of detecting the presence of CD155 for diagnosis of cancer and to determine treatment
|
|
KR20010103046A
(ko)
*
|
1999-03-08 |
2001-11-17 |
제넨테크, 인크. |
면역 관련 질환 치료용 조성물 및 치료 방법
|
|
CA2368467A1
(en)
*
|
1999-03-26 |
2000-10-05 |
Human Genome Sciences, Inc. |
50 human secreted proteins
|
|
US7282570B2
(en)
*
|
1999-04-20 |
2007-10-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
AU4011300A
(en)
*
|
1999-07-20 |
2001-02-05 |
Genentech Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US20080050809A1
(en)
*
|
1999-09-28 |
2008-02-28 |
Alejandro Abuin |
Novel human kinases and polynucleotides encoding the same
|
|
WO2001029221A2
(en)
|
1999-10-20 |
2001-04-26 |
Zymogenetics, Inc. |
Proteins and polynucleotides encoding them
|
|
US20040219521A1
(en)
*
|
2000-01-21 |
2004-11-04 |
Tang Y. Tom |
Novel nucleic acids and polypeptides
|
|
IL151865A0
(en)
|
2000-03-31 |
2003-04-10 |
Genentech Inc |
Compositions and methods for detecting and quantifying gene expression
|
|
WO2001075116A2
(en)
|
2000-04-04 |
2001-10-11 |
Schering Corporation |
ISOLATED NUCLEIC ACIDS FROM MICROMONOSPORA ROSARIA PLASMID pMR2 AND VECTORS MADE THEREFROM
|
|
US6965018B2
(en)
|
2000-06-06 |
2005-11-15 |
Bristol-Myers Squibb Company |
Antibodies directed to B7-related polypeptide, BSL-2
|
|
US7713705B2
(en)
*
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
|
US20040101876A1
(en)
|
2002-05-31 |
2004-05-27 |
Liat Mintz |
Methods and systems for annotating biomolecular sequences
|
|
CA2469941A1
(en)
|
2001-12-10 |
2003-07-03 |
Nuvelo, Inc. |
Novel nucleic acids and polypeptides
|
|
WO2003068943A2
(en)
*
|
2002-02-13 |
2003-08-21 |
Incyte Corporation |
Secreted proteins
|
|
WO2003072035A2
(en)
|
2002-02-22 |
2003-09-04 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US7193069B2
(en)
*
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
|
AU2003281200A1
(en)
|
2002-07-03 |
2004-01-23 |
Tasuku Honjo |
Immunopotentiating compositions
|
|
JP2006521082A
(ja)
|
2002-09-11 |
2006-09-21 |
ジェネンテック・インコーポレーテッド |
免疫関連疾患の治療のための新規組成物と方法
|
|
ES2357505T3
(es)
|
2002-09-11 |
2011-04-27 |
Genentech, Inc. |
Composición y procedimientos novedosos para el tratamiento de enfermedades inmunorelacionadas.
|
|
EP1481993A1
(en)
|
2003-05-28 |
2004-12-01 |
Xerion Pharmaceuticals AG |
Modulation of the poliovirus receptor function
|
|
TW200526684A
(en)
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
|
AR047729A1
(es)
|
2003-11-28 |
2006-02-15 |
Astrazeneca Ab |
Anticuerpos terapeuticos que se unen a la apolipoproteina e (apoe)
|
|
CN101035807A
(zh)
|
2004-06-09 |
2007-09-12 |
泰勒公司 |
Siglec-6相关疾病的诊断和治疗
|
|
TW200630106A
(en)
|
2004-10-08 |
2006-09-01 |
Wyeth Corp |
Immunotherapy of autoimmune disorders
|
|
CN109485727A
(zh)
|
2005-05-09 |
2019-03-19 |
小野药品工业株式会社 |
程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
|
|
US20070054360A1
(en)
|
2005-05-12 |
2007-03-08 |
Zeren Gao |
Compositions and methods for modulating immune responses
|
|
US20070243584A1
(en)
|
2006-04-13 |
2007-10-18 |
West James W |
Tetramerizing polypeptides and methods of use
|
|
US20100075377A1
(en)
|
2006-04-13 |
2010-03-25 |
West James W |
Tetramerizing polypeptides and methods of use
|
|
EP2004682A2
(en)
|
2006-04-13 |
2008-12-24 |
Zymogenetics, Inc. |
Tetramerizing polypeptides and methods of use
|
|
WO2007124383A2
(en)
|
2006-04-19 |
2007-11-01 |
Oregon Health & Science University |
1,1'-binaphthyl-based inhibitors of nad+-dependent deacetylase activity and sir2-family members
|
|
MX2010011088A
(es)
|
2008-04-09 |
2010-11-05 |
Genentech Inc |
Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
|
|
WO2010077634A1
(en)
|
2008-12-09 |
2010-07-08 |
Genentech, Inc. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
|
US8822642B2
(en)
|
2010-06-09 |
2014-09-02 |
Zymogenetics, Inc. |
Dimeric fusion proteins and related compositions and methods
|
|
AR087405A1
(es)
|
2011-08-01 |
2014-03-19 |
Genentech Inc |
Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek
|
|
AU2012369202A1
(en)
|
2012-02-06 |
2014-09-25 |
Providence Health & Services - Oregon |
Cancer treatment and monitoring methods using OX40 agonists
|
|
DK2925350T3
(da)
|
2012-12-03 |
2019-05-13 |
Bristol Myers Squibb Co |
Øgning af virksomheden mod cancer af immunomodulatoriske fc- fusionsproteiner
|
|
US9327014B2
(en)
|
2012-12-04 |
2016-05-03 |
Oncomed Pharmaceuticals, Inc. |
Immunotherapy with binding agents
|
|
EP2948475A2
(en)
|
2013-01-23 |
2015-12-02 |
AbbVie Inc. |
Methods and compositions for modulating an immune response
|
|
DK3021869T3
(da)
|
2013-07-16 |
2020-09-21 |
Hoffmann La Roche |
Fremgangsmåder til behandling af cancer ved anvendelse af PD-1-aksebindende antagonister og TIGIT-hæmmere
|
|
RU2016142476A
(ru)
|
2014-03-31 |
2018-05-07 |
Дженентек, Инк. |
Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40
|
|
EP3632934A1
(en)
|
2014-03-31 |
2020-04-08 |
F. Hoffmann-La Roche AG |
Anti-ox40 antibodies and methods of use
|
|
WO2016011264A1
(en)
|
2014-07-16 |
2016-01-21 |
Genentech, Inc. |
Methods of treating cancer using tigit inhibitors and anti-cancer agents
|
|
RU2017119428A
(ru)
|
2014-11-06 |
2018-12-06 |
Дженентек, Инк. |
Комбинированная терапия, включающая применение агонистов, связывающихся с ох40, и ингибиторов tigit
|
|
EP3353210B8
(en)
|
2015-09-25 |
2024-12-18 |
F. Hoffmann-La Roche AG |
Anti-tigit antibodies and methods of use
|