|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4943529A
(en)
|
1982-05-19 |
1990-07-24 |
Gist-Brocades Nv |
Kluyveromyces as a host strain
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
AU2353384A
(en)
|
1983-01-19 |
1984-07-26 |
Genentech Inc. |
Amplification in eukaryotic host cells
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4675187A
(en)
|
1983-05-16 |
1987-06-23 |
Bristol-Myers Company |
BBM-1675, a new antibiotic complex
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
AU3145184A
(en)
|
1983-08-16 |
1985-02-21 |
Zymogenetics Inc. |
High expression of foreign genes in schizosaccharomyces pombe
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4736866B1
(en)
|
1984-06-22 |
1988-04-12 |
|
Transgenic non-human mammals
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
JPS63502716A
(ja)
|
1986-03-07 |
1988-10-13 |
マサチューセッツ・インステチュート・オブ・テクノロジー |
糖タンパク安定性の強化方法
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946783A
(en)
|
1987-01-30 |
1990-08-07 |
President And Fellows Of Harvard College |
Periplasmic protease mutants of Escherichia coli
|
|
US5010182A
(en)
|
1987-07-28 |
1991-04-23 |
Chiron Corporation |
DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
|
|
IL87737A
(en)
|
1987-09-11 |
1993-08-18 |
Genentech Inc |
Method for culturing polypeptide factor dependent vertebrate recombinant cells
|
|
GB8724885D0
(en)
|
1987-10-23 |
1987-11-25 |
Binns M M |
Fowlpox virus promotors
|
|
US5169770A
(en)
|
1987-12-21 |
1992-12-08 |
The University Of Toledo |
Agrobacterium mediated transformation of germinating plant seeds
|
|
AU4005289A
(en)
|
1988-08-25 |
1990-03-01 |
Smithkline Beecham Corporation |
Recombinant saccharomyces
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
ES2038579T3
(es)
|
1989-04-28 |
1997-02-16 |
Rhein Biotech Proz & Prod Gmbh |
Celulas de levadura del genero schwanniomyces.
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
DE69029036T2
(de)
|
1989-06-29 |
1997-05-22 |
Medarex Inc |
Bispezifische reagenzien für die aids-therapie
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
US5206161A
(en)
|
1991-02-01 |
1993-04-27 |
Genentech, Inc. |
Human plasma carboxypeptidase B
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
EP0617706B1
(en)
|
1991-11-25 |
2001-10-17 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
WO1994011026A2
(en)
|
1992-11-13 |
1994-05-26 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
|
|
EP0616812B1
(en)
|
1993-03-24 |
1999-11-03 |
Berlex Biosciences |
Combination with anti-hormonal compounds and binding molecules for the treatment of cancer
|
|
US5989811A
(en)
*
|
1994-09-29 |
1999-11-23 |
Urocor, Inc. |
Sextant core biopsy predictive mechanism for non-organ confined disease status
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5750345A
(en)
*
|
1995-10-31 |
1998-05-12 |
Evanston Hospital Corporation |
Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
|
|
US6458939B1
(en)
|
1996-03-15 |
2002-10-01 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
|
|
DK1516629T3
(da)
|
1996-11-27 |
2013-06-03 |
Genentech Inc |
Humaniseret anti-CD-11a antibodies
|
|
WO1999063063A1
(en)
|
1998-06-03 |
1999-12-09 |
Northwestern University |
Cellular proteins which mediate herpesvirus entry
|
|
US6518033B1
(en)
|
1998-08-05 |
2003-02-11 |
The Research Foundation Of State University Of New York |
Method of detecting the presence of CD155 for diagnosis of cancer and to determine treatment
|
|
AU3514400A
(en)
*
|
1999-03-08 |
2000-09-28 |
Genentech Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
JP2002539814A
(ja)
*
|
1999-03-26 |
2002-11-26 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
50個のヒト分泌タンパク質
|
|
US7282570B2
(en)
*
|
1999-04-20 |
2007-10-16 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
ATE368110T1
(de)
*
|
1999-07-20 |
2007-08-15 |
Genentech Inc |
Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
|
|
US20080050809A1
(en)
*
|
1999-09-28 |
2008-02-28 |
Alejandro Abuin |
Novel human kinases and polynucleotides encoding the same
|
|
AU1220001A
(en)
|
1999-10-20 |
2001-04-30 |
Zymogenetics Inc. |
Novel proteins and polynucleotides encoding them
|
|
US20040219521A1
(en)
*
|
2000-01-21 |
2004-11-04 |
Tang Y. Tom |
Novel nucleic acids and polypeptides
|
|
AU2001249727A1
(en)
|
2000-03-31 |
2001-10-15 |
Genentech, Inc. |
Compositions and methods for detecting and quantifying gene expression
|
|
AU2001249673A1
(en)
|
2000-04-04 |
2001-10-15 |
Schering Corporation |
Isolated nucleic acids from micromonospora rosaria plasmid pmr2 and vectors made therefrom
|
|
ES2300340T3
(es)
|
2000-06-06 |
2008-06-16 |
Bristol-Myers Squibb Company |
Acidos nucleicos y polipeptidos relacionados con b7 y sus usos para inmunomodulacion.
|
|
US7713705B2
(en)
*
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
|
US20040101876A1
(en)
|
2002-05-31 |
2004-05-27 |
Liat Mintz |
Methods and systems for annotating biomolecular sequences
|
|
AU2002366951A1
(en)
|
2001-12-10 |
2003-07-09 |
Nuvelo,Inc. |
Novel nucleic acids and polypeptides
|
|
AU2003211112A1
(en)
*
|
2002-02-13 |
2003-09-04 |
Incyte Corporation |
Secreted proteins
|
|
CA2476518A1
(en)
|
2002-02-22 |
2003-09-04 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
US7193069B2
(en)
|
2002-03-22 |
2007-03-20 |
Research Association For Biotechnology |
Full-length cDNA
|
|
ATE481985T1
(de)
|
2002-07-03 |
2010-10-15 |
Ono Pharmaceutical Co |
Immunpotenzierende zusammensetzungen
|
|
AU2003270439B2
(en)
|
2002-09-11 |
2009-09-24 |
Genentech, Inc. |
Novel composition and methods for the treatment of immune related diseases
|
|
AU2003276874B2
(en)
|
2002-09-11 |
2009-09-03 |
Genentech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
EP1481993A1
(en)
|
2003-05-28 |
2004-12-01 |
Xerion Pharmaceuticals AG |
Modulation of the poliovirus receptor function
|
|
TW200526684A
(en)
|
2003-11-21 |
2005-08-16 |
Schering Corp |
Anti-IGFR1 antibody therapeutic combinations
|
|
EP2343318A3
(en)
|
2003-11-28 |
2013-02-27 |
MedImmune Limited |
Antibodies binding to a C-terminal fragment of apolipoprotein E
|
|
CN101035807A
(zh)
|
2004-06-09 |
2007-09-12 |
泰勒公司 |
Siglec-6相关疾病的诊断和治疗
|
|
AR052774A1
(es)
|
2004-10-08 |
2007-04-04 |
Wyeth Corp |
Inmunoterapia para trastornos autoinmunes
|
|
KR101498834B1
(ko)
|
2005-05-09 |
2015-03-05 |
오노 야꾸힝 고교 가부시키가이샤 |
예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
|
|
ATE515512T1
(de)
|
2005-05-12 |
2011-07-15 |
Zymogenetics Inc |
Zusammensetzungen und verfahren zur modulierung von immunreaktionen
|
|
US20100075377A1
(en)
|
2006-04-13 |
2010-03-25 |
West James W |
Tetramerizing polypeptides and methods of use
|
|
WO2007124283A2
(en)
|
2006-04-13 |
2007-11-01 |
Zymogenetics, Inc. |
Tetramerizing polypeptides and methods of use
|
|
CA2648925A1
(en)
|
2006-04-13 |
2007-10-25 |
Zymogenetics, Inc. |
Tetramerizing polypeptides and methods of use
|
|
WO2007124383A2
(en)
|
2006-04-19 |
2007-11-01 |
Oregon Health & Science University |
1,1'-binaphthyl-based inhibitors of nad+-dependent deacetylase activity and sir2-family members
|
|
PL3208612T3
(pl)
|
2008-04-09 |
2020-03-31 |
Genentech, Inc. |
Kompozycje i sposoby leczenia chorób o podłożu immunologicznym
|
|
CA3120172A1
(en)
|
2008-12-09 |
2010-07-08 |
Genentech, Inc. |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
|
CA2802017A1
(en)
|
2010-06-09 |
2011-12-15 |
Zymogenetics, Inc. |
Dimeric vstm3 fusion proteins and related compositions and methods
|
|
TWI835048B
(zh)
|
2011-08-01 |
2024-03-11 |
美商建南德克公司 |
利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
|
|
EP2812022B1
(en)
|
2012-02-06 |
2019-06-26 |
Providence Health & Services - Oregon |
Method of monitoring cancer treatment using ox40 agonists
|
|
US20150322119A1
(en)
|
2012-12-03 |
2015-11-12 |
Bristol-Myers Squibb Company |
Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
|
|
TW201439115A
(zh)
|
2012-12-04 |
2014-10-16 |
Oncomed Pharm Inc |
使用結合劑之免疫治療
|
|
WO2014116846A2
(en)
|
2013-01-23 |
2014-07-31 |
Abbvie, Inc. |
Methods and compositions for modulating an immune response
|
|
MX384142B
(es)
|
2013-07-16 |
2025-03-14 |
Genentech Inc |
Antagonista de unión al eje pd-1 e inhibidores de tigit para usarse en el tratamiento de cáncer.
|
|
CA2943834A1
(en)
|
2014-03-31 |
2015-10-08 |
Genentech, Inc. |
Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
|
|
JP6637439B2
(ja)
|
2014-03-31 |
2020-01-29 |
ジェネンテック, インコーポレイテッド |
抗ox40抗体及び使用方法
|
|
CR20170014A
(es)
|
2014-07-16 |
2017-10-17 |
Hoffmann La Roche |
Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer
|
|
CA2963974A1
(en)
|
2014-11-06 |
2016-05-12 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and tigit inhibitors
|
|
HUE069796T2
(hu)
|
2015-09-25 |
2025-04-28 |
Hoffmann La Roche |
Anti-TIGIT ellenanyagok és alkalmazásukra szolgáló eljárások
|