JP2006508192A - 抗細菌薬としてのオキサゾリジノンおよび/またはイソオキサゾリン誘導体 - Google Patents

抗細菌薬としてのオキサゾリジノンおよび/またはイソオキサゾリン誘導体 Download PDF

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Publication number
JP2006508192A
JP2006508192A JP2005510253A JP2005510253A JP2006508192A JP 2006508192 A JP2006508192 A JP 2006508192A JP 2005510253 A JP2005510253 A JP 2005510253A JP 2005510253 A JP2005510253 A JP 2005510253A JP 2006508192 A JP2006508192 A JP 2006508192A
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JP
Japan
Prior art keywords
alkyl
ring
group
alkoxy
substituted
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Pending
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JP2005510253A
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English (en)
Japanese (ja)
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JP2006508192A5 (enExample
Inventor
カーカナグ,ダニエル・ロバート
グレイブストック,マイケル・バリー
ヘイルズ,ニール・ジェームズ
ハウック,シーラ・アイリーン
ウェーバー,トーマス・ピーター
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AstraZeneca AB
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AstraZeneca AB
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Filing date
Publication date
Priority claimed from GB0227702A external-priority patent/GB0227702D0/en
Priority claimed from GB0304725A external-priority patent/GB0304725D0/en
Priority claimed from GB0318608A external-priority patent/GB0318608D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2006508192A publication Critical patent/JP2006508192A/ja
Publication of JP2006508192A5 publication Critical patent/JP2006508192A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2005510253A 2002-11-28 2003-11-24 抗細菌薬としてのオキサゾリジノンおよび/またはイソオキサゾリン誘導体 Pending JP2006508192A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0227702A GB0227702D0 (en) 2002-11-28 2002-11-28 Chemical compounds
GB0304725A GB0304725D0 (en) 2003-03-01 2003-03-01 Chemical compounds
GB0318608A GB0318608D0 (en) 2003-08-08 2003-08-08 Chemical compounds
PCT/GB2003/005087 WO2004048392A1 (en) 2002-11-28 2003-11-24 Oxazolidinone and / or isoxazoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
JP2006508192A true JP2006508192A (ja) 2006-03-09
JP2006508192A5 JP2006508192A5 (enExample) 2007-01-25

Family

ID=32397650

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005510253A Pending JP2006508192A (ja) 2002-11-28 2003-11-24 抗細菌薬としてのオキサゾリジノンおよび/またはイソオキサゾリン誘導体

Country Status (15)

Country Link
US (1) US20060116400A1 (enExample)
EP (1) EP1567532A1 (enExample)
JP (1) JP2006508192A (enExample)
KR (1) KR20050085193A (enExample)
AU (1) AU2003302404B2 (enExample)
BR (1) BR0316688A (enExample)
CA (1) CA2507468A1 (enExample)
HK (1) HK1079794A1 (enExample)
IL (1) IL168747A0 (enExample)
MX (1) MXPA05005651A (enExample)
NO (1) NO20052534L (enExample)
NZ (1) NZ540147A (enExample)
SA (1) SA04250088A (enExample)
TW (1) TW200533666A (enExample)
WO (1) WO2004048392A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519247A (ja) * 2003-03-01 2006-08-24 アストラゼネカ アクチボラグ 抗生物質として有用なヒドロキシメチル置換ジヒドロイソオキサゾール誘導体
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP2015505846A (ja) * 2011-12-19 2015-02-26 サウディ ベーシック インダストリーズ コーポレイション メタロセン錯体を調製するプロセス
JP2015506916A (ja) * 2011-12-19 2015-03-05 サウディ ベーシック インダストリーズ コーポレイション メタロセン錯体を調製するプロセス

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0401005A3 (en) * 2001-09-11 2007-11-28 Astrazeneca Ab Oxazolidinone and/or isoxazoline antibacterials, process for their preparation, their use and pharmaceutical compositions containing them
AU2003207340A1 (en) 2002-02-28 2003-09-09 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
AU2003209994A1 (en) 2002-02-28 2003-09-09 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
US7498350B2 (en) 2002-11-28 2009-03-03 Astrazeneca Ab Oxazolidinones as antibacterial agents
SG2009082793A (en) 2003-06-03 2015-03-30 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1660465B1 (en) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
WO2005116024A1 (en) * 2004-05-25 2005-12-08 Astrazeneca Ab 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections
ATE496914T1 (de) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
US8426389B2 (en) 2009-02-03 2013-04-23 Trius Therapeutics, Inc. Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
WO2021000297A1 (en) 2019-07-03 2021-01-07 Merck Sharp & Dohme Corp. Compounds and methods of use thereof as antibacterial agents
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JP2003535860A (ja) * 2000-06-05 2003-12-02 ドン・ア・ファーム・カンパニー・リミテッド 新規なオキサゾリジノン誘導体及びその製造方法
JP2005507386A (ja) * 2001-09-11 2005-03-17 アストラゼネカ アクチボラグ 抗菌剤としてのオキサゾリジノン及び/又はイソオキサゾリン
JP2006515286A (ja) * 2002-11-28 2006-05-25 アストラゼネカ アクチボラグ 抗細菌性化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JP2003535860A (ja) * 2000-06-05 2003-12-02 ドン・ア・ファーム・カンパニー・リミテッド 新規なオキサゾリジノン誘導体及びその製造方法
JP2005507386A (ja) * 2001-09-11 2005-03-17 アストラゼネカ アクチボラグ 抗菌剤としてのオキサゾリジノン及び/又はイソオキサゾリン
JP2006515286A (ja) * 2002-11-28 2006-05-25 アストラゼネカ アクチボラグ 抗細菌性化合物

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519247A (ja) * 2003-03-01 2006-08-24 アストラゼネカ アクチボラグ 抗生物質として有用なヒドロキシメチル置換ジヒドロイソオキサゾール誘導体
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP2011137007A (ja) * 2003-07-29 2011-07-14 Rib-X Pharmaceuticals Inc ビアリールオキサゾリジノンの合成方法
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP2015505846A (ja) * 2011-12-19 2015-02-26 サウディ ベーシック インダストリーズ コーポレイション メタロセン錯体を調製するプロセス
JP2015506916A (ja) * 2011-12-19 2015-03-05 サウディ ベーシック インダストリーズ コーポレイション メタロセン錯体を調製するプロセス

Also Published As

Publication number Publication date
NZ540147A (en) 2008-03-28
US20060116400A1 (en) 2006-06-01
AU2003302404B2 (en) 2008-06-19
AU2003302404A1 (en) 2004-06-18
WO2004048392A1 (en) 2004-06-10
IL168747A0 (en) 2009-02-11
NO20052534L (no) 2005-08-22
EP1567532A1 (en) 2005-08-31
NO20052534D0 (no) 2005-05-26
HK1079794A1 (zh) 2006-04-13
CA2507468A1 (en) 2004-06-10
KR20050085193A (ko) 2005-08-29
MXPA05005651A (es) 2005-07-27
SA04250088A (ar) 2005-12-03
TW200533666A (en) 2005-10-16
BR0316688A (pt) 2005-10-18

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