NO20052534L - Oksazolidinon- og/eller isokazolinderivater som antibakterielle stoffer - Google Patents

Oksazolidinon- og/eller isokazolinderivater som antibakterielle stoffer

Info

Publication number
NO20052534L
NO20052534L NO20052534A NO20052534A NO20052534L NO 20052534 L NO20052534 L NO 20052534L NO 20052534 A NO20052534 A NO 20052534A NO 20052534 A NO20052534 A NO 20052534A NO 20052534 L NO20052534 L NO 20052534L
Authority
NO
Norway
Prior art keywords
antibacterial agents
isocazoline
oxazolidinone
derivatives
het
Prior art date
Application number
NO20052534A
Other languages
English (en)
Other versions
NO20052534D0 (no
Inventor
Michael Barry Gravestock
Neil James Hales
Sheila Irene Hauck
Daniel Robert Carcanague
Thomas Peter Weber
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0227702A external-priority patent/GB0227702D0/en
Priority claimed from GB0304725A external-priority patent/GB0304725D0/en
Priority claimed from GB0318608A external-priority patent/GB0318608D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20052534D0 publication Critical patent/NO20052534D0/no
Publication of NO20052534L publication Critical patent/NO20052534L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Forbindelse med formel (I) eller et farmasøytisk akseptabelt salt eller in vivo-hydrolyserbar ester derav: hvor C i (I) er for eksempel hvor A og B er uavhengig valgt fra m er 1 eller 2; R2b og R6b, R2a og R6a, R3a og R5a er for eksempel valgt fra H, F, OMe og Me; R2b' og R6b', R2a' og R6a', R3a', R5a' er for eksempel valgt fra H, OMe og Me; R1a er for eksempel eventuelt substituert (l-10C)alkyl; R1b er for eksempel valgt fra -NR5C(=W)R4, hvor HET-1 er for eksempel isoksazolyl og HET-2 er for eksempel triazolyl eller tetrazolyl. Metoder for fremstilling av forbindelser med formel (I), preparater som inneholder dem og anvendelse av dem som antibakterielle midler, er også beskrevet.
NO20052534A 2002-11-28 2005-05-26 Oksazolidinon- og/eller isokazolinderivater som antibakterielle stoffer NO20052534L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0227702A GB0227702D0 (en) 2002-11-28 2002-11-28 Chemical compounds
GB0304725A GB0304725D0 (en) 2003-03-01 2003-03-01 Chemical compounds
GB0318608A GB0318608D0 (en) 2003-08-08 2003-08-08 Chemical compounds
PCT/GB2003/005087 WO2004048392A1 (en) 2002-11-28 2003-11-24 Oxazolidinone and / or isoxazoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
NO20052534D0 NO20052534D0 (no) 2005-05-26
NO20052534L true NO20052534L (no) 2005-08-22

Family

ID=32397650

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052534A NO20052534L (no) 2002-11-28 2005-05-26 Oksazolidinon- og/eller isokazolinderivater som antibakterielle stoffer

Country Status (15)

Country Link
US (1) US20060116400A1 (no)
EP (1) EP1567532A1 (no)
JP (1) JP2006508192A (no)
KR (1) KR20050085193A (no)
AU (1) AU2003302404B2 (no)
BR (1) BR0316688A (no)
CA (1) CA2507468A1 (no)
HK (1) HK1079794A1 (no)
IL (1) IL168747A0 (no)
MX (1) MXPA05005651A (no)
NO (1) NO20052534L (no)
NZ (1) NZ540147A (no)
SA (1) SA04250088A (no)
TW (1) TW200533666A (no)
WO (1) WO2004048392A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2244802T3 (es) * 2001-09-11 2005-12-16 Astrazeneca Ab Derivados de oxazolidinona y/o isoxazolina como agentes antibacterianos.
IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
PL372090A1 (en) 2002-02-28 2005-07-11 Astrazeneca Ab Chemical compounds
EP1581524A2 (en) 2002-11-28 2005-10-05 AstraZeneca AB Oxazolidinones as antibacterial agents
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
DK1656370T3 (da) 2003-06-03 2012-11-26 Rib X Pharmaceuticals Inc Heterocykliske biarylforbindelser og fremgangsmåder til fremstilling og anvendelse af samme
ES2536001T3 (es) * 2003-07-29 2015-05-19 Melinta Therapeutics, Inc. Procedimiento para la síntesis de biariloxazolidinonas
EP1660465B1 (en) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones
TW200526649A (en) 2003-12-17 2005-08-16 Rib X Pharmaceuticals Inc Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
US20070208062A1 (en) * 2004-05-25 2007-09-06 Astrazeneca Ab 3-(4-(2-dihydroisoxazol-3-ylpyridin-5-yl)phenyl)-5-triazol-1-ylmethyloxazolidin-2-one derivatives as mao inhibitors for the treatment of bacterial infections
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
RU2556234C2 (ru) 2008-10-10 2015-07-10 Траюс Терапьютикс Способы получения оксазолидинонов и содержащих их композиций
RU2011136537A (ru) * 2009-02-03 2013-03-10 Траюс Терапьютикс Кристаллическая форма (r)-3-(4-(2-метилтетразол-5-ил)пиридин-5-ил)-3-фторфенил)-5-гидроксиметил оксазолидин-2-он диводород фосфата
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
US9234054B2 (en) * 2011-12-19 2016-01-12 Saudi Basic Industries Corporation Process for the preparation of metallocene complexes
US9000200B2 (en) * 2011-12-19 2015-04-07 Saudi Basic Industries Corporation Process for the preparation of metallocene complexes
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
MXPA02012045A (es) * 2000-06-05 2003-10-15 Dong A Pharm Co Ltd Nuevos derivados de oxazolidinona y proceso para su preparacion.
ES2244802T3 (es) * 2001-09-11 2005-12-16 Astrazeneca Ab Derivados de oxazolidinona y/o isoxazolina como agentes antibacterianos.
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
HK1079794A1 (zh) 2006-04-13
MXPA05005651A (es) 2005-07-27
NO20052534D0 (no) 2005-05-26
US20060116400A1 (en) 2006-06-01
SA04250088A (ar) 2005-12-03
EP1567532A1 (en) 2005-08-31
JP2006508192A (ja) 2006-03-09
CA2507468A1 (en) 2004-06-10
AU2003302404A1 (en) 2004-06-18
TW200533666A (en) 2005-10-16
KR20050085193A (ko) 2005-08-29
NZ540147A (en) 2008-03-28
BR0316688A (pt) 2005-10-18
IL168747A0 (en) 2009-02-11
AU2003302404B2 (en) 2008-06-19
WO2004048392A1 (en) 2004-06-10

Similar Documents

Publication Publication Date Title
NO20052534L (no) Oksazolidinon- og/eller isokazolinderivater som antibakterielle stoffer
NO20053133L (no) Kjemiske forbindelser.
MXPA03010877A (es) Derivados de 2-anilin-pirimida como inhibidores de cinasa dependientes de ciclina.
WO2006034446A3 (en) Pyridine derivatives for inhibiting human stearoyl-coa-desaturase
NO20070032L (no) Hetroarylbenzamid-derivater for anvendelse som GLK-aktivatorer ved behandling av diabetes
WO2006034341A3 (en) Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
NO2015020I2 (no) Ceritinib eller et farmasøytisk akseptabelt salt derav
MY140528A (en) Spiroketal derivatives and their use as therapeutic agents for diabetes
WO2006034440A3 (en) Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
DE60317326D1 (de) Phenylalkansäure- und phenyloxyalkansäure-derivate als hppar aktivatore
WO2004016578A8 (en) Arylethanolamine beta2-adrenoreceptor agonist compounds
WO2008114819A1 (ja) 新規アデニン化合物
EP1714961A4 (en) INDAZOL COMPOUND AND THEIR PHARMACEUTICAL USE
TW200640900A (en) 1-(2h)-isoquinolone derivative
NO20061839L (no) Benzimidazolderivater, sammensetninger inneholdende dem, fremstilling derav, og anvendelse derav
WO2006067392A3 (en) Indole derivatives for the treatment of tuberculosis
NO20050666L (no) 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
CA2665931C (en) Hydrobenzamide derivatives as inhibitors of hsp90
WO2003084938A3 (en) Pyrimidone derivatives useful for the treatment of inflammatin and immunological diseases
GEP20104875B (en) Pyrimidine derivatives for the treatment of abnormal cell growth
UA95223C2 (ru) Производные пиридопиримидина, их получение, их применение в терапии
MY186650A (en) Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
WO2006110884A8 (en) 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
WO2000068198A3 (en) Heterosubstituted pyridine derivatives as pde 4 inhibitors
AU2003237955A8 (en) Phenyloxyalkanonic acid derivatives as hppar activators

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application