JP2006507328A5 - - Google Patents
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- Publication number
- JP2006507328A5 JP2006507328A5 JP2004551940A JP2004551940A JP2006507328A5 JP 2006507328 A5 JP2006507328 A5 JP 2006507328A5 JP 2004551940 A JP2004551940 A JP 2004551940A JP 2004551940 A JP2004551940 A JP 2004551940A JP 2006507328 A5 JP2006507328 A5 JP 2006507328A5
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- JP
- Japan
- Prior art keywords
- group
- peptide
- chemical moiety
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 239000000126 substance Substances 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 29
- 210000004899 c-terminal region Anatomy 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 125000001165 hydrophobic group Chemical group 0.000 claims description 12
- -1 t-butyloxycarbonyl group Chemical group 0.000 claims description 11
- 125000000539 amino acid group Chemical group 0.000 claims description 9
- 125000003277 amino group Chemical group 0.000 claims description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 6
- 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims description 6
- 229920000642 polymer Chemical group 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 125000003368 amide group Chemical group 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- 150000001720 carbohydrates Chemical class 0.000 claims 8
- 150000002632 lipids Chemical class 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 206010054261 Flavivirus infection Diseases 0.000 claims 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42474602P | 2002-11-08 | 2002-11-08 | |
| US60/424,746 | 2002-11-08 | ||
| PCT/US2003/035666 WO2004044220A2 (en) | 2002-11-08 | 2003-11-07 | Flaviviris fusion inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010167496A Division JP2010280682A (ja) | 2002-11-08 | 2010-07-26 | フラビウイルス融合インヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006507328A JP2006507328A (ja) | 2006-03-02 |
| JP2006507328A5 true JP2006507328A5 (https=) | 2006-12-28 |
| JP5250179B2 JP5250179B2 (ja) | 2013-07-31 |
Family
ID=32312869
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004551940A Expired - Fee Related JP5250179B2 (ja) | 2002-11-08 | 2003-11-07 | フラビウイルス融合インヒビター |
| JP2010167496A Pending JP2010280682A (ja) | 2002-11-08 | 2010-07-26 | フラビウイルス融合インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010167496A Pending JP2010280682A (ja) | 2002-11-08 | 2010-07-26 | フラビウイルス融合インヒビター |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7416733B2 (https=) |
| EP (3) | EP2338894A1 (https=) |
| JP (2) | JP5250179B2 (https=) |
| AU (1) | AU2003295427A1 (https=) |
| CA (1) | CA2503303A1 (https=) |
| DK (1) | DK1558276T3 (https=) |
| ES (1) | ES2390874T3 (https=) |
| WO (1) | WO2004044220A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005002501A2 (en) * | 2003-04-22 | 2005-01-13 | Children's Medical Center Corporation | Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same |
| ATE474587T1 (de) | 2004-09-29 | 2010-08-15 | Univ Tulane | Inhibitoren des hepatitis-c-virus |
| US7592315B2 (en) | 2004-11-02 | 2009-09-22 | Schering Corporation | Peptide viral entry inhibitors |
| AU2006311938A1 (en) * | 2005-11-02 | 2007-05-18 | Ambrx, Inc. | Biosynthetic polypeptide fusion inhibitors |
| UA101597C2 (uk) * | 2006-02-27 | 2013-04-25 | Зе Боард Оф Регентс Оф Зе Універсіті Оф Тексас Сістем | Псевдоінфекційний флавівірус та його використання |
| US7943148B1 (en) * | 2007-04-04 | 2011-05-17 | The United States Of America As Represented By The Secretary Of The Army | Amino acid sites in Flavivirus E proteins useful for development of diagnostics and vaccines |
| EP2202298A1 (en) | 2008-12-23 | 2010-06-30 | Stichting Dienst Landbouwkundig Onderzoek | Recombinant classical swine fever virus (CSFV) comprising a modified E2 protein and methods for generating said recombinant CSFV |
| US20130203655A1 (en) * | 2010-02-12 | 2013-08-08 | Margaret Kielian | Methods for preventing or treating viral infection |
| WO2016037985A1 (en) * | 2014-09-08 | 2016-03-17 | Ruprecht-Karls-Universität Heidelberg | Construct for the delivery of a molecule into the cytoplasm of a cell |
| KR101886286B1 (ko) * | 2016-11-21 | 2018-08-10 | 주식회사 옵티팜 | 돼지파보바이러스 및 돼지열병바이러스에 대한 동시 항원성 복합 항원 단백질의 제조 방법 |
| CN111454989B (zh) * | 2020-04-04 | 2022-03-08 | 中国农业科学院兰州兽医研究所 | 一种嵌合型基因i型乙型脑炎病毒病毒样颗粒疫苗及其制备方法和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0768267B2 (ja) * | 1986-06-05 | 1995-07-26 | 財団法人阪大微生物病研究会 | フラビウイルス抗原 |
| KR940000755B1 (ko) * | 1990-02-16 | 1994-01-29 | 유나이티드 바이오메디칼 인코오포레이티드 | Hcv에 대한 항체 검출, hcv 감염의 진단 및 백신으로서의 그 예방에 특히 적합한 합성 펩티드 |
| US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| DE4041304A1 (de) * | 1990-12-21 | 1992-06-25 | Mikrogen Molekularbiol Entw | Von strukturproteinen des hepatitis c-virus abgeleitete polypeptide, testkits, die diese polypeptide enthalten und impfstoffe gegen infektionen von hepatitis c-viren |
| JPH06205672A (ja) * | 1992-03-19 | 1994-07-26 | Nippon Zeon Co Ltd | 日本脳炎ウイルス及びｂ型肝炎ウイルスの表面抗原タンパク質の抗原部位を持つキメラタンパク質の製造法、およびそれに用いる組み換えバキュロウイルス |
| US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5610009A (en) | 1994-01-28 | 1997-03-11 | Abbott Laboratories | Mammalian expression systems for hepatitis C virus envelope genes |
| JP3846808B2 (ja) * | 1994-06-17 | 2006-11-15 | インステイテユート・ボール・デイールホウデリイ・エン・デイールゲゾンドハイド | ペスチウイルス株のヌクレオチド配列、それらの配列によりコードされるポリペプチド、ならびにペスチウイルス感染の診断および予防のためのそれらの使用 |
| US6117640A (en) * | 1995-05-02 | 2000-09-12 | The United States Of America As Represented By The Secretary Of The Army | Recombinant vaccine made in E. coli against dengue virus |
| US6037348A (en) * | 1996-02-09 | 2000-03-14 | Eli Lilly And Company | Inhibition of viral replication |
| WO1999024466A2 (en) * | 1997-11-06 | 1999-05-20 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes |
| CA2330086A1 (en) | 1998-04-24 | 1999-11-04 | Washington University | Chimeras of hepatitis c virus and bovine viral diarrhea virus |
| US7227011B2 (en) * | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
| EP0982402A1 (en) * | 1998-08-14 | 2000-03-01 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Pestivirus vaccination |
| EP1185665B1 (en) * | 1999-06-04 | 2008-09-10 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | INFECTIOUS cDNA CLONE OF GB VIRUS B AND USES THEREOF |
| US6750008B1 (en) * | 1999-07-09 | 2004-06-15 | Trimeris, Inc. | Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission |
| US7410757B1 (en) * | 1999-09-17 | 2008-08-12 | Keio University | Method of screening disease depressant gene |
| GB2372991B (en) * | 2001-03-09 | 2004-11-17 | Fiocruz Fundacao Oswaldo Cruz | Flavivirus expression vector |
-
2003
- 2003-11-07 DK DK03786613T patent/DK1558276T3/da active
- 2003-11-07 CA CA 2503303 patent/CA2503303A1/en not_active Abandoned
- 2003-11-07 EP EP20100181693 patent/EP2338894A1/en not_active Withdrawn
- 2003-11-07 JP JP2004551940A patent/JP5250179B2/ja not_active Expired - Fee Related
- 2003-11-07 EP EP03786613A patent/EP1558276B1/en not_active Expired - Lifetime
- 2003-11-07 AU AU2003295427A patent/AU2003295427A1/en not_active Abandoned
- 2003-11-07 ES ES03786613T patent/ES2390874T3/es not_active Expired - Lifetime
- 2003-11-07 US US10/532,480 patent/US7416733B2/en not_active Expired - Fee Related
- 2003-11-07 WO PCT/US2003/035666 patent/WO2004044220A2/en not_active Ceased
- 2003-11-07 EP EP20100181714 patent/EP2360168A1/en not_active Withdrawn
-
2008
- 2008-08-22 US US12/229,436 patent/US7854937B2/en not_active Expired - Fee Related
-
2010
- 2010-07-26 JP JP2010167496A patent/JP2010280682A/ja active Pending
- 2010-11-30 US US12/956,460 patent/US8153360B2/en not_active Expired - Fee Related
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