JP2006506947A - 酵素活性を調節する化合物を同定するための伸長係留アプローチ - Google Patents

酵素活性を調節する化合物を同定するための伸長係留アプローチ Download PDF

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Publication number
JP2006506947A
JP2006506947A JP2003584010A JP2003584010A JP2006506947A JP 2006506947 A JP2006506947 A JP 2006506947A JP 2003584010 A JP2003584010 A JP 2003584010A JP 2003584010 A JP2003584010 A JP 2003584010A JP 2006506947 A JP2006506947 A JP 2006506947A
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Japan
Prior art keywords
extender
target
ptp
functional group
covalent bond
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JP2003584010A
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English (en)
Japanese (ja)
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JP2006506947A5 (https=
Inventor
ダニエル エー． アーラソン，
ロバート エス． マクドウェル，
スティッグ ハンセン，
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サネシス ファーマシューティカルズ， インコーポレイテッド
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Priority claimed from US10/121,216 external-priority patent/US6998233B2/en
Application filed by サネシス ファーマシューティカルズ， インコーポレイテッド filed Critical サネシス ファーマシューティカルズ， インコーポレイテッド
Publication of JP2006506947A publication Critical patent/JP2006506947A/ja
Publication of JP2006506947A5 publication Critical patent/JP2006506947A5/ja
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2003584010A 2002-04-10 2003-02-26 酵素活性を調節する化合物を同定するための伸長係留アプローチ Ceased JP2006506947A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/121,216 US6998233B2 (en) 1998-06-26 2002-04-10 Methods for ligand discovery
US37703402P 2002-05-01 2002-05-01
US10/374,499 US7214487B2 (en) 1998-06-26 2003-02-25 Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
PCT/US2003/006217 WO2003087054A2 (en) 2002-04-10 2003-02-26 Methods for identifying compounds that modulate enzymatic activity

Publications (2)

Publication Number Publication Date
JP2006506947A true JP2006506947A (ja) 2006-03-02
JP2006506947A5 JP2006506947A5 (https=) 2006-04-27

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ID=29255201

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JP2003584010A Ceased JP2006506947A (ja) 2002-04-10 2003-02-26 酵素活性を調節する化合物を同定するための伸長係留アプローチ

Country Status (6)

Country Link
US (2) US7214487B2 (https=)
EP (1) EP1497450A4 (https=)
JP (1) JP2006506947A (https=)
AU (2) AU2003216468B2 (https=)
CA (1) CA2478398A1 (https=)
WO (1) WO2003087054A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
WO2004043405A2 (en) 2002-11-12 2004-05-27 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
WO2005114197A2 (en) * 2004-04-15 2005-12-01 Albert Einstein College Of Medicine Of Yeshiva University Activity-based probes for protein tyrosine phosphatases
US8039194B2 (en) * 2008-01-08 2011-10-18 Internatinal Business Machines Corporation Photoacid generators for extreme ultraviolet lithography
KR20110031393A (ko) 2008-07-21 2011-03-25 더 브리검 앤드 우먼즈 하스피털, 인크. 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
US8859731B2 (en) 2010-04-21 2014-10-14 Novo Nordisk A/S Selective modification of proteins
WO2020163512A1 (en) 2019-02-05 2020-08-13 The Brigham And Women's Hospital, Inc. Polysaccharide compositions for use in treating filariasis
CN114853629B (zh) * 2021-02-03 2023-06-13 沈阳农业大学 一种二肽类化合物及其制备方法和应用
JP7805983B2 (ja) 2022-03-22 2026-01-26 アッヴィ・インコーポレイテッド ブルトン型チロシンキナーゼを分解するためのピリミジン

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000823A1 (en) * 1998-06-26 2000-01-06 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367058A (en) * 1993-08-25 1994-11-22 Becton, Dickinson And Company Modified antibodies with increased affinity
US6998233B2 (en) * 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) * 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
AU2573102A (en) 2000-11-21 2002-06-03 Sunesis Pharmaceuticals Inc An extended tethering approach for rapid identification of ligands
MXPA04001000A (es) 2001-08-07 2004-06-25 Sunesis Pharmaceuticals Inc Mutantes de cisteina y metodos para detectar union de ligando a moleculas biologicas.
EP1421063A1 (en) 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Disulfide and thiosulfonate ligands and libraries comprising these ligands
CA2464094C (en) 2001-11-21 2013-07-02 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000000823A1 (en) * 1998-06-26 2000-01-06 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic ligands

Also Published As

Publication number Publication date
US20040005632A1 (en) 2004-01-08
WO2003087054A3 (en) 2004-08-05
US20080220536A1 (en) 2008-09-11
EP1497450A4 (en) 2010-03-10
CA2478398A1 (en) 2003-10-23
WO2003087054A2 (en) 2003-10-23
AU2003216468A1 (en) 2003-10-27
AU2003216468B2 (en) 2008-08-21
US7214487B2 (en) 2007-05-08
EP1497450A2 (en) 2005-01-19
AU2008246264A1 (en) 2008-12-11

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