AU2003216468B2 - Methods for identifying compounds that modulate enzymatic activity - Google Patents
Methods for identifying compounds that modulate enzymatic activity Download PDFInfo
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- AU2003216468B2 AU2003216468B2 AU2003216468A AU2003216468A AU2003216468B2 AU 2003216468 B2 AU2003216468 B2 AU 2003216468B2 AU 2003216468 A AU2003216468 A AU 2003216468A AU 2003216468 A AU2003216468 A AU 2003216468A AU 2003216468 B2 AU2003216468 B2 AU 2003216468B2
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- C07K—PEPTIDES
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- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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| PCT/US2003/006217 WO2003087054A2 (en) | 2002-04-10 | 2003-02-26 | Methods for identifying compounds that modulate enzymatic activity |
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| US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| WO2004043405A2 (en) | 2002-11-12 | 2004-05-27 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| WO2005114197A2 (en) * | 2004-04-15 | 2005-12-01 | Albert Einstein College Of Medicine Of Yeshiva University | Activity-based probes for protein tyrosine phosphatases |
| US8039194B2 (en) * | 2008-01-08 | 2011-10-18 | Internatinal Business Machines Corporation | Photoacid generators for extreme ultraviolet lithography |
| KR20110031393A (ko) | 2008-07-21 | 2011-03-25 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| US8859731B2 (en) | 2010-04-21 | 2014-10-14 | Novo Nordisk A/S | Selective modification of proteins |
| WO2020163512A1 (en) | 2019-02-05 | 2020-08-13 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| CN114853629B (zh) * | 2021-02-03 | 2023-06-13 | 沈阳农业大学 | 一种二肽类化合物及其制备方法和应用 |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
Citations (1)
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| US5367058A (en) * | 1993-08-25 | 1994-11-22 | Becton, Dickinson And Company | Modified antibodies with increased affinity |
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| US6998233B2 (en) * | 1998-06-26 | 2006-02-14 | Sunesis Pharmaceuticals, Inc. | Methods for ligand discovery |
| US6919178B2 (en) * | 2000-11-21 | 2005-07-19 | Sunesis Pharmaceuticals, Inc. | Extended tethering approach for rapid identification of ligands |
| US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| AU2573102A (en) | 2000-11-21 | 2002-06-03 | Sunesis Pharmaceuticals Inc | An extended tethering approach for rapid identification of ligands |
| MXPA04001000A (es) | 2001-08-07 | 2004-06-25 | Sunesis Pharmaceuticals Inc | Mutantes de cisteina y metodos para detectar union de ligando a moleculas biologicas. |
| EP1421063A1 (en) | 2001-08-07 | 2004-05-26 | Sunesis Pharmaceuticals, Inc. | Disulfide and thiosulfonate ligands and libraries comprising these ligands |
| CA2464094C (en) | 2001-11-21 | 2013-07-02 | Sunesis Pharmaceuticals, Inc. | Methods for ligand discovery |
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2003
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- 2003-02-26 AU AU2003216468A patent/AU2003216468B2/en not_active Ceased
- 2003-02-26 WO PCT/US2003/006217 patent/WO2003087054A2/en not_active Ceased
- 2003-02-26 CA CA002478398A patent/CA2478398A1/en not_active Abandoned
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5367058A (en) * | 1993-08-25 | 1994-11-22 | Becton, Dickinson And Company | Modified antibodies with increased affinity |
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| WO2003087054A3 (en) | 2004-08-05 |
| US20080220536A1 (en) | 2008-09-11 |
| EP1497450A4 (en) | 2010-03-10 |
| CA2478398A1 (en) | 2003-10-23 |
| WO2003087054A2 (en) | 2003-10-23 |
| AU2003216468A1 (en) | 2003-10-27 |
| US7214487B2 (en) | 2007-05-08 |
| JP2006506947A (ja) | 2006-03-02 |
| EP1497450A2 (en) | 2005-01-19 |
| AU2008246264A1 (en) | 2008-12-11 |
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