JP2006506101A5 - - Google Patents
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- Publication number
- JP2006506101A5 JP2006506101A5 JP2005507162A JP2005507162A JP2006506101A5 JP 2006506101 A5 JP2006506101 A5 JP 2006506101A5 JP 2005507162 A JP2005507162 A JP 2005507162A JP 2005507162 A JP2005507162 A JP 2005507162A JP 2006506101 A5 JP2006506101 A5 JP 2006506101A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- dsrna
- compound
- influenza virus
- binding domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 40
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 38
- 238000000034 method Methods 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 27
- 241000712461 unidentified influenza virus Species 0.000 claims 18
- 230000002401 inhibitory effect Effects 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 238000000338 in vitro Methods 0.000 claims 5
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 108700032552 influenza virus INS1 Proteins 0.000 claims 3
- 230000029812 viral genome replication Effects 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 102000005720 Glutathione transferase Human genes 0.000 claims 1
- 108010070675 Glutathione transferase Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 238000013103 analytical ultracentrifugation Methods 0.000 claims 1
- 238000005094 computer simulation Methods 0.000 claims 1
- 238000009510 drug design Methods 0.000 claims 1
- 238000002875 fluorescence polarization Methods 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000001641 gel filtration chromatography Methods 0.000 claims 1
- 238000012188 high-throughput screening assay Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42566102P | 2002-11-13 | 2002-11-13 | |
| US47745303P | 2003-06-10 | 2003-06-10 | |
| PCT/US2003/036292 WO2004043404A2 (en) | 2002-11-13 | 2003-11-13 | Process for designing inhibitors of influenza virus non-structural protein 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506101A JP2006506101A (ja) | 2006-02-23 |
| JP2006506101A5 true JP2006506101A5 (enExample) | 2007-02-01 |
Family
ID=32314599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005507162A Pending JP2006506101A (ja) | 2002-11-13 | 2003-11-13 | インフルエンザウイルス非構造タンパク質１の阻害剤を設計する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20080234175A1 (enExample) |
| JP (1) | JP2006506101A (enExample) |
| AU (1) | AU2003290842A1 (enExample) |
| CA (1) | CA2505949A1 (enExample) |
| WO (1) | WO2004043404A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU771110B2 (en) | 1998-06-12 | 2004-03-11 | Mount Sinai School Of Medicine Of The City University Of New York, The | Novel methods and interferon deficient substrates for the propagation of viruses |
| AU2001257001A1 (en) | 2000-04-10 | 2001-10-23 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
| CN1993140A (zh) | 2004-06-01 | 2007-07-04 | 纽约大学西奈山医学院 | 遗传工程猪流感病毒及其应用 |
| EP1855713B1 (en) * | 2005-02-15 | 2016-04-27 | Mount Sinai School of Medicine | Genetically engineered equine influenza virus and uses thereof |
| EP1948796A1 (en) * | 2005-11-07 | 2008-07-30 | Dow Gloval Technologies Inc. | Process for the preparation of nucleic acid duplexes |
| WO2007061969A2 (en) | 2005-11-18 | 2007-05-31 | Rutgers, The State University | Vaccines against influenza a and influenza b |
| US7709190B2 (en) | 2005-12-02 | 2010-05-04 | Board Of Regents, The University Of Texas System | Influenza A virus vaccines and inhibitors |
| US7601490B2 (en) | 2005-12-02 | 2009-10-13 | Board Of Regents, The University Of Texas System | Development of influenza A antivirals |
| CN102002489B (zh) * | 2009-09-02 | 2013-06-12 | 中国科学院微生物研究所 | 抑制H1N1型流感病毒增殖的microRNA及其应用 |
| WO2011147199A1 (en) * | 2010-05-28 | 2011-12-01 | Versitech Limited | Compounds and methods for treating viral infections |
| KR101471245B1 (ko) * | 2012-05-31 | 2014-12-10 | 충북대학교 산학협력단 | Ａ형 인플루엔자 바이러스 감염 질환의 예방 및 치료용 조성물 |
| US10029005B2 (en) | 2015-02-26 | 2018-07-24 | Boehringer Ingelheim Vetmedica Gmbh | Bivalent swine influenza virus vaccine |
| US20240398941A1 (en) * | 2021-10-06 | 2024-12-05 | Seqirus Inc. | Lipid nanoparticle comprising a nucleic acid-binding protein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750394A (en) * | 1994-05-20 | 1998-05-12 | The Mount Sinai Medical Center | Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication |
| US5843724A (en) * | 1995-04-27 | 1998-12-01 | Rutgers University | Chimeric nucleic acids and proteins for inhibiting HIV-1 expression |
| JP2001516058A (ja) * | 1997-09-12 | 2001-09-25 | ジェネラブス テクノロジーズ，インコーポレイテッド | ｄｓＲＮＡ／ｄｓＲＮＡ結合タンパク質の方法および組成物 |
-
2003
- 2003-11-13 WO PCT/US2003/036292 patent/WO2004043404A2/en not_active Ceased
- 2003-11-13 CA CA002505949A patent/CA2505949A1/en not_active Abandoned
- 2003-11-13 AU AU2003290842A patent/AU2003290842A1/en not_active Abandoned
- 2003-11-13 US US10/534,782 patent/US20080234175A1/en not_active Abandoned
- 2003-11-13 JP JP2005507162A patent/JP2006506101A/ja active Pending
-
2009
- 2009-09-11 US US12/557,927 patent/US20100081126A1/en not_active Abandoned
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