JP2006505522A - チオフェン化合物 - Google Patents
チオフェン化合物 Download PDFInfo
- Publication number
- JP2006505522A JP2006505522A JP2004527723A JP2004527723A JP2006505522A JP 2006505522 A JP2006505522 A JP 2006505522A JP 2004527723 A JP2004527723 A JP 2004527723A JP 2004527723 A JP2004527723 A JP 2004527723A JP 2006505522 A JP2006505522 A JP 2006505522A
- Authority
- JP
- Japan
- Prior art keywords
- benzimidazol
- formula
- oxy
- thiophene
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *CCC*N=C Chemical compound *CCC*N=C 0.000 description 16
- VYKPXPDQESEGAX-UHFFFAOYSA-N CC(C)(C=C1)C=CC([N+]([O-])=O)=C1NC(C)=O Chemical compound CC(C)(C=C1)C=CC([N+]([O-])=O)=C1NC(C)=O VYKPXPDQESEGAX-UHFFFAOYSA-N 0.000 description 1
- RCWLZVUAUKGJOS-UHFFFAOYSA-N CC(CC(c1c(COc2c(C(OC)=O)[s]c(-[n](cnc3c4)c3cc(OCCCN(C)C)c4OC)c2)cccc1)(F)F)=C Chemical compound CC(CC(c1c(COc2c(C(OC)=O)[s]c(-[n](cnc3c4)c3cc(OCCCN(C)C)c4OC)c2)cccc1)(F)F)=C RCWLZVUAUKGJOS-UHFFFAOYSA-N 0.000 description 1
- BAGIJOQVZOJHRQ-UHFFFAOYSA-N COC(c([s]c(-[n]1c(cccc2)c2nc1)c1)c1C#Cc1ccccc1)=O Chemical compound COC(c([s]c(-[n]1c(cccc2)c2nc1)c1)c1C#Cc1ccccc1)=O BAGIJOQVZOJHRQ-UHFFFAOYSA-N 0.000 description 1
- DNMYXFPJIMXZIH-UHFFFAOYSA-N COC(c([s]c(CCC1c(cc(cc2)Br)c2N=C1)c1)c1OCc1ccccc1C(F)(F)F)=O Chemical compound COC(c([s]c(CCC1c(cc(cc2)Br)c2N=C1)c1)c1OCc1ccccc1C(F)(F)F)=O DNMYXFPJIMXZIH-UHFFFAOYSA-N 0.000 description 1
- IBXOXTKGSVNXNS-UHFFFAOYSA-N COC(c1c(CCc2ccccc2)cc(-[n]2c(cccc3)c3nc2)[s]1)=O Chemical compound COC(c1c(CCc2ccccc2)cc(-[n]2c(cccc3)c3nc2)[s]1)=O IBXOXTKGSVNXNS-UHFFFAOYSA-N 0.000 description 1
- IFTFEAPCQSZQTC-UHFFFAOYSA-N COc(c(OC)c1)cc2c1nc[n]2-c1cc(OCc(ccnc2)c2Br)c(C(N)=O)[s]1 Chemical compound COc(c(OC)c1)cc2c1nc[n]2-c1cc(OCc(ccnc2)c2Br)c(C(N)=O)[s]1 IFTFEAPCQSZQTC-UHFFFAOYSA-N 0.000 description 1
- YIZFLZBOIMHEMI-UHFFFAOYSA-N Cc1ccccc1COc1c(C(NS(C)(=O)=O)=O)[s]c(-[n]2c(ccc(OC)c3)c3nc2)c1 Chemical compound Cc1ccccc1COc1c(C(NS(C)(=O)=O)=O)[s]c(-[n]2c(ccc(OC)c3)c3nc2)c1 YIZFLZBOIMHEMI-UHFFFAOYSA-N 0.000 description 1
- XLBUYYZNKFMBQY-UHFFFAOYSA-N Cc1ccccc1COc1c(CNS(C)(=O)=O)[s]c(-[n]2c(cc(cc3)OC)c3nc2)c1 Chemical compound Cc1ccccc1COc1c(CNS(C)(=O)=O)[s]c(-[n]2c(cc(cc3)OC)c3nc2)c1 XLBUYYZNKFMBQY-UHFFFAOYSA-N 0.000 description 1
- QUMZSMIHYLGXCZ-UHFFFAOYSA-N NC(c([s]c(-[n]1c(cccc2)c2nc1)c1)c1OCc(cccc1)c1[N+]([O-])=O)=O Chemical compound NC(c([s]c(-[n]1c(cccc2)c2nc1)c1)c1OCc(cccc1)c1[N+]([O-])=O)=O QUMZSMIHYLGXCZ-UHFFFAOYSA-N 0.000 description 1
- OZQYAZLNEIXMJB-UHFFFAOYSA-N NC(c([s]c(Cc1cc(cccc2)c2nc1)c1)c1OCc(cccc1)c1[F](F)F)=O Chemical compound NC(c([s]c(Cc1cc(cccc2)c2nc1)c1)c1OCc(cccc1)c1[F](F)F)=O OZQYAZLNEIXMJB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40200802P | 2002-08-08 | 2002-08-08 | |
PCT/US2003/024272 WO2004014899A1 (en) | 2002-08-08 | 2003-08-04 | Thiophene compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006505522A true JP2006505522A (ja) | 2006-02-16 |
JP2006505522A5 JP2006505522A5 (xx) | 2006-07-13 |
Family
ID=31715769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004527723A Pending JP2006505522A (ja) | 2002-08-08 | 2003-08-04 | チオフェン化合物 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20060074119A1 (xx) |
EP (1) | EP1546137A1 (xx) |
JP (1) | JP2006505522A (xx) |
KR (1) | KR20050071471A (xx) |
CN (1) | CN1688576A (xx) |
AU (1) | AU2003265348B2 (xx) |
BR (1) | BR0313160A (xx) |
CA (1) | CA2493908A1 (xx) |
IL (1) | IL166328A0 (xx) |
IS (1) | IS7657A (xx) |
MA (1) | MA27427A1 (xx) |
MX (1) | MXPA05001544A (xx) |
NO (1) | NO20050525L (xx) |
NZ (1) | NZ538134A (xx) |
PL (1) | PL375532A1 (xx) |
RU (1) | RU2296758C2 (xx) |
WO (1) | WO2004014899A1 (xx) |
ZA (1) | ZA200500864B (xx) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007502821A (ja) * | 2003-08-21 | 2007-02-15 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | N−置換ベンズイミダゾリルc−Kit阻害剤 |
JP2007519720A (ja) * | 2004-01-28 | 2007-07-19 | スミスクライン ビーチャム コーポレーション | チアゾール化合物 |
JP2007522142A (ja) * | 2004-02-09 | 2007-08-09 | グラクソ グループ リミテッド | Ikk3に対して活性を有するベンゾイミダゾール置換チオフェン誘導体 |
JP2009528284A (ja) * | 2006-02-27 | 2009-08-06 | エフ.ホフマン−ラ ロシュ アーゲー | Plk1阻害剤としての4−フェニル−チアゾール−5−カルボン酸及び4−フェニル−チアゾール−5−カルボン酸アミド |
JP2009533452A (ja) * | 2006-04-13 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なチオフェン−カルボキサミド |
JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
JP2010531887A (ja) * | 2007-06-26 | 2010-09-30 | グラクソスミスクライン エルエルシー | ベンズイミダゾールチオフェンの調製方法 |
JP2015504061A (ja) * | 2011-12-28 | 2015-02-05 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドGlobal Blood Therapeutics,Inc. | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
JP2016516696A (ja) * | 2013-03-15 | 2016-06-09 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
JP2007509070A (ja) | 2003-10-16 | 2007-04-12 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
EP1682538A4 (en) * | 2003-10-27 | 2009-05-27 | S Bio Pte Ltd | BIARYL-ASSOCIATED HYDROXAMATE: PREPARATION AND PHARMACEUTICAL APPLICATIONS |
CA2549869C (en) | 2003-12-18 | 2015-05-05 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents |
DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
DE102004033670A1 (de) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
EP1630163A1 (de) | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP1632493A1 (de) | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
WO2006025567A1 (ja) | 2004-08-31 | 2006-03-09 | Banyu Pharmaceutical Co., Ltd. | 新規置換イミダゾール誘導体 |
JP4935357B2 (ja) | 2004-11-08 | 2012-05-23 | Msd株式会社 | 新規縮環イミダゾール誘導体 |
DE102004058337A1 (de) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
WO2006066172A1 (en) | 2004-12-17 | 2006-06-22 | Amgen, Inc. | Aminopyrimidine compounds and methods of use |
CN101300251B (zh) * | 2005-09-06 | 2011-08-03 | 史密丝克莱恩比彻姆公司 | 作为plk抑制剂的苯并咪唑噻吩化合物 |
KR20080045266A (ko) * | 2005-09-06 | 2008-05-22 | 스미스클라인 비참 코포레이션 | 벤즈이미다졸 티오펜을 제조하기 위한 위치선택적인 방법 |
JP2009507020A (ja) * | 2005-09-06 | 2009-02-19 | スミスクライン ビーチャム コーポレーション | Plk調節物質としてのルベンゾイミダゾールチオフェン化合物 |
US7595330B2 (en) * | 2005-09-06 | 2009-09-29 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
WO2007087283A2 (en) * | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
AU2007267986A1 (en) * | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
WO2007143506A2 (en) * | 2006-06-02 | 2007-12-13 | Smithkline Beecham Corporation | Substituted benzimidazole thiophene benzyl ether compounds |
AR060979A1 (es) * | 2006-06-02 | 2008-07-23 | Smithkline Beecham Corp | Compuestos de tiofeno de bencimidazol |
BRPI0714211B8 (pt) | 2006-07-13 | 2021-05-25 | Janssen Pharmaceutica Nv | derivados de mtki quinazolina, sua utilização e composição farmacêutica que os compreende |
US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
US7618989B2 (en) | 2006-08-15 | 2009-11-17 | Wyeth | Tricyclic oxazolidone derivatives useful as PR modulators |
US7652018B2 (en) | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
TW200815428A (en) | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
US20100056525A1 (en) * | 2006-10-31 | 2010-03-04 | Tara Renae Rheault | 5- and 6- substituted benzimidazole thiophene compounds |
WO2008153701A1 (en) * | 2007-05-24 | 2008-12-18 | Schering Corporation | Compounds for inhibiting ksp kinesin activity |
WO2009003911A1 (en) * | 2007-06-29 | 2009-01-08 | 4Sc Ag | Thiophene-imidazopyridines |
CA2693715C (en) | 2007-07-27 | 2015-10-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
WO2009019205A1 (en) | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Crystalline form of a dihydropteridione derivative |
CN101918389A (zh) * | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
WO2009094224A1 (en) | 2008-01-25 | 2009-07-30 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
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JP2007502821A (ja) * | 2003-08-21 | 2007-02-15 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | N−置換ベンズイミダゾリルc−Kit阻害剤 |
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JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
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JP2015504061A (ja) * | 2011-12-28 | 2015-02-05 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドGlobal Blood Therapeutics,Inc. | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
JP2016516696A (ja) * | 2013-03-15 | 2016-06-09 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
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Also Published As
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IL166328A0 (en) | 2006-01-15 |
WO2004014899A1 (en) | 2004-02-19 |
MA27427A1 (fr) | 2005-07-01 |
NZ538134A (en) | 2006-03-31 |
MXPA05001544A (es) | 2005-04-19 |
AU2003265348A1 (en) | 2004-02-25 |
CN1688576A (zh) | 2005-10-26 |
NO20050525L (no) | 2005-05-06 |
EP1546137A1 (en) | 2005-06-29 |
IS7657A (is) | 2005-01-20 |
RU2296758C2 (ru) | 2007-04-10 |
ZA200500864B (en) | 2006-04-26 |
BR0313160A (pt) | 2005-07-12 |
KR20050071471A (ko) | 2005-07-07 |
PL375532A1 (en) | 2005-11-28 |
US20060074119A1 (en) | 2006-04-06 |
AU2003265348B2 (en) | 2007-08-16 |
RU2005102390A (ru) | 2006-01-10 |
CA2493908A1 (en) | 2004-02-19 |
US20080269298A1 (en) | 2008-10-30 |
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