JP2006501312A - Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環 - Google Patents

Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環 Download PDF

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Publication number
JP2006501312A
JP2006501312A JP2005501778A JP2005501778A JP2006501312A JP 2006501312 A JP2006501312 A JP 2006501312A JP 2005501778 A JP2005501778 A JP 2005501778A JP 2005501778 A JP2005501778 A JP 2005501778A JP 2006501312 A JP2006501312 A JP 2006501312A
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substituted
compound
compound according
hydrogen
compounds
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JP2006501312A5 (cg-RX-API-DMAC7.html
Inventor
ラジンダー シン，
ダン ゴフ，
ジョン パートリッジ，
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2006501312A publication Critical patent/JP2006501312A/ja
Publication of JP2006501312A5 publication Critical patent/JP2006501312A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2005501778A 2002-08-23 2003-08-22 Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環 Pending JP2006501312A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40546702P 2002-08-23 2002-08-23
US41783702P 2002-10-11 2002-10-11
US47137303P 2003-05-15 2003-05-15
PCT/US2003/026478 WO2004018463A2 (en) 2002-08-23 2003-08-22 Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US10/646,348 US7157473B2 (en) 2002-08-23 2003-08-22 Pyridyl substituted heterocycles useful for treating or preventing HCV infection

Publications (2)

Publication Number Publication Date
JP2006501312A true JP2006501312A (ja) 2006-01-12
JP2006501312A5 JP2006501312A5 (cg-RX-API-DMAC7.html) 2006-09-28

Family

ID=31950772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005501778A Pending JP2006501312A (ja) 2002-08-23 2003-08-22 Ｈｃｖ感染を治療または予防するのに有用なピリジル置換複素環

Country Status (15)

Country Link
US (3) US7157473B2 (cg-RX-API-DMAC7.html)
EP (1) EP1530569A2 (cg-RX-API-DMAC7.html)
JP (1) JP2006501312A (cg-RX-API-DMAC7.html)
KR (1) KR20050033653A (cg-RX-API-DMAC7.html)
AU (1) AU2003262831A1 (cg-RX-API-DMAC7.html)
BR (1) BR0313755A (cg-RX-API-DMAC7.html)
CA (1) CA2494164A1 (cg-RX-API-DMAC7.html)
HR (1) HRP20050168A2 (cg-RX-API-DMAC7.html)
IL (1) IL166639A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA05002082A (cg-RX-API-DMAC7.html)
NO (1) NO20051404L (cg-RX-API-DMAC7.html)
NZ (1) NZ537980A (cg-RX-API-DMAC7.html)
PL (1) PL374536A1 (cg-RX-API-DMAC7.html)
RS (1) RS20050175A (cg-RX-API-DMAC7.html)
WO (1) WO2004018463A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516415A (ja) * 2009-12-30 2013-05-13 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウィルス阻害剤

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
HRP20050168A2 (en) * 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
US7115642B2 (en) 2003-05-02 2006-10-03 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection
US7326790B2 (en) * 2003-05-02 2008-02-05 Rigel Pharmaceuticals, Inc. Diphenylisoxazole compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
US20050075309A1 (en) 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
WO2005049065A2 (en) * 2003-11-19 2005-06-02 Rigel Pharmaceuticals, Inc. Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections
JP2007514763A (ja) * 2003-12-19 2007-06-07 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｃ型肝炎ウイルス（ｈｃｖ）の感染を処置するための組成物および方法
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
JP2007530582A (ja) * 2004-03-26 2007-11-01 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝可能部分を含む複素環抗ウイルス化合物およびその使用
JP2008540425A (ja) * 2005-05-02 2008-11-20 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用
US8267868B2 (en) * 2005-08-10 2012-09-18 C. R. Bard, Inc. Single-insertion, multiple sample biopsy device with integrated markers
KR100890862B1 (ko) * 2005-11-07 2009-03-27 주식회사 엘지화학 유기 발광 소자 및 이의 제조 방법
RU2487131C2 (ru) * 2008-03-14 2013-07-10 Оцука Фармасьютикал Ко., Лтд. Ингибитор ммр-2 и/или ммр-9
AU2016281346B2 (en) 2015-06-23 2020-01-02 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, or pharmaceutically acceptable salt thereof
CN116535399B (zh) * 2022-01-25 2024-02-27 中国药科大学 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用
IL326496A (en) * 2023-08-17 2026-04-01 Sanofi Sa Pyridyl imidazoles – their preparation and therapeutic application

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WO2001078648A2 (en) * 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
WO2002006246A1 (en) * 2000-07-19 2002-01-24 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidine carboxylic acids as viral polymerase inhibitors
WO2002046186A1 (en) * 2000-12-08 2002-06-13 Takeda Chemical Industries, Ltd. Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
JP2004531536A (ja) * 2001-04-19 2004-10-14 バイエル アクチェンゲゼルシャフト 抗ウイルス剤としての新規アリールスルホンアミド

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MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
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WO2001078648A2 (en) * 2000-04-17 2001-10-25 Dong Wha Pharm. Ind. Co., Ltd. 6-methylnicotinamide derivatives as antiviral agents
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JP2004531536A (ja) * 2001-04-19 2004-10-14 バイエル アクチェンゲゼルシャフト 抗ウイルス剤としての新規アリールスルホンアミド

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013516415A (ja) * 2009-12-30 2013-05-13 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウィルス阻害剤

Also Published As

Publication number Publication date
WO2004018463A2 (en) 2004-03-04
BR0313755A (pt) 2005-06-21
US7157473B2 (en) 2007-01-02
US20040127497A1 (en) 2004-07-01
MXPA05002082A (es) 2005-06-08
PL374536A1 (en) 2005-10-31
CA2494164A1 (en) 2004-03-04
AU2003262831A1 (en) 2004-03-11
NZ537980A (en) 2007-08-31
EP1530569A2 (en) 2005-05-18
US20080171871A1 (en) 2008-07-17
IL166639A0 (en) 2006-01-15
US7714137B2 (en) 2010-05-11
NO20051404L (no) 2005-05-10
WO2004018463A3 (en) 2004-05-06
KR20050033653A (ko) 2005-04-12
US20070155966A1 (en) 2007-07-05
RS20050175A (sr) 2007-09-21
HRP20050168A2 (en) 2005-10-31
US7332602B2 (en) 2008-02-19

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