JP2006501281A - 油乳化プロバイオティックカプセル封入物のプレバイオティックおよび保存的使用 - Google Patents
油乳化プロバイオティックカプセル封入物のプレバイオティックおよび保存的使用 Download PDFInfo
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- JP2006501281A JP2006501281A JP2004539961A JP2004539961A JP2006501281A JP 2006501281 A JP2006501281 A JP 2006501281A JP 2004539961 A JP2004539961 A JP 2004539961A JP 2004539961 A JP2004539961 A JP 2004539961A JP 2006501281 A JP2006501281 A JP 2006501281A
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- oil
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/856—Lactobacillus casei
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41408302P | 2002-09-26 | 2002-09-26 | |
| PCT/US2003/030381 WO2004028460A2 (en) | 2002-09-26 | 2003-09-26 | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006501281A true JP2006501281A (ja) | 2006-01-12 |
| JP2006501281A5 JP2006501281A5 (https=) | 2006-10-26 |
Family
ID=32043341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004539961A Pending JP2006501281A (ja) | 2002-09-26 | 2003-09-26 | 油乳化プロバイオティックカプセル封入物のプレバイオティックおよび保存的使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8846082B2 (https=) |
| EP (1) | EP1554371A2 (https=) |
| JP (1) | JP2006501281A (https=) |
| AU (1) | AU2003276981B8 (https=) |
| CA (3) | CA2820023A1 (https=) |
| WO (1) | WO2004028460A2 (https=) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008088008A1 (ja) * | 2007-01-17 | 2008-07-24 | Meiji Dairies Corporation | 消化管機能異常症予防及び/又は治療剤 |
| JP2008543290A (ja) * | 2005-06-14 | 2008-12-04 | エルベル・アクチエンゲゼルシヤフト | プロバイオティック健康及び体調増進食品、餌及び/又は飲料水添加物並びにその使用 |
| WO2009142170A1 (ja) * | 2008-05-19 | 2009-11-26 | 森下仁丹株式会社 | シームレスカプセル |
| JP2010535760A (ja) * | 2007-08-08 | 2010-11-25 | コンジュゴン,インコーポレーテッド | 微生物の保存および送達のための組成物および方法 |
| WO2011027719A1 (ja) * | 2009-09-02 | 2011-03-10 | 明治乳業株式会社 | ラクトバチルス属乳酸菌の増殖促進剤及び/又は生残性向上剤 |
| JP2012515167A (ja) * | 2009-01-12 | 2012-07-05 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | プロバイオティクスおよびプレバイオティクス構成要素ならびに無機塩をラクトフェリンとともに含む組成物 |
| JP2013531506A (ja) * | 2010-06-28 | 2013-08-08 | プロバイオティカル・ソシエタ・ペル・アチオニ | 疝痛に罹患した幼児から単離したガス産生大腸菌群を阻害するlactobacilliの使用 |
| JP2013533313A (ja) * | 2010-08-10 | 2013-08-22 | アール.ピー. シェーラー テクノロジーズ エルエルシー | マイクロカプセル化されたプロバイオティクス細菌を含む安定なソフトゲルカプセルを製造する方法 |
| JP2013540079A (ja) * | 2010-09-21 | 2013-10-31 | バイオガイア・エイビー | 乳酸菌及び乾燥剤を含む産物 |
| CN112094785A (zh) * | 2020-10-12 | 2020-12-18 | 中科美大(福建)生物科技有限公司 | 一种动物双歧杆菌及其制剂与应用 |
| WO2021075073A1 (ja) * | 2019-10-17 | 2021-04-22 | 森永乳業株式会社 | 組成物、製造方法及び使用 |
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| US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| US7291326B2 (en) | 2003-01-06 | 2007-11-06 | Nutrition Physiology Corporation | Compositions and methods for reducing the pathogen content of meat and meat products |
| US20040028665A1 (en) | 2002-01-08 | 2004-02-12 | Garner Bryan E. | Compositions and methods for inhibiting pathogenic growth |
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| US20090169585A1 (en) * | 2003-10-23 | 2009-07-02 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity |
| WO2005089564A1 (en) * | 2004-03-19 | 2005-09-29 | Danisco A/S | Emulsifier composition for shortening |
| US7955834B2 (en) * | 2004-06-03 | 2011-06-07 | Biogaia Ab | Method for improved breast milk feeding to reduce the risk of allergy |
| ITMI20041887A1 (it) * | 2004-10-05 | 2005-01-05 | Consiglio Nazionale Ricerche | Procedimento per la preparazione di conserve alimentari vegetali contenenti microorganismi probiotici |
| NO323665B1 (no) * | 2005-06-27 | 2007-06-18 | Pharmalogica As | Drikk omfattende fiskeolje og probiotiske bakterier og fremgangsmate for fremstilling. |
| WO2008047391A1 (en) * | 2006-10-17 | 2008-04-24 | S.I.F.Fr.A. Farmaceutici Srl | Nutriceutic composition comprising lactoferrin and proteasic probiotics |
| EP2073643A2 (en) * | 2006-10-18 | 2009-07-01 | DSMIP Assets B.V. | Encapsulation of heat and moisture sensitive substances |
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| US20080175899A1 (en) * | 2007-01-19 | 2008-07-24 | Ross Mairi R | Formulation for promoting sinus health in nasal cavities |
| US20100098806A1 (en) * | 2007-03-13 | 2010-04-22 | Vdf Futureceuticals, Inc. | Compositions and Methods of Dehydrated Food Fortification |
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| AU2010228525B2 (en) * | 2009-03-24 | 2014-10-09 | Suntory Holdings Limited | Method for producing lactic acid bacteria having enhanced immunoregulating activities |
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| US9456987B2 (en) | 2013-04-03 | 2016-10-04 | Binutra, Inc. | Capsule with internal diaphragm |
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| CN111110703B (zh) * | 2020-01-13 | 2020-12-01 | 华中农业大学 | 动物双歧杆菌及其制备的复合菌制剂在制备治疗或预防禽流感病毒感染的药物中的应用 |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562908A (en) * | 1979-06-20 | 1981-01-13 | Nikken Kagaku Kk | Preparation of stable live bacterial pharmaceutical remedy |
| JPS6041465A (ja) * | 1983-08-12 | 1985-03-05 | Morinaga & Co Ltd | ビフィズス菌含有食品の製造法 |
| JPS62201823A (ja) * | 1986-02-28 | 1987-09-05 | Freunt Ind Co Ltd | 腸内有用細菌含有物およびその製造方法 |
| JPH10287573A (ja) * | 1997-04-14 | 1998-10-27 | Dr A Tosi Farmaceut Srl | トランス粘膜投与に適したラクトバシラスよりなる製薬組成物 |
| JP2001031565A (ja) * | 1999-07-19 | 2001-02-06 | Nisshin Flour Milling Co Ltd | ロキソプロフェンナトリウム含有カプセル製剤 |
| WO2002058712A2 (en) * | 2000-12-18 | 2002-08-01 | Probio Health | Probiotic compounds derived from lactobacillus casei strain ke01 |
| WO2002060437A1 (en) * | 2001-02-01 | 2002-08-08 | Shire Laboratories, Inc. | Pharmaceutical compositions including sampatrilat dispersed in a lipoidic vehicle |
| JP2002537358A (ja) * | 1999-02-26 | 2002-11-05 | サノフィ−サンテラボ | フマギリンを含有する安定な製剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3071513A (en) * | 1959-11-23 | 1963-01-01 | Upjohn Co | Process for sealing capsules |
| AU510985B2 (en) * | 1977-03-29 | 1980-07-24 | Capsugel A.G. | Liquid filled capsule |
| US4539060A (en) | 1983-02-18 | 1985-09-03 | Warner-Lambert Company | Apparatus and method of sealing capsules |
| AUPM823094A0 (en) * | 1994-09-16 | 1994-10-13 | Goodman Fielder Limited | Probiotic compositions |
| US6117477A (en) * | 1998-03-18 | 2000-09-12 | Kal Kan Foods, Inc. | Multicomponent food product and methods of making and using the same |
| AU2001233529A1 (en) * | 2000-02-10 | 2001-08-20 | Andrew W. Bruce | Probiotic therapy for newborns |
| GB0027954D0 (en) * | 2000-11-16 | 2001-01-03 | Mw Encap Ltd | Liquid filled capsules |
-
2003
- 2003-09-26 JP JP2004539961A patent/JP2006501281A/ja active Pending
- 2003-09-26 CA CA2820023A patent/CA2820023A1/en not_active Abandoned
- 2003-09-26 AU AU2003276981A patent/AU2003276981B8/en not_active Ceased
- 2003-09-26 CA CA2503510A patent/CA2503510C/en not_active Expired - Lifetime
- 2003-09-26 CA CA2549115A patent/CA2549115C/en not_active Expired - Lifetime
- 2003-09-26 EP EP03798754A patent/EP1554371A2/en not_active Withdrawn
- 2003-09-26 WO PCT/US2003/030381 patent/WO2004028460A2/en not_active Ceased
-
2006
- 2006-03-21 US US11/386,159 patent/US8846082B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562908A (en) * | 1979-06-20 | 1981-01-13 | Nikken Kagaku Kk | Preparation of stable live bacterial pharmaceutical remedy |
| JPS6041465A (ja) * | 1983-08-12 | 1985-03-05 | Morinaga & Co Ltd | ビフィズス菌含有食品の製造法 |
| JPS62201823A (ja) * | 1986-02-28 | 1987-09-05 | Freunt Ind Co Ltd | 腸内有用細菌含有物およびその製造方法 |
| JPH10287573A (ja) * | 1997-04-14 | 1998-10-27 | Dr A Tosi Farmaceut Srl | トランス粘膜投与に適したラクトバシラスよりなる製薬組成物 |
| JP2002537358A (ja) * | 1999-02-26 | 2002-11-05 | サノフィ−サンテラボ | フマギリンを含有する安定な製剤 |
| JP2001031565A (ja) * | 1999-07-19 | 2001-02-06 | Nisshin Flour Milling Co Ltd | ロキソプロフェンナトリウム含有カプセル製剤 |
| WO2002058712A2 (en) * | 2000-12-18 | 2002-08-01 | Probio Health | Probiotic compounds derived from lactobacillus casei strain ke01 |
| WO2002060437A1 (en) * | 2001-02-01 | 2002-08-08 | Shire Laboratories, Inc. | Pharmaceutical compositions including sampatrilat dispersed in a lipoidic vehicle |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008543290A (ja) * | 2005-06-14 | 2008-12-04 | エルベル・アクチエンゲゼルシヤフト | プロバイオティック健康及び体調増進食品、餌及び/又は飲料水添加物並びにその使用 |
| CN101646444B (zh) * | 2007-01-17 | 2013-11-06 | 株式会社明治 | 功能性胃肠病预防和/或治疗剂 |
| JPWO2008088008A1 (ja) * | 2007-01-17 | 2010-05-13 | 明治乳業株式会社 | 消化管機能異常症予防及び/又は治療剤 |
| US9675647B2 (en) | 2007-01-17 | 2017-06-13 | Meiji Co., Ltd. | Prophylactic and/or therapeutic agent for functional gastrointestinal disorders |
| WO2008088008A1 (ja) * | 2007-01-17 | 2008-07-24 | Meiji Dairies Corporation | 消化管機能異常症予防及び/又は治療剤 |
| JP2010535760A (ja) * | 2007-08-08 | 2010-11-25 | コンジュゴン,インコーポレーテッド | 微生物の保存および送達のための組成物および方法 |
| WO2009142170A1 (ja) * | 2008-05-19 | 2009-11-26 | 森下仁丹株式会社 | シームレスカプセル |
| KR101353692B1 (ko) * | 2009-01-12 | 2014-01-20 | 화이자 이탈리아 에스.알.엘. | 프로바이오틱 및 프리바이오틱 성분 및 무기 염을 락토페린과 함께 포함하는 조성물 |
| JP2012515167A (ja) * | 2009-01-12 | 2012-07-05 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | プロバイオティクスおよびプレバイオティクス構成要素ならびに無機塩をラクトフェリンとともに含む組成物 |
| JPWO2011027719A1 (ja) * | 2009-09-02 | 2013-02-04 | 株式会社明治 | ラクトバチルス属乳酸菌の増殖促進剤及び/又は生残性向上剤 |
| WO2011027719A1 (ja) * | 2009-09-02 | 2011-03-10 | 明治乳業株式会社 | ラクトバチルス属乳酸菌の増殖促進剤及び/又は生残性向上剤 |
| JP2013531506A (ja) * | 2010-06-28 | 2013-08-08 | プロバイオティカル・ソシエタ・ペル・アチオニ | 疝痛に罹患した幼児から単離したガス産生大腸菌群を阻害するlactobacilliの使用 |
| JP2013533313A (ja) * | 2010-08-10 | 2013-08-22 | アール.ピー. シェーラー テクノロジーズ エルエルシー | マイクロカプセル化されたプロバイオティクス細菌を含む安定なソフトゲルカプセルを製造する方法 |
| JP2013540079A (ja) * | 2010-09-21 | 2013-10-31 | バイオガイア・エイビー | 乳酸菌及び乾燥剤を含む産物 |
| JP2016193763A (ja) * | 2010-09-21 | 2016-11-17 | バイオガイア・エイビーBiogaia AB | 乳酸菌及び乾燥剤を含む産物 |
| WO2021075073A1 (ja) * | 2019-10-17 | 2021-04-22 | 森永乳業株式会社 | 組成物、製造方法及び使用 |
| CN112094785A (zh) * | 2020-10-12 | 2020-12-18 | 中科美大(福建)生物科技有限公司 | 一种动物双歧杆菌及其制剂与应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2503510A1 (en) | 2004-04-08 |
| CA2820023A1 (en) | 2007-12-19 |
| EP1554371A2 (en) | 2005-07-20 |
| CA2503510C (en) | 2014-12-02 |
| US20060159745A1 (en) | 2006-07-20 |
| WO2004028460A2 (en) | 2004-04-08 |
| CA2549115A1 (en) | 2007-12-19 |
| WO2004028460A3 (en) | 2004-06-17 |
| AU2003276981B8 (en) | 2008-09-11 |
| AU2003276981B2 (en) | 2008-08-14 |
| US8846082B2 (en) | 2014-09-30 |
| AU2003276981A1 (en) | 2004-04-19 |
| CA2549115C (en) | 2013-07-16 |
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