JP2006500016A5 - - Google Patents
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- Publication number
- JP2006500016A5 JP2006500016A5 JP2004532837A JP2004532837A JP2006500016A5 JP 2006500016 A5 JP2006500016 A5 JP 2006500016A5 JP 2004532837 A JP2004532837 A JP 2004532837A JP 2004532837 A JP2004532837 A JP 2004532837A JP 2006500016 A5 JP2006500016 A5 JP 2006500016A5
- Authority
- JP
- Japan
- Prior art keywords
- allele
- fibrostenosis
- disease
- predisposing
- nod2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700028369 Alleles Proteins 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 30
- 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 claims description 25
- 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 claims description 17
- 108700002045 Nod2 Signaling Adaptor Proteins 0.000 claims description 17
- 101150083031 Nod2 gene Proteins 0.000 claims description 13
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 11
- 208000037804 stenosis Diseases 0.000 claims description 11
- 230000036262 stenosis Effects 0.000 claims description 11
- 208000011231 Crohn disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 230000003176 fibrotic effect Effects 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 5
- 238000012408 PCR amplification Methods 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 108091092724 Noncoding DNA Proteins 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 102000050697 Nod2 Signaling Adaptor Human genes 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 102200146596 rs2066845 Human genes 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40739102P | 2002-08-30 | 2002-08-30 | |
| US10/356,736 US20040053263A1 (en) | 2002-08-30 | 2003-01-30 | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| PCT/US2003/023926 WO2004020968A2 (en) | 2002-08-30 | 2003-07-30 | Mutations in nod2 are associated with fibrostenosing disease in patients with crohn’s disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010174021A Division JP2011015686A (ja) | 2002-08-30 | 2010-08-02 | Ｎｏｄ２における変異は、クローン病を有する患者における線維性狭窄疾患に関連する |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500016A JP2006500016A (ja) | 2006-01-05 |
| JP2006500016A5 true JP2006500016A5 (https=) | 2006-09-14 |
| JP4606877B2 JP4606877B2 (ja) | 2011-01-05 |
Family
ID=31981139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532837A Expired - Fee Related JP4606877B2 (ja) | 2002-08-30 | 2003-07-30 | Ｎｏｄ２における変異は、クローン病を有する患者における線維性狭窄疾患に関連する |
| JP2010174021A Withdrawn JP2011015686A (ja) | 2002-08-30 | 2010-08-02 | Ｎｏｄ２における変異は、クローン病を有する患者における線維性狭窄疾患に関連する |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010174021A Withdrawn JP2011015686A (ja) | 2002-08-30 | 2010-08-02 | Ｎｏｄ２における変異は、クローン病を有する患者における線維性狭窄疾患に関連する |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040053263A1 (https=) |
| EP (1) | EP1556405B1 (https=) |
| JP (2) | JP4606877B2 (https=) |
| AT (1) | ATE462710T1 (https=) |
| AU (1) | AU2003263834A1 (https=) |
| DE (1) | DE60331941D1 (https=) |
| WO (1) | WO2004020968A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828132B2 (en) * | 2001-03-01 | 2004-12-07 | Ultra Biotech Limited | Biological fertilizer compositions comprising garbage |
| US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| US7662569B2 (en) * | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| US7592150B2 (en) * | 2003-12-03 | 2009-09-22 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| EP1692519B1 (en) * | 2003-12-03 | 2010-06-02 | Glycominds Ltd. | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| US20060205022A1 (en) * | 2003-12-03 | 2006-09-14 | Nir Dotan | Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease |
| DE112005001317A5 (de) * | 2004-03-27 | 2007-05-24 | Klein, Hanns-Georg, Dr. | Polymorphismen im NOD2/Card15 Gen |
| US20080260753A1 (en) * | 2004-04-09 | 2008-10-23 | The Regents Of The University Of California | Mouse Models of Crohn's Disease and a Method to Develop Specific Therapeutics |
| US10544459B2 (en) * | 2004-12-08 | 2020-01-28 | Cedars-Sinai Medical Center | Methods of using genetic variants for the diagnosis and treatment of inflammatory bowel disease |
| US20100021455A1 (en) * | 2004-12-08 | 2010-01-28 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of crohn's disease |
| US11268149B2 (en) | 2004-12-08 | 2022-03-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| US12110555B2 (en) | 2004-12-08 | 2024-10-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| WO2010048415A1 (en) * | 2008-10-22 | 2010-04-29 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
| CA2658563A1 (en) * | 2006-07-26 | 2008-01-31 | Genizon Biosciences Inc. | Crohn disease susceptibility gene |
| US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
| JP2010522537A (ja) * | 2006-11-30 | 2010-07-08 | ナビジェニクス インコーポレイティド | 遺伝子分析系および方法 |
| US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
| WO2008106451A2 (en) * | 2007-02-26 | 2008-09-04 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| WO2008116150A2 (en) | 2007-03-21 | 2008-09-25 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease |
| US20100184050A1 (en) * | 2007-04-26 | 2010-07-22 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
| US20100144903A1 (en) * | 2007-05-04 | 2010-06-10 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
| WO2009069007A2 (en) * | 2007-11-30 | 2009-06-04 | Glycominds, Ltd. | Composition and method for prediction of complicated disease course and surgeries in crohn's disease |
| WO2009143278A2 (en) * | 2008-05-20 | 2009-11-26 | Cedars-Sinai Medical Center | Methods of diagnosing and characterizing cannabinoid signaling in crohn's disease |
| US20110177969A1 (en) * | 2008-10-01 | 2011-07-21 | Cedars-Sinai Medical Center | The role of il17rd and the il23-1l17 pathway in crohn's disease |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
| CA2758531C (en) | 2009-04-14 | 2018-11-13 | Derren Barken | Inflammatory bowel disease prognostics |
| WO2011060098A1 (en) | 2009-11-10 | 2011-05-19 | Prometheus Laboratories Inc. | Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis |
| WO2011088306A1 (en) * | 2010-01-15 | 2011-07-21 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose crohn's disease |
| NZ609363A (en) | 2010-10-18 | 2015-04-24 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| DK2676137T3 (en) | 2011-02-17 | 2015-01-19 | Nestec Sa | TESTS TO DETECT AUTO ANTIBODIES FOR ANTI-TNF PHARMACEUTICALS |
| CA2830362A1 (en) * | 2011-03-25 | 2012-10-04 | Dermot P. Mcgovern | Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease |
| JP2014517279A (ja) | 2011-05-10 | 2014-07-17 | ネステク ソシエテ アノニム | 個別治療管理のための疾患活動性プロファイリングの方法 |
| SG11201401536QA (en) | 2011-10-21 | 2014-05-29 | Nestec Sa | Methods for improving inflammatory bowel disease diagnosis |
| KR102343212B1 (ko) | 2013-03-27 | 2021-12-23 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| JP2016522679A (ja) | 2013-04-04 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用 |
| WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| KR20260048600A (ko) | 2015-03-27 | 2026-04-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 변형된 t 세포 및 이의 제조 및 사용 방법 |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
| US11913015B2 (en) | 2017-04-17 | 2024-02-27 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
| CA3124970A1 (en) * | 2018-12-28 | 2020-07-02 | Cedars-Sinai Medical Center | Methods of treating inflammatory bowel diseases that target ripk2 |
| WO2021097131A1 (en) * | 2019-11-12 | 2021-05-20 | Orchard Therapeutics (Europe) Limited | Compositions and methods for treating or preventing crohn's disease |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3157053B2 (ja) * | 1992-09-16 | 2001-04-16 | ティーディーケイ株式会社 | Ｄｎａ作用物質の結合様式特定方法 |
| US5830675A (en) * | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
| EP0615129B1 (en) * | 1993-03-10 | 2000-05-31 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis or primary sclerosing cholangitis |
| US5691151A (en) * | 1994-10-07 | 1997-11-25 | Regents Of University Of California | Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca |
| US6074835A (en) * | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US5874233A (en) * | 1996-04-12 | 1999-02-23 | Cedars-Sinai Medical Center | Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis |
| WO1997038642A1 (en) * | 1996-04-12 | 1997-10-23 | Cedars-Sinai Medical Center | Methods of determining the risk of pouchitis development |
| US5916748A (en) * | 1996-04-12 | 1999-06-29 | Cedars-Sinai Medical Center | Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis |
| US5968741A (en) * | 1997-04-11 | 1999-10-19 | Cedars-Sinai Medical Center | Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis |
| US6514700B1 (en) * | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| JP2001269196A (ja) * | 2000-03-24 | 2001-10-02 | Hamamatsu Photonics Kk | 被検体核酸の定量方法、および被検体核酸の分子数の計数方法 |
| US7138237B1 (en) * | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| US20030092019A1 (en) * | 2001-01-09 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
| US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
-
2003
- 2003-01-30 US US10/356,736 patent/US20040053263A1/en not_active Abandoned
- 2003-07-30 DE DE60331941T patent/DE60331941D1/de not_active Expired - Lifetime
- 2003-07-30 AU AU2003263834A patent/AU2003263834A1/en not_active Abandoned
- 2003-07-30 WO PCT/US2003/023926 patent/WO2004020968A2/en not_active Ceased
- 2003-07-30 AT AT03791618T patent/ATE462710T1/de not_active IP Right Cessation
- 2003-07-30 EP EP03791618A patent/EP1556405B1/en not_active Expired - Lifetime
- 2003-07-30 JP JP2004532837A patent/JP4606877B2/ja not_active Expired - Fee Related
- 2003-07-30 US US10/526,256 patent/US7790370B2/en not_active Expired - Lifetime
-
2010
- 2010-08-02 JP JP2010174021A patent/JP2011015686A/ja not_active Withdrawn
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